Crystal structure of zika virus ns2b-ns3 protease in complex with a boronate inhibitor

Science

Volumn 353, Issue 6298, 2016, Pages 503-505

  Lei, Jian ^a   Hansen, Guido ^a   Nitsche, Christoph ^b,c   Klein, Christian D ^b   Zhang, Linlin ^a   Hilgenfeld, Rolf ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BORONIC ACID DERIVATIVE; GLYCEROL; NS2B NS3 PROTEASE; PHENYLALANINE; PROTEINASE; UNCLASSIFIED DRUG; VIRUS ENZYME; 4-AMINOMETHYLPHENYLALANINE; CN-716; DIPEPTIDE; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; PROTEINASE INHIBITOR; RNA HELICASE; SERINE PROTEINASE; VIRAL PROTEIN;

CATALYSIS; CELL ORGANELLE; CRYSTAL STRUCTURE; DRUG; ENZYME ACTIVITY; NERVOUS SYSTEM DISORDER; PROTEIN; SUBSTRATE; VIRUS;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME ISOLATION; ENZYME PURIFICATION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; ZIKA VIRUS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; X RAY CRYSTALLOGRAPHY;

ZIKA VIRUS;

ANTIVIRAL AGENTS; BORONIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; GLYCEROL; HUMANS; PHENYLALANINE; PROTEASE INHIBITORS; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS;

EID: 84978832859     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aag2419     Document Type: Article

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