Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1

Molecular and Cellular Biology

Volumn 17, Issue 5, 1997, Pages 2576-2586

  Kerkhoff, Eugen ^a   Rapp, Ulf R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ANTIESTROGEN; CYCLIN A; CYCLIN DEPENDENT KINASE INHIBITOR; HYBRID PROTEIN; ONCOPROTEIN; PHOSPHOTRANSFERASE; RAF PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME KINETICS; GROWTH REGULATION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALIA;

EID: 0030901947     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.5.2576     Document Type: Article

References (52)

1. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270: 23589-23597.
2. Beck, T. W., M. Huleihel, M. Gunnell, T. I. Bonner, and U. R. Rapp. 1987. The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res. 15:595-609.
3. Bonner, T. I., H. Oppermann, I. Seeburg, S. B. Kerby, M. A. Gunnel, A. C. Young, and U. R. Rapp. 1986. The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res. 14:1009-1015.
4. Bruder, J. T., G. Heidecker, and U. R. Rapp. 1992. Serum-, TPA, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6:545-556.
5. Büscher, D., P. D. Sbarba, R. A. Hipskind, U. R. Rapp, E. R. Stanley, and M. Baccarini. 1993. v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation. Oncogene 8:3323-3323.
6. Cano, E., and L. C. Mahadevan. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20:117-122.
7. Kip 1 for restriction point control of the fibroblast cell cycle. Science, in press.
8. Daum, G., I. Eisenmann-Tappe, H. W. Fries, J. Troppmair, and U. R. Rapp. 1994. The ins and outs of Raf kinases. Trends Biochem. Sci. 19:474-480.
9. Dunn, G. A., and G. W. Ireland. 1984. New evidence that growth in 3T3 cell cultures is a diffusion-limited process. Nature 312:63-65.
10. Kip 1-deficient mice. Cell 85:733-744.
11. Filmus, J., A. I. Robles, W. Shi, M. J. Wong, LL Colombo, and C. J. Conti. 1994. Induction of cyclin D1 overexpression by activated Ras. Oncogene 9:3627-3633.
12. Firpo, E., A. Koff, M. Solomon, and J. Roberts. 1994. Inactivation of a cdk2 inhibitor during interleukin-2-induced proliferation in human T lymphocytes. Mol. Cell. Biol. 14:4889-4901.
13. Gu, Y., C. W. Turek, and D. O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707-710.
14. Harper, J. W., G. R. Adami, N. Wei, K. Keymarsi, and S. J. Elldege. 1993. The p21 cdk-interacting protein Cip 1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
15. Heidecker, G., M. Huleihel, J. L. Cleveland, W. Kolch, T. W. Beck, P. Lloyd, T. Pawson, and U. R. Rapp. 1990. Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol. Cell. Biol. 10:2503-2512.
16. Higashiyama, S., J. A. Abraham, J. Miller, J. C. Fiddes, and M. Klagsbrun. 1991. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936-939.
17. Huggett, A. C., L. L. Hampton, C. P. Ford, P. J. Wirth, and S. S. Thorgeirsson. 1990. Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf. Cancer Res. 50:7468-7475.
18. Ikawa, S., M. Fukui, Y. Ueyama, N. Tamaoki, T. Yamamoto, and K. Toyshima. 1988. B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol. Cell. Biol. 8:2651-2654.
19. Kip 1) of cyclin dependent kinase 4 activation. Cell 79:487-496.
20. Kerkhoff, E., and U. R. Rapp. Unpublished observations.
21. Kip1. Cell 85:721-732.
22. Kolch, W., G. Heidecker, P. Lloyd, and U. R. Rapp. 1991. Raf-1 protein kinase is required for growth of induced NIH 3T3 cells. Nature 349:426-428.
23. Littlewood, T. D., D. C. Hancock, P. S. Danielian, M. G. Parker, and G. I. Evan. 1995. A modified estrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
24. Macleod, K. F., N. Sherry, G. Hannon, D. Beach, T. Tokino, K. Kinzler, B. Vogelstein, and T. Jacks. 1995. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:935-944.
