phytochemical and biological properties of ajuga decumbens (Labiatae): A review

Tropical Journal of Pharmaceutical Research

Volumn 14, Issue 8, 2015, Pages 1525-1536

  Ni, Boran ^a   Dong, Xiaoxv ^a   Fu, Jing ^a   Yin, Xingbin ^a   Lin, Longfei ^a   Xia, Zhenwen ^a   Zhao, Yang ^a   Xue, Dan ^a   Yang, Chunjing ^a   Ni, Jian ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Ajuga decumbens Thunb; Anti inflammatory; Antibacterial; Antitumor; Antiviral; Cytotoxic; Diterpenes; Insecticidal; Iridoids glycosides

Indexed keywords

8 ACETYLHARPAGIDE; ACACETIN; AJUDECUMINS A; AJUDECUMINS B; AJUDECUMINS C; AJUDECUMINS D; AJUGA DECUMBENS EXTRACT; AJUGACILIATIN J; AJUGACUMBIN J; AJUGACUMBINS A; AJUGANIPPONIN B; AJUGARIN I; AJUGATAKASINS A; AJUGATAKASINS B; APIGENIN; CLERODININS C; CLERODININS D; DECUMBESIDE A; DECUMBESIDE B; DECUMBESIDE C; DECUMBESIDE D; DIHYDROCLERODIN; DITERPENE; ECDYSTEROID; FLAVONOID; IRIDOID; LUTEOLIN; PLANT EXTRACT; REPTOSIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AJUGA; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITIY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; CYTOTOXICITY; DRUG ACTIVITY; HUMAN; INSECTICIDAL ACTIVITY; PHARMACOLOGICAL PARAMETERS; PHYTOCHEMISTRY; REVIEW;

EID: 84940676357     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v14i8.28     Document Type: Review

References (55)

