Biochemical and structural characterization of the interaction between the siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated lipocalin/lipocalin 2) and the N-terminal domain of its endocytic receptor SLC22A17

Journal of Biological Chemistry

Volumn 291, Issue 6, 2016, Pages 2917-2930

  Martinez, Ana Isabel Cabedo ^a   Weinhäupl, Katharina ^a   Lee, Wing Kee ^b   Wolff, Natascha A ^b   Storch, Barbara ^c   Zerko, Szymon ^d   Konrat, Robert ^a   Kozminski, Wiktor ^d   Breuker, Kathrin ^c   Thévenod, Frank ^b   Coudevylle, Nicolas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

BIOCHEMICAL MECHANISMS; CELL DIFFERENTIATION; EXTRACELLULAR DOMAINS; MOLECULAR DETERMINANTS; NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN; PATHOLOGICAL PROCESS; PLEIOTROPIC FUNCTIONS; STRUCTURAL CHARACTERIZATION;

CELL DEATH;

CELL RECEPTOR; ENDOCYTIC RECEPTOR SLC22A17; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; ORGANIC CATION TRANSPORTER; PROTEIN BINDING; SLC22A17 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMICAL ANALYSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISULFIDE BOND; EXTRACELLULAR DOMAIN; HUMAN; INTERNALIZATION; ISOTHERMAL TITRATION CALORIMETRY; MICROSCALE THERMOPHORESIS; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOUSE; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE;

ACUTE-PHASE PROTEINS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIPOCALIN-2; LIPOCALINS; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANIC CATION TRANSPORT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS;

EID: 84957991271     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.685644     Document Type: Article

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