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Volumn 144, Issue , 2016, Pages 158-172

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

Author keywords

Astrocyte; Biomarker; Brain injury; Drug target; Glia; Ischemia; Lipocalin 2; microRNA; Neuroinflammation; Stroke

Indexed keywords

GLIOCALIN; IRON BINDING PROTEIN; MICRORNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG;

EID: 84989858464     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2016.08.001     Document Type: Review
Times cited : (109)

References (104)
  • 2
    • 84896943606 scopus 로고    scopus 로고
    • Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact
    • Almeida-Suhett, C.P., Li, Z., Marini, A.M., Braga, M.F., Eiden, L.E., Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact. J. Neurotrauma 31 (2014), 683–690.
    • (2014) J. Neurotrauma , vol.31 , pp. 683-690
    • Almeida-Suhett, C.P.1    Li, Z.2    Marini, A.M.3    Braga, M.F.4    Eiden, L.E.5
  • 3
    • 0031754132 scopus 로고    scopus 로고
    • Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia
    • Anwaar, I., Gottsater, A., Ohlsson, K., Mattiasson, I., Lindgarde, F., Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia. Cerebrovasc. Dis. 8 (1998), 310–317.
    • (1998) Cerebrovasc. Dis. , vol.8 , pp. 310-317
    • Anwaar, I.1    Gottsater, A.2    Ohlsson, K.3    Mattiasson, I.4    Lindgarde, F.5
  • 6
    • 84892745179 scopus 로고    scopus 로고
    • Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage
    • Beppu, K., Sasaki, T., Tanaka, K.F., Yamanaka, A., Fukazawa, Y., Shigemoto, R., Matsui, K., Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage. Neuron 81 (2014), 314–320.
    • (2014) Neuron , vol.81 , pp. 314-320
    • Beppu, K.1    Sasaki, T.2    Tanaka, K.F.3    Yamanaka, A.4    Fukazawa, Y.5    Shigemoto, R.6    Matsui, K.7
  • 7
    • 84860686727 scopus 로고    scopus 로고
    • Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis
    • Berard, J.L., Zarruk, J.G., Arbour, N., Prat, A., Yong, V.W., Jacques, F.H., Akira, S., David, S., Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis. Glia 60 (2012), 1145–1159.
    • (2012) Glia , vol.60 , pp. 1145-1159
    • Berard, J.L.1    Zarruk, J.G.2    Arbour, N.3    Prat, A.4    Yong, V.W.5    Jacques, F.H.6    Akira, S.7    David, S.8
  • 8
    • 34447561633 scopus 로고    scopus 로고
    • Neutrophil granules: a library of innate immunity proteins
    • Borregaard, N., Sorensen, O.E., Theilgaard-Monch, K., Neutrophil granules: a library of innate immunity proteins. Trends Immunol. 28 (2007), 340–345.
    • (2007) Trends Immunol. , vol.28 , pp. 340-345
    • Borregaard, N.1    Sorensen, O.E.2    Theilgaard-Monch, K.3
  • 11
    • 84908249389 scopus 로고    scopus 로고
    • Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury
    • Chan, J.L., Reeves, T.M., Phillips, L.L., Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury. Exp. Neurol. 261 (2014), 757–771.
    • (2014) Exp. Neurol. , vol.261 , pp. 757-771
    • Chan, J.L.1    Reeves, T.M.2    Phillips, L.L.3
  • 12
    • 84899047640 scopus 로고    scopus 로고
    • Inflammatory response to Escherichia coli urinary tract infection in the neurogenic bladder of the spinal cord injured host
    • Chaudhry, R., Madden-Fuentes, R.J., Ortiz, T.K., Balsara, Z., Tang, Y., Nseyo, U., Wiener, J.S., Ross, S.S., Seed, P.C., Inflammatory response to Escherichia coli urinary tract infection in the neurogenic bladder of the spinal cord injured host. J. Urol. 191 (2014), 1454–1461.
    • (2014) J. Urol. , vol.191 , pp. 1454-1461
    • Chaudhry, R.1    Madden-Fuentes, R.J.2    Ortiz, T.K.3    Balsara, Z.4    Tang, Y.5    Nseyo, U.6    Wiener, J.S.7    Ross, S.S.8    Seed, P.C.9
  • 13
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
    • Cherry, J.D., Olschowka, J.A., O'Banion, M.K., Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J. Neuroinflammation, 11, 2014, 98.
    • (2014) J. Neuroinflammation , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O'Banion, M.K.3
  • 14
    • 80052953969 scopus 로고    scopus 로고
    • Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity
    • Chia, W.J., Dawe, G.S., Ong, W.Y., Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity. Neurochem. Int. 59 (2011), 591–599.
