The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

Biomarkers

Volumn 20, Issue 8, 2015, Pages 565-571

  Abella, Vanessa ^a,b   Scotece, Morena ^a   Conde, Javier ^a   Gómez, Rodolfo ^a   Lois, Ana ^a   Pino, Jesús ^c   Gómez Reino, Juan J ^a   Lago, Francisca ^a   Mobasheri, Ali ^d,e,f   Gualillo, Oreste ^a  

^a Santiago University Clinical Hospital   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d UNIVERSITY OF SURREY   (United Kingdom)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Adipokines; Adipose tissue; Immunity; Kidney diseases; Rheumatic diseases

Indexed keywords

ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; FATTY ACID; IRON; LIPOCALIN; LIPOPOLYSACCHARIDE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; AUTACOID; LCN2 PROTEIN, HUMAN; ONCOPROTEIN;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; HEMATOPOIETIC CELL; HUMAN; IMMUNITY; INFLAMMATION; KIDNEY DISEASE; METABOLIC DISORDER; METABOLISM; MUSCULOSKELETAL DISEASE; NONHUMAN; RHEUMATIC DISEASE; ANIMAL; METABOLIC DISEASES; PREDICTIVE VALUE; PROGNOSIS;

ACUTE-PHASE PROTEINS; ANIMALS; BIOMARKERS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOCALIN-2; LIPOCALINS; METABOLIC DISEASES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS;

EID: 84949807417     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2015.1123354     Document Type: Article

References (72)

