An invivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition

Cell Reports

Volumn 11, Issue 1, 2015, Pages 43-50

  Williams, Charles H ^a   Hempel, Jonathan E ^a   Hao, Jijun ^a,d   Frist, Audrey Y ^a   Williams, Michelle M ^a   Fleming, Jonathan T ^a   Sulikowski, Gary A ^a,b   Cooper, Michael K ^a,c   Chiang, Chin ^a   Hong, Charles C ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHODIESTERASE IV; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; EGGMANONE; G PROTEIN COUPLED RECEPTOR; MOLECULAR LIBRARY; PHOSPHODIESTERASE IV INHIBITOR; PYRIMIDINONE DERIVATIVE; SMOH PROTEIN, ZEBRAFISH; SMOOTHENED PROTEIN; THIOPHENE DERIVATIVE; ZEBRAFISH PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; EGGMANONE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TRANSLOCATION; GENETIC SCREENING; IN VIVO STUDY; INHIBITION KINETICS; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR LIBRARY; TRANSCRIPTION INITIATION; ZEBRA FISH;

DANIO RERIO; ERINACEIDAE; VERTEBRATA;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HEDGEHOG PROTEINS; PHOSPHODIESTERASE 4 INHIBITORS; PYRIMIDINONES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SMOOTHENED RECEPTOR; THIOPHENES; TRANSCRIPTIONAL ACTIVATION; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84927695480     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.03.001     Document Type: Article

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