    • (2011) Neurochem. Int. , vol.59 , pp. 591-599
    • Chia, W.J.1    Dawe, G.S.2    Ong, W.Y.3
  • 15
    • 84937628224 scopus 로고    scopus 로고
    • Expression and localisation of brain-type organic cation transporter (BOCT) in the hippocampus after kainate-induced excitotoxicity
    • Chia, W.J., Tan, F.C., Ong, W.Y., Dawe, G.S., Expression and localisation of brain-type organic cation transporter (BOCT) in the hippocampus after kainate-induced excitotoxicity. Neurochem. Int. 87 (2015), 43–59.
    • (2015) Neurochem. Int. , vol.87 , pp. 43-59
    • Chia, W.J.1    Tan, F.C.2    Ong, W.Y.3    Dawe, G.S.4
  • 16
    • 79955683626 scopus 로고    scopus 로고
    • Increased plasma levels of lipocalin 2 in mild cognitive impairment
    • Choi, J., Lee, H.W., Suk, K., Increased plasma levels of lipocalin 2 in mild cognitive impairment. J. Neurol. Sci. 305 (2011), 28–33.
    • (2011) J. Neurol. Sci. , vol.305 , pp. 28-33
    • Choi, J.1    Lee, H.W.2    Suk, K.3
  • 17
    • 84949729995 scopus 로고    scopus 로고
    • Reactive astrocytes and therapeutic potential in focal ischemic stroke
    • Choudhury, G.R., Ding, S., Reactive astrocytes and therapeutic potential in focal ischemic stroke. Neurobiol. Dis. 85 (2015), 234–244.
    • (2015) Neurobiol. Dis. , vol.85 , pp. 234-244
    • Choudhury, G.R.1    Ding, S.2
  • 18
    • 84938125350 scopus 로고    scopus 로고
    • Changes of gene expression of Gal3, Hsp27, Lcn2, and Timp1 in rat substantia nigra following medial forebrain bundle transection using a candidate gene microarray
    • Choy, Y.J., Hong, S.Y., Pack, S.J., Woo, R.S., Baik, T.K., Song, D.Y., Changes of gene expression of Gal3, Hsp27, Lcn2, and Timp1 in rat substantia nigra following medial forebrain bundle transection using a candidate gene microarray. J. Chem. Neuroanat. 66–67 (2015), 10–18.
    • (2015) J. Chem. Neuroanat. , vol.66-67 , pp. 10-18
    • Choy, Y.J.1    Hong, S.Y.2    Pack, S.J.3    Woo, R.S.4    Baik, T.K.5    Song, D.Y.6
  • 19
    • 84939524976 scopus 로고    scopus 로고
    • Pathological involvement of astrocyte-derived lipocalin-2 in the demyelinating optic neuritis
    • Chun, B.Y., Kim, J.H., Nam, Y., Huh, M.I., Han, S., Suk, K., Pathological involvement of astrocyte-derived lipocalin-2 in the demyelinating optic neuritis. Invest. Ophthalmol. Vis. Sci. 56 (2015), 3691–3698.
    • (2015) Invest. Ophthalmol. Vis. Sci. , vol.56 , pp. 3691-3698
    • Chun, B.Y.1    Kim, J.H.2    Nam, Y.3    Huh, M.I.4    Han, S.5    Suk, K.6
  • 20
    • 79959379095 scopus 로고    scopus 로고
    • Repertoire of microglial and macrophage responses after spinal cord injury
    • David, S., Kroner, A., Repertoire of microglial and macrophage responses after spinal cord injury. Nat. Rev. Neurosci. 12 (2011), 388–399.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 388-399
    • David, S.1    Kroner, A.2
  • 22
    • 84875230010 scopus 로고    scopus 로고
    • Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats
    • Dong, M., Xi, G., Keep, R.F., Hua, Y., Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats. Brain Res. 1505 (2013), 86–92.
    • (2013) Brain Res. , vol.1505 , pp. 86-92
    • Dong, M.1    Xi, G.2    Keep, R.F.3    Hua, Y.4
  • 23
    • 84903768776 scopus 로고    scopus 로고
    • Acute white matter injury after experimental subarachnoid hemorrhage: potential role of lipocalin 2
    • Egashira, Y., Hua, Y., Keep, R.F., Xi, G., Acute white matter injury after experimental subarachnoid hemorrhage: potential role of lipocalin 2. Stroke 45 (2014), 2141–2143.
    • (2014) Stroke , vol.45 , pp. 2141-2143
    • Egashira, Y.1    Hua, Y.2    Keep, R.F.3    Xi, G.4
  • 24
    • 0029762478 scopus 로고    scopus 로고
    • Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases
    • Elneihoum, A.M., Falke, P., Axelsson, L., Lundberg, E., Lindgarde, F., Ohlsson, K., Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. Stroke 27 (1996), 1734–1738.