1. Aigner F, Maier HT, Schwelberger HG, et al. (2007). Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart. Am J Transplant 7: 779-88
2. Bao, G, Clifton M, Hoette TM, et al. (2010). Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol 6: 602-9
3. Bartsch S, Tschesche H. (1995). Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells. FEBS Lett 357: 255-9
4. Berard JL, Zarruk JG, Arbour N, et al. (2012). Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis. Glia 60: 1145-59
5. Bolignano D, Donato V, Coppolino G, et al. (2008). Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 52: 595-605
6. Borregaard N, Cowland JB. (2006). Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein. Biometals 19: 211-15
7. Brunner HI, Bennett MR, Mina R, et al. (2012). Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum 64: 2687-97
8. Chakraborty S, Kaur S, Guha S, et al. (2012). The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim Biophys Acta 1826: 129-69
9. Chassaing B, Srinivasan G, Delgado MA,. et al. (2012). Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One 9: e44328. doi: 10.1371/journal.pone.0044328
10. Chu ST, Lin HJ, Huang HL, Chen YH. (1998). The hydrophobic pocket of 24p3 protein from mouse uterine luminal fluid: fatty acid and retinol binding activity and predicted structural similarity to lipocalins. J Pept Res 52: 390-7
11. Conde J, Gomez R, Bianco G, et al. (2011b). Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis 70: 551-9
12. Conde J, Scotece M, Gómez R, et al. (2011a). Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. BioFactors 37: 413-20
13. Costa D, Biticchi R, Negrini S, et al. (2010). Lipocalin-2 controls the expression of SDF-1 and the number of responsive cells in bone. Cytokine 51: 47-52
14. Costa D, Lazzarini E, Canciani B, et al. (2013). Altered bone development and turnover in transgenic mice over-expressing lipocalin-2 in bone. J Cell Physiol 228: 2210-21
15. Cowland JB, Borregaard N. (1997). Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45: 17-23
16. Dejaco C, Duftner C, Grubeck-Loebenstein B, et al. (2006). Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117: 289-300
17. Devireddy LR, Teodoro JG, Richard FA, Green MR. (2001). Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293: 829-34
18. Devireddy LR, Gazin C, Zhu X, Green MR. (2005). A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123: 1293-305
19. Devireddy LR, Hart DO, Goetz DH, Green MR. (2010). A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 141: 1006-17
20. Elewa EA, El Tokhy MA, Fathy SE, et al. (2015). Predictive role of urinary neutrophil gelatinase-associated lipocalin in lupus nephritis. Lupus 24: 138-46
21. Filiopoulos V, Biblaki D, Vlassopoulos D. (2014). Neutrophil gelatinase-associated lipocalin (NGAL): a promising biomarker of contrast-induced nephropathy after computed tomography. Ren Fail 36: 979-86
22. Flo TH, Smith KD, Sato S, et al. (2004). Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432: 917-21
23. Friedl, A, Stoesz SP, Buckley P, Gould MN. (1999). Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J 31: 433-41
24. Garay-Rojas E, Harper M, Hraba-Renevey S, Kress M. (1996). An apparent autocrine mechanism amplifies the dexamethasone-and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3. Gene 170: 173-80
25. Gómez R, Conde J, Scotece M, et al. (2011). Whats new in our understanding of the role of adipokines in rheumatic diseases? Nat Rev Rheumatol 7: 528-36
26. Gómez R, Scotece M, Conde J, et al. (2013). Nitric oxide boosts TLR-4 mediated lipocalin 2 expression in chondrocytes. J Orthop Res 31: 1046-52
27. Gregor MF, Hotamisligil GS. (2011). Inflammatory mechanisms in obesity. Annu Rev Immunol 29: 415-45
28. Guo H, Jin D, Zhang Y, et al. (2010). Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes 59: 1376-85
29. Guo H, Jin D, Chen X. (2014). Lipocalin 2 is a regulator of macrophage polarization and NF-B/STAT3 pathway activation. Mol Endocrinol 28: 1616-28
30. Guo H, Zhang Y, Brockman DA, et al. (2012). Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice. Endocrinology 153: 1183-93
31. Gupta K, Shukla M, Cowland JB, et al. (2007). Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9. Arthritis Rheum 56: 3326-35
32. Haase-Fielitz A, Haase M, Devarajan P. (2014). Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status. Ann Clin Biochem 51: 335-51
33. Hammad A, Mosaad Y, Elhanbly S, et al. (2013). Urinary neutrophil gelatinase-associated lipocalin as a marker of severe lupus nephritis in children. Lupus 22: 486-91
34. Hawlisch H, Wills-Karp M, Karp CL, Köhl J. (2004). The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Mol Immunol 41: 123-31
35. Hu, X, Luo P, Peng X, et al. (2015). Molecular cloning, expression pattern analysis of porcine Rb1 gene and its regulatory roles during primary dedifferentiated fat cells adipogenic differentiation. Gen Comp Endocrinol 214: 77-86
36. Huang HL, Chu ST, Chen YH. (1999). Ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantation period. J Endocrinol 162: 11-19
37. Hvidberg V, Jacobsen C, Strong RK, et al. (2005). The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579: 773-7
38. Jacobson AC, Weis JJ, Weis JH. (2008). Complement receptors 1 and 2 influence the immune environment in a B cell receptor-independent manner. J Immunol 180: 5057-66
39. Jang Y, Lee JH, Wang Y, Sweeney G. (2012). Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome. Clin Exp Pharmacol Physiol 39: 194-9
40. Jin D, Guo H, Bu SY, et al. (2011). Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure. FASEB J 25: 754-64
41. Katano M, et al. (2009). Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis. Arthritis Res Ther 11: R3
42. Kjeldsen L, Cowland JB, Borregaard N. (2000). Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim Biophys Acta 1482: 272-83
43. Kjeldsen L, Okamoto K, Arito M, et al. (1994). Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 83: 799-807
44. Lago F, Dieguez C, Gómez-Reino J, et al. (2007). Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 3: 716-24
45. La Manna G, Ghinatti G, Tazzari PL, et al. (2014). Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC. PLoS One 9: e89497
46. Law IKM, Xu A, Lam KS, et al. (2010). Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes 59: 872-82
47. Li Y, Hu FL, Dai YJ, et al. (2014). Serum anti-lipocalin 2 IgG is a novel biomarker in the diagnosis of systemic lupus erythematosus. Lupus 23: 868-75
48. Lindberg S, Jensen JS, Mogelvang R, et al. (2014). Plasma neutrophil gelatinase-associated lipocalinin in the general population: association with inflammation and prognosis. Arterioscler Thromb Vasc Biol 34: 2135-42
49. Malemud CJ. (2015). Biologic basis of osteoarthritis: state of the evidence. Curr Opin Rheumatol 27: 289-94
50. Mishra J, Ma Q, Prada A, et al. (2003). Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-43
51. Moreno-Navarrete JM, Manco M, Ibáñez J, et al. (2010). Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. Int J Obes (Lond) 34: 240-9
52. Nairz M, Haschka D, Demetz E, et al. (2014). Iron at the interface of immunity and infection. Front Pharmacol 5: 152
53. Nakamura A, Takai T. (2004). A role of FcgammaRIIB in the development of collagen-induced arthritis. Biomed Pharmacother 58: 292-8
54. Nam Y, Kim JH, Seo M, et al. (2014). Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues. J Biol Chem 289: 16773-89
55. Nickolas TL, Forster CS, Sise ME, et al. (2012). NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int 82: 718-22
56. Owen HC, Roberts SJ, Ahmed SF, Farquharson C. (2008). Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metabol 294: 1023-34
57. Rubinstein T, Pitashny M, Levine B, et al. (2010). Urinary neutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis. Rheumatology (Oxford) 49: 960-71
58. Seo WH, Nam SW, Lee EH, et al. (2014). A rapid plasma neutrophil gelatinase-associated lipocalin assay for diagnosis of acute pyelonephritis in infants with acute febrile urinary tract infections: a preliminary study. Eur J Pediatr 173: 229-32
59. Shashidharamurthy R, Machiah D, Aitken JD, et al. (2013). Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice. Arthritis Rheum 65: 1064-73
60. Shen F, Hu Z, Goswami J, Gaffen SL. (2006). Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 281: 24138-48
61. Sommer G, Weise S, Kralisch S, et al. (2009). Lipocalin-2 is induced by interleukin-1beta in murine adipocytes in vitro. J Cell Biochem 106: 103-8
62. Srinivasan G, Aitken JD, Zhang B, et al. (2012). Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol 189: 1911-19
63. Wang Y, Lam KS, Kraegen EW, et al. (2007). Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 53: 34-41
64. Wilson R, Belluoccio D, Little CB, et al. (2008). Proteomic characterization of mouse cartilage degradation in vitro. Arthritis Rheum 58: 3120-31
65. Yan QW, Yang Q, Mody N, et al. (2007). The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56: 2533-40
66. Yang CC, Hsieh SC, Li KJ, et al. (2012). Urinary neutrophil gelatinase-associated lipocalin is a potential biomarker for renal damage in patients with systemic lupus erythematosus. J Biomed Biotechnol 2012: 759313
67. Yang J, Goetz D, Li JY, et al. (2002). An iron delivery pathway mediated by a lipocalin. Mol Cell 10: 1045-56
68. Yuen PST, Jo SK, Holly MK, et al. (2006). Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses. Physiol Genomics 25: 375-86
69. Zhang Y, Foncea R, Deis JA, et al. (2014a). Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes. PLoS One 9: e96997
70. Zhang Y, Guo H, Deis JA, et al. (2014b). Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism. J Biol Chem 289: 22063-77
71. Zhao H, Konishi A, Fujita Y, et al. (2012). Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe 12: 705-16
72. Zhao P, Elks CM, Stephens JM. (2014). The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 289: 5960-9