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Volumn 60, Issue 7, 2012, Pages 1145-1159

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

Author keywords

EAE; Lipocalin 2; Multiple sclerosis; Neuroinflammation

Indexed keywords

CD71 ANTIGEN; ERYTHROPOIETIN; FERRITIN; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 4; IRON; MATRIX METALLOPROTEINASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860686727     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22342     Document Type: Article
Times cited : (103)

References (60)
  • 1
    • 84856808348 scopus 로고    scopus 로고
    • Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis
    • Baker D, Amor S. 2012. Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis. J Neuroimmunol 242: 78-83.
    • (2012) J Neuroimmunol , vol.242 , pp. 78-83
    • Baker, D.1    Amor, S.2
  • 2
    • 76549083899 scopus 로고    scopus 로고
    • Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice
    • Berard JL, Wolak K, Fournier S, David S. 2010. Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice. Glia 58: 434-445.
    • (2010) Glia , vol.58 , pp. 434-445
    • Berard, J.L.1    Wolak, K.2    Fournier, S.3    David, S.4
  • 3
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation
    • Brambilla R, Persaud T, Hu X, Karmally S, Shestopalov VI, Dvoriantchikova G, Ivanov D, Nathanson L, Barnum SR, Bethea JR. 2009. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J Immunol 182: 2628-2640.
    • (2009) J Immunol , vol.182 , pp. 2628-2640
    • Brambilla, R.1    Persaud, T.2    Hu, X.3    Karmally, S.4    Shestopalov, V.I.5    Dvoriantchikova, G.6    Ivanov, D.7    Nathanson, L.8    Barnum, S.R.9    Bethea, J.R.10
  • 5
    • 80052953969 scopus 로고    scopus 로고
    • Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity
    • Chia WJ, Dawe GS, Ong WY. 2011. Expression and localization of the iron-siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity. Neurochem Int 59: 591-599.
    • (2011) Neurochem Int , vol.59 , pp. 591-599
    • Chia, W.J.1    Dawe, G.S.2    Ong, W.Y.3
  • 6
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. 2008. Multiple sclerosis. Lancet 372: 1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 7
    • 51249118191 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin: New paths for an old shuttle
    • Devarajan P. 2007. Neutrophil gelatinase-associated lipocalin: New paths for an old shuttle. Cancer Ther 5: 463-470.
    • (2007) Cancer Ther , vol.5 , pp. 463-470
    • Devarajan, P.1
  • 8
    • 29244492306 scopus 로고    scopus 로고
    • A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    • Devireddy LR, Gazin C, Zhu X, Green MR. 2005. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123: 1293-1305.
    • (2005) Cell , vol.123 , pp. 1293-1305
    • Devireddy, L.R.1    Gazin, C.2    Zhu, X.3    Green, M.R.4
  • 9
    • 0035800508 scopus 로고    scopus 로고
    • Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation
    • Devireddy LR, Teodoro JG, Richard FA, Green MR. 2001. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293: 829-834.
    • (2001) Science , vol.293 , pp. 829-834
    • Devireddy, L.R.1    Teodoro, J.G.2    Richard, F.A.3    Green, M.R.4
  • 10
    • 77954884148 scopus 로고    scopus 로고
    • Neural injury following stroke: Are Toll-like receptors the link between the immune system and the CNS?
    • Downes CE, Crack PJ. 2010. Neural injury following stroke: Are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol 160: 1872-1888.
    • (2010) Br J Pharmacol , vol.160 , pp. 1872-1888
    • Downes, C.E.1    Crack, P.J.2
  • 11
    • 0033773770 scopus 로고    scopus 로고
    • Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response
    • Emerson MR, LeVine SM. 2000. Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response. J Neurochem 75: 2555-2562.
    • (2000) J Neurochem , vol.75 , pp. 2555-2562
    • Emerson, M.R.1    LeVine, S.M.2
  • 14
    • 0029790266 scopus 로고    scopus 로고
    • The lipocalin protein family: Structure and function
    • Flower DR. 1996. The lipocalin protein family: Structure and function. Biochem J 318 (Pt 1): 1-14.
