Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

Neurobiology of Disease

Volumn 54, Issue , 2013, Pages 382-391

  Choi, Bo Young ^a   Jang, Bong Geom ^a   Kim, Jin Hee ^a   Seo, Jae Nam ^a   Wu, Guang ^a   Sohn, Min ^b   Chung, Tae Nyoung ^c   Suh, Sang Won ^a  

^a Hallym University   (South Korea)

^b Inha University   (South Korea)

^c CHA University School of Medicine   (South Korea)

Author keywords

Autophagy; BBB disruption; Copper; Experimental autoimmune encephalomyelitis; Microglia; MMP 9; Multiple sclerosis; Zinc

Indexed keywords

CD11B ANTIGEN; CD20 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CLIOQUINOL; COPPER; GELATINASE B; MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; ZINC;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASTROCYTE; AUTOPHAGY; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BRAIN CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CEREBELLUM; CHELATION THERAPY; CONTROLLED STUDY; DEMYELINATION; FEMALE; MONONUCLEAR CELL; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SPINAL CORD; UPREGULATION; WHITE MATTER LESION;

ANIMALS; AXONS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CHELATING AGENTS; CLIOQUINOL; COPPER; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; SPINAL CORD; ZINC;

EID: 84876311482     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.01.012     Document Type: Article

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