메뉴 건너뛰기




Volumn 34, Issue 19, 2015, Pages 2437-2449

Inhibition of BMP signaling suppresses metastasis in mammary cancer

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; DMH1 COMPOUND; PYRAZOLE DERIVATIVE; QUINOLINE DERIVATIVE;

EID: 84938152098     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.189     Document Type: Article
Times cited : (87)

References (59)
  • 1
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. J Biochem 2010; 147: 35-51.
    • (2010) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 3
    • 34547122921 scopus 로고    scopus 로고
    • Selective inhibitory effects of Smad6 on bone morphogenetic protein type i receptors
    • Goto K, Kamiya Y, Imamura T, Miyazono K, Miyazawa K. Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors. J Biol Chem 2007; 282: 20603-20611.
    • (2007) J Biol Chem , vol.282 , pp. 20603-20611
    • Goto, K.1    Kamiya, Y.2    Imamura, T.3    Miyazono, K.4    Miyazawa, K.5
  • 4
    • 0034972978 scopus 로고    scopus 로고
    • Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
    • Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 2001; 28: 184-187.
    • (2001) Nat Genet , vol.28 , pp. 184-187
    • Howe, J.R.1    Bair, J.L.2    Sayed, M.G.3    Anderson, M.E.4    Mitros, F.A.5    Petersen, G.M.6
  • 6
    • 2942580631 scopus 로고    scopus 로고
    • Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis
    • Ming Kwan K, Li AG, Wang XJ, Wurst W, Behringer RR. Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis. Genesis 2004; 39: 10-25.
    • (2004) Genesis , vol.39 , pp. 10-25
    • Ming Kwan, K.1    Li, A.G.2    Wang, X.J.3    Wurst, W.4    Behringer, R.R.5
  • 7
    • 3042832819 scopus 로고    scopus 로고
    • Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
    • Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST et al. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 2004; 131: 2257-2268.
    • (2004) Development , vol.131 , pp. 2257-2268
    • Andl, T.1    Ahn, K.2    Kairo, A.3    Chu, E.Y.4    Wine-Lee, L.5    Reddy, S.T.6
  • 8
    • 0242425844 scopus 로고    scopus 로고
    • Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    • Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol 2003; 163: 609-623.
    • (2003) J Cell Biol , vol.163 , pp. 609-623
    • Kobielak, K.1    Pasolli, H.A.2    Alonso, L.3    Polak, L.4    Fuchs, E.5
  • 9
    • 2342418311 scopus 로고    scopus 로고
    • BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice
    • Yuhki M, Yamada M, Kawano M, Iwasato T, Itohara S, Yoshida H et al. BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development 2004; 131: 1825-1833.
    • (2004) Development , vol.131 , pp. 1825-1833
    • Yuhki, M.1    Yamada, M.2    Kawano, M.3    Iwasato, T.4    Itohara, S.5    Yoshida, H.6
  • 10
    • 84865218588 scopus 로고    scopus 로고
    • The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    • Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 2012; 150: 764-779.
    • (2012) Cell , vol.150 , pp. 764-779
    • Gao, H.1    Chakraborty, G.2    Lee-Lim, A.P.3    Mo, Q.4    Decker, M.5    Vonica, A.6
  • 11
    • 84857407558 scopus 로고    scopus 로고
    • Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
    • Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME et al. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc Natl Acad Sci USA 2012; 109: 2814-2819.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2814-2819
    • Owens, P.1    Pickup, M.W.2    Novitskiy, S.V.3    Chytil, A.4    Gorska, A.E.5    Aakre, M.E.6
  • 12
    • 77953590859 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in breast cancer: Dual role in tumourigenesis?
    • Alarmo EL, Kallioniemi A. Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? Endocr Relat Cancer 2010; 17: R123-R139.
    • (2010) Endocr Relat Cancer , vol.17 , pp. R123-R139
    • Alarmo, E.L.1    Kallioniemi, A.2
  • 13
    • 84879426981 scopus 로고    scopus 로고
    • Bi-directional roles of bone morphogenetic proteins in cancer: Another molecular Jekyll and Hyde?
    • Ehata S, Yokoyama Y, Takahashi K, Miyazono K. Bi-directional roles of bone morphogenetic proteins in cancer: another molecular Jekyll and Hyde? Pathol Int 2013; 63: 287-296.
    • (2013) Pathol Int , vol.63 , pp. 287-296
    • Ehata, S.1    Yokoyama, Y.2    Takahashi, K.3    Miyazono, K.4
  • 14
    • 78649334675 scopus 로고    scopus 로고
    • Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4
    • Ketolainen JM, Alarmo EL, Tuominen VJ, Kallioniemi A. Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4. Breast Cancer Res Treat 2010; 124: 377-386.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 377-386
    • Ketolainen, J.M.1    Alarmo, E.L.2    Tuominen, V.J.3    Kallioniemi, A.4
  • 16
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011; 145: 926-940.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 18
    • 39149132827 scopus 로고    scopus 로고
    • A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer
    • Yang S, Pham LK, Liao CP, Frenkel B, Reddi AH, Roy-Burman P. A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer. Cancer Res 2008; 68: 198-205.
