Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity

Neurochemistry International

Volumn 59, Issue 5, 2011, Pages 591-599

  Chia, Wan Jie ^a,b   Dawe, Gavin S ^a,b   Ong, Wei Yi ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

24p3; Adipokines; Iron siderophore; Lipocalins; Neurodegeneration; Oxidative stress

Indexed keywords

APOLIPOPROTEIN D; KAINIC ACID; LIPOCALIN; LIPOCALIN 5; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROSTAGLANDIN D2; RETINOL BINDING PROTEIN 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN STEM; CEREBELLUM; EXCITOTOXICITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL LESION; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOKINES; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN CHEMISTRY; EXCITATORY AMINO ACIDS; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; LIPOCALINS; MALE; NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

BACTERIA (MICROORGANISMS); MAMMALIA; RATTUS;

EID: 80052953969     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.04.007     Document Type: Article

References (47)

1. G. Bao, M. Clifton, T.M. Hoette, K. Mori, S.X. Deng, A. Qiu, M. Viltard, D. Williams, N. Paragas, T. Leete, R. Kulkarni, X. Li, B. Lee, A. Kalandadze, A.J. Ratner, J.C. Pizarro, K.M. Schmidt-Ott, D.W. Landry, K.N. Raymond, R.K. Strong, and J. Barasch Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex Nat. Chem. Biol. 6 2010 602 609
2. J. Barasch, and K. Mori Cell biology: iron thievery Nature 432 2004 811 813
3. M.L. Berger, J.M. Lefauconnier, E. Tremblay, and Y. Ben-Ari Limbic seizures induced by systemically applied kainic acid: how much kainic acid reaches the brain? Adv. Exp. Med. Biol. 203 1986 199 209
4. R.H. Bonow, S. Aid, Y. Zhang, K.G. Becker, and F. Bosetti The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice Pharmacogenomics J. 9 2009 116 126
5. L.R. Devireddy, C. Gazin, X. Zhu, and M.R. Green A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake Cell 123 2005 1293 1305 (Pubitemid 41821786)
6. L.R. Devireddy, D.O. Hart, D.H. Goetz, and M.R. Green A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production Cell 141 2010 1006 1017
7. T.H. Flo, K.D. Smith, S. Sato, D.J. Rodriguez, M.A. Holmes, R.K. Strong, S. Akira, and A. Aderem Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron Nature 432 2004 917 921 (Pubitemid 40037155)
8. D.R. Flower The lipocalin protein family: structure and function Biochem. J. 318 Pt. 1 1996 1 14 (Pubitemid 26283618)
9. D.H. Goetz, M.A. Holmes, N. Borregaard, M.E. Bluhm, K.N. Raymond, and R.K. Strong The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition Mol. Cell 10 2002 1033 1043 (Pubitemid 36001971)
10. T.E. Graham, Q. Yang, M. Bluher, A. Hammarstedt, T.P. Ciaraldi, R.R. Henry, C.J. Wason, A. Oberbach, P.A. Jansson, U. Smith, and B.B. Kahn Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects N. Engl. J. Med. 354 2006 2552 2563 (Pubitemid 43882351)
11. E. Huang, and W.Y. Ong Distribution of ferritin in the rat hippocampus after kainate-induced neuronal injury Exp. Brain Res. 161 2005 502 511 (Pubitemid 40386310)
12. M.B. Jorgensen, B.R. Finsen, M.B. Jensen, B. Castellano, N.H. Diemer, and J. Zimmer Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus Exp. Neurol. 120 1993 70 88 (Pubitemid 23114031)
