Zika virus: From pathogenesis to disease control

FEMS Microbiology Letters

Volumn 363, Issue 18, 2016, Pages

  Barzon, Luisa ^a   Trevisan, Marta ^a   Sinigaglia, Alessandro ^a   Lavezzo, Enrico ^a   Palù, Giorgio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antiviral drugs; Clinical features; Diagnosis; Pathogenesis; Transmission; Vaccines; Zika virus

Indexed keywords

7 DEAZA 2' C METHYLADENOSINE; ANTIVIRUS AGENT; BORTEZOMIB; CYCLOSPORIN A; DAPTOMYCIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; IVERMECTIN; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2A; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5; PYRIMETHAMINE; SERTRALINE; UNCLASSIFIED DRUG; ZIKA VIRUS VACCINE;

AGYRIA; ANHYDRAMNIOS; ARTHROGRYPOSIS; BRAIN ATROPHY; BRAIN CALCIFICATION; BRAIN VENTRICLE DILATATION; CASE CONTROL STUDY; CHORIORETINITIS; CORPUS CALLOSUM AGENESIS; CYTOTROPHOBLAST; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE TRANSMISSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS HYDROPS; GUILLAIN BARRE SYNDROME; HUMAN; HYDRAMNIOS; HYDROCEPHALUS; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTRAUTERINE GROWTH RETARDATION; LEUKOPENIA; LIFE CYCLE STAGE; MENINGOENCEPHALITIS; MICROCEPHALY; MOLECULAR DYNAMICS; MUCOSAL BLEEDING; MYELITIS; NEXT GENERATION SEQUENCING; NONHUMAN; OLIGOHYDRAMNIOS; PETECHIA; PLACENTA DISORDER; PLACENTAL CALCIFICATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION LOOP MEDIATED ISOTHERMAL AMPLIFICATION; REVIEW; THROMBOCYTOPENIA; VACCINATION; VIRUS ISOLATION; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; ZIKA FEVER; ZIKA VIRUS;

EID: 84991031805     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1093/femsle/fnw202     Document Type: Review

References (209)

1. Abbink P, Larocca RA, De La Barrera RA et al. Protective efficacy ofmultiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science 2016;353:1129-32.
2. Akey DL, Brown WC, Dutta S et al. Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science 2014;343:881-5.
3. Aliota MT, Caine EA, Walker EC et al. Characterization of lethal Zika virus infection in AG129 mice. PLoS Negl Trop Dis 2016a;10:e0004682.
4. Aliota MT, Dudley DM, Newman CM et al. Heterologous protection against Asian Zika virus challenge in rhesus macaques. bioRxiv 2016b, DOI: http://dx.doi.org/10.1101/059592.
5. Andries AC, Duong V, Ly S et al. Value of routine dengue diagnostic tests in urine and saliva specimens. PLoS Negl Trop Dis 2015;9:e0004100.
6. Barba-Spaeth G, Dejnirattisai W, Rouvinski A et al. Structural basis of potent Zika-dengue virus antibody crossneutralization. Nature 2016;536:48-53.
7. Barjas-Castro ML, Angerami RN, Cunha MS et al. Probable transfusion-transmitted Zika virus in Brazil. Transfusion 2016;56:1684-8.
8. Barrows NJ, Campos RK, Powell ST et al. A Screen of FDAapproved drugs for inhibitors of Zika virus infection. Cell Host Microbe 2016;20:259-270.
9. Barthel A, Gourinat AC, Cazorla C et al. Breast milk as a possible route of vertical transmission of dengue virus? Clin Infect Dis 2013;57:415-7.
10. Barzon L, Pacenti M, Berto A et al. Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning fromthe Dominican Republic to Italy, January 2016. Euro Surveill 2016a;21:30159.
11. Barzon L, Pacenti M, Franchin E et al. Novel West Nile virus lineage 1a full genome sequences from human cases of infection in north-eastern Italy, 2011. Clin Microbiol Infect 2012;18:E541-4.
12. Barzon L, Pacenti M, Franchin E et al. Excretion of West Nile virus in urine during acute infection. J Infect Dis 2013;208: 1086-92.
13. Barzon L, Pacenti M, Franchin E et al. Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016. Euro Surveill 2016b;21:30316.
14. Barzon L, Pacenti M, Sinigaglia A et al. West Nile virus infection in children. Expert Rev Anti Infect Ther 2015a;13:1373-86.
15. Barzon L, PacentiM, Ulbert S et al. Latest developments and challenges in the diagnosis of human West Nile virus infection. Expert Rev Anti Infect Ther 2015b;13:327-42.
