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Volumn , Issue 46, 2010, Pages

Large scale zebrafish-based in vivo small molecule screen

Author keywords

Chemical genetics; Chemical screen; Developmental Biology; Drug discovery; Issue 46; Phenotype; Small molecule library; Zebrafish

Indexed keywords


EID: 80055105591     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2243     Document Type: Article
Times cited : (17)

References (10)
  • 1
    • 33646455462 scopus 로고    scopus 로고
    • Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish
    • Bayliss, P.E. et al. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature chemical biology 2, 265-273 (2006).
    • (2006) Nature chemical biology , vol.2 , pp. 265-273
    • Bayliss, P.E.1
  • 2
    • 33644824638 scopus 로고    scopus 로고
    • High-throughput assay for small molecules that modulate zebrafish embryonic heart rate
    • Burns, C.G. et al. High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nature chemical biology 1, 263-264 (2005).
    • (2005) Nature chemical biology , vol.1 , pp. 263-264
    • Burns, C.G.1
  • 3
    • 77449108244 scopus 로고    scopus 로고
    • In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors
    • Hao, J. et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS chemical biology 5, 245-253 (2010).
    • (2010) ACS chemical biology , vol.5 , pp. 245-253
    • Hao, J.1
  • 4
    • 33745646792 scopus 로고    scopus 로고
    • Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling
    • Hong, C.C., Peterson, Q.P., Hong, J.Y. & Peterson, R.T. Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Curr Biol 16, 1366-1372 (2006).
    • (2006) Curr Biol , vol.16 , pp. 1366-1372
    • Hong, C.C.1    Peterson, Q.P.2    Hong, J.Y.3    Peterson, R.T.4
  • 5
    • 0037453021 scopus 로고    scopus 로고
    • Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    • Milan, D.J., Peterson, T.A., Ruskin, J.N., Peterson, R.T. & MacRae, C.A. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107, 1355-1358 (2003).
    • (2003) Circulation , vol.107 , pp. 1355-1358
    • Milan, D.J.1    Peterson, T.A.2    Ruskin, J.N.3    Peterson, R.T.4    McRae, C.A.5
  • 7
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu, P.B. et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology 4, 33-41 (2008).
    • (2008) Nature chemical biology , vol.4 , pp. 33-41
    • Yu, P.B.1
  • 8
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon, L.I. & Peterson, R.T. In vivo drug discovery in the zebrafish. Nature reviews 4, 35-44 (2005).
    • (2005) Nature reviews , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 9
    • 33644788489 scopus 로고    scopus 로고
    • Small molecules that delay S phase suppress a zebrafish bmyb mutant
    • Stern, H.M. et al. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nature chemical biology 1, 366-370 (2005).
    • (2005) Nature chemical biology , vol.1 , pp. 366-370
    • Stern, H.M.1
  • 10
    • 2342454415 scopus 로고    scopus 로고
    • Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
    • Peterson, R.T. et al. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nature biotechnology 22, 595-599 (2004).
    • (2004) Nature biotechnology , vol.22 , pp. 595-599
    • Peterson, R.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.