1. Cai ZY, Yi GQ, Li YY, Liang XL, Gan L, He GX. Nuclear magnetic resonance characteristics of neo-clerodane diterpene in Genus Ajuga. Cent South Pharm 2014; 12: 1108-1112.
2. Israili ZH, Lyoussi B. Ethnopharmacology of the plants of genus Ajuga. Pak J Pharma Sci 2009; 22: 425-462
3. Liu B, Shi RB, Ge XX, Zhou Y, Zhou J. Chemical constituents and Pharmacological activities of Ajuga. World Phytomedicine 2001; 16: 96-101.
4. Nawaz HR, Malik A, Khan PM, Ahmed S. Ajugin EF: Two withanolides from Ajuga parviflora. Phytochem 1999; 52: 1357-1360.
5. Akbay P, Calis I, Heimann J, Sticher O. Ionon, iridoid and phenylethanoid glycosides from Ajuga salicifolia. Z Naturforsch 2003; 58c: 177-180.
6. Hilaly JE, Israili ZH, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnophar 2004; 91: 43-50.
7. Naghibi F, Mosaddegh M, Mohammadi Motamed S, Ghorbani A. Labiatae family in folk medicine in Iran: from ethnobotany to pharmacology. Iran J Pharm Res 2005; 2: 63-79.
8. Ono Y, Fukaya Y, Imai S, Yamakuni T. Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol Pharm Bull 2008; 31: 1199-1204.
9. Jiangsu New Medical College. Dictionary of Chinese Materia Medica. Shanghai: People's Publishing House; 1986; p 751.
10. Konoshima, M, Shibata, S, Shimomura, T, Azuma, T. Tokyo: Yakuyo Shokubutu Daijiten Hirokawa Publishing Co; 1963. 111p.
11. Zhang LQ, Feng L, Jia Q, Xu JW, Wang R, Wang ZT, Wu YC, Li YM. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2(COX-2) in vitro. Bioo Med Chem 2011; 19: 4882-4886.
12. Wang L, Lu W, Shen Q, Wang SJ, Zhou H, Yu LS, Wang S, Jiang HD, He LC, Zeng S. Simultaneous determination of imperatorin and its 2 metabolites in dog plasma by using liquid chromatography-tandem mass spectrometry. J Pharmaceut Biomed 2012; 70: 640-646.
13. Takasaki M, Tokuda H, Nishino H, Konoshima T. Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. J Nat Prod 1999; 62: 972-975.
14. Jannet HB, Harzallah-Skhiri F, Mighri Z, Simmonds MSJ and Blaney WM. Responses of Spodoptera littoralis larvae to Tunisian plant extracts and to neoclerodane diterpenoids isolated from Ajuga pseudoiva leaves. Fitoterapia 2000; 71: 105-112.
15. Bondì ML, Al-Hillo MRY, Lamara K, Ladjel S, BrunoM, Piozzi F, Simmonds MSJ. Occurrence of the antifeedant 14, 15-dihydroajugapitin in the aerial parts of Ajuga iva from Algeria. Biochem Syst Ecol 2000; 2: 1023-1025.
16. Jannet HB, Chaari A, Mighri Z, Martin MT, Loukaci A. Neo-clerodane diterpenoids from Ajuga pseudoiva leaves. Phytochem 1999; 52: 1541-1545.
17. Chen H, Tan RX, Liu ZL, Zhao CY, Sun J. A clerodane diterpene with antibacterial activity from Ajuga lupulina. Acta Cryst C 1997; 53: 814-816.
18. Kuria KAM, Chepkwony H, Govaerts C, Roets E, Busson R, de Witte P, Zupko I, Hoornaert G, Quirynen L, Maes L, et al. The antiplasmodial activity of isolates from Ajuga remota. J Nat Prod 2002; 65: 789-793.
19. Takasaki M, Tokuda H, Nishino H, Konoshima T. Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. J Nat Prod 1999; 62: 972-975.
20. Min ZD, Wang SQ, Zheng QT, Wu B, Tanaka T, Iinuma M. Four new insect antifeedant neo-clerodane diterpenoids, ajugacumbins A, B, C and D, from Ajuga decumbens. Chem Pharma Bull 1989; 37: 2505-2508.
21. Shimomura H, Sashida Y, Ogawa K. neo-Clerodane diterpenes from Ajuga decumbens. Chem Pharma Bull 1989; 37: 996-998.
22. Min ZD, Mizuno M, Wang SQ, Linuma M, Tanaka T. Two new neo-clerodane diterpenes in Ajuga decumbens. Chem Pharma Bull 1990; 38: 3167-3168.
23. Chen HM, Min ZD, Iinuma M, Tanaka T. Clerodane diterpenoids from Ajuga decumbens. Chem Pharma Bull 1995; 43: 2253-2255.
24. Amano T, Nishida R, Kuwahara Y. Ajugatakasins A and B, new diterpenoids from Ajuga decumbens, and feeding stimulative activity of related neoclerodane analogs toward the turnip sawfly. Biosci Biotech Bioch 1997; 61: 1518-1522.
25. Takasaki M, Yamauchi I, Haruna M, Konoshima T. New glycosides from Ajuga decumbens. J Nat Prod 1998; 61: 1105-1109.
26. Sang JS, Huang ZH, Min ZD. A New neo-Clerodane Diterpene Isolated from Ajuga decumbens. Chin J Nat Med 2005; 3: 284-286.
27. Huang XC, Qin S, Guo YW, Krohn K. Four New Neoclerodane Diterpenoids from Ajuga decumbens. Helvetica Chimica Acta 2008; 91: 628-634.
28. Sun ZP, Gui LP, Guo YQ, Xu J, Li YS. Isolation and identification of chemical constituents from the whole plants of Ajuga decumbens. J Shenyang Pharm Univy 2012; 29: 758-760.
