-
1
-
-
84962440911
-
Targeting CDK4 and CDK6: from discovery to therapy
-
COI: 1:CAS:528:DC%2BC28Xlslaqu70%3D, PID: 26658964
-
Sherr CJ, Beach D, Shapiro GI (2016) Targeting CDK4 and CDK6: from discovery to therapy. Cancer Discov 6:353–367
-
(2016)
Cancer Discov
, vol.6
, pp. 353-367
-
-
Sherr, C.J.1
Beach, D.2
Shapiro, G.I.3
-
2
-
-
84893870115
-
A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition
-
PID: 24500246
-
Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H et al (2014) A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep 4:4012
-
(2014)
Sci Rep
, vol.4
, pp. 4012
-
-
Oki, T.1
Nishimura, K.2
Kitaura, J.3
Togami, K.4
Maehara, A.5
Izawa, K.6
Sakaue-Sawano, A.7
Niida, A.8
Miyano, S.9
Aburatani, H.10
-
3
-
-
0029645935
-
The crystal structure of cyclin A
-
COI: 1:CAS:528:DyaK2MXps1KmsrY%3D, PID: 8591034
-
Brown NR, Noble ME, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN (1995) The crystal structure of cyclin A. Structure 3:1235–1247
-
(1995)
Structure
, vol.3
, pp. 1235-1247
-
-
Brown, N.R.1
Noble, M.E.2
Endicott, J.A.3
Garman, E.F.4
Wakatsuki, S.5
Mitchell, E.6
Rasmussen, B.7
Hunt, T.8
Johnson, L.N.9
-
4
-
-
38849187293
-
CDK inhibitors: cell cycle regulators and beyond
-
COI: 1:CAS:528:DC%2BD1cXit1Ojsrc%3D, PID: 18267085
-
Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159–169
-
(2008)
Dev Cell
, vol.14
, pp. 159-169
-
-
Besson, A.1
Dowdy, S.F.2
Roberts, J.M.3
-
5
-
-
0027133239
-
Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1
-
COI: 1:CAS:528:DyaK2cXhtlSmurc%3D, PID: 7505440
-
Kato JY, Sherr CJ (1993) Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. Proc Natl Acad Sci U S A 90:11513–11517
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 11513-11517
-
-
Kato, J.Y.1
Sherr, C.J.2
-
6
-
-
0035736241
-
A family outing: small GTPases cyclin’ through G1
-
COI: 1:CAS:528:DC%2BD3MXosVeitL4%3D, PID: 11715034
-
Coleman ML, Marshall CJ (2001) A family outing: small GTPases cyclin’ through G1. Nat Cell Biol 3:E250–E251
-
(2001)
Nat Cell Biol
, vol.3
, pp. E250-E251
-
-
Coleman, M.L.1
Marshall, C.J.2
-
7
-
-
79960836823
-
Cyclin D as a therapeutic target in cancer
-
COI: 1:CAS:528:DC%2BC3MXos1Srsr0%3D, PID: 21734724
-
Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL (2011) Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 11:558–572
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 558-572
-
-
Musgrove, E.A.1
Caldon, C.E.2
Barraclough, J.3
Stone, A.4
Sutherland, R.L.5
-
8
-
-
84924070571
-
Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells
-
PID: 25731618
-
Xu Y, Li H, Huang C, Zhao T, Zhang H, Zheng C, Ren H, Hao J (2015) Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells. Med Oncol 32:97
-
(2015)
Med Oncol
, vol.32
, pp. 97
-
-
Xu, Y.1
Li, H.2
Huang, C.3
Zhao, T.4
Zhang, H.5
Zheng, C.6
Ren, H.7
Hao, J.8
-
9
-
-
33644878286
-
WNT2B: comparative integromics and clinical applications (review)
-
PID: 16273293
-
Katoh M (2005) WNT2B: comparative integromics and clinical applications (review). Int J Mol Med 16:1103–1108
-
(2005)
Int J Mol Med
, vol.16
, pp. 1103-1108
-
-
Katoh, M.1
-
10
-
-
0033545845
-
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
-
COI: 1:CAS:528:DyaK1MXjtFCnsbc%3D, PID: 10318916
-
Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 96:5522–5527
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 5522-5527
-
-
Shtutman, M.1
Zhurinsky, J.2
Simcha, I.3
Albanese, C.4
D'Amico, M.5
Pestell, R.6
Ben-Ze'ev, A.7
-
11
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
COI: 1:CAS:528:DyaK1MXisFGksrY%3D, PID: 10201372
-
Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422–426
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
12
-
-
0032533225
-
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
-
COI: 1:CAS:528:DyaK1cXnvVOgs7s%3D, PID: 9832503
-
Diehl JA, Cheng M, Roussel MF, Sherr CJ (1998) Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499–3511
-
(1998)
Genes Dev
, vol.12
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
13
-
-
0034640541
-
Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation
-
COI: 1:CAS:528:DC%2BD3cXjt1CntLk%3D, PID: 10748202
-
Rimerman RA, Gellert-Randleman A, Diehl JA (2000) Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation. J Biol Chem 275:14736–14742
-
(2000)
J Biol Chem
, vol.275
, pp. 14736-14742
-
-
Rimerman, R.A.1
Gellert-Randleman, A.2
Diehl, J.A.3
-
14
-
-
0030883584
-
Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
-
COI: 1:CAS:528:DyaK2sXlvFChsLk%3D, PID: 9337851
-
Weber JD, Raben DM, Phillips PJ, Baldassare JJ (1997) Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 326(Pt 1):61–68
-
(1997)
Biochem J
, vol.326
, pp. 61-68
-
-
Weber, J.D.1
Raben, D.M.2
Phillips, P.J.3
Baldassare, J.J.4
-
15
-
-
0034801952
-
Epidermal growth factor induces cyclin D1 in human pancreatic carcinoma: evidence for a cyclin D1-dependent cell cycle progression
-
COI: 1:STN:280:DC%2BD3MrltVertg%3D%3D, PID: 11590324
-
Poch B, Gansauge F, Schwarz A, Seufferlein T, Schnelldorfer T, Ramadani M, Beger HG, Gansauge S (2001) Epidermal growth factor induces cyclin D1 in human pancreatic carcinoma: evidence for a cyclin D1-dependent cell cycle progression. Pancreas 23:280–287
-
(2001)
Pancreas
, vol.23
, pp. 280-287
-
-
Poch, B.1
Gansauge, F.2
Schwarz, A.3
Seufferlein, T.4
Schnelldorfer, T.5
Ramadani, M.6
Beger, H.G.7
Gansauge, S.8
-
16
-
-
79953308071
-
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
-
COI: 1:CAS:528:DC%2BC3MXks1Wqt74%3D, PID: 21474065
-
Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J (2011) Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell 42:9–22
-
(2011)
Mol Cell
, vol.42
, pp. 9-22
-
-
Jura, N.1
Zhang, X.2
Endres, N.F.3
Seeliger, M.A.4
Schindler, T.5
Kuriyan, J.6
-
17
-
-
0031921230
-
Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line
-
COI: 1:CAS:528:DyaK1cXjtFaqs7c%3D, PID: 9568675
-
Perry JE, Grossmann ME, Tindall DJ (1998) Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line. Prostate 35:117–124
-
(1998)
Prostate
, vol.35
, pp. 117-124
-
-
Perry, J.E.1
Grossmann, M.E.2
Tindall, D.J.3
-
18
-
-
18344390418
-
ERBB receptors and cancer: the complexity of targeted inhibitors
-
COI: 1:CAS:528:DC%2BD2MXjslertb0%3D, PID: 15864276
-
Hynes NE, Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5:341–354
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
19
-
-
0033961809
-
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
-
COI: 1:CAS:528:DC%2BD3cXjtVKltA%3D%3D, PID: 10611246
-
Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, Haines GK 3rd, Siegel PM, Hung MC, Yarden Y et al (2000) Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 20:672–683
-
