Changes of gene expression of Gal3, Hsp27, Lcn2, and Timp1 in rat substantia nigra following medial forebrain bundle transection using a candidate gene microarray

Journal of Chemical Neuroanatomy

Volumn 66-67, Issue , 2015, Pages 10-18

  Choy, Yoon Jung ^a,b   Hong, Sung Young ^a   Pack, Sang Jin ^a   Woo, Ran Sook ^a   Baik, Tai Kyoung ^a   Song, Dae Yong ^a  

^a Eulji University School of Medicine   (South Korea)

^b Eulji University   (South Korea)

Author keywords

DNA microarray; Galectin 3; Heat shock protein 27; Lipocalin 2; Tissue inhibitory metalloproteinase 1

Indexed keywords

GALECTIN 3; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 27; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; LCN2 PROTEIN, RAT; LIPOCALIN; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL MATURATION; CELL METABOLISM; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; GENE LOCATION; GENETIC ANALYSIS; GLIA CELL; IMMUNITY; MALE; MEDIAL FOREBRAIN BUNDLE; MICROARRAY ANALYSIS; MICROGLIA; NERVE FIBER TRANSECTION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; UPREGULATION; ANIMAL; BIOSYNTHESIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INJURIES; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; AXOTOMY; BLOTTING, WESTERN; GALECTIN 3; HSP27 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPOCALINS; MALE; MEDIAL FOREBRAIN BUNDLE; MICROGLIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTOME;

EID: 84938125350     PISSN: 08910618     EISSN: 18736300     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2015.03.003     Document Type: Article

References (44)

