σ 1 receptor ligands control a switch between passive and active threat responses

Nature Chemical Biology

Volumn 12, Issue 7, 2016, Pages 552-558

  Rennekamp, Andrew J ^a,b,c   Huang, Xi Ping ^d,e   Wang, You ^a,b,c   Patel, Samir ^a,b,c   Lorello, Paul J ^a,f   Cade, Lindsay ^a,b,c   Gonzales, Andrew P W ^a,b,c   Yeh, Jing Ruey Joanna ^a,b   Caldarone, Barbara J ^a,f   Roth, Bryan L ^d,e,g   Kokel, David ^h   Peterson, Randall T ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g University of North Carolina   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIGMA 1 OPIATE RECEPTOR; ANILIDE; FINAZINE; LIGAND; MOLECULAR LIBRARY; PIPERAZINE DERIVATIVE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; AVOIDANCE BEHAVIOR; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ESCAPE BEHAVIOR; FEAR CONDITIONING TEST; FOOTSHOCK; FREEZING; GENE MUTATION; HIGH THROUGHPUT SCREENING; LIGHT EXPOSURE; LOCOMOTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STIMULUS RESPONSE; THREAT RESPONSE BEHAVIOR; ZEBRA FISH; ANIMAL; CATALEPSY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; LIGHT; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; RADIATION RESPONSE;

ANILIDES; ANIMALS; ESCAPE REACTION; FREEZING REACTION, CATALEPTIC; HIGH-THROUGHPUT SCREENING ASSAYS; LARVA; LIGANDS; LIGHT; MICE; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTORS, SIGMA; SMALL MOLECULE LIBRARIES; ZEBRAFISH;

EID: 84973140842     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2089     Document Type: Article

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