    • (2008) Cancer Res , vol.68 , pp. 198-205
    • Yang, S.1    Pham, L.K.2    Liao, C.P.3    Frenkel, B.4    Reddi, A.H.5    Roy-Burman, P.6
  • 19
    • 84879541683 scopus 로고    scopus 로고
    • Bone morphogenetic proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion
    • Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK et al. Bone morphogenetic proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS ONE 2013; 8: e67533.
    • (2013) PLoS ONE , vol.8 , pp. e67533
    • Owens, P.1    Polikowsky, H.2    Pickup, M.W.3    Gorska, A.E.4    Jovanovic, B.5    Shaw, A.K.6
  • 20
    • 79957910125 scopus 로고    scopus 로고
    • Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein
    • Wiley DM, Kim JD, Hao J, Hong CC, Bautch VL, Jin SW. Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nat Cell Biol 2011; 13: 686-692.
    • (2011) Nat Cell Biol , vol.13 , pp. 686-692
    • Wiley, D.M.1    Kim, J.D.2    Hao, J.3    Hong, C.C.4    Bautch, V.L.5    Jin, S.W.6
  • 21
    • 84879089097 scopus 로고    scopus 로고
    • BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages
    • Lee JH, Lee GT, Woo SH, Ha YS, Kwon SJ, Kim WJ et al. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res 2013; 73: 3604-3614.
    • (2013) Cancer Res , vol.73 , pp. 3604-3614
    • Lee, J.H.1    Lee, G.T.2    Woo, S.H.3    Ha, Y.S.4    Kwon, S.J.5    Kim, W.J.6
  • 22
    • 79957870612 scopus 로고    scopus 로고
    • Bone morphogenetic protein 6-induced interleukin-1beta expression in macrophages requires PU.1/Smad1 interaction
    • Lee GT, Jung YS, Lee JH, Kim WJ, Kim IY. Bone morphogenetic protein 6-induced interleukin-1beta expression in macrophages requires PU.1/Smad1 interaction. Mol Immunol 2011; 48: 1540-1547.
    • (2011) Mol Immunol , vol.48 , pp. 1540-1547
    • Lee, G.T.1    Jung, Y.S.2    Lee, J.H.3    Kim, W.J.4    Kim, I.Y.5
  • 23
    • 78549263769 scopus 로고    scopus 로고
    • Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways
    • Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY et al. Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways. J Biol Chem 2010; 285: 39401-39408.
    • (2010) J Biol Chem , vol.285 , pp. 39401-39408
    • Lee, G.T.1    Kwon, S.J.2    Lee, J.H.3    Jeon, S.S.4    Jang, K.T.5    Choi, H.Y.6
  • 25
    • 84872573955 scopus 로고    scopus 로고
    • DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells
    • Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB et al. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res 2013; 73: 1020-1030.
    • (2013) Cancer Res , vol.73 , pp. 1020-1030
    • Balboni, A.L.1    Hutchinson, J.A.2    Decastro, A.J.3    Cherukuri, P.4    Liby, K.5    Sporn, M.B.6
  • 26
    • 84876081183 scopus 로고    scopus 로고
    • Bone morphogenetic protein type i receptor antagonists decrease growth and induce cell death of lung cancer cell lines
    • Langenfeld E, Hong CC, Lanke G, Langenfeld J. Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. PLoS ONE 2013; 8: e61256.
    • (2013) PLoS ONE , vol.8 , pp. e61256
    • Langenfeld, E.1    Hong, C.C.2    Lanke, G.3    Langenfeld, J.4
  • 28
    • 77449108244 scopus 로고    scopus 로고
    • In vivo structureactivity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors
    • Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR et al. In vivo structureactivity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol 2010; 5: 245-253.
    • (2010) ACS Chem Biol , vol.5 , pp. 245-253
    • Hao, J.1    Ho, J.N.2    Lewis, J.A.3    Karim, K.A.4    Daniels, R.N.5    Gentry, P.R.6
  • 29
    • 84857119750 scopus 로고    scopus 로고
    • BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFbeta receptor to promote invasion
    • Hill CR, Sanchez NS, Love JD, Arrieta JA, Hong CC, Brown CB et al. BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFbeta receptor to promote invasion. Cell Signal 2012; 24: 1012-1022.