16. Bayer A, Lennemann NJ, Ouyang Y et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe 2016;19: 705-12.
17. Beasley DW1, Whiteman MC, Zhang S et al. Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains. J Virol 2005;79:8339-47.
18. Bell TM, Field EJ, Narang HK. Zika virus infection of the central nervous system of mice. Arch Gesamte Virusforsch 1971;35:183-93.
19. BesnardM, Eyrolle-Guignot D, Guillemette-Artur P et al. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia. Euro Surveill 2016;21:30181.
20. BesnardM, Lastere S, Teissier A et al. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 2014;19:20751.
21. Bingham AM, Cone M, Mock V et al. Comparison of test results for Zika virus RNA in urine, serum, and saliva specimens from persons with travel-associated Zika virus disease-Florida, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 475-8.
22. Bollati M, Alvarez K, Assenberg R et al. Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res 2010;87:125-48.
23. Bonaldo MC, Ribeiro IP, Lima NS et al. Isolation of infective Zika virus from urine and saliva of patients in Brazil. PLoS Negl Trop Dis 2016;10:e0004816.
24. Brasil P, Calvet GA, de Souza RV et al. Exanthema associated with Zika virus infection. Lancet Infect Dis 2016b;16:866.
25. Brasil P, Calvet GA, Siqueira AM et al. Zika virus outbreak in Rio de Janeiro, Brazil: clinical characterization, epidemiological and virological aspects. PLoS Negl Trop Dis 2016a;10:e0004636.
26. Brasil P, Pereira JP, Raja Gabaglia C et al. Zika virus infection in pregnantwomen in Rio de Janeiro-Preliminary report. N Engl J Med 2016c, DOI: 10.1056/NEJMoa1602412.
27. Broutet N, Krauer F, Riesen M et al. Zika virus as a cause of neurologic disorders. N Engl J Med 2016;374:1506-9.
28. Brown WC, Akey DL, Konwerski JR et al. Extended surface for membrane association in Zika virus NS1 structure. Nat Struct Mol Biol 2016;23:865-7.
29. Calvet G, Aguiar RS, Melo AS et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 2016;16: 653-60.
30. Calvet GA, Filippis AM, Mendonca MC et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J Clin Virol 2015;74:1-3.
31. Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis 2015;21:1885-6.
32. Cao-Lormeau VM, Blake A,Mons S et al. Guillain-Barré syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 2016;387:1531-9.
33. Cao-Lormeau VM, Roche C, Teissier A et al. Zika virus, French Polynesia, South Pacific, 2014. Emerg Infect Dis 2014;20: 1085-6.
34. Cardoso CW, Paploski IA, Kikuti M et al. Outbreak of exanthematous illness associated with Zika, chikungunya, and dengue viruses, Salvador, Brazil. Emerg Infect Dis 2015;21:2274-6.
35. Carteaux G, Maquart M, Bedet A et al. Zika virus associated with meningoencephalitis. N Engl J Med 2016;374:1595-6.
36. Cauchemez S, Besnard M, Bompard P et al. Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet 2016;387:2125-32.
37. Centers for Disease Control and Prevention (CDC). PossibleWest Nile virus transmission to an infant through breast-feeding-Michigan, 2002. MMWR Morb Mortal Wkly Rep 2002;51:877-8.
38. Centers for Disease Control and Prevention (CDC). HAN Priority Professional and Media Partners Update. Update: Interim Guidelines for Prevention of Sexual Transmission of Zika Virus-United States, 2016. Atlanta: CDC, 2016a. http://content. govdelivery.com/accounts/USCDC/bulletins/1383154 (13 August 2016, date last accessed).
39. Centers for Disease Control and Prevention (CDC). Zika and Blood Transfusion. Atlanta: CDC, 2016b. http://www.cdc. gov/zika/transmission/blood-transfusion.html (13 August 2016, date last accessed).
40. Centers for Disease Control and Prevention (CDC). Zika Virus. Atlanta: CDC, 2016c. http://www.cdc.gov/zika/(13 August 2016, date last accessed).
41. Chouin-Carneiro T, Vega-Rua A, VazeilleMet al. Differential susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika virus. PLoS Negl Trop Dis 2016;10:e0004543.
42. Center for Infectious Disease Research and Policy (CIDRAP). Brazil Confirms Blood-Transfusion Zika; PAHO Calls for Global Support: CIDRAP. Minneapolis: CIDRAP, 2016. http://www.cidrap.umn.edu/news-perspective/2016/02/brazilconfirms-blood-transfusion-zika-paho-calls-global-support (13 August 2016, date last accessed).