(2000)
Mol Cell Biol
, vol.20
, pp. 672-683
-
-
Lee, R.J.1
Albanese, C.2
Fu, M.3
D'Amico, M.4
Lin, B.5
Watanabe, G.6
Haines, G.K.7
Siegel, P.M.8
Hung, M.C.9
Yarden, Y.10
-
20
-
-
0035963435
-
Specific protection against breast cancers by cyclin D1 ablation
-
COI: 1:CAS:528:DC%2BD3MXltVClu7g%3D, PID: 11429595
-
Yu Q, Geng Y, Sicinski P (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature 411:1017–1021
-
(2001)
Nature
, vol.411
, pp. 1017-1021
-
-
Yu, Q.1
Geng, Y.2
Sicinski, P.3
-
21
-
-
30344470210
-
Requirement for CDK4 kinase function in breast cancer
-
COI: 1:CAS:528:DC%2BD28XosFersw%3D%3D, PID: 16413469
-
Yu Q, Sicinska E, Geng Y, Ahnstrom M, Zagozdzon A, Kong Y, Gardner H, Kiyokawa H, Harris LN, Stal O et al (2006) Requirement for CDK4 kinase function in breast cancer. Cancer Cell 9:23–32
-
(2006)
Cancer Cell
, vol.9
, pp. 23-32
-
-
Yu, Q.1
Sicinska, E.2
Geng, Y.3
Ahnstrom, M.4
Zagozdzon, A.5
Kong, Y.6
Gardner, H.7
Kiyokawa, H.8
Harris, L.N.9
Stal, O.10
-
22
-
-
84937512066
-
Palbociclib: first global approval
-
COI: 1:CAS:528:DC%2BC2MXlslCrsrs%3D, PID: 25792301
-
Dhillon S (2015) Palbociclib: first global approval. Drugs 75:543–551
-
(2015)
Drugs
, vol.75
, pp. 543-551
-
-
Dhillon, S.1
-
23
-
-
78650546282
-
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains
-
COI: 1:CAS:528:DC%2BC3cXhsVyntL3P, PID: 21041639
-
Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV et al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A 107:20126–20131
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20126-20131
-
-
Miao, B.1
Skidan, I.2
Yang, J.3
Lugovskoy, A.4
Reibarkh, M.5
Long, K.6
Brazell, T.7
Durugkar, K.A.8
Maki, J.9
Ramana, C.V.10
-
24
-
-
0032911889
-
Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
-
COI: 1:CAS:528:DyaK1MXhtVKhtbw%3D, PID: 9891068
-
Takuwa N, Fukui Y, Takuwa Y (1999) Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts. Mol Cell Biol 19:1346–1358
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1346-1358
-
-
Takuwa, N.1
Fukui, Y.2
Takuwa, Y.3
-
25
-
-
84903736435
-
Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation
-
COI: 1:CAS:528:DC%2BC2cXhtVKls7vP, PID: 24979279
-
Daniel P, Filiz G, Brown DV, Hollande F, Gonzales M, D'Abaco G, Papalexis N, Phillips WA, Malaterre J, Ramsay RG et al (2014) Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation. Oncogenesis 3:e108
-
(2014)
Oncogenesis
, vol.3
-
-
Daniel, P.1
Filiz, G.2
Brown, D.V.3
Hollande, F.4
Gonzales, M.5
D'Abaco, G.6
Papalexis, N.7
Phillips, W.A.8
Malaterre, J.9
Ramsay, R.G.10
-
26
-
-
78650907445
-
A single NFkappaB system for both canonical and non-canonical signaling
-
COI: 1:CAS:528:DC%2BC3MXhtlaqtg%3D%3D, PID: 21102550
-
Shih VF, Tsui R, Caldwell A, Hoffmann A (2011) A single NFkappaB system for both canonical and non-canonical signaling. Cell Res 21:86–102
-
(2011)
Cell Res
, vol.21
, pp. 86-102
-
-
Shih, V.F.1
Tsui, R.2
Caldwell, A.3
Hoffmann, A.4
-
27
-
-
0032588186
-
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr (1999) NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19:5785–5799
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin, A.S.5
-
28
-
-
0036546501
-
NF-kappaB in cancer: from innocent bystander to major culprit
-
COI: 1:CAS:528:DC%2BD38XivFGqt7k%3D, PID: 12001991
-
Karin M, Cao Y, Greten FR, Li ZW (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301–310
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
29
-
-
33645118564
-
Cyclin D1: polymorphism, aberrant splicing and cancer risk
-
COI: 1:CAS:528:DC%2BD28XisFyhtbw%3D, PID: 16550162
-
Knudsen KE, Diehl JA, Haiman CA, Knudsen ES (2006) Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 25:1620–1628
-
(2006)
Oncogene
, vol.25
, pp. 1620-1628
-
-
Knudsen, K.E.1
Diehl, J.A.2
Haiman, C.A.3
Knudsen, E.S.4
-
30
-
-
0242526150
-
An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene
-
COI: 1:CAS:528:DC%2BD3sXovVGlsLw%3D, PID: 14612495
-
Lu F, Gladden AB, Diehl JA (2003) An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 63:7056–7061
-
(2003)
Cancer Res
, vol.63
, pp. 7056-7061
-
-
Lu, F.1
Gladden, A.B.2
Diehl, J.A.3
-
31
-
-
77952796886
-
Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene
-
COI: 1:CAS:528:DC%2BC3cXlvFyrurg%3D, PID: 20460515
-
Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, Sette C, Zhang J, Parysek LM, Knudsen KE (2010) Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. Cancer Res 70:3975–3984
-
(2010)
Cancer Res
, vol.70
, pp. 3975-3984
-
-
Olshavsky, N.A.1
Comstock, C.E.2
Schiewer, M.J.3
Augello, M.A.4
Hyslop, T.5
Sette, C.6
Zhang, J.7
Parysek, L.M.8
Knudsen, K.E.9
-
32
-
-
75149187424
-
Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68
-
COI: 1:CAS:528:DC%2BC3cXkvF2g, PID: 20028857
-
Paronetto MP, Cappellari M, Busa R, Pedrotti S, Vitali R, Comstock C, Hyslop T, Knudsen KE, Sette C (2010) Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res 70:229–239
-
(2010)
Cancer Res
, vol.70
, pp. 229-239
-
-
Paronetto, M.P.1
Cappellari, M.2
Busa, R.3
Pedrotti, S.4
Vitali, R.5
Comstock, C.6
Hyslop, T.7
Knudsen, K.E.8
Sette, C.9
-
33
-
-
0041528506
-
Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
-
COI: 1:CAS:528:DC%2BD3sXlvFOnurY%3D, PID: 12746453
-
Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Knudsen ES (2003) Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 278:30339–30347
-
(2003)
J Biol Chem
, vol.278
, pp. 30339-30347
-
-
Solomon, D.A.1
Wang, Y.2
Fox, S.R.3
Lambeck, T.C.4
Giesting, S.5
Lan, Z.6
Senderowicz, A.M.7
Knudsen, E.S.8
-
34
-
-
45849131324
-
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer
-
COI: 1:CAS:528:DC%2BD1cXos1ektL8%3D, PID: 18598945
-
Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA (2008) Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14:68–78
-
(2008)
Cancer Cell
, vol.14
, pp. 68-78
-
-
Barbash, O.1
Zamfirova, P.2
Lin, D.I.3
Chen, X.4
Yang, K.5
Nakagawa, H.6
Lu, F.7
Rustgi, A.K.8
Diehl, J.A.9
-
35
-
-
0034671768
-
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
-
COI: 1:CAS:528:DC%2BD3MXhs1Wgtg%3D%3D, PID: 11124803
-
Alt JR, Cleveland JL, Hannink M, Diehl JA (2000) Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 14:3102–3114
-
(2000)
Genes Dev
, vol.14
, pp. 3102-3114
-
-
Alt, J.R.1
Cleveland, J.L.2
Hannink, M.3
Diehl, J.A.4
-
36
-
-
0030916209
-
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
-
COI: 1:CAS:528:DyaK2sXivFWhurw%3D, PID: 9136925
-
Diehl JA, Zindy F, Sherr CJ (1997) Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 11:957–972
-
(1997)
Genes Dev
, vol.11
, pp. 957-972
-
-
Diehl, J.A.1
Zindy, F.2
Sherr, C.J.3
-
37
-
-
36248975284
-
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
-