    • (2012) Cell Signal , vol.24 , pp. 1012-1022
    • Hill, C.R.1    Sanchez, N.S.2    Love, J.D.3    Arrieta, J.A.4    Hong, C.C.5    Brown, C.B.6
  • 30
    • 80053586217 scopus 로고    scopus 로고
    • Application of small organic molecules reveals cooperative TGFbeta and BMP regulation of mesothelial cell behaviors
    • Cross EE, Thomason RT, Martinez M, Hopkins CR, Hong CC, Bader DM. Application of small organic molecules reveals cooperative TGFbeta and BMP regulation of mesothelial cell behaviors. ACS Chem Biol 2011; 6: 952-961.
    • (2011) ACS Chem Biol , vol.6 , pp. 952-961
    • Cross, E.E.1    Thomason, R.T.2    Martinez, M.3    Hopkins, C.R.4    Hong, C.C.5    Bader, D.M.6
  • 31
    • 80051471864 scopus 로고    scopus 로고
    • The specificities of small molecule inhibitors of the TGF-b and BMP pathways
    • Vogt J, Traynor R, Sapkota GP. The specificities of small molecule inhibitors of the TGF-b and BMP pathways. Cell Signal 2011; 23: 1831-1842.
    • (2011) Cell Signal , vol.23 , pp. 1831-1842
    • Vogt, J.1    Traynor, R.2    Sapkota, G.P.3
  • 33
    • 34249036783 scopus 로고    scopus 로고
    • A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    • Alarmo EL, Kuukasjarvi T, Karhu R, Kallioniemi A. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat 2007; 103: 239-246.
    • (2007) Breast Cancer Res Treat , vol.103 , pp. 239-246
    • Alarmo, E.L.1    Kuukasjarvi, T.2    Karhu, R.3    Kallioniemi, A.4
  • 34
    • 38849140207 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas
    • Alarmo EL, Korhonen T, Kuukasjarvi T, Huhtala H, Holli K, Kallioniemi A. Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas. Ann Oncol 2008; 19: 308-314.
    • (2008) Ann Oncol , vol.19 , pp. 308-314
    • Alarmo, E.L.1    Korhonen, T.2    Kuukasjarvi, T.3    Huhtala, H.4    Holli, K.5    Kallioniemi, A.6
  • 35
    • 84871925853 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development
    • Alarmo EL, Huhtala H, Korhonen T, Pylkkanen L, Holli K, Kuukasjarvi T et al. Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development. Mod Pathol 2013; 26: 10-21.
    • (2013) Mod Pathol , vol.26 , pp. 10-21
    • Alarmo, E.L.1    Huhtala, H.2    Korhonen, T.3    Pylkkanen, L.4    Holli, K.5    Kuukasjarvi, T.6
  • 36
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 37
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2012; 2: 401-404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5    Aksoy, B.A.6
  • 38
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6: pl1.
    • (2013) Sci Signal , vol.6 , pp. pl1
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3    Dresdner, G.4    Gross, B.5    Sumer, S.O.6
  • 39
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signaling
    • ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004; 29: 265-273.
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 40
    • 70349467638 scopus 로고    scopus 로고
    • Lessons in signaling and tumorigenesis from polyomavirus middle T antigen
    • Fluck MM, Schaffhausen BS. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev 2009; 73: 542-563.
    • (2009) Microbiol Mol Biol Rev , vol.73 , pp. 542-563
    • Fluck, M.M.1    Schaffhausen, B.S.2
  • 41
    • 34547769774 scopus 로고    scopus 로고
    • Paradoxical roles for lysyl oxidases in cancer - A prospect
    • Payne SL, Hendrix MJ, Kirschmann DA. Paradoxical roles for lysyl oxidases in cancer-a prospect. J Cell Biochem 2007; 101: 1338-1354.
    • (2007) J Cell Biochem , vol.101 , pp. 1338-1354
    • Payne, S.L.1    Hendrix, M.J.2    Kirschmann, D.A.3
  • 42
    • 84864350704 scopus 로고    scopus 로고
    • The rationale for targeting the LOX family in cancer
    • Barker HE, Cox TR, Erler JT. The rationale for targeting the LOX family in cancer. Nat Rev Cancer 2012; 12: 540-552.
    • (2012) Nat Rev Cancer , vol.12 , pp. 540-552
    • Barker, H.E.1    Cox, T.R.2    Erler, J.T.3
  • 43
    • 67449108314 scopus 로고    scopus 로고
    • Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells
    • Hollosi P, Yakushiji JK, Fong KS, Csiszar K, Fong SF. Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. Int J Cancer 2009; 125: 318-327.
    • (2009) Int J Cancer , vol.125 , pp. 318-327
    • Hollosi, P.1    Yakushiji, J.K.2    Fong, K.S.3    Csiszar, K.4    Fong, S.F.5
  • 44
    • 84875445066 scopus 로고    scopus 로고
    • LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
    • Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G et al. LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis. Cancer Res 2013; 73: 1721-1732.
