NS4A and NS4B proteins from dengue virus: Membranotropic regions

Biochimica et Biophysica Acta - Biomembranes

Volumn 1818, Issue 11, 2012, Pages 2818-2830

  Nemésio, Henrique ^a   Palomares Jerez, Francis ^a   Villalaín, José ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

DENV; DENV replication; Lipid peptide interaction; Membranous web; Replication complex

Indexed keywords

NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 4B;

ARTICLE; DENGUE VIRUS; PEPTIDE LIBRARY; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS ENTRY; VIRUS MORPHOLOGY; VIRUS REPLICATION;

AMINO ACID SEQUENCE; CALORIMETRY, DIFFERENTIAL SCANNING; CELL MEMBRANE; DENGUE VIRUS; FLUORESCENCE POLARIZATION; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL NONSTRUCTURAL PROTEINS;

DENGUE VIRUS;

EID: 84864188513     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2012.06.022     Document Type: Article

References (55)

1. M.G. Guzman, and G. Kouri Dengue: an update Lancet Infect. Dis. 2 2002 33 42 (Pubitemid 36109304)
2. S.B. Halstead Dengue Lancet 370 2007 1644 1652 (Pubitemid 350052290)
3. S. Urcuqui-Inchima, C. Patino, S. Torres, A.L. Haenni, and F.J. Diaz Recent developments in understanding dengue virus replication Adv. Virus Res. 77 2010 1 39
4. B. Pastorino, A. Nougairede, N. Wurtz, E. Gould, and X. de Lamballerie Role of host cell factors in flavivirus infection: implications for pathogenesis and development of antiviral drugs Antiviral. Res. 87 2010 281 294
5. R. Perera, and R.J. Kuhn Structural proteomics of dengue virus Curr. Opin. Microbiol. 11 2008 369 377
6. S. Bressanelli, K. Stiasny, S.L. Allison, E.A. Stura, S. Duquerroy, J. Lescar, F.X. Heinz, and F.A. Rey Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation EMBO J. 23 2004 728 738 (Pubitemid 38425440)
7. M. Kielian, and F.A. Rey Virus membrane-fusion proteins: more than one way to make a hairpin Nat. Rev. Microbiol. 4 2006 67 76 (Pubitemid 43135288)
8. S. Mukhopadhyay, R.J. Kuhn, and M.G. Rossmann A structural perspective of the flavivirus life cycle Nat. Rev. Microbiol. 3 2005 13 22 (Pubitemid 40028466)
9. S. Miller, S. Kastner, J. Krijnse-Locker, S. Buhler, and R. Bartenschlager The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner J. Biol. Chem. 282 2007 8873 8882 (Pubitemid 47093477)
10. S. Miller, and J. Krijnse-Locker Modification of intracellular membrane structures for virus replication Nat. Rev. Microbiol. 6 2008 363 374 (Pubitemid 351552657)
11. S. Welsch, S. Miller, I. Romero-Brey, A. Merz, C.K. Bleck, P. Walther, S.D. Fuller, C. Antony, J. Krijnse-Locker, and R. Bartenschlager Composition and three-dimensional architecture of the dengue virus replication and assembly sites Cell Host Microbe 5 2009 365 375
12. M.M. Samsa, J.A. Mondotte, N.G. Iglesias, I. Assuncao-Miranda, G. Barbosa-Lima, A.T. Da Poian, P.T. Bozza, and A.V. Gamarnik Dengue virus capsid protein usurps lipid droplets for viral particle formation PLoS Pathog. 5 2009 e1000632
13. J.M. Mackenzie, A.A. Khromykh, M.K. Jones, and E.G. Westaway Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A Virology 245 1998 203 215 (Pubitemid 28394183)
14. B.D. Lindenbach, and C.M. Rice Trans-complementation of yellow fever virus NS1 reveals a role in early RNA replication J. Virol. 71 1997 9608 9617 (Pubitemid 27492408)
15. B.D. Lindenbach, and C.M. Rice Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function J. Virol. 73 1999 4611 4621 (Pubitemid 29246719)
16. A.E. Gorbalenya, A.P. Donchenko, E.V. Koonin, and V.M. Blinov N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases Nucleic Acids Res. 17 1989 3889 3897 (Pubitemid 19153373)
