Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity

Neurochemistry International

Volumn 87, Issue , 2015, Pages 43-59

  Chia, Wan Jie ^a,b   Tan, Francis Chee Kuan ^a,b,c   Ong, Wei Yi ^a,b   Dawe, Gavin S ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Centre for Life Sciences   (Singapore)

Author keywords

Apoptosis; Bim; BOCT; Iron; Lipocalin 2; Lipocalins; Megalin; Neurodegeneration; Siderophore

Indexed keywords

BIM PROTEIN; BRAIN TYPE ORGANIC CATION TRANSPORTER; IRON; KAINIC ACID; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN RECEPTOR; ORGANIC CATION TRANSPORTER; PROTEIN 24P3R; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EXCITOTOXICITY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; MALE; MICROGLIA; NERVE CELL DEGENERATION; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TUNEL ASSAY; UPREGULATION; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; WISTAR RAT;

RATTUS;

ANIMALS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IN SITU NICK-END LABELING; KAINIC ACID; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84937628224     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.04.009     Document Type: Article

References (53)

1. R.J. Abergel, M.C. Clifton, J.C. Pizarro, J.A. Warner, D.K. Shuh, R.K. Strong, and et al. The siderocalin/enterobactin interaction: a link between mammalian immunity and bacterial iron transport J. Am. Chem. Soc 130 2008 11524 11534
2. W. Alpizar-Alpizar, O.D. Laerum, M. Illemann, J.A. Ramirez, A. Arias, W. Malespin-Bendana, and et al. Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori Virchows Arch 455 2009 225 233
3. Bao G., M. Clifton, T.M. Hoette, K. Mori, Deng S.X., Qiu A., and et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex Nat. Chem. Biol 6 2010 602 609
4. K.M. Bennett, Liu J., C. Hoelting, and J. Stoll Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23 Mol. Cell. Biochem 352 2011 143 154
5. T. Berger, A. Togawa, G.S. Duncan, A.J. Elia, A. You-Ten, A. Wakeham, and et al. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury Proc. Natl. Acad. Sci. U.S.A. 103 2006 1834 1839
6. R.H. Bonow, S. Aid, Zhang Y., K.G. Becker, and F. Bosetti The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice Pharmacogenomics J. 9 2009 116 126
7. E. Borkham-Kamphorst, F. Drews, and R. Weiskirchen Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1beta through nuclear factor-kappaB activation Liver Int 31 2011 656 665
8. W.J. Chia, G.S. Dawe, and W.Y. Ong Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity Neurochem. Int 59 2011 591 599
9. C. Correnti, V. Richardson, A.K. Sia, A.D. Bandaranayake, M. Ruiz, Y. Suryo Rahmanto, and et al. Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines PLoS ONE 7 2012 e43696
10. L.R. Devireddy, C. Gazin, Zhu X., and M.R. Green A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake Cell 123 2005 1293 1305
11. L.R. Devireddy, D.O. Hart, D.H. Goetz, and M.R. Green A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production Cell 141 2010 1006 1017
12. A.M. Dittrich, M. Krokowski, H.A. Meyer, D. Quarcoo, A. Avagyan, B. Ahrens, and et al. Lipocalin2 protects against airway inflammation and hyperresponsiveness in a murine model of allergic airway disease Clin. Exp. Allergy 40 2010 1689 1700
13. Fang W.K., Xu L.Y., Lu X.F., Liao L.D., Cai W.J., Shen Z.Y., and et al. A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells Biochem. J. 403 2007 297 303
14. T.H. Flo, K.D. Smith, S. Sato, D.J. Rodriguez, M.A. Holmes, R.K. Strong, and et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron Nature 432 2004 917 921
15. D.H. Goetz, M.A. Holmes, N. Borregaard, M.E. Bluhm, K.N. Raymond, and R.K. Strong The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition Mol. Cell 10 2002 1033 1043
16. B. Halliwell Reactive oxygen species and the central nervous system J. Neurochem. 59 1992 1609 1623
17. J. Hanai, T. Mammoto, P. Seth, K. Mori, S.A. Karumanchi, J. Barasch, and et al. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells J. Biol. Chem 280 2005 13641 13647
18. Huang E., and W.Y. Ong Distribution of ferritin in the rat hippocampus after kainate-induced neuronal injury Exp. Brain Res 161 2005 502 511
19. V. Hvidberg, C. Jacobsen, R.K. Strong, J.B. Cowland, S.K. Moestrup, and N. Borregaard The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake FEBS Lett 579 2005 773 777
20. J.P. Ip, A.L. Nocon, M.J. Hofer, S.L. Lim, M. Muller, and I.L. Campbell Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration J. Neuroinflammation 8 2011 124
21. J.P. Kehrer Lipocalin-2: pro- or anti-apoptotic? Cell Biol. Toxicol 26 2010 83 89
22. L. Korhonen, N. Belluardo, G. Mudo, and D. Lindholm Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain Eur. J. Neurosci 18 2003 1121 1134
23. C. Langelueddecke, E. Roussa, R.A. Fenton, N.A. Wolff, W.K. Lee, and F. Thevenod Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis J. Biol. Chem 287 2012 159 169