    • (1996) Biochem J , vol.318 , Issue.PART 1 , pp. 1-14
    • Flower, D.R.1
  • 15
    • 77950857433 scopus 로고    scopus 로고
    • Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve
    • Girolami EI, Bouhy D, Haber M, Johnson H, David S. 2009. Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve. Exp Neurol 2010: 173-182.
    • (2009) Exp Neurol , vol.2010 , pp. 173-182
    • Girolami, E.I.1    Bouhy, D.2    Haber, M.3    Johnson, H.4    David, S.5
  • 16
    • 2142821430 scopus 로고    scopus 로고
    • Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function
    • Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC. 2004. Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. J Neurosci 24: 4043-4051.
    • (2004) J Neurosci , vol.24 , pp. 4043-4051
    • Gris, D.1    Marsh, D.R.2    Oatway, M.A.3    Chen, Y.4    Hamilton, E.F.5    Dekaban, G.A.6    Weaver, L.C.7
  • 17
    • 40749156754 scopus 로고    scopus 로고
    • Identification of cellular pathways of "type 1," Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis
    • Haider AS, Lowes MA, Suarez-Farinas M, Zaba LC, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG. 2008. Identification of cellular pathways of "type 1, " Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis. J Immunol 180: 1913-1920.
    • (2008) J Immunol , vol.180 , pp. 1913-1920
    • Haider, A.S.1    Lowes, M.A.2    Suarez-Farinas, M.3    Zaba, L.C.4    Cardinale, I.5    Khatcherian, A.6    Novitskaya, I.7    Wittkowski, K.M.8    Krueger, J.G.9
  • 19
    • 0020665658 scopus 로고
    • Tissue distribution, structural characterization, and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity
    • Ho MK, Springer TA. 1983. Tissue distribution, structural characterization, and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity. J Biol Chem 258: 636-642.
    • (1983) J Biol Chem , vol.258 , pp. 636-642
    • Ho, M.K.1    Springer, T.A.2
  • 20
    • 0030580053 scopus 로고    scopus 로고
    • S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway
    • Hu J, Van Eldik LJ. 1996. S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochim Biophys Acta 1313: 239-245.
    • (1996) Biochim Biophys Acta , vol.1313 , pp. 239-245
    • Hu, J.1    Van Eldik, L.J.2
  • 21
    • 65349173063 scopus 로고    scopus 로고
    • Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
    • Huang H, Constante M, Layoun A, Santos MM. 2009. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood 113: 3593-3599.
    • (2009) Blood , vol.113 , pp. 3593-3599
    • Huang, H.1    Constante, M.2    Layoun, A.3    Santos, M.M.4
  • 22
    • 0029022855 scopus 로고
    • Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats
    • Huitinga I, Ruuls SR, Jung S, Van Rooijen N, Hartung HP, Dijkstra CD. 1995. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clin Exp Immunol 100: 344-351.
    • (1995) Clin Exp Immunol , vol.100 , pp. 344-351
    • Huitinga, I.1    Ruuls, S.R.2    Jung, S.3    Van Rooijen, N.4    Hartung, H.P.5    Dijkstra, C.D.6
  • 23
    • 0025015655 scopus 로고
    • Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages
    • Huitinga I, van Rooijen N, de Groot CJ, Uitdehaag BM, Dijkstra CD. 1990. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J Exp Med 172: 1025-1033.
    • (1990) J Exp Med , vol.172 , pp. 1025-1033
    • Huitinga, I.1    van Rooijen, N.2    de Groot, C.J.3    Uitdehaag, B.M.4    Dijkstra, C.D.5
  • 24
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlen C, Goverman J. 2001. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med 194: 669-676.
    • (2001) J Exp Med , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlen, C.5    Goverman, J.6
  • 25
    • 12744272449 scopus 로고    scopus 로고
    • The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    • Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N. 2005. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579: 773-777.