COI: 1:CAS:528:DC%2BD2sXhtlGmsrjL, PID: 18006686
-
Aggarwal P, Lessie MD, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJ, Rustgi AK et al (2007) Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev 21:2908–2922
-
(2007)
Genes Dev
, vol.21
, pp. 2908-2922
-
-
Aggarwal, P.1
Lessie, M.D.2
Lin, D.I.3
Pontano, L.4
Gladden, A.B.5
Nuskey, B.6
Goradia, A.7
Wasik, M.A.8
Klein-Szanto, A.J.9
Rustgi, A.K.10
-
38
-
-
77957966270
-
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
-
COI: 1:CAS:528:DC%2BC3cXhtlSnu77K, PID: 20951943
-
Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB et al (2010) Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 18:329–340
-
(2010)
Cancer Cell
, vol.18
, pp. 329-340
-
-
Aggarwal, P.1
Vaites, L.P.2
Kim, J.K.3
Mellert, H.4
Gurung, B.5
Nakagawa, H.6
Herlyn, M.7
Hua, X.8
Rustgi, A.K.9
McMahon, S.B.10
-
39
-
-
84959300244
-
PRMT5-dependent p53 escape in tumorigenesis
-
PID: 26425661
-
Li Y, Diehl JA (2015) PRMT5-dependent p53 escape in tumorigenesis. Oncoscience 2:700–702
-
(2015)
Oncoscience
, vol.2
, pp. 700-702
-
-
Li, Y.1
Diehl, J.A.2
-
40
-
-
84925302177
-
PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers
-
COI: 1:CAS:528:DC%2BC2MXktVGktb8%3D, PID: 25582697
-
Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, Li Z, Wasik M, Klein-Szanto AJ, Rustgi AK et al (2015) PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers. Cancer Discov 5:288–303
-
(2015)
Cancer Discov
, vol.5
, pp. 288-303
-
-
Li, Y.1
Chitnis, N.2
Nakagawa, H.3
Kita, Y.4
Natsugoe, S.5
Yang, Y.6
Li, Z.7
Wasik, M.8
Klein-Szanto, A.J.9
Rustgi, A.K.10
-
41
-
-
79959469863
-
Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases
-
COI: 1:CAS:528:DC%2BC3MXht12ktbbI, PID: 21710433
-
Hindley CJ, McDowell GS, Wise H, Philpott A (2011) Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases. Int J Dev Biol 55:249–260
-
(2011)
Int J Dev Biol
, vol.55
, pp. 249-260
-
-
Hindley, C.J.1
McDowell, G.S.2
Wise, H.3
Philpott, A.4
-
42
-
-
84899431646
-
SCFs in the new millennium
-
COI: 1:CAS:528:DC%2BC3sXms1WnsL4%3D, PID: 23624913
-
Lee EK, Diehl JA (2014) SCFs in the new millennium. Oncogene 33:2011–2018
-
(2014)
Oncogene
, vol.33
, pp. 2011-2018
-
-
Lee, E.K.1
Diehl, J.A.2
-
43
-
-
0030602813
-
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
-
COI: 1:CAS:528:DyaK28Xks1Gns7s%3D, PID: 8706131
-
Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86:263–274
-
(1996)
Cell
, vol.86
, pp. 263-274
-
-
Bai, C.1
Sen, P.2
Hofmann, K.3
Ma, L.4
Goebl, M.5
Harper, J.W.6
Elledge, S.J.7
-
44
-
-
7544234937
-
Systematic analysis and nomenclature of mammalian F-box proteins
-
COI: 1:CAS:528:DC%2BD2cXpvVykuro%3D, PID: 15520277
-
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (2004) Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 18:2573–2580
-
(2004)
Genes Dev
, vol.18
, pp. 2573-2580
-
-
Jin, J.1
Cardozo, T.2
Lovering, R.C.3
Elledge, S.J.4
Pagano, M.5
Harper, J.W.6
-
45
-
-
33750460897
-
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
-
COI: 1:CAS:528:DC%2BD28XhtF2qs7jI, PID: 17081987
-
Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA (2006) Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell 24:355–366
-
(2006)
Mol Cell
, vol.24
, pp. 355-366
-
-
Lin, D.I.1
Barbash, O.2
Kumar, K.G.3
Weber, J.D.4
Harper, J.W.5
Klein-Szanto, A.J.6
Rustgi, A.7
Fuchs, S.Y.8
Diehl, J.A.9
-
46
-
-
53649106818
-
SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough
-
COI: 1:CAS:528:DC%2BD1cXhsVOgsrrJ, PID: 18818515
-
Barbash O, Diehl JA (2008) SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough. Cell Cycle 7:2983–2986
-
(2008)
Cell Cycle
, vol.7
, pp. 2983-2986
-
-
Barbash, O.1
Diehl, J.A.2
-
47
-
-
84887014270
-
The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3sXhslSqsL7F, PID: 24019069
-
Lee EK, Lian Z, D'Andrea K, Letrero R, Sheng W, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L et al (2013) The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol 33:4422–4433
-
(2013)
Mol Cell Biol
, vol.33
, pp. 4422-4433
-
-
Lee, E.K.1
Lian, Z.2
D'Andrea, K.3
Letrero, R.4
Sheng, W.5
Liu, S.6
Diehl, J.N.7
Pytel, D.8
Barbash, O.9
Schuchter, L.10
-
48
-
-
79955470404
-
Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3varepsilon
-
COI: 1:CAS:528:DC%2BC3MXmsFGgug%3D%3D, PID: 21242966
-
Barbash O, Lee EK, Diehl JA (2011) Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3varepsilon. Oncogene 30:1995–2002
-
(2011)
Oncogene
, vol.30
, pp. 1995-2002
-
-
Barbash, O.1
Lee, E.K.2
Diehl, J.A.3
-
49
-
-
83255192193
-
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
-
COI: 1:CAS:528:DC%2BC3MXhsVKjsr3M, PID: 21911473
-
Vaites LP, Lee EK, Lian Z, Barbash O, Roy D, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA (2011) The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol 31:4513–4523
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4513-4523
-
-
Vaites, L.P.1
Lee, E.K.2
Lian, Z.3
Barbash, O.4
Roy, D.5
Wasik, M.6
Klein-Szanto, A.J.7
Rustgi, A.K.8
Diehl, J.A.9
-
50
-
-
84899489535
-
Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer
-
COI: 1:CAS:528:DC%2BC2cXmt1GktLY%3D, PID: 24704453
-
Chu X, Zhang T, Wang J, Li M, Zhang X, Tu J, Sun S, Chen X, Lu F (2014) Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer. Biochem Biophys Res Commun 447:158–164
-
(2014)
Biochem Biophys Res Commun
, vol.447
, pp. 158-164
-
-
Chu, X.1
Zhang, T.2
Wang, J.3
Li, M.4
Zhang, X.5
Tu, J.6
Sun, S.7
Chen, X.8
Lu, F.9
-
51
-
-
66649117243
-
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
-
COI: 1:CAS:528:DC%2BD1MXltlSrsL4%3D, PID: 19412162
-
Santra MK, Wajapeyee N, Green MR (2009) F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459:722–725
-
(2009)
Nature
, vol.459
, pp. 722-725
-
-
Santra, M.K.1
Wajapeyee, N.2
Green, M.R.3
-
52
-
-
57349191639
-
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
-
COI: 1:CAS:528:DC%2BD1cXhsVCjsb3F, PID: 18809569
-
Pontano LL, Aggarwal P, Barbash O, Brown EJ, Bassing CH, Diehl JA (2008) Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. Mol Cell Biol 28:7245–7258
-
(2008)
Mol Cell Biol
, vol.28
, pp. 7245-7258
-
-
Pontano, L.L.1
Aggarwal, P.2
Barbash, O.3
Brown, E.J.4
Bassing, C.H.5
Diehl, J.A.6
-
53
-
-
0037040984
-
p21(Cip1) promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
-
COI: 1:CAS:528:DC%2BD38XitFymtbc%3D, PID: 11751903
-
Alt JR, Gladden AB, Diehl JA (2002) p21(Cip1) promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J Biol Chem 277:8517–8523
-
(2002)
J Biol Chem
, vol.277
, pp. 8517-8523
-
-
Alt, J.R.1
Gladden, A.B.2
Diehl, J.A.3
-
54
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
COI: 1:CAS:528:DyaK1MXltlSjtr0%3D, PID: 10559916
-