    • (1996) Stroke , vol.27 , pp. 1734-1738
    • Elneihoum, A.M.1    Falke, P.2    Axelsson, L.3    Lundberg, E.4    Lindgarde, F.5    Ohlsson, K.6
  • 25
    • 0033974568 scopus 로고    scopus 로고
    • Leukocyte activation: relation to cardiovascular mortality after cerebrovascular ischemia
    • Falke, P., Elneihoum, A.M., Ohlsson, K., Leukocyte activation: relation to cardiovascular mortality after cerebrovascular ischemia. Cerebrovasc. Dis. 10 (2000), 97–101.
    • (2000) Cerebrovasc. Dis. , vol.10 , pp. 97-101
    • Falke, P.1    Elneihoum, A.M.2    Ohlsson, K.3
  • 28
    • 0034684168 scopus 로고    scopus 로고
    • The lipocalin protein family: structural and sequence overview
    • Flower, D.R., North, A.C., Sansom, C.E., The lipocalin protein family: structural and sequence overview. Biochim Biophys. Acta 1482 (2000), 9–24.
    • (2000) Biochim Biophys. Acta , vol.1482 , pp. 9-24
    • Flower, D.R.1    North, A.C.2    Sansom, C.E.3
  • 29
    • 0029790266 scopus 로고    scopus 로고
    • The lipocalin protein family: structure and function
    • Flower, D.R., The lipocalin protein family: structure and function. Biochem. J. 318:Pt. 1 (1996), 1–14.
    • (1996) Biochem. J. , vol.318 , pp. 1-14
    • Flower, D.R.1
  • 31
    • 84937812996 scopus 로고    scopus 로고
    • An integrated In silico approach for the structural and functional exploration of lipocalin 2 and its functional insights with metalloproteinase 9 and lipoprotein receptor-related protein 2
    • Ghosh, M., Sodhi, S.S., Kim, J.H., Kim, N.E., Mongre, R.K., Sharma, N., Kim, S.W., Oh, S.J., Pulicherla, K.K., Jeong, D.K., An integrated In silico approach for the structural and functional exploration of lipocalin 2 and its functional insights with metalloproteinase 9 and lipoprotein receptor-related protein 2. Appl. Biochem. Biotechnol. 176 (2015), 712–729.
    • (2015) Appl. Biochem. Biotechnol. , vol.176 , pp. 712-729
    • Ghosh, M.1    Sodhi, S.S.2    Kim, J.H.3    Kim, N.E.4    Mongre, R.K.5    Sharma, N.6    Kim, S.W.7    Oh, S.J.8    Pulicherla, K.K.9    Jeong, D.K.10
  • 32
    • 0036865552 scopus 로고    scopus 로고
    • The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    • Goetz, D.H., Holmes, M.A., Borregaard, N., Bluhm, M.E., Raymond, K.N., Strong, R.K., The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10 (2002), 1033–1043.
    • (2002) Mol. Cell , vol.10 , pp. 1033-1043
    • Goetz, D.H.1    Holmes, M.A.2    Borregaard, N.3    Bluhm, M.E.4    Raymond, K.N.5    Strong, R.K.6
  • 33
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S., Alternative activation of macrophages. Nat. Rev. Immunol. 3 (2003), 23–35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 36
    • 84874222139 scopus 로고    scopus 로고
    • Immune-induced expression of lipocalin-2 in brain endothelial cells: relationship with interleukin-6, cyclooxygenase-2 and the febrile response
    • Hamzic, N., Blomqvist, A., Nilsberth, C., Immune-induced expression of lipocalin-2 in brain endothelial cells: relationship with interleukin-6, cyclooxygenase-2 and the febrile response. J. Neuroendocrinol. 25 (2013), 271–280.
    • (2013) J. Neuroendocrinol. , vol.25 , pp. 271-280
    • Hamzic, N.1    Blomqvist, A.2    Nilsberth, C.3
  • 37
    • 2442678025 scopus 로고    scopus 로고
    • The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    • Hawlisch, H., Wills-Karp, M., Karp, C.L., Kohl, J., The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Mol. Immunol. 41 (2004), 123–131.
    • (2004) Mol. Immunol. , vol.41 , pp. 123-131
    • Hawlisch, H.1    Wills-Karp, M.2    Karp, C.L.3    Kohl, J.4
  • 39
    • 0027272746 scopus 로고
    • Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase
    • Hoffmann, A., Conradt, H.S., Gross, G., Nimtz, M., Lottspeich, F., Wurster, U., Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J. Neurochem. 61 (1993), 451–456.