    • (2005) FEBS Lett , vol.579 , pp. 773-777
    • Hvidberg, V.1    Jacobsen, C.2    Strong, R.K.3    Cowland, J.B.4    Moestrup, S.K.5    Borregaard, N.6
  • 26
    • 18044382584 scopus 로고    scopus 로고
    • Cytokines in multiple sclerosis: From bench to bedside
    • Imitola J, Chitnis T, Khoury SJ. 2005. Cytokines in multiple sclerosis: From bench to bedside. Pharmacol Ther 106: 163-177.
    • (2005) Pharmacol Ther , vol.106 , pp. 163-177
    • Imitola, J.1    Chitnis, T.2    Khoury, S.J.3
  • 27
    • 80053368420 scopus 로고    scopus 로고
    • Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration
    • Ip JP, Nocon AL, Hofer MJ, Lim SL, Muller M, Campbell IL. 2011. Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J Neuroinflammation 8: 124.
    • (2011) J Neuroinflammation , vol.8 , pp. 124
    • Ip, J.P.1    Nocon, A.L.2    Hofer, M.J.3    Lim, S.L.4    Muller, M.5    Campbell, I.L.6
  • 28
    • 33646417072 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in inflammation
    • Iwakura Y, Ishigame H. 2006. The IL-23/IL-17 axis in inflammation. J Clin Invest 116: 1218-1222.
    • (2006) J Clin Invest , vol.116 , pp. 1218-1222
    • Iwakura, Y.1    Ishigame, H.2
  • 29
    • 1242293632 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease
    • Kalyvas A, David S. 2004. Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease. Neuron 41: 323-335.
    • (2004) Neuron , vol.41 , pp. 323-335
    • Kalyvas, A.1    David, S.2
  • 30
    • 0034022078 scopus 로고    scopus 로고
    • Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release
    • Kingham PJ, Pocock JM. 2000. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. J Neurochem 74: 1452-1462.
    • (2000) J Neurochem , vol.74 , pp. 1452-1462
    • Kingham, P.J.1    Pocock, J.M.2
  • 31
    • 0034684233 scopus 로고    scopus 로고
    • Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse
    • Kjeldsen L, Cowland JB, Borregaard N. 2000. Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim Biophys Acta 1482: 272-283.
    • (2000) Biochim Biophys Acta , vol.1482 , pp. 272-283
    • Kjeldsen, L.1    Cowland, J.B.2    Borregaard, N.3
  • 32
    • 38449114990 scopus 로고    scopus 로고
    • A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia
    • Lee S, Lee J, Kim S, Park JY, Lee WH, Mori K, Kim SH, Kim IK, Suk K. 2007. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. J Immunol 179: 3231-3241.
    • (2007) J Immunol , vol.179 , pp. 3231-3241
    • Lee, S.1    Lee, J.2    Kim, S.3    Park, J.Y.4    Lee, W.H.5    Mori, K.6    Kim, S.H.7    Kim, I.K.8    Suk, K.9
  • 34
    • 0029115795 scopus 로고
    • Identification of a new acute phase protein
    • Liu Q, Nilsen-Hamilton M. 1995. Identification of a new acute phase protein. J Biol Chem 270: 22565-22570.
    • (1995) J Biol Chem , vol.270 , pp. 22565-22570
    • Liu, Q.1    Nilsen-Hamilton, M.2
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 34547663526 scopus 로고    scopus 로고
    • Molecular targets for disrupting leukocyte trafficking during multiple sclerosis
    • McCandless EE, Klein RS. 2007. Molecular targets for disrupting leukocyte trafficking during multiple sclerosis. Expert Rev Mol Med 9: 1-19.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-19
    • McCandless, E.E.1    Klein, R.S.2
  • 37
    • 0021328623 scopus 로고
    • Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
    • Mokhtarian F, McFarlin DE, Raine CS. 1984. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309: 356-358.