Carrano AC, Eytan E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1:193–199
-
(1999)
Nat Cell Biol
, vol.1
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
55
-
-
0035956971
-
Role of the F-box protein Skp2 in lymphomagenesis
-
COI: 1:CAS:528:DC%2BD3MXhslKms7w%3D, PID: 11226270
-
Latres E, Chiarle R, Schulman BA, Pavletich NP, Pellicer A, Inghirami G, Pagano M (2001) Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A 98:2515–2520
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 2515-2520
-
-
Latres, E.1
Chiarle, R.2
Schulman, B.A.3
Pavletich, N.P.4
Pellicer, A.5
Inghirami, G.6
Pagano, M.7
-
56
-
-
0031048236
-
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
-
COI: 1:CAS:528:DyaK2sXpsFWgsQ%3D%3D, PID: 9018245
-
Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M (1997) Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3:231–234
-
(1997)
Nat Med
, vol.3
, pp. 231-234
-
-
Loda, M.1
Cukor, B.2
Tam, S.W.3
Lavin, P.4
Fiorentino, M.5
Draetta, G.F.6
Jessup, J.M.7
Pagano, M.8
-
57
-
-
0038152755
-
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
-
COI: 1:CAS:528:DC%2BD3sXlt1Cls78%3D, PID: 12730199
-
Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A (2003) Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 278:25752–25757
-
(2003)
J Biol Chem
, vol.278
, pp. 25752-25757
-
-
Bornstein, G.1
Bloom, J.2
Sitry-Shevah, D.3
Nakayama, K.4
Pagano, M.5
Hershko, A.6
-
58
-
-
0032530151
-
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
-
ZK Y, Gervais JL, Zhang H (1998) Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A 95:11324–11329
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11324-11329
-
-
Zk, Y.1
Gervais, J.L.2
Zhang, H.3
-
59
-
-
77955535107
-
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
-
COI: 1:CAS:528:DC%2BC3cXhtVejs7vE, PID: 20708156
-
Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H et al (2010) Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell 18:147–159
-
(2010)
Cancer Cell
, vol.18
, pp. 147-159
-
-
Inuzuka, H.1
Tseng, A.2
Gao, D.3
Zhai, B.4
Zhang, Q.5
Shaik, S.6
Wan, L.7
Ang, X.L.8
Mock, C.9
Yin, H.10
-
60
-
-
55549109429
-
A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells
-
COI: 1:CAS:528:DC%2BD1cXhtFejtrrF, PID: 18650423
-
Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, PJ L, Lai MD, Chen CS (2008) A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. J Biol Chem 283:26759–26770
-
(2008)
J Biol Chem
, vol.283
, pp. 26759-26770
-
-
Wei, S.1
Yang, H.C.2
Chuang, H.C.3
Yang, J.4
Kulp, S.K.5
Pj, L.6
Lai, M.D.7
Chen, C.S.8
-
61
-
-
34548306411
-
Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma
-
COI: 1:CAS:528:DC%2BD2sXhtVSgu77J, PID: 17569795
-
Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS (2007) Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma. Mol Pharmacol 72:725–733
-
(2007)
Mol Pharmacol
, vol.72
, pp. 725-733
-
-
Wei, S.1
Lin, L.F.2
Yang, C.C.3
Wang, Y.C.4
Chang, G.D.5
Chen, H.6
Chen, C.S.7
-
62
-
-
34248174014
-
Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation
-
COI: 1:CAS:528:DC%2BD2sXksVGksrs%3D, PID: 17409431
-
Yang CC, Wang YC, Wei S, Lin LF, Chen CS, Lee CC, Lin CC, Chen CS (2007) Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation. Cancer Res 67:3229–3238
-
(2007)
Cancer Res
, vol.67
, pp. 3229-3238
-
-
Yang, C.C.1
Wang, Y.C.2
Wei, S.3
Lin, L.F.4
Chen, C.S.5
Lee, C.C.6
Lin, C.C.7
Chen, C.S.8
-
63
-
-
79952940456
-
State of the APC/C: organization, function, and structure
-
COI: 1:CAS:528:DC%2BC3MXjsFyqtL4%3D, PID: 21261459
-
McLean JR, Chaix D, Ohi MD, Gould KL (2011) State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol 46:118–136
-
(2011)
Crit Rev Biochem Mol Biol
, vol.46
, pp. 118-136
-
-
McLean, J.R.1
Chaix, D.2
Ohi, M.D.3
Gould, K.L.4
-
64
-
-
0034616913
-
Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
-
COI: 1:CAS:528:DC%2BD3cXkvFCrtr8%3D, PID: 10929713
-
Agami R, Bernards R (2000) Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102:55–66
-
(2000)
Cell
, vol.102
, pp. 55-66
-
-
Agami, R.1
Bernards, R.2
-
65
-
-
0037648338
-
Skp2 regulates Myc protein stability and activity
-
COI: 1:CAS:528:DC%2BD3sXksVOjt78%3D, PID: 12769843
-
Kim SY, Herbst A, Tworkowski KA, Salghetti SE, Tansey WP (2003) Skp2 regulates Myc protein stability and activity. Mol Cell 11:1177–1188
-
(2003)
Mol Cell
, vol.11
, pp. 1177-1188
-
-
Kim, S.Y.1
Herbst, A.2
Tworkowski, K.A.3
Salghetti, S.E.4
Tansey, W.P.5
-
66
-
-
12444264823
-
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription
-
PID: 12769844
-
von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C, Hydbring P, Weidung I, Nakayama K, Nakayama KI et al (2003) The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 11:1189–1200
-
(2003)
Mol Cell
, vol.11
, pp. 1189-1200
-
-
von der Lehr, N.1
Johansson, S.2
Wu, S.3
Bahram, F.4
Castell, A.5
Cetinkaya, C.6
Hydbring, P.7
Weidung, I.8
Nakayama, K.9
Nakayama, K.I.10
-
67
-
-
81755160906
-
Role of Pirh2 in mediating the regulation of p53 and c-Myc
-
COI: 1:CAS:528:DC%2BC3MXhs1Smt77K, PID: 22125490
-
Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S et al (2011) Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet 7:e1002360
-
(2011)
PLoS Genet
, vol.7
-
-
Hakem, A.1
Bohgaki, M.2
Lemmers, B.3
Tai, E.4
Salmena, L.5
Matysiak-Zablocki, E.6
Jung, Y.S.7
Karaskova, J.8
Kaustov, L.9
Duan, S.10
-
68
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
COI: 1:CAS:528:DC%2BD2cXltlWqsbo%3D, PID: 15150404
-
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 101:9085–9090
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.E.4
Harper, J.W.5
Eisenman, R.N.6
Clurman, B.E.7
-
69
-
-
84856781262
-
Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation
-
COI: 1:CAS:528:DC%2BC38XhsV2mtbk%3D, PID: 22124152
-
Kanie T, Onoyama I, Matsumoto A, Yamada M, Nakatsumi H, Tateishi Y, Yamamura S, Tsunematsu R, Matsumoto M, Nakayama KI (2012) Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol 32:590–605
-
(2012)
Mol Cell Biol
, vol.32
, pp. 590-605
-
-
Kanie, T.1
Onoyama, I.2
Matsumoto, A.3
Yamada, M.4
Nakatsumi, H.5
Tateishi, Y.6
Yamamura, S.7
Tsunematsu, R.8
Matsumoto, M.9
Nakayama, K.I.10
-
70
-
-
84891705159
-
ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis
-
COI: 1:CAS:528:DC%2BC3sXntF2nsw%3D%3D, PID: 23318439
-
Vaites LP, Lian Z, Lee EK, Yin B, DeMicco A, Bassing CH, Diehl JA (2014) ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis. Oncogene 33:129–133
-
(2014)
Oncogene
, vol.33
, pp. 129-133
-
-
Vaites, L.P.1
Lian, Z.2
Lee, E.K.3
Yin, B.4
DeMicco, A.5
Bassing, C.H.6
Diehl, J.A.7
-
71
-
-
79958254560
-
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
-
COI: 1:CAS:528:DC%2BC3MXntFKktLg%3D, PID: 21654808
-
Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB et al (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474:230–234
-
(2011)
Nature
, vol.474
, pp. 230-234
-
-
Jirawatnotai, S.1
Hu, Y.2
Michowski, W.3
Elias, J.E.4
Becks, L.5
Bienvenu, F.6
Zagozdzon, A.7
Goswami, T.8
Wang, Y.E.9
Clark, A.B.10
-
72
-
-
84863256545
-
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
-
COI: 1:CAS:528:DC%2BC38XjsV2msLo%3D, PID: 22307325
-
Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z et al (2012) ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 122:833–843
-
(2012)
J Clin Invest
, vol.122
, pp. 833-843
-
-
Casimiro, M.C.1
Crosariol, M.2
Loro, E.3
Ertel, A.4
Yu, Z.5
Dampier, W.6
Saria, E.A.7
Papanikolaou, A.8
Stanek, T.J.9
Li, Z.10
-
73
-
-
84960805544
-
Tumor progression and the different faces of the PERK kinase
-
PID: 26028033
-
Pytel D, Majsterek I, Diehl JA (2015) Tumor progression and the different faces of the PERK kinase. Oncogene. doi:10.1038/onc.2015.178
-
(2015)
Oncogene
-
-
Pytel, D.1
Majsterek, I.2
Diehl, J.A.3
-
74
-
-
0033587675
-
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression
-
COI: 1:CAS:528:DyaK1MXkslOksbg%3D, PID: 10411905
-
Brewer JW, Hendershot LM, Sherr CJ, Diehl JA (1999) Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci U S A 96:8505–8510
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 8505-8510
-
-
Brewer, J.W.1
Hendershot, L.M.2
Sherr, C.J.3
Diehl, J.A.4
-
75
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
COI: 1:CAS:528:DC%2BD3cXjsl2ku7c%3D, PID: 10882126
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5:897–904
-
(2000)
Mol Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
76
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
COI: 1:CAS:528:DyaK1MXpvVGrtA%3D%3D, PID: 9930704
-
Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271–274
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
77
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
-
COI: 1:CAS:528:DyaK1cXnvVKqtLo%3D, PID: 9819435
-
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC (1998) Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 18:7499–7509
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
78
-
-
28644441875
-
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway
-
COI: 1:CAS:528:DC%2BD2MXht12gsLjI, PID: 16176978
-
Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA (2005) PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell 16:5493–5501
-
(2005)
Mol Biol Cell
, vol.16
, pp. 5493-5501
-
-
Hamanaka, R.B.1
Bennett, B.S.2
Cullinan, S.B.3
Diehl, J.A.4
-
79
-
-
0033739622
-
PERK mediates cell-cycle exit during the mammalian unfolded protein response
-
COI: 1:CAS:528:DC%2BD3cXotFygtLY%3D, PID: 11035797
-
Brewer JW, Diehl JA (2000) PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A 97:12625–12630
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12625-12630
-
-
Brewer, J.W.1
Diehl, J.A.2
-
80
-
-
50149120366
-
Cellular mechanisms of tumour suppression by the retinoblastoma gene
-
COI: 1:CAS:528:DC%2BD1cXhtVWksLfP, PID: 18650841
-
Burkhart DL, Sage J (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8:671–682
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 671-682
-
-
Burkhart, D.L.1
Sage, J.2
-
81
-
-
0027288908
-
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
-
COI: 1:CAS:528:DyaK3sXltFertL4%3D, PID: 8449399
-
Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7:331–342
-
(1993)
Genes Dev
, vol.7
, pp. 331-342
-
-
Kato, J.1
Matsushime, H.2
Hiebert, S.W.3
Ewen, M.E.4
Sherr, C.J.5
-
82
-
-
0026778547
-
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
-
COI: 1:CAS:528:DyaK3sXkvV2hs74%3D, PID: 1423597
-
Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ (1992) Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71:323–334
-
(1992)
Cell
, vol.71
, pp. 323-334
-
-
Matsushime, H.1
Ewen, M.E.2
Strom, D.K.3
Kato, J.Y.4
Hanks, S.K.5
Roussel, M.F.6
Sherr, C.J.7
-
83
-
-
81255205373
-
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
-
COI: 1:CAS:528:DC%2BC3MXhsFSktLnE, PID: 22094256
-
Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, Zhai H, Vidal M, Gygi SP, Braun P et al (2011) A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20:620–634
-
(2011)
Cancer Cell
, vol.20
, pp. 620-634
-
-
Anders, L.1
Ke, N.2
Hydbring, P.3
Choi, Y.J.4
Widlund, H.R.5
Chick, J.M.6
Zhai, H.7
Vidal, M.8
Gygi, S.P.9
Braun, P.10
-
84
-
-
84886438147
-
The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma
-
COI: 1:CAS:528:DC%2BC3sXhsFyns7bO, PID: 24089445
-
Sheppard KE, McArthur GA (2013) The cell-cycle regulator CDK4: an emerging therapeutic target in melanoma. Clinical Cancer Research 19:5320–5328
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 5320-5328
-
-
Sheppard, K.E.1
McArthur, G.A.2
-
85
-
-
84981489352
-
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
-
COI: 1:CAS:528:DC%2BC28Xlslers7w%3D, PID: 27058669
-
Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC et al (2016) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 165:498
-
(2016)
Cell
, vol.165
, pp. 498
-
-
Lin, X.1
Duan, X.2
Liang, Y.Y.3
Su, Y.4
Wrighton, K.H.5
Long, J.6
Hu, M.7
Davis, C.M.8
Wang, J.9
Brunicardi, F.C.10
-
86
-
-
30944436222
-
Smad3 phosphorylation by cyclin-dependent kinases
-
PID: 16289004
-
Liu F (2006) Smad3 phosphorylation by cyclin-dependent kinases. Cytokine Growth Factor Rev 17:9–17
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 9-17
-
-
Liu, F.1
-
87
-
-
0037067653
-
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
-
COI: 1:CAS:528:DC%2BD38XlsV2mt74%3D, PID: 12150994
-
Chen CR, Kang Y, Siegel PM, Massague J (2002) E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110:19–32
-
(2002)
Cell
, vol.110
, pp. 19-32
-
-
Chen, C.R.1
Kang, Y.2
Siegel, P.M.3
Massague, J.4
-
88
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
COI: 1:CAS:528:DC%2BD2cXlsVGjsr0%3D, PID: 15241418
-
Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F (2004) Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430:226–231
-
(2004)
Nature
, vol.430
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
89
-
-
84912079534
-
Inhibition of CDK-mediated phosphorylation of Smad3 results in decreased oncogenesis in triple negative breast cancer cells
-
COI: 1:CAS:528:DC%2BC2cXitFalsLnJ, PID: 25485498
-
Tarasewicz E, Rivas L, Hamdan R, Dokic D, Parimi V, Bernabe BP, Thomas A, Shea LD, Jeruss JS (2014) Inhibition of CDK-mediated phosphorylation of Smad3 results in decreased oncogenesis in triple negative breast cancer cells. Cell Cycle 13:3191–3201
-
(2014)
Cell Cycle
, vol.13
, pp. 3191-3201
-
-
Tarasewicz, E.1
Rivas, L.2
Hamdan, R.3
Dokic, D.4
Parimi, V.5
Bernabe, B.P.6