29. Sun ZP, Li YS, Jin DQ, Guo P, Song HB, Xu J, Guo YQ, Zhang L. neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPSinduced NO production. Fitoterapia 2012; 83: 1409- 1414.
30. Sun ZP, Li Y, Jin DQ, Guo P, Xu J, Guo YQ, Zhang L. Structure Elucidation and Inhibitory Effects on NO Production of Clerodane Diterpenes from Ajuga decumbens. Planta Med 2012; 78: 1579-1593.
31. Lv H, Luo J, Kong L. A new neo-clerodane diterpene from Ajuga decumbens. Nat Pro Res2014; 28: 196-200.32
32. Wang B, Wang X N, Shen T, Wang SQ, Guo DX, Lou HX. Rearranged abietane diterpenoid hydroquinones from aerial parts of Ajuga decumbens Thunb. Phytochem Letts, 2012; 5: 271-275.
33. Israili Z H, Lyoussi B. Ethnopharmacology of the plants of genus Ajuga. Pak J Pharm Sci 2009; 22: 425-462.
34. Takeda Y, Tsuchida S, Fujita T. Four new iridoid glucoside p-coumaroyl esters from Ajuga decumbens. Phytochem 1987; 26: 2303-2306.
35. Jin JS, Dou SH. Study on the flavonoids of Ajuga decumbens. Anhui Med J 1994; 15: 51.
36. Guo XD, Huang ZS, Bao YD, An DK, Ma L, Gu LQ. Chemical constituents of Ajuga decumbens. Chinese Tradit Herbal Drugs 2005; 36: 645-648.
37. Ramazanov NS. Phytoecdysteroids and other biologically active compounds from plants of the genus Ajuga. Chem Nat Compd 2005; 41: 361-369.
38. Koreeda M, Nakanishi K, Goto M. Ajugalactone, an insect moulting inhibitor as tested by the Chilo dipping method. J Amer Chem Soc 1970, 92:7512-7513.
39. Takasaki M, Tokuda H, Nishino H, Konoshima T. Cancer Chemopreventive Agents (Antitumor-promoters) from Ajuga decumbens. J Nat Prod 1999; 62: 972-975.
40. D'Abrosca B, DellaGreca M, Fiorentino A, Monaco P, Oriano P, Temussi F. Structure elucidation and phytotoxicity of C13 nor-isoprenoids from Cestrum parqui. Phytochem 2004; 65: 497-505.
41. Metuno R, Ngandeu F, Tchinda AT, Ngamenni B, Kapche GDWF, Djemgou PC, Ngadjui BT, Bezabih M, Abegaz BM. Chemical constituents of Treculia acuminata and Treculia africana (Moraceae). Biochem Syst Ecol 2008; 36: 148-152.
42. Edita. Dictionary of Chinese Materia Medica. Shanghai: Shanghai Science and Technology Publishing House; 2006; p 1035.
43. Chinese Pharmacopoeia Commission. Chinese pharmacopoeia. Beijing: The Medicine Science and Technology Press of China; 2010; p 325.
44. Ono Y, Fukaya Y, Imai S, Yamakuni T. Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol Pharm Bull 2008; 31: 1199-1204.
45. Nan LH, Peng WH, Zheng SL, Fang TH, Wu FH, Xu ZT. Experimental Effects Study of Total Flavonoids of Ajuga on Free Radical Damage in Chronic Serum Sickness Glomerulonephritis Rats. Chinese J Interg Tradit West Nephrol CHTWN 2009; 10: 967-969.
46. Konoshima T, Takasaki M, Tokuda H, Nishno H. Cancer chemopreventive activity of an iridoid glycoside, 8- acetylharpagide, from Ajuga decumbens. Cancer Lett 2000; 57: 87-92.
47. Peng B, He R, Xu QH, Gao J, Lu YL, Li JR. Correlation between antimetastatic action of Ajuga decumbens and expression of MMPs and TIMPs. China J Chinese Materia Medica 2011; 36: 3511-3513.
48. Li D, Jiang M. Anticancer Research of water extracts from Ajuga decumbens in vitro. Jilin Journal of TCM 2009; 29: 434-435.
49. Zeng FM, Jia R, Wu FW. Experiment of Tumor Inhibition of Ciliate Bugle Herb in S180 Sarcom Mice. J Fujian Coll Tradit Chinese Med 2003; 13: 30-32.
50. Zhang XX, Wu J, Li D, Zou X. Effects of Ajuga Decumbens Thunb on Liver Carcinoma Cells in vitro and in vivo. J Liaoning Univ Tradit Chinese MedM. 2013; 15: 58-61.
51. Zhang B, Zeng FJ, Zhang XY. Study on anti-infection effect of Ajuga decumbens. Chin J Nosocomiol 2014; 24: 2937-3939.
52. Li M, Peng WH. Chemical constituents and pharmacological research progress of Ajuga decumbens. J pr tradit Chinese mede 2012; 28: 322- 323.
53. Ma SC, Du J, But PPH, Deng XL, Zhang YW, Ooi VEC, Xu HX, Lee SHS, Lee SF. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol 2002; 79: 205-211.
54. Luo MC, Zheng XF, Fan XP. In vitro Inhibition of Infectious Bronchitis Virus by Ciliate Bugle Herb (Jin Gu Cao). J Longyan Univ 2009; 27: 77-79.
55. Lin T, Wang G, Shan W, Zeng D, Ding R, Jiang X, Zhu D, Liu XX, Yang SY, Chen HF. Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens. Bioorg Med Chem Lett 2014; 24: 2504-2507.