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Volumn 14, Issue , 2016, Pages 350-356

Zebrafish small molecule screens: Taking the phenotypic plunge

Author keywords

High throughput screening; Phenome wide association study; Phenotypic screening; Whole organism screening

Indexed keywords

DIAGNOSIS; SCREENING;

EID: 84989325743     PISSN: None     EISSN: 20010370     Source Type: Journal    
DOI: 10.1016/j.csbj.2016.09.001     Document Type: Review
Times cited : (24)

References (73)
  • 1
    • 84857519732 scopus 로고    scopus 로고
    • In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling
    • [1] Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., MacRae, C.A., In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res 93 (2012), 463–470.
    • (2012) Cardiovasc Res , vol.93 , pp. 463-470
    • Becker, J.R.1    Robinson, T.Y.2    Sachidanandan, C.3    Kelly, A.E.4    Coy, S.5    Peterson, R.T.6    MacRae, C.A.7
  • 2
    • 62749199801 scopus 로고    scopus 로고
    • Why animal studies are often poor predictors of human reactions to exposure
    • [2] Bracken, M.B., Why animal studies are often poor predictors of human reactions to exposure. J R Soc Med 102 (2009), 120–122.
    • (2009) J R Soc Med , vol.102 , pp. 120-122
    • Bracken, M.B.1
  • 5
    • 33644824638 scopus 로고    scopus 로고
    • High-throughput assay for small molecules that modulate zebrafish embryonic heart rate
    • [5] Burns, C.G., Milan, D.J., Grande, E.J., Rottbauer, W., MacRae, C.A., Fishman, M.C., High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol 1 (2005), 263–264.
    • (2005) Nat Chem Biol , vol.1 , pp. 263-264
    • Burns, C.G.1    Milan, D.J.2    Grande, E.J.3    Rottbauer, W.4    MacRae, C.A.5    Fishman, M.C.6
  • 7
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • [7] Cohen, J., Pertsemlidis, A., Kotowski, I.K., Graham, R., Garcia, C.K., Hobbs, H.H., Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 37 (2005), 161–165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 8
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • [8] Cohen, J.C., Boerwinkle, E., Mosley, T.H., Hobbs, H.H., Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354 (2006), 1264–1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 10
    • 84984922391 scopus 로고    scopus 로고
    • Phenome-wide association studies as a tool to advance precision medicine
    • [10] Denny, J.C., Bastarache, L., Roden, D.M., Phenome-wide association studies as a tool to advance precision medicine. Annu Rev Genomics Hum Genet 17 (2016), 353–373.
    • (2016) Annu Rev Genomics Hum Genet , vol.17 , pp. 353-373
    • Denny, J.C.1    Bastarache, L.2    Roden, D.M.3
  • 11
    • 84989352193 scopus 로고    scopus 로고
    • Fate therapeutics provides update on adoptive immunotherapy programs for hematopoietic cell transplantation (NASDAQ:FATE)
    • [11] Fate Therapeutics, Fate therapeutics provides update on adoptive immunotherapy programs for hematopoietic cell transplantation (NASDAQ:FATE). 2016.
    • (2016)
    • Fate Therapeutics1
  • 12
    • 80055105591 scopus 로고    scopus 로고
    • Large scale zebrafish-based in vivo small molecule screen
    • pii:2243
    • [12] Hao, J., Williams, C.H., Webb, M.E., Hong, C.C., Large scale zebrafish-based in vivo small molecule screen. J Vis Exp, 46, 2010 pii:2243.
    • (2010) J Vis Exp , vol.46
    • Hao, J.1    Williams, C.H.2    Webb, M.E.3    Hong, C.C.4
  • 13
    • 84884132973 scopus 로고    scopus 로고
    • Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen
    • [13] Hao, J., Ao, A., Zhou, L., Murphy, C.K., Frist, A.Y., Keel, J.J., Thorne, C.A., Kim, K., Lee, E., Hong, C.C., Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep 4 (2013), 898–904.