    • (1993) J. Neurochem. , vol.61 , pp. 451-456
    • Hoffmann, A.1    Conradt, H.S.2    Gross, G.3    Nimtz, M.4    Lottspeich, F.5    Wurster, U.6
  • 40
  • 41
    • 80053368420 scopus 로고    scopus 로고
    • Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration
    • Ip, J.P., Nocon, A.L., Hofer, M.J., Lim, S.L., Muller, M., Campbell, I.L., Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J. Neuroinflammation, 8, 2011, 124.
    • (2011) J. Neuroinflammation , vol.8 , pp. 124
    • Ip, J.P.1    Nocon, A.L.2    Hofer, M.J.3    Lim, S.L.4    Muller, M.5    Campbell, I.L.6
  • 42
    • 84887445769 scopus 로고    scopus 로고
    • Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes
    • Jang, E., Kim, J.H., Lee, S., Seo, J.W., Jin, M., Lee, M.G., Jang, I.S., Lee, W.H., Suk, K., Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes. J. Immunol. 191 (2013), 5204–5219.
    • (2013) J. Immunol. , vol.191 , pp. 5204-5219
    • Jang, E.1    Kim, J.H.2    Lee, S.3    Seo, J.W.4    Jin, M.5    Lee, M.G.6    Jang, I.S.7    Lee, W.H.8    Suk, K.9
  • 43
    • 84874615861 scopus 로고    scopus 로고
    • Secreted protein lipocalin-2 promotes microglial M1 polarization
    • Jang, E., Lee, S., Kim, J.H., Seo, J.W., Lee, W.H., Mori, K., Nakao, K., Suk, K., Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J. 27 (2013), 1176–1190.
    • (2013) FASEB J. , vol.27 , pp. 1176-1190
    • Jang, E.1    Lee, S.2    Kim, J.H.3    Seo, J.W.4    Lee, W.H.5    Mori, K.6    Nakao, K.7    Suk, K.8
  • 44
    • 84882412414 scopus 로고    scopus 로고
    • Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury
    • Jeon, S., Jha, M.K., Ock, J., Seo, J., Jin, M., Cho, H., Lee, W.H., Suk, K., Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury. J. Biol. Chem. 288 (2013), 24116–24127.
    • (2013) J. Biol. Chem. , vol.288 , pp. 24116-24127
    • Jeon, S.1    Jha, M.K.2    Ock, J.3    Seo, J.4    Jin, M.5    Cho, H.6    Lee, W.H.7    Suk, K.8
  • 45
    • 84920195880 scopus 로고    scopus 로고
    • Acute phase protein lipocalin-2 is associated with formalin-induced nociception and pathological pain
    • Jha, M.K., Jeon, S., Jin, M., Lee, W.H., Suk, K., Acute phase protein lipocalin-2 is associated with formalin-induced nociception and pathological pain. Immune Netw. 13 (2013), 289–294.
    • (2013) Immune Netw. , vol.13 , pp. 289-294
    • Jha, M.K.1    Jeon, S.2    Jin, M.3    Lee, W.H.4    Suk, K.5
  • 46
    • 84893404407 scopus 로고    scopus 로고
    • The pivotal role played by lipocalin-2 in chronic inflammatory pain
    • Jha, M.K., Jeon, S., Jin, M., Ock, J., Kim, J.H., Lee, W.H., Suk, K., The pivotal role played by lipocalin-2 in chronic inflammatory pain. Exp. Neurol. 254 (2014), 41–53.
    • (2014) Exp. Neurol. , vol.254 , pp. 41-53
    • Jha, M.K.1    Jeon, S.2    Jin, M.3    Ock, J.4    Kim, J.H.5    Lee, W.H.6    Suk, K.7
  • 48
    • 84912031553 scopus 로고    scopus 로고
    • Optogenetic control of astrocytes: is it possible to treat astrocyte-related epilepsy?
    • Ji, Z.G., Wang, H., Optogenetic control of astrocytes: is it possible to treat astrocyte-related epilepsy?. Brain Res. Bull. 110 (2015), 20–25.
    • (2015) Brain Res. Bull. , vol.110 , pp. 20-25
    • Ji, Z.G.1    Wang, H.2
  • 49
    • 84920183458 scopus 로고    scopus 로고
    • Lipocalin-2 acts as a neuroinflammatogen in lipopolysaccharide-injected mice
    • Jin, M., Jang, E., Suk, K., Lipocalin-2 acts as a neuroinflammatogen in lipopolysaccharide-injected mice. Exp. Neurobiol. 23 (2014), 155–162.
    • (2014) Exp. Neurobiol. , vol.23 , pp. 155-162
    • Jin, M.1    Jang, E.2    Suk, K.3
  • 50
    • 84905495037 scopus 로고    scopus 로고
    • Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice
    • Jin, M., Kim, J.H., Jang, E., Lee, Y.M., Soo Han, H., Woo, D.K., Park, D.H., Kook, H., Suk, K., Lipocalin-2 deficiency attenuates neuroinflammation and brain injury after transient middle cerebral artery occlusion in mice. J. Cereb. Blood Flow Metab. 34 (2014), 1306–1314.
