Lipocalin 2 modulates the cellular response to amyloid beta

Cell Death and Differentiation

Volumn 21, Issue 10, 2014, Pages 1588-1599

  Mesquita, S D ^a,b   Ferreira, A C ^a,b   Falcao, A M ^a,b   Sousa, J C ^a,b   Oliveira, T G ^a,b   Correia Neves, M ^a,b   Sousa, N ^a,b   Marques, F ^a,b   Palha, J A ^a,b  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; HEME OXYGENASE; HMOX1 PROTEIN, RAT; IRON; LCN2 PROTEIN, MOUSE; LCN2 PROTEIN, RAT; LIPOCALIN; MEMBRANE PROTEIN; ONCOPROTEIN;

ALZHEIMER DISEASE; ANIMAL; ASTROCYTE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MICROGLIA; MOUSE; NERVE CELL; RAT;

ACUTE-PHASE PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS REGULATORY PROTEINS; ASTROCYTES; CELLS, CULTURED; EPITHELIAL CELLS; HEME OXYGENASE (DECYCLIZING); INFLAMMATION; IRON; LIPOCALINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS; RATS;

EID: 84900894981     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.68     Document Type: Article

References (55)

1. Benilova I, Karran E, De Strooper B. The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012; 15: 349-357.
2. Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC et al. Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. J Biol Chem 2011; 286: 4248-4256.
3. Wang L, Xi G, Keep RF, Hua Y. Iron enhances the neurotoxicity of amyloid beta. Transl Stroke Res 2012; 3: 107-113.
4. Crichton RR, Dexter DT, Ward RJ. Brain iron metabolism and its perturbation in neurological diseases. J Neural Transm 2011; 118: 301-314.
5. Leskovjan AC, Kretlow A, Lanzirotti A, Barrea R, Vogt S, Miller LM. Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease. Neuroimage 2011; 55: 32-38.
6. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem 2002; 277: 45518-45528.
7. Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E, Liu B et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci 2009; 29: 1335-1347.
8. Naude PJ, Nyakas C, Eiden LE, Ait-Ali D, van der Heide R, Engelborghs S et al. Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease. FASEB J 2012; 26: 2811-2823.
9. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993; 268: 10425-10432.
10. Liu Q, Nilsen-Hamilton M. Identification of a new acute phase protein. J Biol Chem 1995; 270: 22565-22570.
11. Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophoremediated iron acquisition. Mol Cell 2002; 10: 1033-1043.
12. Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol 2010; 6: 602-609.
13. Devireddy LR, Hart DO, Goetz DH, Green MR. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 2010; 141: 1006-1017.
14. Devireddy LR, Gazin C, Zhu X, Green MR. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005; 123: 1293-1305.
15. Lee S, Lee WH, Lee MS, Mori K, Suk K. Regulation by lipocalin-2 of neuronal cell death, migration, and morphology. J Neurosci Res 2012; 90: 540-550.
16. Lee S, Kim JH, Seo JW, Han HS, Lee WH, Mori K et al. Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration. J Biol Chem 2011; 286: 43855-43870.
17. Lee S, Park JY, Lee WH, Kim H, Park HC, Mori K et al. Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J Neurosci 2009; 29: 234-249.
18. Marques F, Rodrigues AJ, Sousa JC, Coppola G, Geschwind DH, Sousa N et al. Lipocalin 2 is a choroid plexus acute-phase protein. J Cereb Blood Flow Metab 2008; 28: 450-455.
19. Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH et al. Lipocalin 2 is present in the EAE brain and is modulated by natalizumab. Front Cell Neurosci 2012; 6: 33.
20. Park LC, Calingasan NY, Uchida K, Zhang H, Gibson GE. Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. J Neurochem 2000; 74: 114-124.
21. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999; 3: 287-296.
22. Crossgrove JS, Li GJ, Zheng W. The choroid plexus removes beta-amyloid from brain cerebrospinal fluid. Exp Biol Med (Maywood) 2005; 230: 771-776.
23. Mesquita SD, Ferreira AC, Sousa JC, Santos NC, Correia-Neves M, Sousa N et al. Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus. Front Cell Neurosci 2012; 6: 25.
24. Carro E, Spuch C, Trejo JL, Antequera D, Torres-Aleman I. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci 2005; 25: 10884-10893.
25. Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD et al. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J Neurosci 2012; 32: 16129-16140.
26. Bi F, Huang C, Tong J, Qiu G, Huang B, Wu Q et al. Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci USA 2013; 110: 4069-4074.