    • (2013) Cell Rep , vol.4 , pp. 898-904
    • Hao, J.1    Ao, A.2    Zhou, L.3    Murphy, C.K.4    Frist, A.Y.5    Keel, J.J.6    Thorne, C.A.7    Kim, K.8    Lee, E.9    Hong, C.C.10
  • 15
    • 70849128432 scopus 로고    scopus 로고
    • Applications of small molecule BMP inhibitors in physiology and disease
    • [15] Hong, C.C., Yu, P.B., Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev 20 (2009), 409–418.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 409-418
    • Hong, C.C.1    Yu, P.B.2
  • 16
    • 84940467157 scopus 로고    scopus 로고
    • Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth
    • [16] Hover, L.D., Young, C.D., Bhola, N.E., Wilson, A.J., Khabele, D., Hong, C.C., Moses, H.L., Owens, P., Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer Lett 368 (2015), 79–87.
    • (2015) Cancer Lett , vol.368 , pp. 79-87
    • Hover, L.D.1    Young, C.D.2    Bhola, N.E.3    Wilson, A.J.4    Khabele, D.5    Hong, C.C.6    Moses, H.L.7    Owens, P.8
  • 19
    • 84862230727 scopus 로고    scopus 로고
    • A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening
    • [19] Jung, D.-W., Oh, E.-S., Park, S.-H., Chang, Y.-T., Kim, C.-H., Choi, S.-Y., Williams, D.R., A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening. Mol Biosyst 8 (2012), 1930–1939.
    • (2012) Mol Biosyst , vol.8 , pp. 1930-1939
    • Jung, D.-W.1    Oh, E.-S.2    Park, S.-H.3    Chang, Y.-T.4    Kim, C.-H.5    Choi, S.-Y.6    Williams, D.R.7
  • 20
    • 84875736063 scopus 로고    scopus 로고
    • Zebrafish based small molecule screens for novel DMD drugs
    • [20] Kawahara, G., Kunkel, L.M., Zebrafish based small molecule screens for novel DMD drugs. Drug Discov Today Technol 10 (2013), e91–e96.
    • (2013) Drug Discov Today Technol , vol.10 , pp. e91-e96
    • Kawahara, G.1    Kunkel, L.M.2
  • 21
    • 84906303552 scopus 로고    scopus 로고
    • An overview of FDA-approved new molecular entities: 1827–2013
    • [21] Kinch, M.S., Haynesworth, A., Kinch, S.L., Hoyer, D., An overview of FDA-approved new molecular entities: 1827–2013. Drug Discov Today 19 (2014), 1033–1039.
    • (2014) Drug Discov Today , vol.19 , pp. 1033-1039
    • Kinch, M.S.1    Haynesworth, A.2    Kinch, S.L.3    Hoyer, D.4
  • 22
    • 80053189736 scopus 로고    scopus 로고
    • Using the zebrafish photomotor response for psychotropic drug screening
    • [22] Kokel, D., Peterson, R.T., Using the zebrafish photomotor response for psychotropic drug screening. Methods Cell Biol 105 (2011), 517–524.
    • (2011) Methods Cell Biol , vol.105 , pp. 517-524
    • Kokel, D.1    Peterson, R.T.2
  • 24
    • 84894663373 scopus 로고    scopus 로고
    • A multiplexed luciferase-based screening platform for interrogating cancer-associated signal transduction in cultured cells
    • [24] Kulak, O., Lum, L., A multiplexed luciferase-based screening platform for interrogating cancer-associated signal transduction in cultured cells. J Vis Exp, 77, 2013, e50369.
    • (2013) J Vis Exp , vol.77 , pp. e50369
    • Kulak, O.1    Lum, L.2
  • 25
    • 84922032208 scopus 로고    scopus 로고
    • Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts
    • [25] Kulak, O., Yamaguchi, K., Lum, L., Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts. Methods Mol Biol 1263 (2015), 3–14.
    • (2015) Methods Mol Biol , vol.1263 , pp. 3-14
    • Kulak, O.1    Yamaguchi, K.2    Lum, L.3
  • 26
    • 84936089460 scopus 로고    scopus 로고
    • Brave new genome
    • [26] Lander, E.S., Brave new genome. N Engl J Med 373 (2015), 5–8.
    • (2015) N Engl J Med , vol.373 , pp. 5-8
    • Lander, E.S.1
  • 27
    • 84916912350 scopus 로고    scopus 로고
    • Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase
    • [27] Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., et al. Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med, 6, 2014, 266ra170.
    • (2014) Sci Transl Med , vol.6 , pp. 266ra170
    • Liu, Y.1    Asnani, A.2    Zou, L.3    Bentley, V.L.4    Yu, M.5    Wang, Y.6    Dellaire, G.7    Sarkar, K.S.8    Dai, M.9    Chen, H.H.10
  • 28
    • 84877697688 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway
    • [28] Liu, Y.-J., Fan, H.-B., Jin, Y., Ren, C.-G., Jia, X.-E., Wang, L., Chen, Y., Dong, M., Zhu, K.-Y., Dong, Z.-W., et al. Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway. J Biol Chem 288 (2013), 13551–13562.
    • (2013) J Biol Chem , vol.288 , pp. 13551-13562
    • Liu, Y.-J.1    Fan, H.-B.2    Jin, Y.3    Ren, C.-G.4    Jia, X.-E.5    Wang, L.6    Chen, Y.7    Dong, M.8    Zhu, K.-Y.9    Dong, Z.-W.10
  • 29
    • 84893387504 scopus 로고    scopus 로고
    • Cell biology by the numbers
    • Garland Science New York, NY
    • [29] Milo, R., Phillips, R., Cell biology by the numbers. 2015, Garland Science, New York, NY.
    • (2015)
    • Milo, R.1    Phillips, R.2
  • 31
    • 0028062665 scopus 로고
    • History of drugs for thrombotic disease. Discovery, development, and directions for the future
    • [31] Mueller, R.L., Scheidt, S., History of drugs for thrombotic disease. Discovery, development, and directions for the future. Circulation 89 (1994), 432–449.
    • (1994) Circulation , vol.89 , pp. 432-449
    • Mueller, R.L.1    Scheidt, S.2
  • 32
    • 84948660289 scopus 로고    scopus 로고
    • The phenotypic screening pendulum swings
    • [32] Mullard, A., The phenotypic screening pendulum swings. Nat Rev Drug Discov 14 (2015), 807–809.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 807-809
    • Mullard, A.1
  • 37
    • 0022387153 scopus 로고
    • William withering and the purple foxglove: a bicentennial tribute
    • [37] Norman, J.N., William withering and the purple foxglove: a bicentennial tribute. J Clin Pharmacol 25 (1985), 479–483.
    • (1985) J Clin Pharmacol , vol.25 , pp. 479-483
    • Norman, J.N.1
  • 43
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • [43] Peterson, R.T., Link, B.A., Dowling, J.E., Schreiber, S.L., Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci 97 (2000), 12965–12969.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 45
    • 84949117256 scopus 로고    scopus 로고
    • 15 years of zebrafish chemical screening
    • [45] Rennekamp, A.J., Peterson, R.T., 15 years of zebrafish chemical screening. Curr Opin Chem Biol 24 (2015), 58–70.
    • (2015) Curr Opin Chem Biol , vol.24 , pp. 58-70
    • Rennekamp, A.J.1    Peterson, R.T.2
  • 50
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    • [50] Roth, B.L., Sheffler, D.J., Kroeze, W.K., Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 3 (2004), 353–359.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 52
    • 84880781533 scopus 로고    scopus 로고
    • Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia
    • [52] Shelton, E.L., Galindo, C.L., Williams, C.H., Pfaltzgraff, E., Hong, C.C., Bader, D.M., Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia. PLoS One, 8, 2013, e69712.
    • (2013) PLoS One , vol.8 , pp. e69712
    • Shelton, E.L.1    Galindo, C.L.2    Williams, C.H.3    Pfaltzgraff, E.4    Hong, C.C.5    Bader, D.M.6
  • 53
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • [53] Shoemaker, R.H., The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 6 (2006), 813–823.
    • (2006) Nat Rev Cancer , vol.6 , pp. 813-823
    • Shoemaker, R.H.1
  • 56
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • [56] Swinney, D.C., Anthony, J., How were new medicines discovered?. Nat Rev Drug Discov 10 (2011), 507–519.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 57