    • (2014) J. Cereb. Blood Flow Metab. , vol.34 , pp. 1306-1314
    • Jin, M.1    Kim, J.H.2    Jang, E.3    Lee, Y.M.4    Soo Han, H.5    Woo, D.K.6    Park, D.H.7    Kook, H.8    Suk, K.9
  • 51
    • 77952243719 scopus 로고    scopus 로고
    • Lipocalin-2: pro- or anti-apoptotic?
    • Kehrer, J.P., Lipocalin-2: pro- or anti-apoptotic?. Cell Biol. Toxicol. 26 (2010), 83–89.
    • (2010) Cell Biol. Toxicol. , vol.26 , pp. 83-89
    • Kehrer, J.P.1
  • 52
    • 0027420678 scopus 로고
    • Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation
    • Kjeldsen, L., Bainton, D.F., Sengelov, H., Borregaard, N., Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation. Blood 82 (1993), 3183–3191.
    • (1993) Blood , vol.82 , pp. 3183-3191
    • Kjeldsen, L.1    Bainton, D.F.2    Sengelov, H.3    Borregaard, N.4
  • 53
    • 0027955338 scopus 로고
    • Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils
    • Kjeldsen, L., Bainton, D.F., Sengelov, H., Borregaard, N., Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 83 (1994), 799–807.
    • (1994) Blood , vol.83 , pp. 799-807
    • Kjeldsen, L.1    Bainton, D.F.2    Sengelov, H.3    Borregaard, N.4
  • 54
    • 0034684233 scopus 로고    scopus 로고
    • Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse
    • Kjeldsen, L., Cowland, J.B., Borregaard, N., Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim. Biophys. Acta 1482 (2000), 272–283.
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 272-283
    • Kjeldsen, L.1    Cowland, J.B.2    Borregaard, N.3
  • 55
    • 84934436897 scopus 로고    scopus 로고
    • Self, non-self, and danger: a complementary view
    • Kohl, J., Self, non-self, and danger: a complementary view. Adv. Exp. Med. Biol 586 (2006), 71–94.
    • (2006) Adv. Exp. Med. Biol , vol.586 , pp. 71-94
    • Kohl, J.1
  • 58
    • 38449114990 scopus 로고    scopus 로고
    • A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia
    • Lee, S., Lee, J., Kim, S., Park, J.Y., Lee, W.H., Mori, K., Kim, S.H., Kim, I.K., Suk, K., A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. J. Immunol. 179 (2007), 3231–3241.
    • (2007) J. Immunol. , vol.179 , pp. 3231-3241
    • Lee, S.1    Lee, J.2    Kim, S.3    Park, J.Y.4    Lee, W.H.5    Mori, K.6    Kim, S.H.7    Kim, I.K.8    Suk, K.9
  • 59
    • 58149400146 scopus 로고    scopus 로고
    • Lipocalin-2 is an autocrine mediator of reactive astrocytosis
    • Lee, S., Park, J.Y., Lee, W.H., Kim, H., Park, H.C., Mori, K., Suk, K., Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J. Neurosci. 29 (2009), 234–249.
    • (2009) J. Neurosci. , vol.29 , pp. 234-249
    • Lee, S.1    Park, J.Y.2    Lee, W.H.3    Kim, H.4    Park, H.C.5    Mori, K.6    Suk, K.7
  • 60
    • 83755181397 scopus 로고    scopus 로고
    • Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration
    • Lee, S., Kim, J.H., Seo, J.W., Han, H.S., Lee, W.H., Mori, K., Nakao, K., Barasch, J., Suk, K., Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration. J. Biol. Chem. 286 (2011), 43855–43870.
    • (2011) J. Biol. Chem. , vol.286 , pp. 43855-43870
    • Lee, S.1    Kim, J.H.2    Seo, J.W.3    Han, H.S.4    Lee, W.H.5    Mori, K.6    Nakao, K.7    Barasch, J.8    Suk, K.9
  • 61
    • 84863341420 scopus 로고    scopus 로고
    • Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects
    • Lee, S., Jang, E., Kim, J.H., Lee, W.H., Suk, K., Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. J. Biol. Chem. 287 (2012), 9414–9428.
    • (2012) J. Biol. Chem. , vol.287 , pp. 9414-9428
    • Lee, S.1    Jang, E.2    Kim, J.H.3    Lee, W.H.4    Suk, K.5
  • 62
    • 84930652691 scopus 로고    scopus 로고
    • Aptamer-based sandwich assay and its clinical outlooks for detecting lipocalin-2 in hepatocellular carcinoma (HCC)
    • Lee, K.A., Ahn, J.Y., Lee, S.H., Singh Sekhon, S., Kim, D.G., Min, J., Kim, Y.H., Aptamer-based sandwich assay and its clinical outlooks for detecting lipocalin-2 in hepatocellular carcinoma (HCC). Sci. Rep., 5, 2015, 10897.