Thomas, A.7
Shea, L.D.8
Jeruss, J.S.9
-
90
-
-
84927575175
-
FOXM1: a key oncofoetal transcription factor in health and disease
-
COI: 1:CAS:528:DC%2BC2cXhtlSqt7nI, PID: 25068996
-
Bella L, Zona S, Nestal de Moraes G, Lam EW (2014) FOXM1: a key oncofoetal transcription factor in health and disease. Semin Cancer Biol 29:32–39
-
(2014)
Semin Cancer Biol
, vol.29
, pp. 32-39
-
-
Bella, L.1
Zona, S.2
Nestal de Moraes, G.3
Lam, E.W.4
-
91
-
-
84908583907
-
FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance
-
COI: 1:CAS:528:DC%2BC2cXhslehsbvK, PID: 25287128
-
Zona S, Bella L, Burton MJ, Nestal de Moraes G, Lam EW (2014) FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Biophys Acta 1839:1316–1322
-
(2014)
Biochim Biophys Acta
, vol.1839
, pp. 1316-1322
-
-
Zona, S.1
Bella, L.2
Burton, M.J.3
Nestal de Moraes, G.4
Lam, E.W.5
-
92
-
-
84940118739
-
Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention
-
COI: 1:CAS:528:DC%2BC2MXhtlSnt7nM, PID: 26254094
-
Bugno M, Daniel M, Chepelev NL, Willmore WG (2015) Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention. Biochim Biophys Acta 1849:1260–1276
-
(2015)
Biochim Biophys Acta
, vol.1849
, pp. 1260-1276
-
-
Bugno, M.1
Daniel, M.2
Chepelev, N.L.3
Willmore, W.G.4
-
93
-
-
33746814985
-
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
-
COI: 1:CAS:528:DC%2BD28XotFegur8%3D, PID: 16864783
-
Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM et al (2006) Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 103:11567–11572
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11567-11572
-
-
Wang, C.1
Li, Z.2
Lu, Y.3
Du, R.4
Katiyar, S.5
Yang, J.6
Fu, M.7
Leader, J.E.8
Quong, A.9
Novikoff, P.M.10
-
94
-
-
84987620524
-
Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
-
PID: 26962452
-
Otto AM (2016) Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism. Cancer Metab 4:5
-
(2016)
Cancer Metab
, vol.4
, pp. 5
-
-
Otto, A.M.1
-
95
-
-
0028268284
-
D-type cyclin-dependent kinase activity in mammalian cells
-
COI: 1:CAS:528:DyaK2cXis1Knsb4%3D, PID: 8114738
-
Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14:2066–2076
-
(1994)
Mol Cell Biol
, vol.14
, pp. 2066-2076
-
-
Matsushime, H.1
Quelle, D.E.2
Shurtleff, S.A.3
Shibuya, M.4
Sherr, C.J.5
Kato, J.Y.6
-
96
-
-
0037121081
-
Linking cyclins to transcriptional control
-
COI: 1:CAS:528:DC%2BD38XovFSksr4%3D, PID: 12459251
-
Coqueret O (2002) Linking cyclins to transcriptional control. Gene 299:35–55
-
(2002)
Gene
, vol.299
, pp. 35-55
-
-
Coqueret, O.1
-
97
-
-
0037047269
-
Cyclin D1 is a ligand-independent Co-repressor for thyroid hormone receptors
-
COI: 1:CAS:528:DC%2BD38XmsVGqtbs%3D, PID: 12048199
-
Lin HM, Zhao L, Cheng SY (2002) Cyclin D1 is a ligand-independent Co-repressor for thyroid hormone receptors. J Biol Chem 277:28733–28741
-
(2002)
J Biol Chem
, vol.277
, pp. 28733-28741
-
-
Lin, H.M.1
Zhao, L.2
Cheng, S.Y.3
-
98
-
-
0032533881
-
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1
-
COI: 1:CAS:528:DyaK1cXnvVOhu7c%3D, PID: 9832502
-
Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (1998) Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev 12:3488–3498
-
(1998)
Genes Dev
, vol.12
, pp. 3488-3498
-
-
Zwijsen, R.M.1
Buckle, R.S.2
Hijmans, E.M.3
Loomans, C.J.4
Bernards, R.5
-
99
-
-
0033563091
-
D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability
-
COI: 1:CAS:528:DyaK1MXjsVygt7g%3D, PID: 10344732
-
Knudsen KE, Cavenee WK, Arden KC (1999) D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res 59:2297–2301
-
(1999)
Cancer Res
, vol.59
, pp. 2297-2301
-
-
Knudsen, K.E.1
Cavenee, W.K.2
Arden, K.C.3
-
100
-
-
0029851287
-
Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1
-
COI: 1:CAS:528:DyaK28XmsVSjs7c%3D, PID: 8887674
-
Hirai H, Sherr CJ (1996) Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol Cell Biol 16:6457–6467
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6457-6467
-
-
Hirai, H.1
Sherr, C.J.2
-
101
-
-
6344222803
-
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes
-
COI: 1:CAS:528:DC%2BD2MXltl2htQ%3D%3D, PID: 15485929
-
Pal S, Vishwanath SN, Erdjument-Bromage H, Tempst P, Sif S (2004) Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol 24:9630–9645
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9630-9645
-
-
Pal, S.1
Vishwanath, S.N.2
Erdjument-Bromage, H.3
Tempst, P.4
Sif, S.5
-
102
-
-
57049087451
-
Arginine methylation regulates the p53 response
-
COI: 1:CAS:528:DC%2BD1cXhsVentbfN, PID: 19011621
-
Jansson M, Durant ST, Cho EC, Sheahan S, Edelmann M, Kessler B, La Thangue NB (2008) Arginine methylation regulates the p53 response. Nat Cell Biol 10:1431–1439
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1431-1439
-
-
Jansson, M.1
Durant, S.T.2
Cho, E.C.3
Sheahan, S.4
Edelmann, M.5
Kessler, B.6
La Thangue, N.B.7
-
103
-
-
84948990932
-
Complex coordination of cell plasticity by a PGC-1alpha-controlled transcriptional network in skeletal muscle
-
PID: 26617528
-
Kupr B, Handschin C (2015) Complex coordination of cell plasticity by a PGC-1alpha-controlled transcriptional network in skeletal muscle. Front Physiol 6:325
-
(2015)
Front Physiol
, vol.6
, pp. 325
-
-
Kupr, B.1
Handschin, C.2
-
104
-
-
84903521363
-
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
-
COI: 1:CAS:528:DC%2BC2cXpslGitb8%3D, PID: 24870244
-
Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X et al (2014) Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510:547–551
-
(2014)
Nature
, vol.510
, pp. 547-551
-
-
Lee, Y.1
Dominy, J.E.2
Choi, Y.J.3
Jurczak, M.4
Tolliday, N.5
Camporez, J.P.6
Chim, H.7
Lim, J.H.8
Ruan, H.B.9
Yang, X.10
-
105
-
-
84957959125
-
Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities
-
COI: 1:CAS:528:DC%2BC28XhsVKiu7c%3D, PID: 26804906
-
Franco J, Balaji U, Freinkman E, Witkiewicz AK, Knudsen ES (2016) Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities. Cell Rep 14:979–990
-
(2016)
Cell Rep
, vol.14
, pp. 979-990
-
-
Franco, J.1
Balaji, U.2
Freinkman, E.3
Witkiewicz, A.K.4
Knudsen, E.S.5
-
106
-
-
84864386776
-
Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4alpha
-
COI: 1:CAS:528:DC%2BC38Xht1Oks7zM, PID: 22751438
-
Hanse EA, Mashek DG, Becker JR, Solmonson AD, Mullany LK, Mashek MT, Towle HC, Chau AT, Albrecht JH (2012) Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4alpha. Cell Cycle 11:2681–2690
-
(2012)
Cell Cycle
, vol.11
, pp. 2681-2690
-
-
Hanse, E.A.1
Mashek, D.G.2
Becker, J.R.3
Solmonson, A.D.4
Mullany, L.K.5
Mashek, M.T.6
Towle, H.C.7
Chau, A.T.8
Albrecht, J.H.9
-
107
-
-
84955726951
-
The front and rear of collective cell migration
-
COI: 1:CAS:528:DC%2BC28Xhtlyjtw%3D%3D, PID: 26726037
-