43. Cohen J. Zika vaccine has a good shot. Science 2016;353:529-30.
44. Cordeiro MT, Pena LJ, Brito CA et al. Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil. Lancet 2016;387:1811-2.
45. Corman VM, Rasche A, Baronti C et al. Clinical comparison, standardization and optimization of Zika virus molecular detection [Submitted]. Bull World Health Organ April 19, 2016, DOI: 10.2471/BLT.16.175950.
46. Cugola FR, Fernandes IR, Russo FB et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 2016;534:267-71.
47. Dai L, Song J, LuXet al. Structures of the Zika virus envelope protein andi complex with a flavivirus broadly protective antibody. Cell Host Microbe 2016;19:696-704.
48. Dang J, Tiwari SK, Lichinchi G et al. Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell 2016;19:258-65.
49. Davidson A, Slavinski S, Komoto K et al. Suspected female-tomale sexual transmission of Zika virus-New York City, 2016. MMWR Morb Mortal Wkly Rep 2016;65:716-7.
50. Deckard DT, Chung WM, Brooks JT et al. Male-to-male sexual transmission of Zika virus-Texas, January 2016.MMWRMorb Mortal Wkly Rep 2016;65:372-4.
51. Dejnirattisai W, Supasa P, Wongwiwat W et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol 2016;17:1102-8.
52. de Paula Freitas B, de Oliveira Dias JR, Prazeres J et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol 2016;134:529-35.
53. Diallo D, Sall AA, Diagne CT et al. Zika virus emergence in mosquitoes in southeastern Senegal, 2011. PLoS One 2014;9:e109442.
54. Dick GW. Zika virus. II. Pathogenicity and physical properties. Trans R Soc Trop Med Hyg 1952;46:521-34.
55. Dick GW, Kitchen SF, Haddow AJ et al. Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952;46:509-20.
56. Di Luca M, Severini F, Toma L et al. Experimental studies of susceptibility of Italian Aedes albopictus to Zika virus. Euro Surveill 2016;21:30223.
57. D'Ortenzio E, Matheron S, de Lamballerie X et al. Evidence of sexual transmission of Zika virus. N Engl J Med 2016;374:2195-8.
58. Dowall SD, Graham VA, Rayner E et al. A susceptible mouse model for Zika virus infection. PLoS Negl Trop Dis 2016;10:e0004658.
59. Dowd KA, DeMaso CR, Pelc RS et al. Broadly neutralizing activity of Zika virus-immune sera identifies a single viral serotype. Cell Rep 2016;16:1485-91.
60. Driggers RW, Ho CY, Korhonen EM et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med 2016;374:2142-51.
61. Dudley DM, Aliota MT, Mohr EL et al. A rhesus macaque model of Asian-lineage Zika virus infection. Nat Commun 2016;7: 12204.
62. Duffy MR, Chen TH, Hancock WT et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009;360:2536-43.
63. Dupont-Rouzeyrol M, Biron A, O'Connor O et al. Infectious Zika viral particles in breastmilk. Lancet 2016;387:1051.
64. Dupont-Rouzeyrol M, O'Connor O, Calvez E et al. Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis 2015;21:381-2.
65. European Centre for Disease Prevention and Control (ECDC). ECDC Proposed Case Definition for Surveillance of Zika Virus Infection. Solna, Sweden: ECDC, 2016a. http://ecdc.europa.eu/en/healthtopics/zika virus infection/patient-case-management/Pages/case-definition.aspx#sthash.T4Ref5nF.dpuf (13 August 2016, date last accessed).
66. European Centre for Disease Prevention and Control (ECDC). Zika Virus. Solna, Sweden: ECDC, 2016b. http://ecdc.europa. eu/en/healthtopics/zika virus infection/zika-outbreak/Pages/epidemiological-situation.aspx#sthash.PRFMsQip.dpuf (13 August 2016, date last accessed).
67. European Centre for Disease Prevention and Control (ECDC). Interim Guidance for Healthcare Providers and Zika Virus Laboratory Diagnosis. Solna, Sweden: ECDC, 2016c. http://ecdc. europa.eu/en/publications/layouts/forms/Publication Disp Form.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID =1461 (13 August 2016, date last accessed).