1. Achanta P., Thompson K.J., Fuss M., Martinez J.L. Gene expression changes in the rodent hippocampus following whole brain irradiation. Neurosci. Lett. 2007, 418:143-148.
2. Aguzzi A., Barres B.A., Bennett M.L. Microglia: scapegoat, saboteur, or something else?. Science (New York, NY) 2013, 339:156-161.
3. Baranzini S.E. Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain. Neuromol. Med. 2004, 6:31-51.
4. Bernardes E.S., Silva N.M., Ruas L.P., Mineo J.R., Loyola A.M., Hsu D.K., Liu F.T., Chammas R., Roque-Barreira M.C. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am. J. Pathol. 2006, 168:1910-1920.
5. Bi F., Huang C., Tong J., Qiu G., Huang B., Wu Q., Li F., Xu Z., Bowser R., Xia X.G., Zhou H. Reactive astrocytes secrete lcn2 to promote neuron death. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:4069-4074.
6. Bolignano D., Donato V., Coppolino G., Campo S., Buemi A., Lacquaniti A., Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am. J. Kidney Dis. 2008, 52:595-605.
7. Brew K., Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim. Biophys. Acta 2010, 1803:55-71.
8. Cecchinelli B., Lavra L., Rinaldo C., Iacovelli S., Gurtner A., Gasbarri A., Ulivieri A., Del Prete F., Trovato M., Piaggio G., Bartolazzi A., Soddu S., Sciacchitano S. Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis. Mol. Cell. Biol. 2006, 26:4746-4757.
9. Cho B.P., Song D.Y., Sugama S., Shin D.H., Shimizu Y., Kim S.S., Kim Y.S., Joh T.H. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 2006, 53:92-102.
10. Craig E.A., Weissman J.S., Horwich A.L. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell 1994, 78:365-372.
11. Croisier E., Moran L.B., Dexter D.T., Pearce R.K., Graeber M.B. Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J. Neuroinflamm. 2005, 2:14.
12. Dickson D.W., Lee S.C., Mattiace L.A., Yen S.H., Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 1993, 7:75-83.
13. Dumic J., Dabelic S., Flogel M. Galectin-3: an open-ended story. Biochim. Biophys. Acta 2006, 1760:616-635.
14. Ginsberg S.D., Elarova I., Ruben M., Tan F., Counts S.E., Eberwine J.H., Trojanowski J.Q., Hemby S.E., Mufson E.J., Che S. Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders. Neurochem. Res. 2004, 29:1053-1064.
15. Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
16. Jain N., Thatte J., Braciale T., Ley K., O'Connell M., Lee J.K. Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays. Bioinformatics (Oxford, Engl.) 2003, 19:1945-1951.
17. Jourquin J., Tremblay E., Bernard A., Charton G., Chaillan F.A., Marchetti E., Roman F.S., Soloway P.D., Dive V., Yiotakis A., Khrestchatisky M., Rivera S. Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. Eur. J. Neurosci. 2005, 22:2569-2578.
18. Kehrer J.P. Lipocalin-2: pro- or anti-apoptotic?. Cell Biol. Toxicol. 2010, 26:83-89.
19. Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 2000, 20:6309-6316.
20. Kim Y.S., Joh T.H. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp. Mol. Med. 2006, 38:333-347.
21. Lee S., Lee J., Kim S., Park J.Y., Lee W.H., Mori K., Kim S.H., Kim I.K., Suk K. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. J. Immunol. (Baltimore, Md.: 1950) 2007, 179:3231-3241.
22. Liu F.T., Rabinovich G.A. Galectins: regulators of acute and chronic inflammation. Ann. N. Y. Acad. Sci. 2010, 1183:158-182.
23. Maddahi A., Chen Q., Edvinsson L. Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci. 2009, 10:56.
24. Maroni P., Bendinelli P., Tiberio L., Rovetta F., Piccoletti R., Schiaffonati L. In vivo heat-shock response in the brain: signalling pathway and transcription factor activation. Brain Res. Mol. Brain Res. 2003, 119:90-99.
25. Matarrese P., Fusco O., Tinari N., Natoli C., Liu F.T., Semeraro M.L., Malorni W., Iacobelli S. Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties. Int. J. Cancer 2000, 85:545-554.
26. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291.
27. Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (New York, NY) 2005, 308:1314-1318.
28. Ochieng J., Furtak V., Lukyanov P. Extracellular functions of galectin-3. Glycoconj. J. 2004, 19:527-535.
29. Pesheva P., Urschel S., Frei K., Probstmeier R. Murine microglial cells express functionally active galectin-3 in vitro. J. Neurosci. Res. 1998, 51:49-57.
30. Rabinovich G.A., Baum L.G., Tinari N., Paganelli R., Natoli C., Liu F.T., Iacobelli S. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?. Trends Immunol. 2002, 23:313-320.
31. Raine C.S. Multiple sclerosis: immune system molecule expression in the central nervous system. J. Neuropathol. Exp. Neurol. 1994, 53:328-337.
32. Renkawek K., Stege G.J., Bosman G.J. Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease. Neuroreport 1999, 10:2273-2276.
33. Rogers J., Luber-Narod J., Styren S.D., Civin W.H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol. Aging 1988, 9:339-349.
34. Song D.Y., Oh K.M., Yu H.N., Park C.R., Woo R.S., Jung S.S., Baik T.K. Role of activating transcription factor 3 in ischemic penumbra region following transient middle cerebral artery occlusion and reperfusion injury. Neurosci. Res. 2011, 70:428-434.
35. Song D.Y., Yang Y.C., Shin D.H., Sugama S., Kim Y.S., Lee B.H., Joh T.H., Cho B.P. Axotomy-induced dopaminergic neurodegeneration is accompanied with c-Jun phosphorylation and activation transcription factor 3 expression. Exp. Neurol. 2008, 209:268-278.
36. Song D.Y., Yu H.N., Park C.R., Lee J.S., Lee J.Y., Park B.G., Woo R.S., Han J.T., Cho B.P., Baik T.K. Down-regulation of microglial activity attenuates axotomized nigral dopaminergic neuronal cell loss. BMC Neurosci. 2013, 14:112.
37. Takenaka Y., Fukumori T., Raz A. Galectin-3 and metastasis. Glycoconj. J. 2004, 19:543-549.
38. Tansey M.G., Goldberg M.S. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol. Dis. 2010, 37:510-518.
39. Ueno M., Fujita Y., Tanaka T., Nakamura Y., Kikuta J., Ishii M., Yamashita T. Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 2013, 16:543-551.
40. Wake H., Moorhouse A.J., Jinno S., Kohsaka S., Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci.: Off. J. Soc. Neurosci. 2009, 29:3974-3980.
41. Yang J., Bielenberg D.R., Rodig S.J., Doiron R., Clifton M.C., Kung A.L., Strong R.K., Zurakowski D., Moses M.A. Lipocalin 2 promotes breast cancer progression. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:3913-3918.
42. Yang J.W., Kang S.U., Engidawork E., Rodrigo R., Felipo V., Lubec G. Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes. Neurochem. Res. 2006, 31:945-955.
43. Yang X.S., He G.L., Hao Y.T., Xiao Y., Chen C.H., Zhang G.B., Yu Z.P. Exposure to 2.45GHz electromagnetic fields elicits an HSP-related stress response in rat hippocampus. Brain Res. Bull. 2012, 88:371-378.
44. Zamanian J.L., Xu L., Foo L.C., Nouri N., Zhou L., Giffard R.G., Barres B.A. Genomic analysis of reactive astrogliosis. J. Neurosci.: Off. J. Soc. Neurosci. 2012, 32:6391-6410.