    • (1984) Nature , vol.309 , pp. 356-358
    • Mokhtarian, F.1    McFarlin, D.E.2    Raine, C.S.3
  • 39
    • 81055126115 scopus 로고    scopus 로고
    • Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
    • Mucha M, Skrzypiec AE, Schiavon E, Attwood BK, Kucerova E, Pawlak R. 2011. Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation. Proc Natl Acad Sci USA 108: 18436-18441.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 18436-18441
    • Mucha, M.1    Skrzypiec, A.E.2    Schiavon, E.3    Attwood, B.K.4    Kucerova, E.5    Pawlak, R.6
  • 40
    • 51349134916 scopus 로고    scopus 로고
    • Astrocytes in multiple sclerosis: A product of their environment
    • Nair A, Frederick TJ, Miller SD. 2008. Astrocytes in multiple sclerosis: A product of their environment. Cell Mol Life Sci 65: 2702-2720.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2702-2720
    • Nair, A.1    Frederick, T.J.2    Miller, S.D.3
  • 41
    • 0019465748 scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: Requirement for Lyt 1+ 2- T lymphocytes
    • Pettinelli CB, McFarlin DE. 1981. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: Requirement for Lyt 1+ 2- T lymphocytes. J Immunol 127: 1420-1423.
    • (1981) J Immunol , vol.127 , pp. 1420-1423
    • Pettinelli, C.B.1    McFarlin, D.E.2
  • 42
    • 0028864801 scopus 로고
    • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
    • Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G. 1995. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci USA 92: 11294-11298.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11294-11298
    • Probert, L.1    Akassoglou, K.2    Pasparakis, M.3    Kontogeorgos, G.4    Kollias, G.5
  • 43
    • 9644310402 scopus 로고    scopus 로고
    • Brain microglia and blood-derived macrophages: Molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease
    • Raivich G, Banati R. 2004. Brain microglia and blood-derived macrophages: Molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res Brain Res Rev 46: 261-281.
    • (2004) Brain Res Brain Res Rev , vol.46 , pp. 261-281
    • Raivich, G.1    Banati, R.2
  • 46
    • 37649022459 scopus 로고    scopus 로고
    • The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis
    • Rubinstein T, Pitashny M, Putterman C. 2008. The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis. Autoimmun Rev 7: 229-234.
    • (2008) Autoimmun Rev , vol.7 , pp. 229-234
    • Rubinstein, T.1    Pitashny, M.2    Putterman, C.3
  • 47
    • 14244256520 scopus 로고    scopus 로고
    • Cytokines link osteoblasts and inflammation: Microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells
    • Shen F, Ruddy MJ, Plamondon P, Gaffen SL. 2005. Cytokines link osteoblasts and inflammation: Microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J Leukoc Biol 77: 388-399.
    • (2005) J Leukoc Biol , vol.77 , pp. 388-399
    • Shen, F.1    Ruddy, M.J.2    Plamondon, P.3    Gaffen, S.L.4
  • 48
    • 58849083367 scopus 로고    scopus 로고
    • Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome
    • Stirling DP, Liu S, Kubes P, Yong VW. 2009. Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci 29: 753-764.
    • (2009) J Neurosci , vol.29 , pp. 753-764
    • Stirling, D.P.1    Liu, S.2    Kubes, P.3    Yong, V.W.4
  • 49
    • 48249146633 scopus 로고    scopus 로고
    • Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry
    • Stirling DP, Yong VW. 2008. Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry. J Neurosci Res 86: 1944-1958.
    • (2008) J Neurosci Res , vol.86 , pp. 1944-1958
    • Stirling, D.P.1    Yong, V.W.2
  • 50
    • 0036312939 scopus 로고    scopus 로고
    • Essential role of caspase-11 in activation-induced cell death of rat astrocytes
    • Suk K, Kim SY, Kim H. 2002. Essential role of caspase-11 in activation-induced cell death of rat astrocytes. J Neurochem 80: 230-238.
