Secondary metabolite content and in vitro biological effects of Ajuga chamaepitys (L.)Schreb. subsp. chamaepitys

Archives of Biological Sciences

Volumn 67, Issue 4, 2015, Pages 1195-1202

  Jakovljević, Dragana Z ^a   Vasić, Sava M ^a   Stanković, Milan S ^a   Čomić, Ljiljana R ^a   Topuzović, Marina D ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

Author keywords

Ajuga chamaepitys; Antimicrobial; Antioxidants; Flavonoids; Phenolics

Indexed keywords

EID: 84951741638     PISSN: 03544664     EISSN: None     Source Type: Journal    
DOI: 10.2298/ABS150225095J     Document Type: Article

References (51)

1. Abbas, S. R., Sabir, S. M., Ahmad, S. D., Zulfiqar, A., Wajid, A., Hamid, A., Batool, A. and M. R. Abbas. (2013). Antioxidant activity and biochemical variation among juices of different genotypes of sugarcane. Ital. J. Food Sci. 25, 453-458.
2. Aly, R., Ravid, U., Abu-Nassar, J., Botnick, I., Lebedev, G., Gal, S., Ziadna, H., Achdari, G., Smirov, E., Meirand, A. and M. Ghanim. (2011). Biological activity of natural phytoecdysteroids from Ajuga iva against the sweetpotato whitefly Bemisia tabaci and the persea mite Oligonychus perseae. Pest. Manag. Sci. 67, 1493-1498.
3. Amoo, S. O., Aremu, A. O. and J. Van Staden. (2012). In vitro plant regeneration, secondary metabolite production and antioxidant activity of micropropagated Aloe arborescens Mill. Plant Cell Tiss Org. 111, 345-358.
4. Amri, I., Hanana, M., Gargouri, S., Jamoussi, B. and L. Hamrouni. (2013). Comparative study of two coniferous species (Pinus pinaster Aiton and Cupressus sempervirens L. var dupreziana [A. Camus] Silba) essential oils: chemical composition and biological activity. Chil. J. Agr. Res. 7, 259-266.
5. Anagnostopoulou, M. A., Kefalas, P., Papageorgiou, V. P., Assimopoulou, A. N. and D. Boskou. (2006). Radical scavenging activity of various extracts and fractions of sweet orange peel (Citrus sinensis). Food Chem. 94, 19-25.
6. Andrews, J. M. (2005). BSAC standardized disc susceptibility testing method (version 4). J. Antimicrob. Chemother. 56, 60-76.
7. Anokwuru, P. C., Esiaba, I., Ajibaye, O. and O. A. Adesuyi. (2011). Polyphenolic content and antioxidant activity of Hibiscus sabdariffa Calyx. Res. J. Med. Plant. 5, 557-566.
8. Ball, P. W. (1972) Ajuga. In: Flora Europaea III, (Tutin, T. G., Heywood, V. H., Burges, N. A., Moore, D. M., Valentine, D. H., Walters, S. M., Webb, D. A.), 128-129. Cambridge University Press, Cambridge
9. Baser, K. H. C., Erdemgil, Z., Özek, T. and B. Demirci. (1990). Composition of essential oils from two varieties of Ajuga chamaepitys subsp chia from Turkey. J. Essent. Oil Res. 11, 203-205.
10. Biradar, Y. S., Jagatap, S., Khandelwal, K. R. and S. S. Singhania. (2008). Exploring of antimicrobial activity of Triphala Mashi-an Ayurvedic Formulation. Evid. Based. Complement Alternat. Med. 5, 107-113.
11. Boneva, I. M., Mikhova, B. P., Malakov, P. Y., Papanov, G. Y., Duddeck, H. and S. L. Spassov. (1990). Neo-clerodane diterpenoids from Ajuga chamaepitys. Phytochem. 29, 2931-2933.
12. Çali, I. Ö., Cansaran, A. and C. Yildirim. (2014). Trichome morphology of Ajuga orientalis L (Lamiaceae) from Turkey. Bangladesh. J. Botany. 43, 91-95.
13. Chebil, L., Humeau, C., Anthoni, J., Dehez, F., Engasser, J. and M. Ghoul. (2007). Solubility of flavonoids in organic solvents. J. Chem. Eng. Data. 52, 1552-1556.
14. Ćurčić, M., Stanković, M., Radojević, I., Stefanović, O., Čomić, Lj., Topuzović, M., Djačić, D. and S. Marković. (2012). Biological effects, total phenolic content and flavonoid concentrations of fragrant yellow onion (Allium flavum L). Med. Chem. 8, 46-51.