24. C. Langelueddecke, E. Roussa, R.A. Fenton, and F. Thevenod Expression and function of the lipocalin-2 (24p3/NGAL) receptor in rodent and human intestinal epithelia PLoS ONE 8 2013 e71586
25. S. Lee, J. Lee, S. Kim, J.Y. Park, W.H. Lee, K. Mori, and et al. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia J. Immunol 179 2007 3231 3241
26. S. Lee, J.Y. Park, W.H. Lee, H. Kim, H.C. Park, K. Mori, and et al. Lipocalin-2 is an autocrine mediator of reactive astrocytosis J. Neurosci 29 2009 234 249
27. S. Lee, W.H. Lee, M.S. Lee, K. Mori, and K. Suk Regulation by lipocalin-2 of neuronal cell death, migration, and morphology J. Neurosci. Res 90 3 2011 540 550
28. Liu Q., and M. Nilsen-Hamilton Identification of a new acute phase protein J. Biol. Chem 270 1995 22565 22570
29. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
30. F. Marques, A.J. Rodrigues, J.C. Sousa, G. Coppola, D.H. Geschwind, N. Sousa, and et al. Lipocalin 2 is a choroid plexus acute-phase protein J. Cereb. Blood Flow Metab 28 2008 450 455
31. N. Morishima, K. Nakanishi, K. Tsuchiya, T. Shibata, and E. Seiwa Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis J. Biol. Chem 279 2004 50375 50381
32. M. Mucha, A.E. Skrzypiec, E. Schiavon, B.K. Attwood, E. Kucerova, and R. Pawlak Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation Proc. Natl. Acad. Sci. U.S.A. 108 45 2011 18436 18441
33. Y. Nam, J.H. Kim, M. Seo, J.H. Kim, Jin M., S. Jeon, and et al. Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and peripheral lymphoid tissues J. Biol. Chem 289 2014 16773 16789
34. Ni W., Zheng M., Xi G., R.F. Keep, and Hua Y. Role of lipocalin-2 in brain injury after intracerebral hemorrhage J. Cereb. Blood Flow Metab 2015 2015 10.1038/jcbfm.2015.52 25853903 Epub ahead of print
35. L. O'Connor, A. Strasser, L.A. O'Reilly, G. Hausmann, J.M. Adams, S. Cory, and et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis EMBO J. 17 1998 384 395
36. W.Y. Ong, Ren M.Q., J. Makjanic, T.M. Lim, and F. Watt A nuclear microscopic study of elemental changes in the rat hippocampus after kainate-induced neuronal injury J. Neurochem 72 1999 1574 1579
37. H. Puthalakath, L.A. O'Reilly, P. Gunn, L. Lee, P.N. Kelly, N.D. Huntington, and et al. ER stress triggers apoptosis by activating BH3-only protein Bim Cell 129 2007 1337 1349
38. K.I. Rathore, J.L. Berard, A. Redensek, S. Chierzi, R. Lopez-Vales, M. Santos, and et al. Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury J. Neurosci 31 2011 13412 13419
39. D.R. Richardson 24p3 and its receptor: dawn of a new iron age? Cell 123 2005 1175 1177
40. K.M. Schmidt-Ott, K. Mori, A. Kalandadze, Li J.Y., N. Paragas, T. Nicholas, and et al. Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia Curr. Opin. Nephrol. Hypertens 15 2006 442 449
41. K.M. Schmidt-Ott, K. Mori, Li J.Y., A. Kalandadze, D.J. Cohen, P. Devarajan, and et al. Dual action of neutrophil gelatinase-associated lipocalin J. Am. Soc. Nephrol 18 2007 407 413
42. S. Shinoda, C.K. Schindler, R. Meller, N.K. So, T. Araki, A. Yamamoto, and et al. Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy J. Clin. Invest 113 2004 1059 1068
43. G. Sperk, H. Lassmann, H. Baran, S.J. Kish, F. Seitelberger, and O. Hornykiewicz Kainic acid induced seizures: neurochemical and histopathological changes Neuroscience 10 1983 1301 1315
44. P. Theofilas, P. Bedner, K. Huttmann, M. Theis, C. Steinhauser, and S. Frank The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death J. Neuropathol. Exp. Neurol 68 2009 102 110
45. M. Thomas, and J. Jankovic Neurodegenerative disease and iron storage in the brain Curr. Opin. Neurol 17 2004 437 442
46. D. Tokuhara, S. Sakuma, H. Hattori, O. Matsuoka, and T. Yamano Kainic acid dose affects delayed cell death mechanism after status epilepticus Brain Dev 29 2007 2 8
47. Wang X.S., W.Y. Ong, and J.R. Connor Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury Exp. Brain Res 143 2002 137 148
48. Wang Y., K.S. Lam, E.W. Kraegen, G. Sweeney, Zhang J., A.W. Tso, and et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans Clin. Chem 53 2007 34 41
49. Yan Q.W., Yang Q., N. Mody, T.E. Graham, C.H. Hsu, Xu Z., and et al. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance Diabetes 56 2007 2533 2540
50. Yang J., A. Blum, T. Novak, R. Levinson, Lai E., and J. Barasch An epithelial precursor is regulated by the ureteric bud and by the renal stroma Dev. Biol 246 2002 296 310
51. Yang J., D. Goetz, Li J.Y., Wang W., K. Mori, D. Setlik, and et al. An iron delivery pathway mediated by a lipocalin Mol. Cell 10 2002 1045 1056
52. L. Zecca, M.B. Youdim, P. Riederer, J.R. Connor, and R.R. Crichton Iron, brain ageing and neurodegenerative disorders Nat. Rev. Neurosci 5 2004 863 873
53. Zhang J., Wu Y., Zhang Y., D. Leroith, D.A. Bernlohr, and Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages Mol. Endocrinol 22 2008 1416 1426