Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

Nature Biotechnology

Volumn 22, Issue 5, 2004, Pages 595-599

  Peterson, Randall T ^a,b   Shaw, Stanley Y ^a,b,c   Peterson, Travis A ^a,b   Milan, David J ^a,b   Zhong, Tao P ^a,b,d   Schreiber, Stuart L ^c   MacRae, Calum A ^a,b   Fishman, Mark C ^a,b,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; DRUG PRODUCTS; GENES; MATHEMATICAL MODELS; PHYSIOLOGY;

DRUG DISCOVERY; MOLECULAR TARGET; MUTATION;

BIOTECHNOLOGY;

MESSENGER RNA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA COARCTATION; AORTA FLOW; ARTICLE; CELL FUNCTION; CELL MIGRATION; CHEMICAL BINDING; CONTROLLED STUDY; DISEASE MODEL; DRUG DESIGN; DRUG TARGETING; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; GRL GENE; HEY2 GENE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SURVIVAL; SYNDROME DELINEATION; TERATOLOGY; ZEBRA FISH;

ANIMALS; AORTIC COARCTATION; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA PRIMERS; MUTATION; ZEBRAFISH;

ANIMALIA; DANIO RERIO;

EID: 2342454415     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt963     Document Type: Article

References (30)

1. Crews, C.M. & Splittgerber, U. Chemical genetics; exploring and controlling cellular processes with chemical probes. Trends Biochem. Sci. 24, 317-320 (1999).
2. Schreiber, S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery-Science-287,-1-964-1-969 (2000).
3. Zhong, T.P., Rosenberg, M., Mohideen, M.A., Weinstein, B. & Fishman, M.C. gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science 287, 1820-1824 (2000).
4. Weinstein, B.M., Stemple, D.L., Driever, W. & Fishman, M.C. Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nat. Med. 1, 1143-1147 (1995).
5. Towbin, J.A. & McQuinn, T.C. Gridlock; a model for coarctation of the aorta? Nat. Med. 1, 1141-1142 (1995).
6. St. Johnston, D. The art and design of genetic screens: Drosophila melanogaster. Nat. Rev. Genet. 3, 176-188 (2002).
7. Sakata, Y. et al. Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc. Natl. Acad. Sci. USA 99, 16197-16202 (2002).
8. Donovan, J., Kordylewska, A., Jan, Y.N. & Utset, M.F. Tetralogy of fallot and other congenital heart defects in hey2 mutant mice. Curr. Biol. 12, 1605-1610 (2002).
9. -/- mice. Curr. Biol. 183, 37-48 (1997).
10. Eriksson, J. & Lofberg, J. Development of the hypochord and dorsal aorta in the zebrafish embryo (Danio rerio). J. Morphol. 244, 167-176 (2000).
11. Fouquet, B., Weinstein, B.M., Serluca, F.C. & Fishman, M.C. Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev. Biol. 183, 37-48 (1997).
12. Cleaver, O. & Krieg, P.A. VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus. Development 125, 3905-3914 (1998).
13. Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996).
14. Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
15. Stalmans, I. et al. VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Nat. Med. 9, 173-182 (2003).
16. Liang, D. et al. The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development. Mech. Dev. 108, 29-43 (2001).
17. Zhong, T.P., Childs, S., Leu, J.P. & Fishman, M.C. Gridlock signaling pathway fashions the first embryonic artery. Nature 414, 216-220 (2001).
18. Iso, T., Chung, G., Hamamori, Y. & Kedes, L. HERP1 is a cell type-specific primary target of Notch J. Biol. Chem. 277, 6598-6607 (2002).
19. Nakagawa, O. et al. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc. Natl. Acad. Sci. USA 97, 13655-13660 (2000).
20. Lawson, N.D., Vogel, A.M. & Weinstein, B.M. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev. Cell 3, 127-136 (2002).
21. Ash, J.D. & Overbeek, P.A. Lens-specific VEGF-A expression induces angioblast migration and proliferation and stimulates angiogenic remodeling. Dev. Biol. 223, 383-398 (2000).
22. Shin, J.T. & Fishman, M.C. From Zebrafish to human: modular medical models, Annu. Rev. Genomics Hum. Genet. 3, 311-340 (2002).
23. Dooley, K. & Zoo, L.I. Zebrafish: a model system for the study of human disease. Curr. Opin. Genet. Dev. 10, 252-256 (2000).
24. Xu, X. et al. Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat. Genet. 30, 205-209 (2002).
25. Roman, B.L. et al. Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development 129, 3009-3019 (2002).
26. Langheinrich, U. Zebrafish: a new model on the pharmaceutical catwalk. Bioessays 25, 904-912 (2003).
27. Milan, D.J., Peterson, T.A., Ruskin, J.N., Peterson, R.T. & MacRae, C.A. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107, 1355-1358 (2003).
28. Thomas, C.E., Ehrhardt, A. & Kay, M.A. Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4, 346-358 (2003).
29. Check, E. Cancer risk prompts US to curb gene therapy. Nature 422, 7 (2003).
30. Wienholds, E., Schulte-Merker, S., Walderich, B. & Plasterk, R.H. Target-selected inactivation of the zebrafish rag1 gene. Science 297, 99-102 (2002).