15. Delazar, A., Delnavazi, M. R., Yassa, N., Parkhideh, S., Delazar, N., Nahar, L. and S. D. Sarker. (2012). Essential oil composition and isolation of freeradical-scavenging phenolic glycosides from the aerial parts of Ajuga chamaepitys growing in Iran. Rev. Bras. Farmacogn. 22, 399-305.
16. Filippini, R., Piovan, A., Borsarini, A. and R. Caniato. (2010). Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum. Fitoterapia 81, 115-119.
17. Gitua, J. N., Muchiri, D. R. and X. A. Nguyen. (2012). In vivo antimalarial activity of Ajuga remota water extracts against Plasmodium berghei in mice. Southeast Asian J. Trop. Med. Public Health. 43, 545.
18. Hailu, W. and E. Engidawork. (2014). Evaluation of the diuretic activity of the aqueous and 80% methanol extracts of Ajuga remota Benth (Lamiaceae) leaves in mice. BMC. Complement. Altern. Med. 14, 135.
19. Holderbaum, D. F., Kon, T. and M. P. Guerra. (2014). Dynamics of total phenolic content in different apple tissues and genotypes: impacts and relevance for breeding programs. Sci. Hortic-Amsterdam. 168, 58-63.
20. Israili, Z. H., and B. Lyoussi. (2009). Ethnopharmacology of the plants of genus Ajuga. Pak. J. Pharm. Sci. 22, 425-462.
21. Jankovic, M. (1974). Ajuga. In: Flora of Republic of Serbia (Ed. M. Jankovic), 342-349. SASA, Belgrade.
22. Khoddami, A., Wilkes, M. A. and T. H. Roberts. (2013). Techniques for analysis of plant phenolic compounds. Molecules. 18, 2328-2375.
23. Kumarasamy, Y., Byres, M., Cox, P. J., Jasapars, M., Nahar, L. and S. D. Sarker. (2007). Screening seeds of some Scottish plants for free-radical scavenging activity. Phytother. Res. 21, 615-621.
24. Kutas, J. and M. Nádasy. (2005). Antifeedant effects of several plant extracts on Colorado potato beetle larvae. Acta Phytopathol. Hun. 40, 355-365.
25. Kutepova, T. A., Syrov, V. N., Khushbaktova, Z. A. and Z. Saatov. (2001). Hypoglicemic activity of the total ecdysteroid extract from Ajuga turkestanica. Pharm. Chem. J. 35, 608-609.
26. Lombardo, S., Pandino, G., Mauromicale, G., Knödler, M., Carle, R. and A. Schieber. (2010). Influence of genotype, harvest time and plant part on polyphenolic composition of globe artichoke Cynara cardunculus L. var. scolymus (L.) Fiori. Food. Chem. 119, 1175-1181.
27. Makni, M., Haddar, A., Kriaa, W. and N. Zeghal. (2013). Antioxidant, free radical scavenging, and antimicrobial activities of Ajuga iva leaf extracts. Int. J. Food. Prop. 16, 756-765.
28. Mamadalieva, N. Z., El-Readi, M. Z., Ovidi, E., Ashour, M. L., Hamoud, R., Sagdullaev, S. S., Azimova, S., Tiezzi, A. and M. Wink. (2013). Antiproliferative, antimicrobial and antioxidant activities of the chemical constituents of Ajuga turkestanica. Phytopharm. 4, 1-18.
29. Mandal, P., Misra, T. K. and M. Ghosal. (2009). Free-radical scavenging activity and phytochemical analysis in the leaf and stem of Drymaria diandra Blume. Int. J. Integr. Biol. 7, 80-84.
30. Matejic, J. S., Džamic, A. M., Mihajilov-Krstev, T. M., Randelovic, V. N., Mileski, K. S. and P. D. Marin. (2014). Total phenolic and flavonoid contents and biological activities of Cachrys cristata DC extracts. Arch. Biol. Sci. 66, 1117-1123.
31. Mazid, M., Khan, T. A. and F. Mohammad. (2011). Role of secondary metabolites in defense mechanisms of plants. Biol Med 3, 232-249.
32. Min, G. and L. Chun-Zao. (2005). Comparison of techniques for the extraction of flavonoids from cultured cells of Saussurea medusa Maxim. World J. Microb. Biot. 21, 1461-1463.
33. Mitic, V. D., Stankov-Jovanović, V. P., Jovanović, O. P., Palić, I. R., Djordjević, A. S. and G. S. Stojanović. (2011). Composition and antioxidant activity of hydrodistilled essential oil of Serbian Ajuga chamaepitys (L.) Schreber ssp. chia (Schreber) Arcangeli. J. Essent. Oil Res. 23, 70-74.