68. European Centre for Disease Prevention and Control (ECDC). Rapid Risk Assessment: Zika Virus Disease Epidemic: Potential Association With Microcephaly and Guillain-Barré Syndrome, Fifth Update, 11 April 2016. Solna, Sweden: ECDC, 2016d. http://ecdc.europa.eu/en/publications/layouts/forms/Publication DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=1466#sthash.iQcraYA2.dpuf (13 August 2016, date last accessed).
69. Eyer L, Nencka R, Huvarová I et al. Nucleoside inhibitors of Zika virus. J Infect Dis 2016;214:707-11.
70. Faria NR, Azevedo Rdo S, Kraemer MU et al. Zika virus in the Americas: early epidemiological and genetic findings. Science 2016;352:345-9.
71. Faye O, Faye O, Diallo D et al. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes. Virol J 2013;10:311.
72. Faye O, Faye O, Dupressoir A et al. One-step RT-PCR for detection of Zika virus. J Clin Virol 2008;43:96-101.
73. Faye O, Freire CC, Iamarino A et al. Molecular evolution of Zika virus during its emergence in the 20th century. PLoS Negl Trop Dis 2014;8:e2636.
74. Foy BD, Kobylinski KC, Chilson Foy JL et al. Probable non-vectorborne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 2011;17:880-2.
75. França GV, Schuler-Faccini L, Oliveira WK et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 2016;388: 891-7.
76. Frumence E, Roche M, Krejbich-Trotot P et al. The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-β production and apoptosis induction. Virology 2016;493:217-26.
77. Furtado JM, Espósito DL, Klein TM et al. Uveitis associated with Zika virus infection. N Engl J Med 2016;375:394-6.
78. Garcez PP, Loiola EC, Madeiro da Costa R et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 2016;352:816-8.
79. Gardner LM, Chen N, Sarkar S. Global risk of Zika virus depends critically on vector status of Aedes albopictus. Lancet Infect Dis 2016;16:522-3.
80. GauntMW, Sall AA, de Lamballerie X et al. Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography. J Gen Virol 2001;82:1867-76.
81. Gourinat AC, O'Connor O, Calvez E et al. Detection of Zika virus in urine. Emerg Infect Dis 2015;21:84-6.
82. Grant A, Ponia SS, Tripathi S et al. Zika virus targets human STAT2 to inhibit type I interferon signaling. Cell Host Microbe 2016;19:882-90.
83. Grard G, Caron M, Mombo IM et al. Zika Virus in Gabon (Central Africa)-2007: a new threat from Aedes albopictus? PLoS Negl Trop Dis 2014;8:e2681.
84. Guerbois M, Fernandez-Salas I, Azar SR et al. Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by Aedes aegypti mosquitoes in the Americas. J Infect Dis 2016, DOI: 10.1093/infdis/jiw302.
85. Guzman MG, Alvarez M, Halstead SB. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol 2013;158:1445-59.
86. Haddow AD, Schuh AJ, Yasuda CY et al. Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis 2012;6:e1477.
87. Hamel R, Dejarnac O,Wichit S et al. Biology of Zika virus infection in human skin cells. J Virol 2015;89:8880-96.
88. Hanners NW, Eitson JL, Usui N et al. Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects. Cell Rep 2016;15:2315-22.
89. Hayes EB. Zika virus outside Africa. Emerg Infect Dis 2009;15:1347-50.
90. Hirayama T, Mizuno Y, Takeshita N et al. Detection of dengue virus genome in urine by real-time reverse transcriptase PCR: a laboratory diagnostic method useful after disappearance of the genome in serum. J Clin Microbiol 2012;50: 2047-52.
91. Huzly D, Hanselmann I, Schmidt-Chanasit J et al. High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses. Euro Surveill 2016;21: 30203.
92. Karimi O, Goorhuis A, Schinkel J et al. Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection. Lancet 2016;387:939-40.
93. Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy-Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016;65:242-7.
94. Klema VJ, Ye M, Hindupur A et al. Dengue virus nonstructural protein 5 (NS5) assembles into a dimer with a unique methyltransferase and polymerase interface. PLoS Pathog 2016;12:e1005451.
95. Korhonen EM, Huhtamo E, Virtala AM et al. Approach to noninvasive sampling in dengue diagnostics: exploring virus and NS1 antigen detection in saliva and urine of travelers with dengue. J Clin Virol 2014;61:353-8.
96. Kostyuchenko VA, Lim EX, Zhang S et al. Structure of the thermally stable Zika virus. Nature 2016;533:425-8.
97. Kuehnert MJ, Basavaraju SV, Moseley RR et al. Screening of blood donations for Zika virus infection-Puerto Rico, April 3-June 11, 2016. MMWR Morb Mortal Wkly Rep 2016;65:627-8.