13. D.B. Kell Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples Arch. Toxicol. 84 2010 825 889
14. L. Kjeldsen, A.H. Johnsen, H. Sengelov, and N. Borregaard Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase J. Biol. Chem. 268 1993 10425 10432 (Pubitemid 23150227)
15. S. Lee, J. Lee, S. Kim, J.Y. Park, W.H. Lee, K. Mori, S.H. Kim, I.K. Kim, and K. Suk A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia J. Immunol. 179 2007 3231 3241
16. S. Lee, J.Y. Park, W.H. Lee, H. Kim, H.C. Park, K. Mori, and K. Suk Lipocalin-2 is an autocrine mediator of reactive astrocytosis J. Neurosci. 29 2009 234 249
17. F. Marques, A.J. Rodrigues, J.C. Sousa, G. Coppola, D.H. Geschwind, N. Sousa, M. Correia-Neves, and J.A. Palha Lipocalin 2 is a choroid plexus acute-phase protein J. Cereb. Blood Flow Metab. 28 2008 450 455 (Pubitemid 351304271)
18. J. Mishra, C. Dent, R. Tarabishi, M.M. Mitsnefes, Q. Ma, C. Kelly, S.M. Ruff, K. Zahedi, M. Shao, J. Bean, K. Mori, J. Barasch, and P. Devarajan Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery Lancet 365 2005 1231 1238 (Pubitemid 40469655)
19. J. Mitchell, L.E. Sundstrom, and H.V. Wheal Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection Exp. Neurol. 121 1993 224 230 (Pubitemid 23234741)
20. T. Moos, and E.H. Morgan The metabolism of neuronal iron and its pathogenic role in neurological disease: review Ann. N.Y. Acad. Sci. 1012 2004 14 26 (Pubitemid 38453512)
21. J.H. Morais Cabral, G.L. Atkins, L.M. Sanchez, Y.S. Lopez-Boado, C. Lopez-Otin, and L. Sawyer Arachidonic acid binds to apolipoprotein D: implications for the protein's function FEBS Lett. 366 1995 53 56
22. K. Mori, H.T. Lee, D. Rapoport, I.R. Drexler, K. Foster, J. Yang, K.M. Schmidt-Ott, X. Chen, J.Y. Li, S. Weiss, J. Mishra, F.H. Cheema, G. Markowitz, T. Suganami, K. Sawai, M. Mukoyama, C. Kunis, V. D'Agati, P. Devarajan, and J. Barasch Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury J. Clin. Invest. 115 2005 610 621 (Pubitemid 40322235)
23. J.V. Nadler, B.W. Perry, and C.W. Cotman Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells Nature 271 1978 676 677 (Pubitemid 8278952)
24. J.V. Nadler, B.W. Perry, C. Gentry, and C.W. Cotman Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid J. Comp. Neurol. 192 1980 333 359 (Pubitemid 10035307)
25. D.E. Ong, M.E. Newcomer, J.J. Lareyre, and M.C. Orgebin-Crist Epididymal retinoic acid-binding protein Biochim. Biophys. Acta 1482 2000 209 217
26. W.Y. Ong, and B. Halliwell Iron, atherosclerosis, and neurodegeneration: a key role for cholesterol in promoting iron-dependent oxidative damage? Ann. N.Y. Acad. Sci. 1012 2004 51 64 (Pubitemid 38453515)
27. W.Y. Ong, X. He, L.H. Chua, and C.N. Ong Increased uptake of divalent metals lead and cadmium into the brain after kainite-induced neuronal injury Exp. Brain Res. 173 2006 468 474 (Pubitemid 44222342)
28. W.Y. Ong, Y. He, S. Suresh, and S.C. Patel Differential expression of apolipoprotein D and apolipoprotein E in the kainic acid-lesioned rat hippocampus Neuroscience 79 1997 359 367 (Pubitemid 27232395)
29. W.Y. Ong, M.Q. Ren, J. Makjanic, T.M. Lim, and F. Watt A nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury J. Neurochem. 72 1999 1574 1579 (Pubitemid 29140830)
