Sequestration of iron by Lewy bodies in Parkinson's disease

Acta Neuropathologica

Volumn 100, Issue 2, 2000, Pages 111-114

  Castellani, Rudy J ^a   Siedlak, Sandra L ^a   Perry, George ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Diffuse Lewy body disease; Iron; Lewy body; Oxidative stress; Parkinson's disease

Indexed keywords

HYDROXYL RADICAL; IRON;

ADULT; AGED; ARTICLE; BRAIN STEM; CASE REPORT; HUMAN; HUMAN TISSUE; LEWY BODY; NERVE CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTECTION; SUBSTANTIA NIGRA;

EID: 0033947467     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050001     Document Type: Article

References (24)

1. Alam ZI, Daniel SE, Lees AJ, Marsden DC, Jenner P, Halliwell B (1997) A generalized increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease. J Neurochem 69: 1326-1329
2. Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P, Halliwell B (1997) Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 69: 1196-1203
3. Ben-Shachar D, Eshel G, Finberg JPM, Youdim MBH (1991) The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J Neurochem 56: 1441-1444
4. Castellani R, Smith M, Richey P, Perry G (1996) Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res 737: 195-200
5. Connor JR, Menzies SL, St. Martin SM, Mufson EJ (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res 31: 75-83
6. Connor JR, Snyder BS, Arosio P, et al (1995) Quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer disease brains. J Neurochem 65: 717-724
7. Dexter DT, Wells FR, Lees AJ, et al (1989) Increased nigral iron content and alternations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 52: 1830-1836
8. Dexter DT, Sian J, Rose S, et al (1994) Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol 35: 38-44
9. Good PF, Olanow CW, Perl DP (1992) Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Res 593: 343-346
10. Hirsch EC, Brandel J-P, Galle P, et al (1991) Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J Neurochem 56: 446-451
11. Jellinger K, Kienzl E, Rumpelmair G, Riederer P, Stachelberger H, Ben-Shachar D, Youdim MB (1992) Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis. J Neurochem 59: 1168-1171
12. Jenner P, Olanow CW (1998) Understanding cell death in Parkinson's disease. Ann Neurol 44 [Suppl 1]: S72-S84
13. Kienzl E, Puchinger L, Jellinger K, Linert W, Stachelberger H, Jameson RF (1995) The role of transition metals in the pathogenesis of Parkinson's disease. J Neurol Sci 134: 69-78
14. Manetto V, Perry G, Tabaton M, Mulvihill P, Fried VA, Smith HT, Gambetti P, Autilio-Gambetti L (1988) Ubiquitin is associated with abnormal cyloplasmic filaments characteristic of neurodegenerative diseases. Proc Natl Acad Sci USA 85: 4501-4505
15. Mizuno Y, Ohta S, Tanaka M, et al (1989) Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 163: 1450-1455
16. Olanow CW (1990) Oxidation reactions in Parkinson's disease. Neurology 40: 32-37
17. Perry TL, Godin DV, Hansen S (1982) Parkinson's disease: a disorder due to nigral glutathione deficiency. Neurosci Lett 33: 305-310
18. Schapira AHV, Cooper JM, Dexter D, et al (1990) Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 54: 823-827
19. Sengstock G, Olanow CW, Dunn AJ, et al (1994) Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Exp Neurol 130: 82-94
20. Smith MA, Perry G (1994) Is a Lewy body always a Lewy body? In: Korczyn AD (ed) Dementia in Parkinson's disease. Monduzzi Editore, Bologna, pp 187-193
21. Smith MA, Harris PLR, Sayre LM, Perry G (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci USA 94: 9866-9868
22. Sofic E, Paulus W, Jellinger K, et al (1991) Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J Neurchem 56: 978-892
23. Valberg LS, Flanagan PR, Kertesz A, Ebers GC (1989) Abnormalities in iron metabolism in multiple sclerosis. Can J Neurol Sci 16: 184-186
24. Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, Montine TJ (1999) Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 154: 1423-1429