98. Kuhn S, Twele-Montecinos L, MacDonald J et al. Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk. CMAJ 2011;183:E243-5.
99. Lanciotti RS, Kosoy OL, Laven JJ et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008;14:1232-9.
100. Larocca RA, Abbink P, Peron JP et al. Vaccine protection against Zika virus from Brazil. Nature 2016;536:474-8.
101. Lavezzo E, Barzon L, Toppo S et al. Third generation sequencing technologies applied to diagnosticmicrobiology: benefits and challenges in applications and data analysis. Expert Rev Mol Diagn 2016;16:1011-23.
102. Lazear HM, Govero J, SmithAMet al. Amousemodel of Zika virus pathogenesis. Cell Host Microbe 2016;19:720-30.
103. Leal MC, Muniz LF, Caldas Neto SD et al. Sensorineural hearing loss in a case of congenital Zika virus. Braz J Otorhinolaryngol 2016, DOI: 10.1016/j.bjorl.2016.06.001.
104. Ledermann JP, Guillaumot L, Yug L et al. Aedes hensilli as a potential vector of chikungunya and Zika viruses. PLoS Negl Trop Dis 2014;8:e3188.
105. Lei J, Hansen G, Nitsche C et al. Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor. Science 2016;353:503-5.
106. Lesser J, Ott CT, Carcelen A et al. Times to key events in the course of Zika infection and their implications: a systematic review and pooled analysis [Submitted]. BullWorld Health Organ April 1, 2016. DOI: 10.2471/BLT.16.174540.
107. Leung GH, Baird RW, Druce J et al. Zika virus infection in Australia following a monkey bite in Indonesia. Southeast Asian J Trop Med Public Health 2015;46:460-4.
108. Leung JY, Pijlman GP, Kondratieva N et al. Role of nonstructural protein NS2A in flavivirus assembly. J Virol 2008;82:4731-41.
109. Li C, Xu D, Ye Q et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 2016;19:120-6.
110. Li MI,Wong PS, Ng LC et al. Oral susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika virus. PLoS Negl Trop Dis 2012;6:e1792.
111. Lustig Y, Mendelson E, Paran N et al. Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016. Euro Surveill 2016;21:30269.
112. Ma L, Jones CT, Groesch TD et al. Solution structure of dengue virus capsid protein reveals another fold. Proc Natl Acad Sci U S A 2004;101:3414-9.
113. Makhluf H, Kim K, Shresta S. Novel strategies for discovering inhibitors of Dengue and Zika fever. Expert Opin Drug Discov 2016;11:921-3.
114. Marceau CD, Puschnik AS, Majzoub K et al. Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature 2016;535:159-63.
115. Marchette NJ, Garcia R, Rudnick A et al. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg 1969;18:411-5.
116. Martines RB, Bhatnagar J, de Oliveira Ramos AM et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet 2016a;388:898-904.
117. Martines RB, Bhatnagar J, Keating MK et al. Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses-Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016b;65:159-60.
118. Martins KA, Dye JM, Bavari S. Considerations for the development of Zika virus vaccines. Vaccine 2016;34:3711-2.
119. Meaney-Delman D, Hills SL,Williams C et al. Zika virus infection among U.S. pregnant travelers-August 2015-February 2016. MMWR Morb Mortal Wkly Rep 2016a;65:211-4.
120. Meaney-Delman D, Oduyebo T, Polen KN et al. Prolonged detection of Zika virus RNA in pregnant women. Obstet Gynecol 2016b, DOI: 10.1097/AOG.0000000000001625.
121. Mécharles S, Herrmann C, Poullain P et al. Acute myelitis due to Zika virus infection. Lancet 2016;387:1481.
122. Meertens L, Carnec X, LecoinMP et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe 2012;12:544-57.
123. Meltzer E, Leshem E, Lustig Y et al. The clinical spectrum of Zika virus in returning travelers. Am J Med 2016, DOI: 10.1016/j.amjmed.2016.04.034.
124. Microcephaly Epidemic Research Group. Microcephaly in infants, Pernambuco State, Brazil, 2015. Emerg Infect Dis 2016;22:1090-3.
125. Miner JJ, Cao B, Govero J et al. Zika virus infection during pregnancy inmice causes placental damage and fetal demise. Cell 2016;165:1081-91.
126. Ministeŕio da Saúde (Brasil). Ministeŕio da Saúde investiga aumento de casos de microcefalia em Pernambuco. Brasília: Ministério da Saúde, 2015. http://portalsaude.saude.gov.br/index. php/cidadao/principal/agencia-saude/20629-ministerio-dasaude-investiga-aumento-de-casos-de-microcefalia-empernambuco (13 August 2016, date last accessed).