30. W.Y. Ong, B. Tan, N. Pan, A. Jenner, M. Whiteman, C.N. Ong, F. Watt, and B. Halliwell Increased iron staining in the cerebral cortex of cholesterol fed rabbits Mech. Ageing Dev. 125 2004 305 313 (Pubitemid 38438510)
31. R.C. Patel, D. Lange, W.J. McConathy, Y.C. Patel, and S.C. Patel Probing the structure of the ligand binding cavity of lipocalins by fluorescence spectroscopy Protein Eng. 10 1997 621 625 (Pubitemid 27332068)
32. T. Ravizza, M. Rizzi, C. Perego, C. Richichi, J. Veliskova, S.L. Moshe, M.G. De Simoni, and A. Vezzani Inflammatory response and glia activation in developing rat hippocampus after status epilepticus Epilepsia 46 Suppl. 5 2005 113 117 (Pubitemid 40962132)
33. D.R. Richardson 24p3 and its receptor: dawn of a new iron age? Cell 123 2005 1175 1177 (Pubitemid 41821772)
34. M. Rizzi, C. Perego, M. Aliprandi, C. Richichi, T. Ravizza, D. Colella, J. Veliskova, S.L. Moshe, M.G. De Simoni, and A. Vezzani Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development Neurobiol. Dis. 14 2003 494 503 (Pubitemid 37543527)
35. K.M. Schmidt-Ott, K. Mori, A. Kalandadze, J.Y. Li, N. Paragas, T. Nicholas, P. Devarajan, and J. Barasch Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia Curr. Opin. Nephrol. Hypertens. 15 2006 442 449 (Pubitemid 44297988)
36. K.M. Schmidt-Ott, K. Mori, J.Y. Li, A. Kalandadze, D.J. Cohen, P. Devarajan, and J. Barasch Dual action of neutrophil gelatinase-associated lipocalin J. Am. Soc. Nephrol. 18 2007 407 413 (Pubitemid 46193306)
37. G. Sperk, H. Lassmann, H. Baran, S.J. Kish, F. Seitelberger, and O. Hornykiewicz Kainic acid induced seizures: neurochemical and histopathological changes Neuroscience 10 1983 1301 1315 (Pubitemid 14178574)
38. R.G. Thorne, G.J. Pronk, V. Padmanabhan, and W.H. Frey 2nd Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127 2004 481 496 (Pubitemid 38950662)
39. Y. Urade, and O. Hayaishi Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase Biochim. Biophys. Acta 1482 2000 259 271
40. M. Vogt, and A. Skerra Bacterially produced apolipoprotein D binds progesterone and arachidonic acid, but not bilirubin or E-3M2H J. Mol. Recognit. 14 2001 79 86
41. Q. Wang, S. Yu, A. Simonyi, G.Y. Sun, and A.Y. Sun Kainic acid-mediated excitotoxicity as a model for neurodegeneration Mol. Neurobiol. 31 2005 3 16 (Pubitemid 41271190)
42. X.S. Wang, W.Y. Ong, and J.R. Connor Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury Exp. Brain Res. 143 2002 137 148
43. Y. Wang, K.S. Lam, E.W. Kraegen, G. Sweeney, J. Zhang, A.W. Tso, W.S. Chow, N.M. Wat, J.Y. Xu, R.L. Hoo, and A. Xu Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans Clin. Chem. 53 2007 34 41 (Pubitemid 46047761)
44. J. Yang, D. Goetz, J.Y. Li, W. Wang, K. Mori, D. Setlik, T. Du, H. Erdjument-Bromage, P. Tempst, R. Strong, and J. Barasch An iron delivery pathway mediated by a lipocalin Mol. Cell 10 2002 1045 1056 (Pubitemid 35453824)
45. J. Yang, K. Mori, J.Y. Li, and J. Barasch Iron, lipocalin, and kidney epithelia Am. J. Physiol. Renal Physiol. 285 2003 F9 F18
46. L. Zecca, M.B. Youdim, P. Riederer, J.R. Connor, and R.R. Crichton Iron, brain ageing and neurodegenerative disorders Nat. Rev. Neurosci. 5 2004 863 873 (Pubitemid 39482155)
47. J. Zhang, Y. Wu, Y. Zhang, D. Leroith, D.A. Bernlohr, and X. Chen The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages Mol. Endocrinol. 22 2008 1416 1426 (Pubitemid 351787001)