Ajuga remota Benth.: From ethnopharmacology to phytomedical perspective in the treatment of malaria

Phytomedicine

Volumn 18, Issue 14, 2011, Pages 1229-1237

  Cocquyt, K ^a   Cos, P ^b   Herdewijn, P ^a   Maes, L ^b   Van Den Steen, P E ^a   Laekeman, G ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Ajuga remota; Ergosterol 5,8 endoperoxide; Ethnopharmacology; Malaria; Phytoecdysteroids; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ECDYSTEROID; ERGOSTEROL 5,8 ENDOPEROXIDE; HEMATIN; HEMOGLOBIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

AJUGA; AJUGA REMOTA; ANTIMALARIAL ACTIVITY; CHEMICAL STRUCTURE; DRUG MECHANISM; ETHNOPHARMACOLOGY; HEMOLYSIS; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; MALARIA; METABOLITE; NONHUMAN; PHYTOTHERAPY; PLASMODIUM FALCIPARUM; PLASMODIUM OVALE; PLASMODIUM VIVAX; PRIORITY JOURNAL; REVIEW; SEXUAL MATURITY; SPECIES IDENTIFICATION;

AJUGA; ANTIMALARIALS; ARTEMISININS; CHLOROQUINE; DEHYDROEPIANDROSTERONE SULFATE; DITERPENES; ERGOSTEROL; ETHNOPHARMACOLOGY; LACTONES; MALARIA; MOLECULAR STRUCTURE; PHYTOSTEROLS; PLANT PREPARATIONS; PLASMODIUM; SPECIES SPECIFICITY;

AJUGA; AJUGA REMOTA; LAMIACEAE; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM;

EID: 80155190085     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.08.063     Document Type: Review

References (52)