127. Mlakar J, Korva M, Tul N et al. Zika virus associated with microcephaly. N Engl J Med 2016;374:951-8.
128. Morrison C. DNA vaccines against Zika virus speed into clinical trials. Nat Rev Drug Discov 2016;15:521-2.
129. Musso D. Zika virus transmission from French Polynesia to Brazil. Emerg Infect Dis 2015;21:1887.
130. Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: following the path of dengue and chikungunya? Lancet 2015a;386:243-4.
131. Musso D, Gubler DJ. Zika virus. Clin Microbiol Rev 2016;29: 487-524.
132. Musso D, Nhan T, Robin E et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill 2014;19:20761.
133. Musso D, Roche C, Nhan TX et al. Detection of Zika virus in saliva. J Clin Virol 2015b;68:53-5.
134. Musso D, Roche C, Robin E et al. Potential sexual transmission of Zika virus. Emerg Infect Dis 2015c;21:359-61.
135. Mysorekar IU, Diamond MS. Modeling Zika virus infection in pregnancy. N Engl J Med 2016;375:481-4.
136. Nemésio H, Palomares-Jerez F, Villalaín J. NS4A and NS4B proteins from dengue virus: membranotropic regions. Biochim Biophys Acta 2012;1818:2818-30.
137. Nicastri E, Castilletti C, Liuzzi G et al. Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016. Euro Surveill 2016;21:30314.
138. Nowakowski TJ, Pollen AA, Di Lullo E et al. Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells. Cell Stem Cell 2016;18:591-6.
139. Oduyebo T, Igbinosa I, Petersen EE et al. Update: interim guidance for health care providers caring for pregnant women with possible Zika virus exposure-United States, July 2016. MMWR Morb Mortal Wkly Rep 2016;65:739-44.
140. Oehler E,Watrin L, Larre P et al. Zika virus infection complicated by Guillain-Barre syndrome-case report, French Polynesia, December 2013. Euro Surveill 2014;19:20720.
141. Oliveira Melo AS, Malinger G, Ximenes R et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol 2016;47:6-7.
142. Pacheco O, Beltrán M, Nelson CA et al. Zika Virus disease in Colombia-Preliminary report. N Engl J Med 2016, DOI: 10.1056/NEJMoa1604037.
143. Pan American Health Organization (PAHO). Epidemic Diseases-Zika in the Americas. Washington: PAHO, 2016a. http://ais. paho.org/phip/viz/ed zika cases.asp (13 August 2016, date last accessed).
144. Pan American Health Organization (PAHO). Epidemiological Update: Neurological Syndrome, Congenital Malformations, and Zika Virus Infection. Washington: PAHO, 2016b. http://www.paho.org/hq/index.php?option=com docman& task=doc download&Itemid=&gid=32879&lang=en (13 August 2016, date last accessed).
145. Pan American Health Organization (PAHO). Regional Zika Epidemiological Update (Americas). Washington: PAHO, 2016c. http://www.paho.org/hq/index.php?option=com content&id =11599&Itemid=41691 (13 August 2016, date last accessed).
146. Pardee K, Green AA, Takahashi MK et al. Rapid, low-cost detection of Zika virus using programmable biomolecular components. Cell 2016;165:1255-66.
147. Paixão ES, Teixeira MG, CostaMD et al. Dengue during pregnancy and adverse fetal outcomes: a systematic review and metaanalysis. Lancet Infect Dis 2016;16:857-65.
148. Petersen EE, Polen KN, Meaney-Delman D et al. Update: interim guidance for health care providers caring for women of reproductive age with possible Zika virus exposure-United States, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 315-22.
149. Pierson TC, Diamond MS. Degrees of maturity: the complex structure and biology of flaviviruses. Curr Opin Virol 2012;2:168-75.
150. Prisant N, Bujan L, Benichou H et al. Zika virus in the female genital tract. Lancet Infect Dis 2016;16:1000-1.
151. Priyamvada L, Quicke KM, Hudson WH et al. Human antibody responses after dengue virus infection are highly crossreactive to Zika virus. Proc Natl Acad Sci U S A 2016;113: 7852-7.
152. Pyke AT, Daly MT, Cameron JN et al. Imported Zika virus infection from the Cook Islands into Australia, 2014. PLoS Curr 2014;6:ecurrents.outbreaks. 4635a54dbffba2156fb2fd76dc49f65e.