    • (2013) Cancer Res , vol.73 , pp. 1721-1732
    • Cox, T.R.1    Bird, D.2    Baker, A.M.3    Barker, H.E.4    Ho, M.W.5    Lang, G.6
  • 45
    • 84872202894 scopus 로고    scopus 로고
    • The Role of the VEGF-C/VEGFRs axis in tumor progression and therapy
    • Chen JC, Chang YW, Hong CC, Yu YH, Su JL. The Role of the VEGF-C/VEGFRs axis in tumor progression and therapy. Int J Mol Sci 2012; 14: 88-107.
    • (2012) Int J Mol Sci , vol.14 , pp. 88-107
    • Chen, J.C.1    Chang, Y.W.2    Hong, C.C.3    Yu, Y.H.4    Su, J.L.5
  • 48
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    • He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 2004; 36: 1117-1121.
    • (2004) Nat Genet , vol.36 , pp. 1117-1121
    • He, X.C.1    Zhang, J.2    Tong, W.G.3    Tawfik, O.4    Ross, J.5    Scoville, D.H.6
  • 49
    • 84862012341 scopus 로고    scopus 로고
    • Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals
    • Nishimori H, Ehata S, Suzuki HI, Katsuno Y, Miyazono K. Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. J Biol Chem 2012; 287: 20037-20046.
    • (2012) J Biol Chem , vol.287 , pp. 20037-20046
    • Nishimori, H.1    Ehata, S.2    Suzuki, H.I.3    Katsuno, Y.4    Miyazono, K.5
  • 50
    • 54549102135 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway
    • Katsuno Y, Hanyu A, Kanda H, Ishikawa Y, Akiyama F, Iwase T et al. Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway. Oncogene 2008; 27: 6322-6333.
    • (2008) Oncogene , vol.27 , pp. 6322-6333
    • Katsuno, Y.1    Hanyu, A.2    Kanda, H.3    Ishikawa, Y.4    Akiyama, F.5    Iwase, T.6
  • 51
    • 76749108468 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment
    • Morrissey C, Brown LG, Pitts TE, Vessella RL, Corey E. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 2010; 12: 192-205.
    • (2010) Neoplasia , vol.12 , pp. 192-205
    • Morrissey, C.1    Brown, L.G.2    Pitts, T.E.3    Vessella, R.L.4    Corey, E.5
  • 52
    • 24944480253 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism
    • Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res 2005; 65: 8274-8285.
    • (2005) Cancer Res , vol.65 , pp. 8274-8285
    • Dai, J.1    Keller, J.2    Zhang, J.3    Lu, Y.4    Yao, Z.5    Keller, E.T.6
  • 53
    • 82055175800 scopus 로고    scopus 로고
    • Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes
    • Rodriguez-Martinez A, Alarmo EL, Saarinen L, Ketolainen J, Nousiainen K, Hautaniemi S et al. Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes. BMC Med Genomics 2011; 4: 80.
    • (2011) BMC Med Genomics , vol.4 , pp. 80
    • Rodriguez-Martinez, A.1    Alarmo, E.L.2    Saarinen, L.3    Ketolainen, J.4    Nousiainen, K.5    Hautaniemi, S.6
  • 54
    • 68249162072 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages
    • Kwon SJ, Lee GT, Lee JH, Kim WJ, Kim IY. Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages. Immunology 2009; 128: e758-e765.
    • (2009) Immunology , vol.128 , pp. e758-e765
    • Kwon, S.J.1    Lee, G.T.2    Lee, J.H.3    Kim, W.J.4    Kim, I.Y.5
  • 55
    • 84883477750 scopus 로고    scopus 로고
    • Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta deficient mouse mammary carcinoma
    • Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A et al. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta deficient mouse mammary carcinoma. Cancer Res 2013; 73: 5336-5346.
    • (2013) Cancer Res , vol.73 , pp. 5336-5346
    • Pickup, M.W.1    Laklai, H.2    Acerbi, I.3    Owens, P.4    Gorska, A.E.5    Chytil, A.6
  • 56
  • 58
    • 84863099094 scopus 로고    scopus 로고
    • TGF-beta receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms
    • Novitskiy SV, Pickup MW, Gorska AE, Owens P, Chytil A, Aakre M et al. TGF-beta receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov 2011; 1: 430-441.
    • (2011) Cancer Discov , vol.1 , pp. 430-441
    • Novitskiy, S.V.1    Pickup, M.W.2    Gorska, A.E.3    Owens, P.4    Chytil, A.5    Aakre, M.6
  • 59
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat 2010; 123: 725-731.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.