Mayor R, Etienne-Manneville S (2016) The front and rear of collective cell migration. Nat Rev Mol Cell Biol 17:97–109
-
(2016)
Nat Rev Mol Cell Biol
, vol.17
, pp. 97-109
-
-
Mayor, R.1
Etienne-Manneville, S.2
-
108
-
-
33646893508
-
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
-
COI: 1:CAS:528:DC%2BD28XltlWit7s%3D, PID: 16705174
-
Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X et al (2006) Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 26:4240–4256
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4240-4256
-
-
Li, Z.1
Wang, C.2
Jiao, X.3
Lu, Y.4
Fu, M.5
Quong, A.A.6
Dye, C.7
Yang, J.8
Dai, M.9
Ju, X.10
-
109
-
-
67249107699
-
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
-
COI: 1:CAS:528:DC%2BD1MXot1SjsLs%3D, PID: 19470470
-
Larrea MD, Hong F, Wander SA, da Silva TG, Helfman D, Lannigan D, Smith JA, Slingerland JM (2009) RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A 106:9268–9273
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9268-9273
-
-
Larrea, M.D.1
Hong, F.2
Wander, S.A.3
da Silva, T.G.4
Helfman, D.5
Lannigan, D.6
Smith, J.A.7
Slingerland, J.M.8
-
110
-
-
84889256981
-
Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer
-
PID: 24287487
-
Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K et al (2013) Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer. Nat Commun 4:2812
-
(2013)
Nat Commun
, vol.4
, pp. 2812
-
-
Yu, Z.1
Wang, L.2
Wang, C.3
Ju, X.4
Wang, M.5
Chen, K.6
Loro, E.7
Li, Z.8
Zhang, Y.9
Wu, K.10
-
111
-
-
72949103929
-
A census of amplified and overexpressed human cancer genes
-
COI: 1:CAS:528:DC%2BD1MXhsF2hs7bF, PID: 20029424
-
Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS (2010) A census of amplified and overexpressed human cancer genes. Nat Rev Cancer 10:59–64
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 59-64
-
-
Santarius, T.1
Shipley, J.2
Brewer, D.3
Stratton, M.R.4
Cooper, C.S.5
-
112
-
-
26244452319
-
Molecular prognostic markers in pancreatic cancer: a systematic review
-
COI: 1:CAS:528:DC%2BD2MXhtVynurfO, PID: 16146690
-
Garcea G, Neal CP, Pattenden CJ, Steward WP, Berry DP (2005) Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer 41:2213–2236
-
(2005)
Eur J Cancer
, vol.41
, pp. 2213-2236
-
-
Garcea, G.1
Neal, C.P.2
Pattenden, C.J.3
Steward, W.P.4
Berry, D.P.5
-
113
-
-
33845951110
-
Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation
-
PID: 17070615
-
Gautschi O, Ratschiller D, Gugger M, Betticher DC, Heighway J (2007) Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer 55:1–14
-
(2007)
Lung Cancer
, vol.55
, pp. 1-14
-
-
Gautschi, O.1
Ratschiller, D.2
Gugger, M.3
Betticher, D.C.4
Heighway, J.5
-
114
-
-
55949119498
-
Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients
-
COI: 1:CAS:528:DC%2BD1cXhtlyltbzN, PID: 18715616
-
Li R, An SJ, Chen ZH, Zhang GC, Zhu JQ, Nie Q, Xie Z, Guo AL, Mok TS, Wu YL (2008) Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients. Hum Pathol 39:1792–1801
-
(2008)
Hum Pathol
, vol.39
, pp. 1792-1801
-
-
Li, R.1
An, S.J.2
Chen, Z.H.3
Zhang, G.C.4
Zhu, J.Q.5
Nie, Q.6
Xie, Z.7
Guo, A.L.8
Mok, T.S.9
Wu, Y.L.10
-
115
-
-
23044508946
-
Cyclin D1 in breast cancer pathogenesis
-
COI: 1:CAS:528:DC%2BD2MXmt1els7c%3D, PID: 15961768
-
Arnold A, Papanikolaou A (2005) Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 23:4215–4224
-
(2005)
J Clin Oncol
, vol.23
, pp. 4215-4224
-
-
Arnold, A.1
Papanikolaou, A.2
-
116
-
-
0242298117
-
Molecular pathogenesis of head and neck squamous cell carcinoma
-
PID: 12736744
-
Hardisson D (2003) Molecular pathogenesis of head and neck squamous cell carcinoma. European Archives of Oto-Rhino-Laryngology 260:502–508
-
(2003)
European Archives of Oto-Rhino-Laryngology
, vol.260
, pp. 502-508
-
-
Hardisson, D.1
-
117
-
-
28544438498
-
Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BD28Xps1emtA%3D%3D, PID: 16309541
-
Thomas GR, Nadiminti H, Regalado J (2005) Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. Int J Exp Pathol 86:347–363
-
(2005)
Int J Exp Pathol
, vol.86
, pp. 347-363
-
-
Thomas, G.R.1
Nadiminti, H.2
Regalado, J.3
-
118
-
-
33747599365
-
The role of cell cycle regulatory proteins in the pathogenesis of melanoma
-
COI: 1:CAS:528:DC%2BD28XhtFyhsbzI, PID: 16916716
-
Li W, Sanki A, Karim RZ, Thompson JF, Soon Lee C, Zhuang L, McCarthy SW, Scolyer RA (2006) The role of cell cycle regulatory proteins in the pathogenesis of melanoma. Pathology 38:287–301
-
(2006)
Pathology
, vol.38
, pp. 287-301
-
-
Li, W.1
Sanki, A.2
Karim, R.Z.3
Thompson, J.F.4
Soon Lee, C.5
Zhuang, L.6
McCarthy, S.W.7
Scolyer, R.A.8
-
119
-
-
2342614719
-
Molecular alterations associated with cyclin D1 overexpression in endometrial cancer
-
COI: 1:CAS:528:DC%2BD2cXjvVeitLc%3D, PID: 15069681
-
Moreno-Bueno G, Rodriguez-Perales S, Sanchez-Estevez C, Marcos R, Hardisson D, Cigudosa JC, Palacios J (2004) Molecular alterations associated with cyclin D1 overexpression in endometrial cancer. Int J Cancer 110:194–200
-
(2004)
Int J Cancer
, vol.110
, pp. 194-200
-
-
Moreno-Bueno, G.1
Rodriguez-Perales, S.2
Sanchez-Estevez, C.3
Marcos, R.4
Hardisson, D.5
Cigudosa, J.C.6
Palacios, J.7
-
120
-
-
33745943652
-
Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma
-
COI: 1:STN:280:DC%2BD28vmtFyrsw%3D%3D
-
Wu W, Slomovitz BM, Soliman PT, Schmeler KM, Celestino J, Milam MR, KH L (2006) Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma. Int J Gynecological Cancer 16:1668–1672
-
(2006)
Int J Gynecological Cancer
, vol.16
, pp. 1668-1672
-
-
Wu, W.1
Slomovitz, B.M.2
Soliman, P.T.3
Schmeler, K.M.4
Celestino, J.5
Milam, M.R.6
Kh, L.7
-
121
-
-
33645228371
-
Update on the molecular biology of mantle cell lymphoma
-
COI: 1:CAS:528:DC%2BD28XjvVajsLY%3D, PID: 16402392
-
Bertoni F, Rinaldi A, Zucca E, Cavalli F (2006) Update on the molecular biology of mantle cell lymphoma. Hematol Oncol 24:22–27
-
(2006)
Hematol Oncol
, vol.24
, pp. 22-27
-
-
Bertoni, F.1
Rinaldi, A.2
Zucca, E.3
Cavalli, F.4
-
122
-
-
34249723211
-
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
-
COI: 1:CAS:528:DC%2BD2sXmt1Ogt7s%3D, PID: 17299095
-
Wiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G et al (2007) Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 109:4599–4606
-
(2007)
Blood
, vol.109
, pp. 4599-4606
-
-
Wiestner, A.1
Tehrani, M.2
Chiorazzi, M.3
Wright, G.4
Gibellini, F.5
Nakayama, K.6
Liu, H.7
Rosenwald, A.8
Muller-Hermelink, H.K.9
Ott, G.10
-
123
-
-
33749863640
-
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1
-
COI: 1:CAS:528:DC%2BD28XhtVKntLbE, PID: 16732330
-
Benzeno S, Lu F, Guo M, Barbash O, Zhang F, Herman JG, Klein PS, Rustgi A, Diehl JA (2006) Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene 25:6291–6303