    • (2015) Sci. Rep. , vol.5 , pp. 10897
    • Lee, K.A.1    Ahn, J.Y.2    Lee, S.H.3    Singh Sekhon, S.4    Kim, D.G.5    Min, J.6    Kim, Y.H.7
  • 63
    • 84934989276 scopus 로고    scopus 로고
    • Lipocalin-2 in the inflammatory activation of brain astrocytes
    • Lee, S., Jha, M.K., Suk, K., Lipocalin-2 in the inflammatory activation of brain astrocytes. Crit. Rev. Immunol. 35 (2015), 77–84.
    • (2015) Crit. Rev. Immunol. , vol.35 , pp. 77-84
    • Lee, S.1    Jha, M.K.2    Suk, K.3
  • 64
    • 84881654585 scopus 로고    scopus 로고
    • Minimal NF-kappaB activity in neurons
    • Listwak, S.J., Rathore, P., Herkenham, M., Minimal NF-kappaB activity in neurons. Neuroscience 250 (2013), 282–299.
    • (2013) Neuroscience , vol.250 , pp. 282-299
    • Listwak, S.J.1    Rathore, P.2    Herkenham, M.3
  • 65
    • 84876783277 scopus 로고    scopus 로고
    • Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections
    • Liu, Z., Petersen, R., Devireddy, L., Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections. J. Immunol. 190 (2013), 4692–4706.
    • (2013) J. Immunol. , vol.190 , pp. 4692-4706
    • Liu, Z.1    Petersen, R.2    Devireddy, L.3
  • 69
    • 0141678253 scopus 로고    scopus 로고
    • Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    • Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., Devarajan, P., Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J. Am. Soc. Nephrol. 14 (2003), 2534–2543.
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2534-2543
    • Mishra, J.1    Ma, Q.2    Prada, A.3    Mitsnefes, M.4    Zahedi, K.5    Yang, J.6    Barasch, J.7    Devarajan, P.8
  • 70
    • 81055126115 scopus 로고    scopus 로고
    • Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
    • Mucha, M., Skrzypiec, A.E., Schiavon, E., Attwood, B.K., Kucerova, E., Pawlak, R., Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 18436–18441.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 18436-18441
    • Mucha, M.1    Skrzypiec, A.E.2    Schiavon, E.3    Attwood, B.K.4    Kucerova, E.5    Pawlak, R.6
  • 71
    • 0025875250 scopus 로고
    • Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins
    • Nagata, A., Suzuki, Y., Igarashi, M., Eguchi, N., Toh, H., Urade, Y., Hayaishi, O., Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proc. Natl. Acad. Sci. U. S. A. 88 (1991), 4020–4024.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 4020-4024
    • Nagata, A.1    Suzuki, Y.2    Igarashi, M.3    Eguchi, N.4    Toh, H.5    Urade, Y.6    Hayaishi, O.7
  • 72
    • 84902477342 scopus 로고    scopus 로고
    • Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues
    • Nam, Y., Kim, J.H., Seo, M., Jin, M., Jeon, S., Seo, J.W., Lee, W.H., Bing, S.J., Jee, Y., Lee, W.K., Park, D.H., Kook, H., Suk, K., Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues. J. Biol. Chem. 289 (2014), 16773–16789.
    • (2014) J. Biol. Chem. , vol.289 , pp. 16773-16789
    • Nam, Y.1    Kim, J.H.2    Seo, M.3    Jin, M.4    Jeon, S.5    Seo, J.W.6    Lee, W.H.7    Bing, S.J.8    Jee, Y.9    Lee, W.K.10    Park, D.H.11    Kook, H.12    Suk, K.13
  • 73
    • 0034669915 scopus 로고    scopus 로고
    • Attenuation of experimental autoimmune demyelination in complement-deficient mice
    • Nataf, S., Carroll, S.L., Wetsel, R.A., Szalai, A.J., Barnum, S.R., Attenuation of experimental autoimmune demyelination in complement-deficient mice. J. Immunol. 165 (2000), 5867–5873.
    • (2000) J. Immunol. , vol.165 , pp. 5867-5873
    • Nataf, S.1    Carroll, S.L.2    Wetsel, R.A.3    Szalai, A.J.4    Barnum, S.R.5
  • 75
    • 84940725091 scopus 로고    scopus 로고
    • Role of lipocalin-2 in brain injury after intracerebral hemorrhage
    • Ni, W., Zheng, M., Xi, G., Keep, R.F., Hua, Y., Role of lipocalin-2 in brain injury after intracerebral hemorrhage. J. Cereb. Blood Flow Metab. 35 (2015), 1454–1461.
