Using the Zebrafish Photomotor Response for Psychotropic Drug Screening

Methods in Cell Biology

Volumn 105, Issue , 2011, Pages 517-524

  Kokel, David ^a,b   Peterson, Randall T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Adaptation; Barcoding; Multiwell; Photomotor; Psychotropic; Stimulus

Indexed keywords

EID: 80053189736     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-381320-6.00022-9     Document Type: Chapter

References (19)

1. Abramoff M.D., Magalhaes P.J., Ram S.J. Image processing with ImageJ. Biophoton. Int. 2004, 11(7):36-42.
2. Best J., et al. Non-associative learning in larval zebrafish. Neuropsychopharmacology 2008, 33:1206-1215.
3. Burgess H.A., Granato M. Sensorimotor gating in larval zebrafish. J. Neurosci. 2007, 27:4984-4994.
4. Eisen M.B., Spellman P.T., Brown P.O., Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 1998, 95:14863-14868.
5. Emran F., Rihel J., Dowling J.E. A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. J. Vis. Exp. 2008, 20. http://www.jove.com/details.php?id=923 doi: 10.3791/923.
6. Gahtan E., Tanger P., Baier H. Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J. Neurosci. 2005, 25:9294-9303.
7. Granato M., et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development 1996, 123:399-413.
8. Kokel D., et al. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat. Chem. Biol. 2010, 6:231-237.
9. Kokel D., Peterson R.T. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief. Funct. Genom. Proteom. 2008, 7:483.
10. Lamb J., et al. The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313:1929-1935.
11. Low S.E., et al. Touché is required for touch-evoked generator potentials within vertebrate sensory neurons. J. Neurosci. 2010, 30:9359-9367.
12. Orger M.B., Smear M.C., Anstis S.M., Baier H. Perception of Fourier and non-Fourier motion by larval zebrafish. Nat. Neurosci. 2000, 3:1128-1133.
13. Perlman Z.E., et al. Multidimensional drug profiling by automated microscopy. Science 2004, 306:1194-1198.
14. Prober D.A., Rihel J., Onah A.A., Sung R.J., Schier A.F. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J. Neurosci. 2006, 26:13400-13410.
15. Rihel J., et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010, 327:348-351.
16. Saint-Amant L., Drapeau P. Time course of the development of motor behaviors in1. The zebrafish embryo. J. Neurobiol. 1998, 37:622-632.
17. Sørlie T., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA 2001, 98:10869-10874.
18. Team, R.D.C. (2008). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.r-project.org/.
19. Zhdanova I.V., Wang S.Y., Leclair O.U., Danilova N.P. Melatonin promotes sleep-like state in zebrafish. Brain Res. 2001, 903:263-268.