1. K. Ayi, G. Giribaldi, A. Skorokhod, E. Schwarzer, P.T. Prendergast, and P. Arese 16α-Bromoepiandrosterone, an antimalarial analogue of the hormone dehydroepiandrosterone, enhances phagocytosis of ring stage parasitized erythrocytes: a novel mechanism for antimalarial activity Antimicrobial Agents and Chemotherapy 46 10 2002 3180 3184
2. C.L. Cantrell, S.G. Franzblau, and N.H. Fischer Antimycobacterial plant terpenoids Planta Medica 67 8 2001 685 694 (Pubitemid 33044471)
3. C.L. Cantrell, M.S. Rajab, S.G. Franzblau, F.R. Fronczek, and N.H. Fischer Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota Planta Medica 65 8 1999 732 734
4. S. Chandel, and U. Bagai Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice The Indian Journal of Medical Research 131 2010 440 444
5. S. Chandel, and U. Bagai Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth Parasitology Research 108 4 2011 801 805
6. A.T. Cordeiro, and O.H. Thiemann 16-Bromoepiandrosterone, an activator of the mammalian immune system, inhibits glucose 6-phosphate dehydrogenase from Trypanosoma cruzi and is toxic to these parasites grown in culture Bioorganic & Medicinal Chemistry 18 13 2010 4762 4768
7. P. Cos, A.J. Vlietinck, D. Vanden Berghe, and L. Maes Anti-infective potential of natural products: how to develop a stronger in vitro "proof-of-concept Journal of Ethnopharmacology 106 3 2006 290 302 (Pubitemid 43949328)
8. H.D Danenberg, A. Ben-Yehuda, Z. Zakay-Rones, and G. Friedman Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection Vaccine 13 15 1995 1445 1448
9. L. Dinan Phytoecdysteroids: biological aspects Phytochemistry 57 3 2001 325 339 (Pubitemid 32448444)
10. L. Dinan The Karlson lecture. Phytoecdysteroids: what use are they? Archives of Insect Biochemistry and Physiology 72 3 2009 126 141
11. A.M. Dondorp, S. Yeung, L. White, C. Nguon, N.P.J. Day, D. Socheat, and L. von Seidlein Artemisinin resistance: current status and scenarios for containment Nature Reviews Microbiology 8 4 2010 272 280
12. N. Duarte, M.-J.U. Ferreira, M. Martins, M. Viveiros, and L. Amaral Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis: dependence upon system and medium employed Phytotherapy Research 21 7 2007 601 604 (Pubitemid 47066770)
13. Eurordis, 2005. Rare diseases: understanding this public health priority. Retrieved December 1, 2010, from: http://www.eurordis.org/publication/rare- diseases-understanding-public-health-priority.
14. G. Fekete, L.A. Polgár, M. Báthori, J. Col, and B. Darvas Per os efficacy of Ajuga extracts against sucking insects Pest Management Science 60 11 2004 1099 1104 (Pubitemid 39424524)
15. D. Freilich, S. Ferris, M. Wallace, L. Leach, A. Kallen, J. Frincke, C. Ahlem, M. Hacker, D. Nelson, and J. Hebert 16α-Bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth The American Journal of Tropical Medicine and Hygiene 63 5-6 2000 280 283 (Pubitemid 32537564)
16. J.M. Frincke, D.R. Stickney, N. Onizuka-Handa, A. Garsd, C. Reading, S. Krudsood, P. Wilairatana, and S. Looareesuwan Reduction of parasite levels in patients with uncomplicated malaria by treatment with HE2000 The American Journal of Tropical Medicine and Hygiene 76 2 2007 232 236 (Pubitemid 351627767)
17. M. Garg, and S. Bondada Reversal of age-associated decline in immune response to Pnu-imune vaccine by supplementation with the steroid hormone dehydroepiandrosterone Infection and Immunity 61 5 1993 2238 2241 (Pubitemid 23145941)
18. J. Gorelick-Feldman, D. MacLean, N. Ilic, A. Poulev, M.A. Lila, D. Cheng, and I. Raskin Phytoecdysteroids increase protein synthesis in skeletal muscle cells Journal of Agricultural and Food Chemistry 56 10 2008 3532 3537 (Pubitemid 351860149)
19. Govaerts, R., Paton, A., Harvey, Y., Navarro, T., 2010. World Checklist of Selected Plant Families. The Board of Trustees of the Royal Botanic Gardens, Kew. Retrieved December 2, 2010, from: http://apps.kew.org/wcsp/synonomy.do? name-id=5288.
20. M.E. Haffner, J. Torrent-Farnell, and P.D. Maher Does orphan drug legislation really answer the needs of patients? The Lancet 371 9629 2008 2041 2044 (Pubitemid 351818196)
21. J. Hazeldine, W. Arlt, and J.M. Lord Dehydroepiandrosterone as a regulator of immune cell function The Journal of Steroid Biochemistry and Molecular Biology 120 2-3 2010 127 136 Elsevier Ltd.
22. R. Hernández-Pando, D. Aguilar-Leon, H. Orozco, A. Serrano, C. Ahlem, R. Trauger, B. Schramm, C. Reading, J. Frincke, and G.A.W. Rook 16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis The Journal of Infectious Diseases 191 2 2005 299 306 (Pubitemid 40096389)
23. R. Hernández-Pando, M. De La Luz Streber, H. Orozco, K. Arriaga, L. Pavon, S.A. Al-Nakhli, and G.A. Rook The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice Immunology 95 2 1998 234 241 (Pubitemid 28459387)
24. Hsi-wen, L., Hedge, I.C., 1994. Lamiaceae. Flora of China 17. Retrieved December 1, 2010, from: http://www.efloras.org/browse.aspx?flora-id=2&name
25. Z.H. Israili, and B. Lyoussi Ethnopharmacology of the plants of genus Ajuga Pakistan Journal of Pharmaceutical Sciences 22 4 2009 425 462
26. Kew Royal Botanic Gardens, 2010. The Mint Family (Lamiaceae). Retrieved December 1, 2010, from: http://www.kew.org/plants-fungi/plant-fungi-groups/mint- family/.