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 1454-1461
    • Ni, W.1    Zheng, M.2    Xi, G.3    Keep, R.F.4    Hua, Y.5
  • 76
    • 84890863464 scopus 로고    scopus 로고
    • The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis
    • Nocon, A.L., Ip, J.P., Terry, R., Lim, S.L., Getts, D.R., Muller, M., Hofer, M.J., King, N.J., Campbell, I.L., The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. J. Virol. 88 (2014), 679–689.
    • (2014) J. Virol. , vol.88 , pp. 679-689
    • Nocon, A.L.1    Ip, J.P.2    Terry, R.3    Lim, S.L.4    Getts, D.R.5    Muller, M.6    Hofer, M.J.7    King, N.J.8    Campbell, I.L.9
  • 78
    • 84887873981 scopus 로고    scopus 로고
    • Astrocyte-neuron interaction at tripartite synapses
    • Perez-Alvarez, A., Araque, A., Astrocyte-neuron interaction at tripartite synapses. Curr. Drug Targets 14 (2013), 1220–1224.
    • (2013) Curr. Drug Targets , vol.14 , pp. 1220-1224
    • Perez-Alvarez, A.1    Araque, A.2
  • 79
    • 84855943334 scopus 로고    scopus 로고
    • Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception
    • Poh, K.W., Yeo, J.F., Stohler, C.S., Ong, W.Y., Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception. J. Neurosci. 32 (2012), 35–45.
    • (2012) J. Neurosci. , vol.32 , pp. 35-45
    • Poh, K.W.1    Yeo, J.F.2    Stohler, C.S.3    Ong, W.Y.4
  • 80
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
    • Prinz, M., Priller, J., Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat. Rev. Neurosci. 15 (2014), 300–312.
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 82
    • 84855989306 scopus 로고    scopus 로고
    • Lipocalin 2 in cancer: when good immunity goes bad
    • Rodvold, J.J., Mahadevan, N.R., Zanetti, M., Lipocalin 2 in cancer: when good immunity goes bad. Cancer Lett. 316 (2012), 132–138.
    • (2012) Cancer Lett. , vol.316 , pp. 132-138
    • Rodvold, J.J.1    Mahadevan, N.R.2    Zanetti, M.3
  • 88
    • 2442496280 scopus 로고    scopus 로고
    • Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration key signaling pathway for astrogliosis in vivo?
    • Sriram, K., Benkovic, S.A., Hebert, M.A., Miller, D.B., O'Callaghan, J.P., Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration key signaling pathway for astrogliosis in vivo?. J. Biol. Chem. 279 (2004), 19936–19947.
    • (2004) J. Biol. Chem. , vol.279 , pp. 19936-19947
    • Sriram, K.1    Benkovic, S.A.2    Hebert, M.A.3    Miller, D.B.4    O'Callaghan, J.P.5
  • 89
    • 84953272841 scopus 로고    scopus 로고
    • The effect of acute and chronic social stress on the hippocampal transcriptome in mice
    • Stankiewicz, A.M., Goscik, J., Majewska, A., Swiergiel, A.H., Juszczak, G.R., The effect of acute and chronic social stress on the hippocampal transcriptome in mice. PLoS One, 10, 2015, e0142195.
    • (2015) PLoS One , vol.10 , pp. e0142195
    • Stankiewicz, A.M.1    Goscik, J.2    Majewska, A.3    Swiergiel, A.H.4    Juszczak, G.R.5
  • 90
    • 34247263694 scopus 로고    scopus 로고
    • Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease
    • Szalai, A.J., Hu, X., Adams, J.E., Barnum, S.R., Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease. Mol. Immunol. 44 (2007), 3132–3136.
    • (2007) Mol. Immunol. , vol.44 , pp. 3132-3136
    • Szalai, A.J.1    Hu, X.2    Adams, J.E.3    Barnum, S.R.4
  • 91
    • 80053576812 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155
    • Tarassishin, L., Loudig, O., Bauman, A., Shafit-Zagardo, B., Suh, H.S., Lee, S.C., Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155. Glia 59 (2011), 1911–1922.
    • (2011) Glia , vol.59 , pp. 1911-1922
    • Tarassishin, L.1    Loudig, O.2    Bauman, A.3    Shafit-Zagardo, B.4    Suh, H.S.5    Lee, S.C.6
  • 92
    • 84855172549 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3 K/Akt pathway
    • Tarassishin, L., Suh, H.S., Lee, S.C., Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3 K/Akt pathway. J. Neuroinflammation, 8, 2011, 187.
