Ajuga chamaecistus subsp. scoparia (Boiss.) Rech.f.: A new source of phytochemicals for antidiabetic, skin-care, and neuroprotective uses

Industrial Crops and Products

Volumn 94, Issue , 2016, Pages 89-96

  Movahhedin, Nasrin ^a   Zengin, Gokhan ^b   Bahadori, Mir Babak ^c   Sarikurkcu, Cengiz ^d   Bahadori, Shahram ^a   Dinparast, Leila ^e  

^a URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SELCUK UNIVERSITY   (Turkey)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ajuga; Alzheimer's disease; Carvacrol; Diabetes mellitus; Thymol; Tyrosinase

Indexed keywords

ANTIOXIDANTS; CHELATION; CHEMICAL ANALYSIS; CHROMATOGRAPHY; ENZYME ACTIVITY; ENZYMES; ETHANOL; EXTRACTION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEURODEGENERATIVE DISEASES; OILS AND FATS; PHENOLS; PLANTS (BOTANY);

AJUGA; ALZHEIMER'S DISEASE; CARVACROL; DIABETES MELLITUS; THYMOL; TYROSINASE;

ESSENTIAL OILS;

ANTIOXIDANT; BIOCHEMICAL COMPOSITION; DIABETES; DISEASE INCIDENCE; DRUG; ENZYME ACTIVITY; ESSENTIAL OIL; HERB; PHENOLIC COMPOUND; PHYTOCHEMISTRY; PLANT EXTRACT; SCAVENGING (CHEMISTRY); SKIN; TOXICITY;

AJUGA; SCOPARIA;

EID: 84989937690     PISSN: 09266690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.indcrop.2016.08.028     Document Type: Article

References (58)

