Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation

The Lancet

Volumn 388, Issue 10047, 2016, Pages 891-897

  França, Giovanny V A ^a   Schuler Faccini, Lavinia ^b   Oliveira, Wanderson K ^a   Henriques, Claudio M P ^a   Carmo, Eduardo H ^a   Pedi, Vaneide D ^a   Nunes, Marília L ^a   Castro, Marcia C ^c   Serruya, Suzanne ^d   Silveira, Mariângela F ^e   Barros, Fernando C ^e,f   Victora, Cesar G ^e  

^a MINISTÉRIO DA SAÚDE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d Women and Reproductive Health   (Uruguay)

^e FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^f CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMETRY; ARTICLE; BRAZIL; CONGENITAL INFECTION; CONGENITAL ZIKA VIRUS SYNDROME; EPIDEMIC; FEMALE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HUMAN; INFANT; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MICROCEPHALY; MORTALITY; NEWBORN; PRIORITY JOURNAL; RASH; SURVIVAL; TERATOGENICITY; THIRD TRIMESTER PREGNANCY; ZIKA FEVER; ZIKA VIRUS; ADULT; CEPHALOMETRY; CONGENITAL; DIAGNOSIS; EPIDEMIOLOGY; INFANT MORTALITY; ISOLATION AND PURIFICATION; NEUROIMAGING; NEWBORN SCREENING; ODDS RATIO; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROCEDURES; STANDARDS; SYNDROME; TRENDS; VIROLOGY;

ADULT; BRAZIL; CEPHALOMETRY; CONFOUNDING FACTORS (EPIDEMIOLOGY); EXANTHEMA; FEMALE; GESTATIONAL AGE; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; MALE; MICROCEPHALY; NEONATAL SCREENING; NEUROIMAGING; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY TRIMESTER, THIRD; SYNDROME; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84978484098     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)30902-3     Document Type: Article

References (26)

1. 1 Faria, NR, Azevedo, RdSdS, Kraemer, MUG, et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science 352 (2016), 345–349.
2. 2 Brito, C, Zika virus: a new chapter in the history of medicine. Acta Med Port 28 (2015), 679–680.
3. 3 Cardoso, CW, Paploski, IAD, Kikuti, M, et al. Outbreak of acute exanthematous illness associated with Zika, chikungunya, and dengue viruses, Salvador, Brazil [letter]. Emerg Infect Dis 21 (2015), 2274–2276.
4. 4 Kleber de Oliveira, W, Cortez-Escalante, J, De Oliveira, WT, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy—Brazil, 2015. Morb Mortal Wkly Rep 65 (2016), 242–247.
5. 5 WHO. Zika Virus, microcephaly, and Guillain Barré Syndrome situation report—14 April 2016. World Health Organization. http://www.who.int/emergencies/zika-virus/situation-report/14-april-2016/en/ (accessed June 11, 2016).
6. 6 Centers for Disease Control and Prevention. CDC Concludes Zika Causes Microcephaly and Other Birth Defects: Centers for Disease Control and Prevention (CDC). http://www.cdc.gov/media/releases/2016/s0413-zika-microcephaly.html (accessed June 11, 2016).
7. 7 Rasmussen, SA, Jamieson, DJ, Honein, MA, Petersen, LR, Zika virus and birth defects—reviewing the evidence for causality. N Engl J Med 374 (2016), 1981–1987.
8. 8 Brasil Ministério da Saúde. Informe Epidemiológico N° 25—Semana Epidemiológica (SE) 18/2016 (01/05 a 07/05/2016)—Monitoramento dos casos de microcefalia no Brasil. http://portalsaude.saude.gov.br/images/pdf/2016/maio/11/COES-Microcefalias–Informe-Epidemiol–gico-25–SE-18-2016–09mai2016-12h13.pdf, 2016 (accessed June 11, 2016).
9. 9 Schuler-Faccini, L, Ribeiro, EM, Feitosa, IM, et al. Possible association between Zika virus infection and microcephaly—Brazil, 2015. Morb Mortal Wkly Rep 65 (2016), 59–62.
10. 10 Aragao, MdFV, van der Linden, V, Brainer-Lima, AM, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ, 353, 2016, i1901.
11. 11 Microcephaly Epidemic Research Group. Microcephaly in infants, Pernambuco State, Brazil, 2015. Emerg Infect Dis 22 (2016), 1090–1093.
12. 12 Hazin, AN, Poretti, A, Cruz, DDCS, et al. Computed tomographic findings in microcephaly associated with Zika virus. N Engl J Med 374 (2016), 2193–2195.
13. 13 Oliveira Melo, AS, Malinger, G, Ximenes, R, Szejnfeld, PO, Alves Sampaio, S, Bispo de Filippis, AM, Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?. Ultrasound Obstet Gynecol 47 (2016), 6–7.
14. 14 Brasil. Ministerio da Saude. Registro de Eventos em Saúde Pública (RESP-Microcefalia). http://resp.saude.gov.br, 2016 (accessed April 25, 2016).
15. 15 Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Protocolo de vigilância e resposta à ocorrência de microcefalia e/ou alterações do sistema nervoso central (SNC), 2016, Ministério da Saúde, Brasília.
16. 16 Brasil. Ministerio da Saude. DATASUS. Sistema Nacional de Nascidos Vivos. http://tabnet.datasus.gov.br/cgi/deftohtm.exe?sinasc/cnv/nvuf.def, 2016 (accessed June 11, 2016).
17. 17 Villar, J, Cheikh Ismail, L, Victora, CG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 384 (2014), 857–868.
18. 18 Brasil. Ministério da Saúde. Informe Epidemiológico N° 15—Semana Epidemiológica (SE) 08/2016 (21 a 27/02/2016) Monitoramento dos casos de microcefalia no Brasil. http://portalsaude.saude.gov.br/images/pdf/2016/marco/01/coes-microcefalia-informe-epid15-se08-2016-01mar2016.pdf, 2016 (accessed May 3, 2016).
19. 19 Victora, CG, Schuler-Faccini, L, Matijasevich, A, Ribeiro, E, Pessoa, A, Barros, FC, Microcephaly in Brazil: how to interpret reported numbers?. Lancet 387 (2016), 621–624.
20. 20 Matijasevich, A, Silveira, MF, Matos, A, et al. Estimativas corrigidas da prevalência de nascimentos pré-termo no Brasil, 2000 a 2011. Epidemiol Serv Saúde Brasília 22 (2013), 557–565.
21. 21 Brasil. Ministerio da Saude. DATASUS. Indicadores de mortalidade. Taxa de mortalidade neonatal precoce. http://tabnet.datasus.gov.br/cgi/idb2012/c0101b.htm (accessed May 10, 2016).
22. 22 Garcez, PP, Loiola, EC, Madeiro da Costa, R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 352 (2016), 816–818.
23. 23 Tang, H, Hammack, C, Ogden Sarah, C, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18 (2016), 587–590.
24. 24 Villar J, Giuliani F, Fenton TR, Ohuma EO, Ismail LC, Kennedy SH. INTERGROWTH-21st very preterm size at birth reference charts. Lancet; 387: 844–45.
25. 25 Duffy, MR, Chen, TH, Hancock, WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 360 (2009), 2536–2543.
26. 26 Organización Panamericana de la Salud. Guía para la vigilancia de la enfermedad por el virus del Zika y sus complicaciones, 2016, Organización Panamericana de la Salud, Washington, DC.