    • (2011) J. Neuroinflammation , vol.8 , pp. 187
    • Tarassishin, L.1    Suh, H.S.2    Lee, S.C.3
  • 93
    • 84949313567 scopus 로고    scopus 로고
    • A role for astrocytes in sensing the brain microenvironment and neuro-metabolic integration
    • Teschemacher, A.G., Gourine, A.V., Kasparov, S., A role for astrocytes in sensing the brain microenvironment and neuro-metabolic integration. Neurochem. Res. 40 (2015), 2386–2393.
    • (2015) Neurochem. Res. , vol.40 , pp. 2386-2393
    • Teschemacher, A.G.1    Gourine, A.V.2    Kasparov, S.3
  • 94
    • 84880217322 scopus 로고    scopus 로고
    • Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
    • Tong, J., Huang, C., Bi, F., Wu, Q., Huang, B., Liu, X., Li, F., Zhou, H., Xia, X.G., Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats. EMBO J. 32 (2013), 1917–1926.
    • (2013) EMBO J. , vol.32 , pp. 1917-1926
    • Tong, J.1    Huang, C.2    Bi, F.3    Wu, Q.4    Huang, B.5    Liu, X.6    Li, F.7    Zhou, H.8    Xia, X.G.9
  • 95
    • 0034684216 scopus 로고    scopus 로고
    • Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase
    • Urade, Y., Hayaishi, O., Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochim. Biophys. Acta 1482 (2000), 259–271.
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 259-271
    • Urade, Y.1    Hayaishi, O.2
  • 96
    • 84933278468 scopus 로고    scopus 로고
    • Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice
    • Wang, G., Weng, Y.C., Han, X., Whaley, J.D., McCrae, K.R., Chou, W.H., Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice. J. Cell. Mol. Med. 19 (2015), 1637–1645.
    • (2015) J. Cell. Mol. Med. , vol.19 , pp. 1637-1645
    • Wang, G.1    Weng, Y.C.2    Han, X.3    Whaley, J.D.4    McCrae, K.R.5    Chou, W.H.6
  • 98
    • 84927547045 scopus 로고    scopus 로고
    • Identification of lipocalin-2 as a PKCdelta phosphorylation substrate in neutrophils
    • Weng, Y.C., Wang, G., Messing, R.O., Chou, W.H., Identification of lipocalin-2 as a PKCdelta phosphorylation substrate in neutrophils. J. Biomed. Sci., 22, 2015, 21.
    • (2015) J. Biomed. Sci. , vol.22 , pp. 21
    • Weng, Y.C.1    Wang, G.2    Messing, R.O.3    Chou, W.H.4
  • 99
    • 84903142822 scopus 로고    scopus 로고
    • Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma
    • Wu, B., Li, C., Du, Z., Yao, Q., Wu, J., Feng, L., Zhang, P., Li, S., Xu, L., Li, E., Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma. Sci. Rep., 4, 2014, 5403.
    • (2014) Sci. Rep. , vol.4 , pp. 5403
    • Wu, B.1    Li, C.2    Du, Z.3    Yao, Q.4    Wu, J.5    Feng, L.6    Zhang, P.7    Li, S.8    Xu, L.9    Li, E.10
  • 100
    • 84924533531 scopus 로고    scopus 로고
    • Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms
    • Wu, L., Du, Y., Lok, J., Lo, E.H., Xing, C., Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J. Neurochem. 132 (2015), 622–628.
    • (2015) J. Neurochem. , vol.132 , pp. 622-628
    • Wu, L.1    Du, Y.2    Lok, J.3    Lo, E.H.4    Xing, C.5
  • 102
    • 84954305581 scopus 로고    scopus 로고
    • Up-regulation of miR-138 inhibits hypoxia-induced cardiomyocyte apoptosis via down-regulating lipocalin-2 expression
    • Xiong, H., Luo, T., He, W., Xi, D., Lu, H., Li, M., Liu, J., Guo, Z., Up-regulation of miR-138 inhibits hypoxia-induced cardiomyocyte apoptosis via down-regulating lipocalin-2 expression. Exp. Biol. Med. (Maywood) 41 (2016), 25–30.
    • (2016) Exp. Biol. Med. (Maywood) , vol.41 , pp. 25-30
    • Xiong, H.1    Luo, T.2    He, W.3    Xi, D.4    Lu, H.5    Li, M.6    Liu, J.7    Guo, Z.8
  • 104
    • 84869413644 scopus 로고    scopus 로고
    • An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2
    • Zhai, L., Wang, T., Kang, K., Zhao, Y., Shrotriya, P., Nilsen-Hamilton, M., An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2. Anal. Chem. 84 (2012), 8763–8770.
    • (2012) Anal. Chem. , vol.84 , pp. 8763-8770
    • Zhai, L.1    Wang, T.2    Kang, K.3    Zhao, Y.4    Shrotriya, P.5    Nilsen-Hamilton, M.6


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