17. E.V. Koonin Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus J. Gen. Virol. 74 Pt 4 1993 733 740 (Pubitemid 23113378)
18. S. Miller, S. Sparacio, and R. Bartenschlager Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B J. Biol. Chem. 281 2006 8854 8863 (Pubitemid 43847992)
19. S.A. Shiryaev, A.V. Chernov, A.E. Aleshin, T.N. Shiryaeva, and A.Y. Strongin NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus J. Gen. Virol. 90 2009 2081 2085
20. J. Roosendaal, E.G. Westaway, A. Khromykh, and J.M. Mackenzie Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein J. Virol. 80 2006 4623 4632
21. J.E. McLean, A. Wudzinska, E. Datan, D. Quaglino, and Z. Zakeri Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication J. Biol. Chem. 286 2011 22147 22159
22. M.L. Ng, and S.S. Hong Flavivirus infection: essential ultrastructural changes and association of Kunjin virus NS3 protein with microtubules Arch. Virol. 106 1989 103 120 (Pubitemid 19209946)
23. E.G. Westaway, J.M. Mackenzie, M.T. Kenney, M.K. Jones, and A.A. Khromykh Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures J. Virol. 71 1997 6650 6661 (Pubitemid 27355323)
24. J.L. Munoz-Jordan, G.G. Sanchez-Burgos, M. Laurent-Rolle, and A. Garcia-Sastre Inhibition of interferon signaling by dengue virus Proc. Natl. Acad. Sci. U. S. A. 100 2003 14333 14338 (Pubitemid 37499237)
25. I. Umareddy, A. Chao, A. Sampath, F. Gu, and S.G. Vasudevan Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA J. Gen. Virol. 87 2006 2605 2614
26. S. Tajima, T. Takasaki, and I. Kurane Restoration of replication- defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B Arch. Virol. 156 2011 63 69
27. A.J. Perez-Berna, A.S. Veiga, M.A. Castanho, and J. Villalain Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2 J. Viral Hepat. 15 2008 346 356 (Pubitemid 351473626)
28. J. Guillen, A.J. Perez-Berna, M.R. Moreno, and J. Villalain Identification of the membrane-active regions of the severe acute respiratory syndrome coronavirus spike membrane glycoprotein using a 16/18-mer peptide scan: implications for the viral fusion mechanism J. Virol. 79 2005 1743 1752 (Pubitemid 40459120)
29. A.J. Perez-Berna, M.R. Moreno, J. Guillen, A. Bernabeu, and J. Villalain The membrane-active regions of the hepatitis C virus E1 and E2 envelope glycoproteins Biochemistry 45 2006 3755 3768
30. M.R. Moreno, M. Giudici, and J. Villalain The membranotropic regions of the endo and ecto domains of HIV gp41 envelope glycoprotein Biochim. Biophys. Acta 1758 2006 111 123 (Pubitemid 44262107)
31. A.J. Perez-Berna, J. Guillen, M.R. Moreno, A. Bernabeu, G. Pabst, P. Laggner, and J. Villalain Identification of the membrane-active regions of hepatitis C virus p7 protein: biophysical characterization of the loop region J. Biol. Chem. 283 2008 8089 8101
32. H. Nemesio, F. Palomares-Jerez, and J. Villalain The membrane-active regions of the dengue virus proteins C and E Biochim. Biophys. Acta 1808 2011 2390 2402
33. T.W. Keenan, and D.J. Morre Phospholipid class and fatty acid composition of Golgi apparatus isolated from rat liver and comparison with other cell fractions Biochemistry 9 1970 19 25
34. A.G. Krainev, D.A. Ferrington, T.D. Williams, T.C. Squier, and D.J. Bigelow Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging Biochim. Biophys. Acta 1235 1995 406 418
35. L.D. Mayer, M.J. Hope, and P.R. Cullis Vesicles of variable sizes produced by a rapid extrusion procedure Biochim. Biophys. Acta 858 1986 161 168