    • 84864296849 scopus 로고    scopus 로고
    • An in vivo platform for rapid high-throughput antitubercular drug discovery
    • [57] Takaki, K., Cosma, C.L., Troll, M.A., Ramakrishnan, L., An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep 2 (2012), 175–184.
    • (2012) Cell Rep , vol.2 , pp. 175-184
    • Takaki, K.1    Cosma, C.L.2    Troll, M.A.3    Ramakrishnan, L.4
  • 58
    • 84955291040 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery
    • [58] Tang, S., Xie, M., Cao, N., Ding, S., Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery. J Med Chem 59 (2016), 2–15.
    • (2016) J Med Chem , vol.59 , pp. 2-15
    • Tang, S.1    Xie, M.2    Cao, N.3    Ding, S.4
  • 60
    • 84886082158 scopus 로고    scopus 로고
    • Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer
    • [60] Walsh, A.J., Cook, R.S., Manning, H.C., Hicks, D.J., Lafontant, A., Arteaga, C.L., Skala, M.C., Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. Cancer Res 73 (2013), 6164–6174.
    • (2013) Cancer Res , vol.73 , pp. 6164-6174
    • Walsh, A.J.1    Cook, R.S.2    Manning, H.C.3    Hicks, D.J.4    Lafontant, A.5    Arteaga, C.L.6    Skala, M.C.7
  • 61
    • 84907494553 scopus 로고    scopus 로고
    • Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer
    • [61] Walsh, A.J., Cook, R.S., Sanders, M.E., Aurisicchio, L., Ciliberto, G., Arteaga, C.L., Skala, M.C., Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer. Cancer Res 74 (2014), 5184–5194.
    • (2014) Cancer Res , vol.74 , pp. 5184-5194
    • Walsh, A.J.1    Cook, R.S.2    Sanders, M.E.3    Aurisicchio, L.4    Ciliberto, G.5    Arteaga, C.L.6    Skala, M.C.7
  • 64
    • 84884198174 scopus 로고    scopus 로고
    • A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system
    • [64] Weger, B.D., Weger, M., Jung, N., Lederer, C., Bräse, S., Dickmeis, T., A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. J Vis Exp, 79, 2013, 10.3791/50439.
    • (2013) J Vis Exp , vol.79
    • Weger, B.D.1    Weger, M.2    Jung, N.3    Lederer, C.4    Bräse, S.5    Dickmeis, T.6
  • 66
    • 79953845021 scopus 로고    scopus 로고
    • Multi-step usage of in vivo models during rational drug design and discovery
    • [66] Williams, C.H., Hong, C.C., Multi-step usage of in vivo models during rational drug design and discovery. Int J Mol Sci 12 (2011), 2262–2274.
    • (2011) Int J Mol Sci , vol.12 , pp. 2262-2274
    • Williams, C.H.1    Hong, C.C.2
  • 67
    • 84922069217 scopus 로고    scopus 로고
    • High content screening for modulators of cardiovascular or global developmental pathways in zebrafish
    • [67] Williams, C.H., Hong, C.C., High content screening for modulators of cardiovascular or global developmental pathways in zebrafish. Methods Mol Biol 1263 (2015), 167–174.
    • (2015) Methods Mol Biol , vol.1263 , pp. 167-174
    • Williams, C.H.1    Hong, C.C.2
  • 69
    • 80053057826 scopus 로고    scopus 로고
    • Chemical modulation of memory formation in larval zebrafish
    • [69] Wolman, M.A., Jain, R.A., Liss, L., Granato, M., Chemical modulation of memory formation in larval zebrafish. Proc Natl Acad Sci 108 (2011), 15468–15473.
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 15468-15473
    • Wolman, M.A.1    Jain, R.A.2    Liss, L.3    Granato, M.4
  • 71
    • 84895784407 scopus 로고    scopus 로고
    • A pharmacological network for lifespan extension in Caenorhabditis elegans
    • [71] Ye, X., Linton, J.M., Schork, N.J., Buck, L.B., Petrascheck, M., A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13 (2014), 206–215.
    • (2014) Aging Cell , vol.13 , pp. 206-215
    • Ye, X.1    Linton, J.M.2    Schork, N.J.3    Buck, L.B.4    Petrascheck, M.5


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