Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice

European Journal of Pharmacology

Volumn 761, Issue , 2015, Pages 279-287

  Saravanan, Settu ^a   Pari, Leelevinothan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Chemical compounds studied in this article Thymol (PubChem CID: 6989)

Indexed keywords

ADIPONECTIN; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDATE PHOSPHATASE; PHOSPHOLIPID; THYMOL; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; LIPID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RESISTANCE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; REVIEW; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; C57BL MOUSE; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DRUG EFFECTS; HYPERLIPIDEMIAS; LIPID DIET; LIVER; METABOLISM; PATHOLOGY; TIME FACTOR;

ANIMALS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; HEMOGLOBIN A, GLYCOSYLATED; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LIPIDS; LIVER; MALE; MICE, INBRED C57BL; THYMOL; TIME FACTORS;

EID: 84932630416     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.034     Document Type: Article

References (53)

1. G. Boden, X. Chen, J. Ruiz, J.V. White, and L. Rossetti Mechanisms of fatty acid-induced inhibition of glucose uptake J. Clin. Invest. 93 1994 2438 2446
2. M.W. Bradbury Lipid metabolism and liver inflammation.I. Hepatic fatty acid uptake: possible role in steatosis Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G194 G198
3. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest. 114 2004 147 152
4. W. Burgi, M. Briner, N. Franken, and A.C. Kessler One-step sandwich enzyme immunoassay for insulin using monoclonal antibodies Clin. Biochem. 21 1998 311 314
5. S. Choi, Y. Choi, Y. Choi, S. Kim, J. Jang, and T. Park Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice Food. Chem. 141 2013 3627 3635
6. R.A. Defronzo Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 58 2009 773 795
7. S. Dhaneshwar, V. Patel, D. Patil, and G. Meena Studies on synthesis, stability, release and pharmacodynamic profile of a novel diacerein-thymol prodrug Bioorg. Med. Chem. Lett. 23 2013 55 61
8. F.M. Finucane, J. Luan, N.J. Wareham, S.J. Sharp, S. O'Rahilly, B. Balkau, A. Flyvbjerg, M. Walker, K. Hojlund, and J.J. Nolan Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals Diabetologia 52 2009 2345 2349
9. H. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J. Biol. Chem. 226 1957 497 509
10. L. Fritsche, C. Weigert, H.U. Haring, and R. Lehmann How insulin receptor substrate proteins regulate the metabolic capacity of the liver - implications for health and disease Cur. Med. Chem. 15 2008 1316 1329
11. A.G. Garfinkel, P. Nilsson-Ehle, and M.C. Schotz Regulation of lipoprotein lipase. Induction by insulin Biochim. Biophys. Acta 424 1976 264 273
12. R. Geldszus, B. Mayr, R. Horn, F. Geisthövel, A. Von zur Mühlen, and G. Brabant Serum leptin and weight reduction in female obesity Eur. J. Endocrinol. 135 1996 659 662
13. N. Hamza, B. Berke, C. Cheze, A.N. Agli, P. Robinson, H. Gin, and N. Moore Prevention of type 2 diabetes induced by high fat diet in the C57BL/6J mouse by two medicinal plants used in traditional treatment of diabetes in the east of Algeria J. Ethnopharmacol. 128 2010 513 518
14. D. Harbilasa, A. Brault, D. Vallerand, L.C. Martineaua, A. Saleem, J.T. Arnason, L. Musallama, and P.S. Haddada Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model J. Enthnopharmacol. 141 2012 1012 1020
15. J. Hitz, J. Steinmetz, and G. Siest Plasma lecithin:cholesterol acyltransferase - reference values and effects of xenobiotics Clin. Chim. Acta. 133 1983 85 96
16. M.L. Hribal, F. Oriente, and D. Accili Mouse models of insulin resistance Am. J. Physiol. Endocrinol. Metab. 10 2002 52 61
17. L. Jing, Y. Zhang, S. Fan, m Gu, Y. Guan, X. Lu, C. Huang, and Z. Zhou Preventive and ameliorating effects of citrus d-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity Eur. J. Pharmacol. 715 2013 46 55
18. D. Jelinek, J.J. Castillo, and W.S. Garver The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight Gene 527 2013 65 70
19. I. Juhan-Vague, and M.C. Alessi PAI-1, obesity, insulin resistance and risk of cardiovascular events Thromb. Haemost. 78 1997 656 660
20. R.J. Koenig, C.M. Peterson, R.L. Jones, C. Saudek, M. Lehrman, and A. Cerami Correlation of glucose regulation and hemoglobin A1 C in diabetes mellitus N. Engl. J. Med. 295 1976 417 420
21. E.D. Korn Clearing factor, a heparin-activated lipoprotein lipase.I. Isolation and characterization of enzyme from normal rats heart J. Biol. Chem. 215 1955 15 26
22. N. Kumar, J. Mudgal, V.K. Parihar, P.G. Nayak, N.G. Kutty, and C.M. Rao Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia Lipids 48 2013 633 638
23. P.B. Lazarow Assay of peroxisomal b-oxidation of fatty acids Method. Enzymol. 72 1981 315 319
24. Z. Li, S. Bowerman, and D. Heber Health ramifications of the obesity epidemic Surg. Clin. North Am. 85 2005 681 701