153. Qian X, Nguyen HN, Song MM et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 2016;165:1238-54.
154. Quicke KM, Bowen JR, Johnson EL et al. Zika virus infects human placental macrophages. Cell Host Microbe 2016;20:83-90.
155. Rabe IB, Staples JE, Villanueva J et al. Interim guidance for interpretation of Zika virus antibody test results. MMWR Morb Mortal Wkly Rep 2016;65:543-6.
156. Rasmussen SA, Jamieson DJ, Honein MA et al. Zika virus and birth defects-Reviewing the evidence for causality. N Engl J Med 2016;374:1981-7.
157. Rossi SL, Tesh RB, Azar SR et al. Characterization of a novel murine model to study Zika virus. Am J Trop Med Hyg 2016;94:1362-9.
158. Roth A, Mercier A, Lepers C et al. Concurrent outbreaks of dengue, chikungunya and Zika virus infections-an unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014. Euro Surveill 2014;19:20929.
159. Sardi S, Somasekar S, Naccache SN et al. Coinfections from Zika and Chikungunya virus in Bahia, Brazil identified by metagenomic next-generation sequencing. J Clin Microbiol 2016;54:2348-53.
160. Sarmiento-Ospina A, Vásquez-Serna H, Jimenez-Canizales CE et al. Zika virus associated deaths in Colombia. Lancet Infect Dis 2016;16:523-4.
161. Sarno M, Sacramento GA, Khouri R et al. Zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. PLoS Negl Trop Dis 2016;10:e0004517.
162. Savidis G, McDougall WM, Meraner P et al. Identification of Zika virus and dengue virus dependency factors using functional genomics. Cell Rep 2016a;16:232-46.
163. Savidis G, Perreira JM, Portmann JM et al. The IFITMs inhibit Zika virus replication. Cell Rep 2016b;15:2323-30.
164. Scaramozzino N, Crance JM, Jouan A et al. Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol 2001;39:1922-7.
165. Scaturro P, Cortese M, Chatel-Chaix L et al. Dengue virus nonstructural protein 1 modulates infectious particle production via interaction with the structural proteins. PLoS Pathog 2015;11:e1005277.
166. Schuler-Faccini L, Ribeiro EM, Feitosa IM et al. Possible association between Zika virus infection and microcephaly-Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016;65:59-62.
167. Septfons A, Leparc-Goffart I, Couturier E et al. Travel-associated and autochthonous Zika virus infection in mainland France, 1 January to 15 July 2016. Euro Surveill 2016;21:30315.
168. Sirohi D, Chen Z, Sun L et al. The 3.8 °A resolution cryo-EM structure of Zika virus. Science 2016;352:467-70.
169. Song H, Qi J, Haywood J et al. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses. Nat Struct Mol Biol 2016a;23:456-8.
170. Song J, Mauk MG, Hackett BA et al. Instrument-free point-of-care molecular detection of Zika virus. Anal Chem 2016b;88:7289-94.
171. Stettler K, Beltramello M, Espinosa DA et al. Specificity, crossreactivity and function of antibodies elicited by Zika virus infection. Science 2016;353:823-6.
172. Suthar MS, Diamond MS, Gale M, Jr. West Nile virus infection and immunity. Nat Rev Microbiol 2013;11:115-28.
173. Swanstrom JA, Plante JA, Plante KS et al. Dengue virus envelope dimer epitope monoclonal antibodies isolated from dengue patients are protective against Zika virus. MBio 2016;7:e01123-16.
174. Tabata T, Petitt M, Puerta-Guardo H et al. Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. Cell Host Microbe 2016;20:155-66.
175. Tamura K, Stecher G, Peterson D et al. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 2013;30:2725-9.
176. Tang H, Hammack C, Ogden SC et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 2016;18:587-90.
177. Tappe D, Rissland J, Gabriel M et al. First case of laboratoryconfirmed Zika virus infection imported into Europe, November 2013. Euro Surveill 2014;19:20685.
178. Thomas DL, Sharp TM, Torres J et al. Local transmission of Zika virus-Puerto Rico, November 23, 2015-January 28, 2016. MMWR Morb Mortal Wkly Rep 2016;65:154-8.
179. Tian H, Ji X, Yang X et al. The crystal structure of Zika virus helicase: basis for antiviral drug design. Protein Cell 2016;7:450-4.
180. Tognarelli J, Ulloa S, Villagra E et al. A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014. Arch Virol 2016;161:665-8.
181. Trevisan M, Sinigaglia A, Desole G et al. Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems. Viruses 2015;7:3835-56.
