Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

Science

Volumn 353, Issue 6304, 2016, Pages 1129-1132

  Abbink, Peter ^a   Larocca, Rafael A ^a   De La Barrera, Rafael A ^b   Bricault, Christine A ^a   Moseley, Edward T ^a   Boyd, Michael ^a   Kirilova, Marinela ^a   Li, Zhenfeng ^a   Ng'ang'a, David ^a   Nanayakkara, Ovini ^a   Nityanandam, Ramya ^a   Mercado, Noe B ^a   Borducchi, Erica N ^a   Agarwal, Arshi ^a   Brinkman, Amanda L ^a   Cabral, Crystal ^a   Chandrashekar, Abishek ^a   Giglio, Patricia B ^a   Jetton, David ^a   Jimenez, Jessica ^a   Lee, Benjamin C ^a   Mojta, Shanell ^a   Molloy, Katherine ^a   Shetty, Mayuri ^a   Neubauer, George H ^a   Stephenson, Kathryn E ^a   Peron, Jean Pierre S ^c   De Zanotto, Paolo M A ^c   Misamore, Johnathan ^d   Finneyfrock, Brad ^d   Lewis, Mark G ^d   Alter, Galit ^e   Modjarrad, Kayvon ^b,f   Jarman, Richard G ^b   Eckels, Kenneth H ^b   Michael, Nelson L ^b   Thomas, Stephen J ^b   Barouch, Dan H ^a,e   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d BIOQUAL INC   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VACCINE; ADENOVIRUS VECTOR; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INACTIVATED VIRUS VACCINE; NEUTRALIZING ANTIBODY; PLASMID DNA; VIRUS ANTIBODY; ZIKA VIRUS VACCINE; IMMUNOGLOBULIN; INACTIVATED VACCINE; PRM PROTEIN, FLAVIVIRUS; VIRUS ENVELOPE PROTEIN; VIRUS VACCINE;

ANTIBODY; EPIDEMIC; PLASMID; PRIMATE; VACCINE; VIRAL DISEASE; VIRUS;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BRAZIL; CELLULAR IMMUNITY; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; IMMUNIZATION; IMMUNOGENICITY; INFECTION PREVENTION; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERTO RICO; RHESUS MONKEY; URINALYSIS; VERO CELL LINE; VIRUS INACTIVATION; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS PARTICLE; VIRUS RECOMBINANT; ZIKA FEVER; ZIKA VIRUS; ADENOVIRIDAE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; VACCINE IMMUNOGENICITY; ZIKA VIRUS INFECTION;

BRAZIL; PUERTO RICO;

ADENOVIRIDAE; MACACA MULATTA; ZIKA VIRUS;

ADENOVIRIDAE; ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, VIRAL; BRAZIL; FEMALE; GENETIC VECTORS; HUMANS; IMMUNOGENICITY, VACCINE; IMMUNOGLOBULINS; MACACA MULATTA; MALE; MICE; MICE, INBRED BALB C; PUERTO RICO; VACCINES, DNA; VACCINES, INACTIVATED; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84981501423     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah6157     Document Type: Article

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