    • (2002) J Neurochem , vol.80 , pp. 230-238
    • Suk, K.1    Kim, S.Y.2    Kim, H.3
  • 51
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D, Whitaker JN, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS. 2001. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 166: 7579-7587.
    • (2001) J Immunol , vol.166 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3    Liu, D.4    Coleclough, C.5    Wekerle, H.6    Raine, C.S.7
  • 52
    • 1942520401 scopus 로고    scopus 로고
    • Astrocyte apoptosis: Implications for neuroprotection
    • Takuma K, Baba A, Matsuda T. 2004. Astrocyte apoptosis: Implications for neuroprotection. Prog Neurobiol 72: 111-127.
    • (2004) Prog Neurobiol , vol.72 , pp. 111-127
    • Takuma, K.1    Baba, A.2    Matsuda, T.3
  • 53
    • 0032193213 scopus 로고    scopus 로고
    • Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice
    • Tran EH, Hoekstra K, van Rooijen N, Dijkstra CD, Owens T. 1998. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol 161: 3767-3775.
    • (1998) J Immunol , vol.161 , pp. 3767-3775
    • Tran, E.H.1    Hoekstra, K.2    van Rooijen, N.3    Dijkstra, C.D.4    Owens, T.5
  • 54
    • 53949095413 scopus 로고    scopus 로고
    • Increased glomerular matrix metalloproteinase activity in murine lupus nephritis
    • Tveita AA, Rekvig OP, Zykova SN. 2008. Increased glomerular matrix metalloproteinase activity in murine lupus nephritis. Kidney Int 74: 1150-1158.
    • (2008) Kidney Int , vol.74 , pp. 1150-1158
    • Tveita, A.A.1    Rekvig, O.P.2    Zykova, S.N.3
  • 55
    • 30344437881 scopus 로고    scopus 로고
    • The expression and function of chemokines involved in CNS inflammation
    • Ubogu EE, Cossoy MB, Ransohoff RM. 2006. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci 27: 48-55.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 48-55
    • Ubogu, E.E.1    Cossoy, M.B.2    Ransohoff, R.M.3
  • 56
    • 0034684232 scopus 로고    scopus 로고
    • Lipocalins as biochemical markers of disease
    • Xu S, Venge P. 2000. Lipocalins as biochemical markers of disease. Biochim Biophys Acta 1482: 298-307.
    • (2000) Biochim Biophys Acta , vol.1482 , pp. 298-307
    • Xu, S.1    Venge, P.2
  • 57
    • 0035813187 scopus 로고    scopus 로고
    • The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL
    • Yan L, Borregaard N, Kjeldsen L, Moses MA. 2001. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 276: 37258-37265.
    • (2001) J Biol Chem , vol.276 , pp. 37258-37265
    • Yan, L.1    Borregaard, N.2    Kjeldsen, L.3    Moses, M.A.4
  • 58
    • 34447104602 scopus 로고    scopus 로고
    • Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators
    • Yong VW, Zabad RK, Agrawal S, Goncalves Dasilva A, Metz LM. 2007. Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. J Neurol Sci 259: 79-84.
    • (2007) J Neurol Sci , vol.259 , pp. 79-84
    • Yong, V.W.1    Zabad, R.K.2    Agrawal, S.3    Goncalves Dasilva, A.4    Metz, L.M.5
  • 59
    • 44649173850 scopus 로고    scopus 로고
    • The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages
    • Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X. 2008. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol 22: 1416-1426.
    • (2008) Mol Endocrinol , vol.22 , pp. 1416-1426
    • Zhang, J.1    Wu, Y.2    Zhang, Y.3    Leroith, D.4    Bernlohr, D.A.5    Chen, X.6
  • 60
    • 24044455679 scopus 로고    scopus 로고
    • The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE)
    • Ziemssen T, Ziemssen F. 2005. The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Autoimmun Rev 4: 460-467.
    • (2005) Autoimmun Rev , vol.4 , pp. 460-467
    • Ziemssen, T.1    Ziemssen, F.2


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