34. Mothana, R. A., Alsaid, M. S., Hasoon, S. S., Al-Mosaiyb, N. M., Al-Rehaily, A. J. and M. A. Al-Yahya. (2012). Antimicrobial and antioxidant activities and gas chromatography mass spectrometry (GC/MS) analysis of the essential oils of Ajuga bracteosa Wall ex Benth and Lavandula dentata L growing wild in Yemen. J. Med. Plant. Res. 6, 3066-3071.
35. Orhan, I., Deliorman-Orhan, D. and B. Özçelik. (2009). Antiviral activity and cytotoxicity of the lipophilic extracts of various edible plants and their fatty acids. Food Chem. 115, 701-705.
36. Pal, A. and R. S. Pawar. (2011). A Study on Ajuga bracteosa Wall ex. Benth for analgesic activity. Int. J. Cur. Bio. Med. Sci. 1, 12-14 .
37. Pavela R. (2011). Screening of Eurasian plants for insecticidal and growth inhibition activity against Spodoptera littoralis larvae. Afr J. Agric. Res. 6, 2895-2907.
38. Quitter, D. C., Gressier, B., Vasseur, J., Dine, T., Brunet, C., Luyckx, M., Cazin, M., Cazin, J. C., Bailleul, F. and F. Troti. (2000). Phenolic compounds and antioxidant activities of buckwheat (F. esculentum Moench) hulls and flour. J. Ethnopharmacol. 72, 35-42.
39. Radojević, I., Stanković, M. S., Stefanović, O., Topuzović, M. and Lj. Ćomić. (2012). Antioxidative and antimicrobial properties of different extracts from Sideritis montana L. Rom. Biotech. Lett. 17, 7160-7168.
40. Sarac, N. and A. Ugur (2007). Antimicrobial activities and usage in folkloric medicine of some Lamiaceae species growing in Mugla, Turkey. EurAsia J. Biosci. 4, 28-37.
41. Sarker, S. D., Nahar, L. and Y. Kumarasamy. (2007). Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods 42, 321-324.
42. Shao, H. B., Chu, L. Y., Lu, Z. H. and C. M. Kang. (2008). Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Int. J. Bio. Sci. 4, 8.
43. Singh, R., Patil, S. M., Pal, G. and M. Ahmad. (2012). Evaluation of in vivo and in vitro anti-inflammatory activity of Ajuga bracteosa Wall ex Benth. Asian Pac. J. Trop. Dis. 2, 404-407.
44. Singleton, V. L., Orthofer, R. and Laumela, R. R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Meth. Enzymol. 299, 152-178.
45. Tekao, T., Watanabe, N., Yagi, I. and K. Sakata. (1994). A simple screening method for antioxidant and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Biosci. Biotechnol. Biochem. 58, 1780-1783.
46. Terpinc, P., Čeh, B., Ulrih, N. P., and H. Abramovič. (2012). Studies of the correlation between antioxidant properties and the total phenolic content of different oil cake extracts. Ind. Crops Prod. 39, 210-217.
47. Topçu, G., Koekdil, G., Tuerkmen, Z., Voelter, W., Adou, E. and G. D. I. Kingston. (2004). A new clerodane diterpene and other constituents from Ajuga chamaepitys subsp. laevigata. Z Naturforsch 59, 584-588.
48. Turkoglu, S., Turkoglu, I., Kahyaoglu, M. and S. Celik. (2010). Determination of antimicrobial and antioxidant activities of Turkish endemic Ajuga chamaepitys (L.) Schreber subsp. euphratica PH Davis (Lamiaceae). J. Med. Plant Res. 4, 1369-1367.
49. Ulukanli, Z., Ulukanli, S., Ozbay, H., Ilcim, A. and M. Tuzcu. (2005). Antimicrobial activities of some plants from the Eastern Anatolia region of Turkey. Pharm. Biol. 43, 334-339.
50. Velasco-Negueruela, A., Pérez-Alonso, M. J., Palá-Paül, J., Iñigo, A., and J. Sanz. (2004). Volatile constituents of the essential oil of Ajuga chamaepitys (L.) Schreber. ssp. chamaepitys from Spain. J. Essent. Oil Res. 16, 372-373.
51. Yanishlieva, N. V. and E. M. Marinova. (2001). Stabilisation of edible oils with natural antioxidants. Eur. J. Lipid. Sci Tech. 103, 752-767.