27. K.A.M. Kuria, H. Chepkwony, C. Govaerts, E. Roets, R. Busson, P. de Witte, I. Zupko, G. Hoornaert, L. Quirynen, L. Maes, L. Janssens, J. Hoogmartens, and G.M. Laekeman The antiplasmodial activity of isolates from Ajuga remota Journal of Natural Products 65 5 2002 789 793 (Pubitemid 34547438)
28. K.A.M. Kuria, S. De Coster, G. Muriuki, W. Masengo, I. Kibwage, J. Hoogmartens, and G.M. Laekeman Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae): in vitro confirmation of ethnopharmacological use Journal of Ethnopharmacology 74 2 2001 141 148 (Pubitemid 32141096)
29. J.D. Kurtis, R. Mtalib, F.K. Onyango, and P.E. Duffy Human resistance to Plasmodium falciparum increases during puberty and is predicted by dehydroepiandrosterone sulfate levels Infection and Immunity 69 1 2001 123 128 (Pubitemid 32038307)
30. T. Leenstra, F.O. ter Kuile, S.K. Kariuki, C.P. Nixon, A.J. Oloo, P.A. Kager, and J.D. Kurtis Dehydroepiandrosterone sulfate levels associated with decreased malaria parasite density and increased hemoglobin concentration in pubertal girls from western Kenya The Journal of Infectious Diseases 188 2 2003 297 304 (Pubitemid 36898164)
31. J. Li, and B. Zhou Biological actions of artemisinin: insights from medicinal chemistry studies Molecules 15 3 2010 1378 1397
32. S.R. Meshnick, T.E. Taylor, and S. Kamchonwongpaisan Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy Microbiological Reviews 60 2 1996 301 315 (Pubitemid 26171692)
33. F.W. Muregi, S.C. Chhabra, E.N.M. Njagi, C.C. Lang□at-Thoruwa, W.M. Njue, A.S.S. Orago, S.A. Omar, and I.O. Ndiege Anti-plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine Phytotherapy Research 18 5 2004 379 384 (Pubitemid 38758240)
34. F.W. Muregi, A. Ishih, T. Miyase, T. Suzuki, H. Kino, T. Amano, G.M. Mkoji, and M. Terada In vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their interactions with chloroquine Journal of Traditional Medicines 23 4 2006 141 146
35. F.W. Muregi, A. Ishih, T. Miyase, T. Suzuki, H. Kino, T. Amano, G.M. Mkoji, and M. Terada Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice Journal of Ethnopharmacology 111 1 2007 190 195 (Pubitemid 46482893)
36. S.A Omar, I.S. Adagu, D.W. Gump, N.P. Ndaru, and D.C. Warhurst Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area Annals of Tropical Medicine and Parasitology 95 7 2001 661 669 (Pubitemid 33116500)
37. P.M. O'Neill, V.E. Barton, and S.A. Ward The molecular mechanism of action of artemisinin - the debate continues Molecules 15 3 2010 1705 1721
38. A.V. Pandey, B.L. Tekwani, R.L. Singh, and V.S. Chauhan Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite The Journal of Biological Chemistry 274 27 1999 19383 19388
39. N.S. Ramazanov Phytoecdysteroids and other biologically active compounds from plants of the genus Ajuga Chemistry of Natural Compounds 41 4 2005 361 369 Springer, New York (Pubitemid 41618561)
40. K. Rharrabe, S. Alla, A. Maria, F. Sayah, and R. Lafont Diversity of detoxification pathways of ingested ecdysteroids among phytophagous insects Archives of Insect Biochemistry and Physiology 65 2 2007 65 73 (Pubitemid 46953736)
41. N. Riaz, S.A. Nawaz, N. Mukhtar, A. Malik, N. Afza, S. Ali, S. Ullah, P. Muhammad, and M.I. Choudhary Isolation and enzyme-inhibition studies of the chemical constituents from Ajuga bracteosa Chemistry & Biodiversity 4 1 2007 72 83 (Pubitemid 46195866)
42. I. Safeukui, F. Mangou, D. Malvy, P. Vincendeau, D. Mossalayi, G. Haumont, R. Vatan, P. Olliaro, and P. Millet Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway Biochemical Pharmacology 68 10 2004 1903 1910 (Pubitemid 39346180)
43. C. Scarparo, P. Ricordi, G. Ruggiero, and P. Piccoli Evaluation of the fully automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide, streptomycin, isoniazid, rifampin, and ethambutol and comparison with the radiometric BACTEC 460TB method Journal of Clinical Microbiology 42 3 2004 1109 1114 (Pubitemid 38332833)
44. K. Sláma, and R. Lafont Insect hormones-ecdysteroids: their presence and actions in vertebrates European Journal of Entomology 92 1995 355 377
45. E. Tortoli, P. Cichero, C. Piersimoni, M. Simonetti, G. Gesu, and D. Nista Use of BACTEC MGIT 960 for recovery of mycobacteria from clinical specimens: multicenter study Journal of Clinical Microbiology 37 11 1999 3578 3582 (Pubitemid 29491095)
46. N. Tóth, A. Szabó, P. Kacsala, J. Héger, and E. Zádor 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat Phytomedicine 15 9 2008 691 698
47. D.S. Trenin, and V.V. Volodin 20-Hydroxyecdysone as a human lymphocyte and neutrophil modulator: in vitro evaluation Archives of Insect Biochemistry and Physiology 41 3 1999 156 161 (Pubitemid 129534058)
48. H. Wagner, and G. Ulrich-Merzenich Synergy research: approaching a new generation of phytopharmaceuticals Phytomedicine 16 2-3 2009 97 110
49. N.J. White Qinghaosu (artemisinin): the price of success Science 320 5874 2008 330 334 (Pubitemid 351555649)
50. C.D. Wilborn, L.W. Taylor, B.I. Campbell, C. Kerksick, C.J. Rasmussen, M. Greenwood, and R.B. Kreider Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males Journal of the International Society of Sports Nutrition 3 2 2006 19 27
51. World Health Organization, 2002. Traditional Medicine Strategy 2002-2005.
52. World Health Organisation, 2007. What is Malaria? Retrieved December 1, 2010, from: http://www.searo.who.int/EN/Section10/Section21/Section334.htm.