36. C.S.F. Böttcher, C.M. Van Gent, and C. Fries A rapid and sensitive sub-micro phosphorus determination Anal. Chim. Acta 1061 1961 203 204
37. H. Edelhoch Spectroscopic determination of tryptophan and tyrosine in proteins Biochemistry 6 1967 1948 1954
38. A. Bernabeu, J. Guillen, A.J. Perez-Berna, M.R. Moreno, and J. Villalain Structure of the C-terminal domain of the pro-apoptotic protein Hrk and its interaction with model membranes Biochim. Biophys. Acta 1768 2007 1659 1670 (Pubitemid 46795476)
39. M.R. Moreno, J. Guillen, A.J. Perez-Berna, D. Amoros, A.I. Gomez, A. Bernabeu, and J. Villalain Characterization of the interaction of two peptides from the N terminus of the NHR domain of HIV-1 gp41 with phospholipid membranes Biochemistry 46 2007 10572 10584 (Pubitemid 47417252)
40. B.R. Lentz Use of fluorescent probes to monitor molecular order and motions within liposome bilayers Chem. Phys. Lipids 64 1993 99 116 (Pubitemid 23290868)
41. J. Guillen, A. Gonzalez-Alvarez, and J. Villalain A membranotropic region in the C-terminal domain of hepatitis C virus protein NS4B Interaction with membranes Biochim. Biophys. Acta 1798 2010 327 337
42. M.F. Palomares-Jerez, and J. Villalain Membrane interaction of segment H1 (NS4B(H1)) from hepatitis C virus non-structural protein 4B Biochim. Biophys. Acta 1808 2011 1219 1229
43. R.A. Gadkari, and N. Srinivasan Prediction of protein-protein interactions in dengue virus coat proteins guided by low resolution cryoEM structures BMC Struct. Biol. 10 2010 17
44. L.M. Contreras, F.J. Aranda, F. Gavilanes, J.M. Gonzalez-Ros, and J. Villalain Structure and interaction with membrane model systems of a peptide derived from the major epitope region of HIV protein gp41: implications on viral fusion mechanism Biochemistry 40 2001 3196 3207 (Pubitemid 32206190)
45. R.M. Epand Lipid polymorphism and protein-lipid interactions Biochim. Biophys. Acta 1376 1998 353 368 (Pubitemid 28517885)
46. A.J. Perez-Berna, G. Pabst, P. Laggner, and J. Villalain Biophysical characterization of the fusogenic region of HCV envelope glycoprotein E1 Biochim. Biophys. Acta 1788 2009 2183 2193
47. J. Gouttenoire, V. Castet, R. Montserret, N. Arora, V. Raussens, J.M. Ruysschaert, E. Diesis, H.E. Blum, F. Penin, and D. Moradpour Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B J. Virol. 83 2009 6257 6268
48. J. Gouttenoire, P. Roingeard, F. Penin, and D. Moradpour Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B J. Virol. 84 2010 12529 12537
49. J.M. Smit, B. Moesker, I. Rodenhuis-Zybert, and J. Wilschut Flavivirus cell entry and membrane fusion Viruses 3 2011 160 171
50. S.H. White, and W.C. Wimley Membrane protein folding and stability: physical principles Annu. Rev. Biophys. Biomol. Struct. 28 1999 319 365 (Pubitemid 29319262)
51. D.M. Engelman, T.A. Steitz, and A. Goldman Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins Annu. Rev. Biophys. Biophys. Chem. 15 1986 321 353
52. T. Hessa, N.M. Meindl-Beinker, A. Bernsel, H. Kim, Y. Sato, M. Lerch-Bader, I. Nilsson, S.H. White, and G. von Heijne Molecular code for transmembrane-helix recognition by the Sec61 translocon Nature 450 2007 1026 1030 (Pubitemid 350273612)
53. C.P. Moon, and K.G. Fleming Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers Proc. Natl. Acad. Sci. U. S. A. 108 2011 10174 10177
54. J. Koehler, N. Woetzel, R. Staritzbichler, C.R. Sanders, and J. Meiler A unified hydrophobicity scale for multispan membrane proteins Proteins 76 2009 13 29
55. D. Eisenberg, R.M. Weiss, and T.C. Terwilliger The helical hydrophobic moment: a measure of the amphiphilicity of a helix Nature 299 1982 371 374 (Pubitemid 12012871)