The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

PLoS Neglected Tropical Diseases

Volumn 10, Issue 5, 2016, Pages

  Zmurko, Joanna ^a   Marques, Rafael E ^b   Schols, Dominique ^a   Verbeken, Erik ^c   Kaptein, Suzanne J F ^a   Neyts, Johan ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 18; VIRUS RNA; 7-DEAZA-2'-C-METHYLADENOSINE; ANTIVIRUS AGENT; TUBERCIDIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CC50; DISEASE COURSE; EC50; FLAVIVIRIDAE; GENE DISRUPTION; HISTOLOGY; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PLAQUE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SCREENING TEST; ULTRACENTRIFUGATION; VIREMIA; VIRUS ENCEPHALITIS; VIRUS INHIBITION; VIRUS REPLICATION; ZIKA VIRUS; ANALOGS AND DERIVATIVES; ANIMAL; CHLOROCEBUS AETHIOPS; DISEASE MODEL; DRUG EFFECTS; MALE; PHYSIOLOGY; VERO CELL LINE; ZIKA VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DISEASE MODELS, ANIMAL; MALE; MICE; TUBERCIDIN; VERO CELLS; VIRUS REPLICATION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84971658665     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004695     Document Type: Article

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