1. Akbay, P., Çalιş, İ., Heilmann, J., Sticher, O., Ionone, iridoid and phenylethanoid glycosides from Ajuga salicifolia. Z. Naturforsch. C 58 (2003), 177–180.
2. Aktumsek, A., Zengin, G., Guler, G.O., Cakmak, Y.S., Duran, A., Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species. Food Chem. Toxicol. 55 (2013), 290–296.
3. Apak, R., Güçlü, K., Özyürek, M., Esin Karademir, S., Erçağ, E., The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. Int. J. Food Sci. Nutr. 57 (2006), 292–304.
4. Ardekani, M.S., Khanavi, M., Taheri, P., Samadi, N., Safaripour, E., Salimpour, F., The essential oil composition of Ajuga chamaecistus Ging: subsp. tomentella Rech. f. J. Essent. Oil Bear Pl. 13 (2010), 45–51.
5. Arun, K., Chandran, J., Dhanya, R., Krishna, P., Jayamurthy, P., Nisha, P., A comparative evaluation of antioxidant and antidiabetic potential of peel from young and matured potato. Food Biosci. 9 (2015), 36–46.
6. Asghari, B., Salehi, P., Sonboli, A., Ebrahimi, S.N., Flavonoids from Salvia chloroleuca with α-amylsae and α-glucosidase inhibitory effect. Iran. J. Pharm. Res.: IJPR, 14, 2015, 609.
7. Atay, I., Kirmizibekmez, H., Kaiser, M., Akaydin, G., Yesilada, E., Tasdemir, D., Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites. Pharm. Biol., 2016, 1–7.
8. Bahadori, M.B., Valizadeh, H., Asghari, B., Dinparast, L., Farimani, M.M., Bahadori, S., Chemical composition and antimicrobial, cytotoxicity, antioxidant and enzyme inhibitory activities of Salvia spinosa L. J. Funct. Foods 18 (2015), 727–736.
9. Bahadori, M.B., Dinparast, L., Valizadeh, H., Farimani, M.M., Ebrahimi, S.N., Bioactive constituents from roots of Salvia syriaca L.: acetylcholinesterase inhibitory activity and molecular docking studies. S. Afr. J. Bot. 106 (2016), 1–4.
10. Baser, K., Kurkcuoglu, M., Erdemgil, F., The essential oil of Ajuga bombycina from Turkey. Chem. Nat. Compd. 37 (2001), 242–244.
11. Camps, F., Coll, J., Insect allelochemicals from Ajuga plants. Phytochemistry 32 (1993), 1361–1370.
12. Can Baser, K., Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr. Pharm. Des. 14 (2008), 3106–3119.
13. Castro, A., Coll, J., Tandrón, Y.A., Pant, A.K., Mathela, C.S., Phytoecdysteroids from Ajuga macrosperma var. breviflora roots. J. Nat. Prod. 71 (2008), 1294–1296.
14. Ceylan, R., Zengin, G., Uysal, S., Ilhan, V., Aktumsek, A., Kandemir, A., Anwar, F., GC–MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen. J. Enzyme Inhib. Med. Chem., 2015, 1–8.
15. Cocquyt, K., Cos, P., Herdewijn, P., Maes, L., Van den Steen, P., Laekeman, G., Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria. Phytomedicine 18 (2011), 1229–1237.
16. Coll, J., Tandrón, Y.A., neo-Clerodane diterpenoids from Ajuga: structural elucidation and biological activity. Phytochem. Rev. 7 (2008), 25–49.
17. Delazar, A., Delnavazi, M.-R., Yassa, N., Parkhideh, S., Delazar, N., Nahar, L., Sarker, S.D., Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran. Rev. Bras. Farmacogn., 22, 2012 399–305.
18. Dinparast, L., Valizadeh, H., Bahadori, M.B., Soltani, S., Asghari, B., Rashidi, M.-R., Design, synthesis, α-glucosidase inhibitory activity, molecular docking and QSAR studies of benzimidazole derivatives. J. Mol. Struct. 1114 (2016), 84–94.
19. Duke, J.A., The garden pharmacy: the evidence for lemon balm. Alternat. Complement. Ther. 13 (2007), 173–177.
20. Eddouks, M., Ouahidi, M., Farid, O., Moufid, A., Khalidi, A., Lemhadri, A., The use of medicinal plants in the treatment of diabetes in Morocco. Phytotherapie 5 (2007), 194–203.
21. El Hilaly, J., Lyoussi, B., Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats. J. Ethnopharmacol. 80 (2002), 109–113.
22. Emmanouil Apostolidis, M., Kwon, Y.-I., Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia. Pac. J. Clin. Nutr. 15 (2006), 433––441.
23. Eskandani, M., Bahadori, M.B., Zengin, G., Dinparast, L., Bahadori, S., Novel natural agents from Lamiaceae family: an evaluation on toxicity and enzyme inhibitory potential linked to diabetes mellitus. Curr. Bioact. Compd. 12 (2016), 34–38.
24. Gautam, R., Jachak, S.M., Saklani, A., Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth: mediated through cyclooxygenase (COX) inhibition. J. Ethnopharmacol. 133 (2011), 928–930.
25. Hassanzadeh, M., Emami, S., Asili, J., Najaran, Z.T., Review of the essential oil composition of Iranian Lamiaceae. J. Essent. Oil Res. 23 (2011), 35–74.
26. Israili, Z.H., Lyoussi, B., Ethnopharmacology of the plants of genus Ajuga. Pak. J. Pharm. Sci. 22 (2009), 425–462.
27. Jakovljević, D.Z., Vasić, S.M., Stanković, M.S., Čomić, L.R., Topuzović, M.D., Secondary metabolite content and in vitro biological effects of Ajuga chamaepitys (L.) Schreb. subsp. chamaepitys. Arch. Biol. Sci., 2015, 95.
28. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., Milos, M., In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother. Res. 21 (2007), 259–261.
29. Kaufmann, D., Dogra, A.K., Wink, M., Myrtenal inhibits acetylcholinesterase, a known Alzheimer target. J. Pharm. Pharmacol. 63 (2011), 1368–1371.
30. Khanavi, M., Davoodipoor, A.M., Sadati, S.N., Ardekani, M.R.S., Sharifzadeh, M., Antinociceptive effect of some extracts from Ajuga chamaecistus Ging ssp. tomentella (Boiss.) Rech. f. aerial parts. Daru J. Pharm. Sci., 22, 2014, 1.
31. Kumar, P., Singh, V., Singh, D., Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata. Phytother. Res. 23 (2009), 172–177.