27. Rathore KI, Berard JL, Redensek A, Chierzi S, Lopez-Vales R, Santos M et al. Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury. J Neurosci 2011; 31: 13412-13419.
28. Jang E, Lee S, Kim JH, Seo JW, Lee WH, Mori K et al. Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J 2013; 27: 1176-1190.
29. Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B et al. Critical role of soluble amyloid-beta for early hippocampal hyperactivity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2012; 109: 8740-8745.
30. Paratore S, Parenti R, Torrisi A, Copani A, Cicirata F, Cavallaro S. Genomic profiling of cortical neurons following exposure to beta-amyloid. Genomics 2006; 88: 468-479.
31. Mucha M, Skrzypiec AE, Schiavon E, Attwood BK, Kucerova E, Pawlak R. Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc Natl Acad Sci USA 2011; 108: 18436-18441.
32. Jang E, Kim JH, Lee S, Kim JH, Seo JW, Jin M et al. Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes. J Immunol 2013; 191: 5204-5219.
33. Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM. The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation. Brain Res Mol Brain Res 1998; 57: 63-72.
34. Hamzic N, Blomqvist A, Nilsberth C. Immune-induced expression of lipocalin-2 in brain endothelial cells: relationship with interleukin-6, cyclooxygenase-2 and the febrile response. J Neuroendocrinol 2013; 25: 271-280.
35. Marques F, Falcao AM, Sousa JC, Coppola G, Geschwind D, Sousa N et al. Altered iron metabolism is part of the choroid plexus response to peripheral inflammation. Endocrinology 2009; 150: 2822-2828.
36. Rathore KI, Redensek A, David S. Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1. Glia 2012; 60: 738-750.
37. Song W, Su H, Song S, Paudel HK, Schipper HM. Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia. J Cell Physiol 2006; 206: 655-663.
38. Kell DB. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics 2009; 2: 2.
39. Ewings KE, Wiggins CM, Cook SJ. Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels. Cell Cycle 2007; 6: 2236-2240.
40. Li J, Ramenaden ER, Peng J, Koito H, Volpe JJ, Rosenberg PA. Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci 2008; 28: 5321-5330.
41. Biswas SC, Shi Y, Vonsattel JP, Leung CL, Troy CM, Greene LA. Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis. J Neurosci 2007; 27: 893-900.
42. Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol 2009; 182: 4947-4956.
43. Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi K. Role of Toll-like receptor signalling in Abeta uptake and clearance. Brain 2006; 129(Pt 11): 3006-3019.
44. Leow-Dyke S, Allen C, Denes A, Nilsson O, Maysami S, Bowie AG et al. Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J Neuroinflammation 2012; 9: 230.
45. Abramov AY, Canevari L, Duchen MR. Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 2004; 24: 565-575.
46. Weintraub S, Wicklund AH, Salmon DP. The neuropsychological profile of Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: a006171.
47. Choi J, Lee HW, Suk K. Increased plasma levels of lipocalin 2 in mild cognitive impairment. J Neurol Sci 2011; 305: 28-33.
48. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917-921.
49. Marques F, Sousa JC, Coppola G, Falcao AM, Rodrigues AJ, Geschwind DH et al. Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation. J Cereb Blood Flow Metab 2009; 29: 921-932.
50. Sousa JC, Cardoso I, Marques F, Saraiva MJ, Palha JA. Transthyretin and Alzheimer's disease: where in the brain? Neurobiol Aging 2007; 28: 713-718.
51. Cerqueira SR, Silva BL, Oliveira JM, Mano JF, Sousa N, Salgado AJ et al. Multifunctionalized CMCht/PAMAM dendrimer nanoparticles modulate the cellular uptake by astrocytes and oligodendrocytes in primary cultures of glial cells. Macromol Biosci 2012; 12: 591-597.
52. Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A et al. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci 2010; 30: 16419-16428.
53. Piras S, Furfaro AL, Piccini A, Passalacqua M, Borghi R, Carminati E et al. Monomeric Abeta1-42 and receptor for advanced glycation end product: key players in neuronal differentiation. Neurobiol Aging 2014; 35: 1301-1308.
54. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365-386.
55. Dunigan DD, Waters SB, Owen TC. Aqueous soluble tetrazolium/formazan MTS as an indicator of NADH-and NADPH-dependent dehydrogenase activity. BioTechniques 1995; 19: 640-649.