25. Matsushime, H., M. F. Roussel, R. A. Ashmun, and C. J. Sherr. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701-713.
26. McCarthy, S. A., M. L. Samuels, C. A. Pritchard, J. A. Abraham, and M. McMahon. 1995. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev. 9:1953-1964.
27. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of Erk and Jnk mitogen-activated protein kinases by Raf-1 and Mekk. Science 266:1719-1723.
28. Motokura, T., and A. Arnold. 1993. Cyclin D and oncogenesis. Curr. Opin. Genet. Dev. 3:5-10.
29. Kip 1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707-720.
30. Naumann, U., A. Hoffmeyer, E. Flory, and U. R. Rapp. 1996. Raf protein serine/threonine kinases, p. 203-236. In F. Marks (ed.), Protein phosphorylation. VCH Verlagsgesellschaft mbH, Weinheim, Germany.
31. Pines, J., and T. Hunter. 1990. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346:760-763.
32. Kip 1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:39-66.
33. Pritchard, C. A., M. L. Samuels, E. Bosch, and M. McMahon. 1995. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinase display different biological and biochemical properties in NIH 3T3 cells. Mol. Cell. Biol. 15:6430-6442.
34. Rapp, U. R. 1991. Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene 6:495-500.
35. Reynisdottir, I., K. Polyak, A. Iavarone, and J. Massague. 1995. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9:1831-1845.
36. Salmeron, A., T. B. Ahmad, G. W. Carlife, D. Pappin, R. P. Narsimhan, and S. C. Ley. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15:817-826.
37. Samuels, M. L., M. J. Weber, J. M. Bishop, and M. McMahon. 1993. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase. Mol. Cell. Biol. 13:6241-6252.
38. Samuels, M. L., and M. Mc Mahon. 1994. Inhibition of platelet-derive growth factor- and epidermal growth factor mediated mitogenesis and signalling in 3T3 cells expressing ΔRaf-1:ER, an estradiol-regulated form of Raf-1. Mol. Cell. Biol. 14:7855-7866.
39. Sgambato, A., E. K. Han, Y. J. Zhang, R. C. Moon, R. M. Santella, and I. B. Weinstein. 1995. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis 16:2193-2198.
40. Sherr, C. J. 1993. Mammalian G1 cyclins. Cell 73:1059-1065.
41. Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551-555.
42. Sithanandam, G., W. Kolch, F.-M. Duh, and U. R. Rapp. 1990. Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene 5:1775-1780.
43. Smith, Mark R., G. Heidecker, U. R. Rapp, and H.-F. Kung. 1990. Induction of transformation and DNA synthesis after microinjection of Raf proteins. Mol. Cell. Biol. 10:3828-3833.
44. Stanton, V. P., D. W. Nicholas, A. P. Laudano, and G. M. Cooper. 1989. Definition of the human Raf amino-terminal regulatory region by deletion mutagenesis. Mol. Cell. Biol. 9:639-647.
45. Stoker, M. G. P. 1973. Role of diffusion boundary in contact inhibition of growth. Nature 246:200-203.
46. Storm, S. M., J. L. Cleveland, and U. R. Rapp. 1990. Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene 5:345-351.
47. Symons, M. 1996. Rho family GTPases: the cytoskeleton and beyond. Trends Biochem. Sci. 21:178-181.
48. Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78:67-74.
49. Wadewitz, A. G., M. A. Winer, and D. J. Wolgemuth. 1993. Developmental and cell lineage specificity of raf family gene expression in mouse testis. Oncogene 8:1055-1062.
50. Winston, J. T., S. R. Coats, Y.-Z. Wang, and W. J. Pledger. 1996. Regulation of the cell cycle machinerie by oncogenic ras. Oncogene 12:127-134.
51. Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
52. Zhang, H., G. J. Hannon, and D. Beach. 1994. p21-containing cyclin kinase exist in both active and inactive state. Genes Dev. 8:1750-1758.