182. Tripp RA, Ross TM. Development of a Zika vaccine. Expert Rev Vaccines 2016;15:1083-5.
183. Turmel JM, Abgueguen P, Hubert B et al. Late sexual transmission of Zika virus related to persistence in the semen. Lancet 2016;387:2501.
184. van der Eijk AA, van Genderen PJ, Verdijk RM et al. Miscarriage associated with Zika virus infection. N Engl J Med 2016;375:1002-4.
185. Ventura CV, Maia M, Bravo-Filho V et al. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet 2016;387:228.
186. Verstrepen BE, Fagrouch Z, van Heteren M et al. Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. PLoS Negl Trop Dis 2014a;8:e2797.
187. Verstrepen BE, Oostermeijer H, Fagrouch Z et al. Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus. PLoS One 2014b;9:e112568.
188. Villamil-Gómez WE, González-Camargo O, Rodriguez-Ayubi J et al. Dengue, chikungunya and Zika co-infection in a patient from Colombia. J Infect Public Health 2016;9:684-6.
189. Villordo SM, Carballeda JM, Filomatori CV et al. RNA Structure duplications and Flavivirus host adaptation. Trends Microbiol 2016;24:270-83.
190. Waggoner JJ, Gresh L, Mohamed-Hadley A et al. Singlereaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses. Emerg Infect Dis 2016;22:1295-7.
191. Waggoner JJ, Pinsky BA. Zika virus: diagnostics for an emerging pandemic threat. J Clin Microbiol 2016;54:860-7.
192. Wang L, Valderramos SG,Wu A et al. From mosquitos to humans: genetic evolution of Zika virus. Cell Host Microbe 2016;19: 561-5.
193. Weitzel T, Cortes CP. Zika virus infection presenting with postauricular lymphadenopathy. Am J Trop Med Hyg 2016;95:255-6.
194. Wong PS, Li MZ, Chong CS et al. Aedes (Stegomyia) albopictus (Skuse): a potential vector of Zika virus in Singapore. PLoS Negl Trop Dis 2013;7:e2348.
195. World Health Organization (WHO). Prevention of Sexual Transmission of Zika virus. Interim Guidance. Geneva: WHO, 2016a. http://www.who.int/csr/resources/publications/zika/sexualtransmission-prevention/en/(13 August 2016, date last accessed).
196. World Health Organization (WHO). WHO Director-General Summarizes the Outcome of the Emergency Committee Regarding Clusters of Microcephaly and Guillain-Barré Syndrome. Geneva: WHO, 2016b. http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/(13 August 2016, date last accessed).
197. World Health Organization (WHO). Zika Situation Report. Geneva: WHO, 2016c. http://www.who.int/emergencies/zika-virus/situation-report/28-july-2016/en/(13 August 2016, date last accessed).
198. World Health Organization (WHO). Zika virus infection: global update on epidemiology and potentially associated clinical manifestations. Wkly Epidemiol Rec 2016d;91: 73-81.
199. Wu KY, Zuo GL, Li XF et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res 2016;26:645-54.
200. Xie X, Gayen S, Kang C et al. Membrane topology and function of dengue virus NS2A protein. J Virol 2013;87:4609-22.
201. Zambrano H,Waggoner JJ, Almeida C et al. Zika virus and chikungunya virus coinfections: a series of three cases from a single center in Ecuador. Am J Trop Med Hyg 2016:16-0323.
202. Zammarchi L, Tappe D, Fortuna C et al. Zika virus infection in a traveller returning to Europe from Brazil, March 2015. Euro Surveill 2015;20:21153.
203. Zanluca C, de Melo VC, Mosimann AL et al. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 2015;110:569-72.
204. Zhang FC, Li XF, Deng YQ et al. Excretion of infectious Zika virus in urine. Lancet Infect Dis 2016a;16:641-2.
205. Zhang R, Miner JJ, Gorman MJ et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 2016b;535:164-8.
206. Zhao H, Fernandez E, Dowd KA et al. Structural basis of Zika virus-specific antibody protection. Cell 2016;166: 1016-27.
207. Zhu Z, Chan JF-W, Tee K-M et al. Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic. Emerg Microbes Infect 2016;5:e22.
208. Zmurko J, Marques RE, Schols D et al. The viral polymerase inhibitor 7-deaza-2'-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model. PLoS Negl Trop Dis 2016;10:e0004695.
209. Zou J, Xie X, Wang QY et al. Characterization of dengue virus NS4A and NS4B protein interaction. J Virol 2015;89:3455-70.