32. Kuria, K., De Coster, S., Muriuki, G., Masengo, W., Kibwage, I., Hoogmartens, J., Laekeman, G., Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae): in vitro confirmation of ethnopharmacological use. J. Ethnopharmacol. 74 (2001), 141–148.
33. Loizzo, M., Tundis, R., Menichini, F., Natural and synthetic tyrosinase inhibitors as antibrowning agents: an update. Compr. Rev. Food Sci. Food Saf. 11 (2012), 378–398.
34. Makni, M., Haddar, A., Kriaa, W., Zeghal, N., Antioxidant, free radical scavenging, and antimicrobial activities of Ajuga iva leaf extracts. Int. J. Food Prop. 16 (2013), 756–765.
35. Mastelic, J., Jerkovic, I., Blažević, M., Poljak-Blaži, S., Borović, I., Ivančić-Baće, N., Smrečki, V., Žarković, K., Brčić-Kostic, D., Vikić-Topić, M., Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives. J. Agric. Food Chem. 56 (2008), 3989–3996.
36. Mitić, V.D., Stankov-Jovanović, V.P., Jovanović, O.P., Palić, I.R., Djordjević, A.S., Stojanović, G.S., Composition and antioxidant activity of hydrodistilled essential oil of Serbian Ajuga chamaepitys (L.) Schreber ssp. chia (Schreber) Arcangeli. J. Essent. Oil Res. 23 (2011), 70–74.
37. Miyazawa, M., Watanabe, H., Umemoto, K., Kameoka, H., Inhibition of acetylcholinesterase activity by essential oils of Mentha species. J. Agric. Food Chem. 46 (1998), 3431–3434.
38. Mohammadhosseini, M., Pazoki, A., Zamani, H.A., Akhlaghi, H., Chemical composition of the essential oil from aerial parts of Ajuga chamaecistus Ging: subsp. scopria in brackish regions of Iran. J. Essent. Oil Bear. Pl. 14 (2011), 101–105.
39. Moradi-Afrapoli, F., Asghari, B., Saeidnia, S., Ajani, Y., Mirjani, M., Malmir, M., Bazaz, R.D., Hadjiakhoondi, A., Salehi, P., Hamburger, M., In vitro α-glucosidase inhibitory activity of phenolic constituents from aerial parts of Polygonum hyrcanicum. Daru J. Pharm. Sci., 20, 2012, 1.
40. Moshefi, M.H., Mehrabani, M., Moeini, M., Saffari, F., Study of antibacterial effects of different fractions of leaves extract of Ajuga Chamaecistus Ging subsp. scoparia (Bioss) Rech. f. and bioautography of effective fraction. J. Kerman Univ. Med. Sci. 21 (2014), 313–320.
41. Mozaffarian, V., A Dictionary of Iranian Plant Names. 1996, Farhang Moaser Publisher, Tehran.
42. Ni, B., Dong, X., Fu, J., Yin, X., Lin, L., Xia, Z., Zhao, Y., Xue, D., Yang, C., Ni, J., Phytochemical and biological properties of Ajuga decumbens (Labiatae): a review. Trop. J. Pharm. Res. 14 (2015), 1525–1536.
43. Ono, Y., Fukaya, Y., Imai, S., Yamakuni, T., Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol. Pharm. Bull. 31 (2008), 1199–1204.
44. Sadati, N., Jenett-Siems, K., Siems, K., Ardekania, M.R.S., Hadjiakhoondi, A., Akbarzadeh, T., Ostad, S.N., Khanavi, M., Major constituents and cytotoxic effects of Ajuga chamaecistus ssp. tomentella. Z. Naturforsch. C 67 (2012), 275–281.
45. Saravanan, S., Pari, L., Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice. Eur. J. Pharmacol. 761 (2015), 279–287.
46. Saravanan, S., Pari, L., Protective effect of thymol on high fat diet induced diabetic nephropathy in C57BL/6J mice. Chem.-Biol. Interact. 245 (2016), 1–11.
47. Sarikurkcu, C., Uren, M.C., Tepe, B., Cengiz, M., Kocak, M.S., Phenolic content: enzyme inhibitory and antioxidative activity potentials of Phlomis nissolii and P. pungens var. pungens. Ind. Crops Prod. 62 (2014), 333–340.
48. Sarikurkcu, C., Zengin, G., Oskay, M., Uysal, S., Ceylan, R., Aktumsek, A., Composition antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils. Ind. Crops Prod. 70 (2015), 178–184.
49. Sarikurkcu, C., Antioxidant activities of solvent extracts from endemic Cyclamen mirabile Hildebr. tubers and leaves. Afr. J. Biotechnol. 10 (2013), 831–839.
50. Slinkard, K., Singleton, V.L., Total phenol analysis: automation and comparison with manual methods. Am. J. Enol. Vitic. 28 (1977), 49–55.
51. Souza, P.M., Elias, S.T., Simeoni, L.A., de Paula, J.E., Gomes, S.M., Guerra, E.N.S., Fonseca, Y.M., Silva, E.C., Silveira, P.O., Magalhaes, D.m., Plants from Brazilian Cerrado with potent tyrosinase inhibitory activity. PLoS One, 7, 2012, e48589.
52. Szwajgier, D., Borowiec, K., Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors. J. Inst. Brew. 118 (2012), 40–48.
53. Terahara, N., Callebaut, A., Ohba, R., Nagata, T., Ohnishi-Kameyama, M., Suzuki, M., Acylated anthocyanidin 3-sophoroside-5-glucosides from Ajuga reptans flowers and the corresponding cell cultures. Phytochemistry 58 (2001), 493–500.
54. Valizadeh, H., Sonboli, A., Kordi, F.M., Dehghan, H., Bahadori, M.B., Cytotoxicity, antioxidant activity and phenolic content of eight fern species from North of Iran. Pharm. Sci., 21, 2015, 18.
55. Zengin, G., Sarikurkcu, C., Aktumsek, A., Ceylan, R., Ceylan, O., A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes. Ind. Crops Prod. 53 (2014), 244–251.
56. Zengin, G., Locatelli, M., Ceylan, R., Aktumsek, A., Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: can Asphodeline roots be considered as a new source of natural compounds?. J. Enzyme Inhib. Med. Chem, 2015, 1–6.
57. Zengin, G., A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: new sources of natural inhibitors for public health problems. Ind. Crops Prod. 83 (2016), 39–43.
58. Zhang, H., Tsao, R., Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr. Opin. Food Sci. 8 (2016), 33–42.