-
(2006)
Oncogene
, vol.25
, pp. 6291-6303
-
-
Benzeno, S.1
Lu, F.2
Guo, M.3
Barbash, O.4
Zhang, F.5
Herman, J.G.6
Klein, P.S.7
Rustgi, A.8
Diehl, J.A.9
-
124
-
-
85002799961
-
-
cBioPortal. http://wwwcbioportalorg/indexdo
-
-
-
-
125
-
-
0141730293
-
Cyclin D1 gene (CCND1) mutations in endometrial cancer
-
COI: 1:CAS:528:DC%2BD3sXmvFansb0%3D, PID: 12955092
-
Moreno-Bueno G, Rodriguez-Perales S, Sanchez-Estevez C, Hardisson D, Sarrio D, Prat J, Cigudosa JC, Matias-Guiu X, Palacios J (2003) Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene 22:6115–6118
-
(2003)
Oncogene
, vol.22
, pp. 6115-6118
-
-
Moreno-Bueno, G.1
Rodriguez-Perales, S.2
Sanchez-Estevez, C.3
Hardisson, D.4
Sarrio, D.5
Prat, J.6
Cigudosa, J.C.7
Matias-Guiu, X.8
Palacios, J.9
-
126
-
-
0006921489
-
Cell-cycle dysregulation and the molecular mechanisms of prostate cancer
-
COI: 1:CAS:528:DC%2BD3cXltlGmtb0%3D
-
Amanatullah DF, Reutens AT, Zafonte BT, Fu M, Mani S, Pestell RG (2000) Cell-cycle dysregulation and the molecular mechanisms of prostate cancer. Front Biosci J Virtual Lib 5:D372–D390
-
(2000)
Front Biosci J Virtual Lib
, vol.5
, pp. D372-D390
-
-
Amanatullah, D.F.1
Reutens, A.T.2
Zafonte, B.T.3
Fu, M.4
Mani, S.5
Pestell, R.G.6
-
127
-
-
0032477854
-
Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1
-
COI: 1:CAS:528:DyaK1cXosFSksA%3D%3D, PID: 9448290
-
Cheng M, Sexl V, Sherr CJ, Roussel MF (1998) Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1. Proc Natl Acad Sci U S A 95:1091–1096)
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 1091-1096
-
-
Cheng, M.1
Sexl, V.2
Sherr, C.J.3
Roussel, M.F.4
-
128
-
-
0030901947
-
Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1
-
COI: 1:CAS:528:DyaK2sXislCgsrs%3D, PID: 9111327
-
Kerkhoff E, Rapp UR (1997) Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol Cell Biol 17:2576–2586
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2576-2586
-
-
Kerkhoff, E.1
Rapp, U.R.2
-
129
-
-
0032959647
-
Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis
-
COI: 1:CAS:528:DyaK1MXhvFOlsw%3D%3D, PID: 9858556
-
Treinies I, Paterson HF, Hooper S, Wilson R, Marshall CJ (1999) Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis. Mol Cell Biol 19:321–329
-
(1999)
Mol Cell Biol
, vol.19
, pp. 321-329
-
-
Treinies, I.1
Paterson, H.F.2
Hooper, S.3
Wilson, R.4
Marshall, C.J.5
-
130
-
-
0030989155
-
Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
-
COI: 1:CAS:528:DyaK2sXktFOisL4%3D, PID: 9199319
-
Aktas H, Cai H, Cooper GM (1997) Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol Cell Biol 17:3850–3857
-
(1997)
Mol Cell Biol
, vol.17
, pp. 3850-3857
-
-
Aktas, H.1
Cai, H.2
Cooper, G.M.3
-
131
-
-
0029786329
-
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
-
COI: 1:CAS:528:DyaK28Xlt1yns74%3D, PID: 8702807
-
Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271:20608–20616
-
(1996)
J Biol Chem
, vol.271
, pp. 20608-20616
-
-
Lavoie, J.N.1
L'Allemain, G.2
Brunet, A.3
Muller, R.4
Pouyssegur, J.5
-
132
-
-
0029017456
-
Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
-
COI: 1:CAS:528:DyaK2MXmsVCls78%3D, PID: 7791772
-
Liu JJ, Chao JR, Jiang MC, Ng SY, Yen JJ, Yang-Yen HF (1995) Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol Cell Biol 15:3654–3663
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3654-3663
-
-
Liu, J.J.1
Chao, J.R.2
Jiang, M.C.3
Ng, S.Y.4
Yen, J.J.5
Yang-Yen, H.F.6
-
133
-
-
67650422613
-
miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BD1MXnvFajsL4%3D, PID: 19549910
-
Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L, Kappeler A, Brunner T, Vassella E (2009) miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res 69:5553–5559
-
(2009)
Cancer Res
, vol.69
, pp. 5553-5559
-
-
Bandi, N.1
Zbinden, S.2
Gugger, M.3
Arnold, M.4
Kocher, V.5
Hasan, L.6
Kappeler, A.7
Brunner, T.8
Vassella, E.9
-
134
-
-
33244481730
-
Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma
-
COI: 1:CAS:528:DC%2BD28XhsVehsrg%3D, PID: 16247460
-
Gladden AB, Woolery R, Aggarwal P, Wasik MA, Diehl JA (2006) Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene 25:998–1007
-
(2006)
Oncogene
, vol.25
, pp. 998-1007
-
-
Gladden, A.B.1
Woolery, R.2
Aggarwal, P.3
Wasik, M.A.4
Diehl, J.A.5
-
135
-
-
84907483798
-
Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1alpha
-
COI: 1:CAS:528:DC%2BC2cXhslWiurvN, PID: 24947365
-
Bhalla K, Liu WJ, Thompson K, Anders L, Devarakonda S, Dewi R, Buckley S, Hwang BJ, Polster B, Dorsey SG et al (2014) Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1alpha. Diabetes 63:3266–3278
-
(2014)
Diabetes
, vol.63
, pp. 3266-3278
-
-
Bhalla, K.1
Liu, W.J.2
Thompson, K.3
Anders, L.4
Devarakonda, S.5
Dewi, R.6
Buckley, S.7
Hwang, B.J.8
Polster, B.9
Dorsey, S.G.10
-
136
-
-
84894211810
-
Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present
-
COI: 1:CAS:528:DC%2BC2cXitFymurg%3D, PID: 24387133
-
Casimiro MC, Velasco-Velazquez M, Aguirre-Alvarado C, Pestell RG (2014) Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present. Expert Opin Investig Drugs 23:295–304
-
(2014)
Expert Opin Investig Drugs
, vol.23
, pp. 295-304
-
-
Casimiro, M.C.1
Velasco-Velazquez, M.2
Aguirre-Alvarado, C.3
Pestell, R.G.4
-
137
-
-
84941337346
-
Targeting cell cycle regulators in hematologic malignancies
-
PID: 25914884
-
Aleem E, Arceci RJ (2015) Targeting cell cycle regulators in hematologic malignancies. Front Cell Dev Biol 3:16
-
(2015)
Front Cell Dev Biol
, vol.3
, pp. 16
-
-
Aleem, E.1
Arceci, R.J.2
-
138
-
-
84907200254
-
Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo
-
COI: 1:CAS:528:DC%2BC2cXhsVOitLvO, PID: 25028469
-
Zhang YX, Sicinska E, Czaplinski JT, Remillard SP, Moss S, Wang Y, Brain C, Loo A, Snyder EL, Demetri GD et al (2014) Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo. Mol Cancer Ther 13:2184–2193
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2184-2193
-
-
Zhang, Y.X.1
Sicinska, E.2
Czaplinski, J.T.3
Remillard, S.P.4
Moss, S.5
Wang, Y.6
Brain, C.7
Loo, A.8
Snyder, E.L.9
Demetri, G.D.10
-
139
-
-
84938817804
-
CDK4/6 inhibitors in breast cancer
-
COI: 1:CAS:528:DC%2BC2MXht1ajs7zI, PID: 26053278
-
Dukelow T, Kishan D, Khasraw M, Murphy CG (2015) CDK4/6 inhibitors in breast cancer. Anti-Cancer Drugs 26:797–806
-
(2015)
Anti-Cancer Drugs
, vol.26
, pp. 797-806
-
-
Dukelow, T.1
Kishan, D.2
Khasraw, M.3
Murphy, C.G.4
-
140
-
-
79952924719
-
Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibility
-
COI: 1:CAS:528:DC%2BC3cXhtlKrt7fP, PID: 21113395
-
Diehl JA, Ponugoti B (2010) Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibility. Genes Cancer 1:717–724
-
(2010)
Genes Cancer
, vol.1
, pp. 717-724
-
-
Diehl, J.A.1
Ponugoti, B.2
|