25. M.A.K. Markwell, E.J. McGroarty, L.L. Bieber, and N.E. Tolbert The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney J. Biol. Chem. 248 1973 3426 3432
26. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
27. M.F. Meeran, and P.S. Prince Protective effects of thymol on altered plasma lipid peroxidation and nonenzymic antioxidants in isoproterenol-induced myocardial infarcted rats J. biochem. Mol. Toxicol. 26 2012 368 373
28. A. Mubarak, J.M. Hodgson, M.J. Considine, K.D. Croft, and V.B. Matthews Supplementation of a high-fat diet with chlorogenic acid is associated with insulin resistance and hepatic lipid accumulation in mice J. Agric. Food. Chem. 61 2013 4371 4378
29. D.M. Muoio, and G. Lynis Dohm Peripheral metabolic actions of leptin Best. Pract. Res. Clin. Endocrinol. Metab. 16 2002 653 666
30. S. Muthulakshmi, and R. Saravanan Efficacy of azelaic acid on hepatic key enzymes of carbohydrate metabolism in high fat diet induced type 2 diabetic mice Biochimie 95 2013 1239 1244
31. S.S. Nayak, and T.N. Pattabiraman A new colorimetric method for the estimation of glycosylated haemoglobin Clin. Chim. Acta 109 1981 267 274
32. C.M. Nepokroeff, M.R. Lakshmanan, and J.W. Poter Fatty acid synthase from rat liver Methods Enzymol. 35 1975 37 44
33. J. O'Connell, L. Lynch, T.J. Cawood, A. Kwasnik, N. Nolan, J. Geoghegan, A. McCormick, C. O'Farrelly, and D. O'Shea The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity PLoS One 5 2010 9997
34. S. Ochoa Malic Enzyme: Malic Enzymes from Pigeon and Wheat Germ S.P. Colowick, N.O. Kaplan, Methods in Enzymology 1995 Academic Press New York 323 326
35. H.J. Park, M.K. Lee, Y.B. Park, Y.C. Shin, and M.S. Choi Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice Food. Chem. Toxicol. 49 2011 727 733
36. F. Peelman, J. Vandekerckhove, and M. Rosseneu Structure and function of lecithin cholesterol acyl transferase: new insights from structural predictions and animal models Curr. Opin. Lipidol. 11 2002 155 160
37. B.W. Philipp, and D.J. Shapiro Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase J. Lipid. Res. 20 1979 588 593
38. E. Pitkanen, O. Pitkanen, and L. Uotila Enzymatic determination of unbound Dmannose in serum Eur. J. Clin. Chem. Clin. Biochem. 35 1997 761 766
39. J. Poornima, and S. Mirunalini Regulation of carbohydrate metabolism by indole-3-carbinol and its metabolite 3,3'-diindolylmethane in high-fat diet-induced C57BL/6J mice Mol. Cell. Biochem. 385 2014 7 15
40. V. Pruneta-Deloche, A. Sassolas, G.M. Dallinga-Thie, F. Berthezène, G. Ponsin, and P. Moulin Alteration in lipoprotein lipase activity bound to triglyceride-rich lipoproteins in the postprandial state in Type 2 diabetes J. Lipid. Res. 45 2004 859 865
41. J. Savel, M. Lafitte, Y. Pucheu, V. Pradeau, A. Tabarin, and T. Couffinhal Very low levels of HDL cholesterol and atherosclerosis, a variable relationship - a review of LCAT deficiency Vasc. Health. Risk. Manag. 8 2012 357 361
42. I. Schneider, G. Kressel, A. Meyer, U. Krings, R.G. Berger, and A. Hahn Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans J. Funct. Foods 3 2011 17 24
43. C.F. Semenkovich Insulin resistance and atherosclerosis J. Clin. Invest. 116 2006 1813 1822
44. Y. Shi, and P. Burn Lipid metabolic enzymes: emerging drug targets for the treatment of obesity Nat. Rev. Drug Discov 3 2004 695 710
45. C.C. Shih, C.H. Lin, and W.L. Lin Effects of Momordica charantiaon insulin resistance and visceral obesity in mice on high-fat diet Diab. Res. Clin. Pract. 81 2008 134 143
46. L.K. Stewart, J.L. Soileau, D. Ribnicky, Z.Q. Wang, I. Raskin, A. Poulev, M. Majewski, W.T. Cefalu, and T.W. Gettys Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet Metabolism 57 2008 39 46
47. K. Te Sligte, I. Bourass, J.P. Sels, A. Driessen, R.W. Stockbrugger, and G.H. Koek Non-alcoholic steatohepatitis: review of a growing medical problem Eur. J. Intern. Med. 15 2004 10 21
48. P. Trinder Determination of blood glucose using an oxidase peroxidase system with a non carcinogenic chromogen J. Clin. Pathol. 22 1969 158 161
49. P.A. Walton, and F. Possmayer Mg2-dependent phosphatidate phosphohydrolase of rat lung: development of an assay employing a defined chemical substrate which reflects the phosphohydrolase activity measured using membranebound substrate Anal. Biochem. 151 1985 479 486
50. Y. Wang, T. Campbell, B. Perry, C. Beaurepaire, and L. Qin Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats Metabolism 60 2011 298 305
51. H. Wong, and M.C. Schotz The lipase gene family J. Lipid. Res. 43 2002 993 999
52. k Wouters, P.J. Van Gorp, V. Bieghs, M.J. Gijbels, H. Duimel, D. Lutjohann, A. Kerksiek, R. Van Kruchten, N. Maeda, B. Staels, M. Van Bilsen, R. Shiri-Sverdlov, and M.H. Hofker Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis Hepatology 48 2008 474 486
53. C.E. Young, R.H. Karas, and J.T. Kuvin High-density lipoprotein cholesterol and coronary heart disease Cardiol. Rev. 12 2004 107 119