메뉴 건너뛰기




Volumn 23, Issue 3, 2014, Pages 295-304

Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: Past and present

Author keywords

Cancer; CDK inhibitors; Cyclin D1; Cyclin dependent kinase

Indexed keywords

ANIMALS; ANTINEOPLASTIC AGENTS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; HUMANS; NEOPLASMS; PROTEIN KINASE INHIBITORS;

EID: 84894211810     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.867017     Document Type: Review
Times cited : (147)

References (126)
  • 1
    • 70349330577 scopus 로고    scopus 로고
    • The regulation of protein phosphorylation
    • Johnson LN. The regulation of protein phosphorylation. Biochem Soc Trans 2009;37:627-41
    • (2009) Biochem Soc Trans , vol.37 , pp. 627-641
    • Johnson, L.N.1
  • 2
    • 84865096530 scopus 로고    scopus 로고
    • Why nature chose phosphate to modify proteins
    • Hunter T. Why nature chose phosphate to modify proteins. Philos Trans R Soc Lond B Biol Sci 2012;367:2513-16
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 2513-2516
    • Hunter, T.1
  • 4
    • 33744493376 scopus 로고    scopus 로고
    • Targeting tyrosine kinases in cancer: The second wave
    • Baselga J. Targeting tyrosine kinases in cancer: The second wave. Science 2006;312:1175-8
    • (2006) Science , vol.312 , pp. 1175-1178
    • Baselga, J.1
  • 5
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle CDKs and cancer: A changing paradigm
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 2009;9:153-66
    • (2009) Nat Rev Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 7
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ. G1 phase progression: Cycling on cue. Cell 1994;79:551-5
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 8
    • 25444444192 scopus 로고    scopus 로고
    • CAK-Cyclin-dependent Activating Kinase: A key kinase in cell cycle control and a target for drugs?
    • Lolli G, Johnson LN. CAK-Cyclin-dependent Activating Kinase: A key kinase in cell cycle control and a target for drugs? Cell Cycle 2005;4:572-7
    • (2005) Cell Cycle , vol.4 , pp. 572-577
    • Lolli, G.1    Johnson, L.N.2
  • 9
    • 0032004973 scopus 로고    scopus 로고
    • The role of Cdk7 in CAK function, a retro-retrospective
    • Harper JW, Elledge SJ. The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev 1998;12:285-9
    • (1998) Genes Dev , vol.12 , pp. 285-289
    • Harper, J.W.1    Elledge, S.J.2
  • 10
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour JW, Dean DC. The Rb/E2F pathway: Expanding roles and emerging paradigms. Genes Dev 2000;14:2393-409
    • (2000) Genes Dev , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 11
    • 0033578816 scopus 로고    scopus 로고
    • Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
    • Harbour JW, Luo RX, Dei Santi A, et al. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999;98:859-69
    • (1999) Cell , vol.98 , pp. 859-869
    • Harbour, J.W.1    Luo, R.X.2    Dei Santi, A.3
  • 12
    • 0033580462 scopus 로고    scopus 로고
    • Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer
    • Russell A, Thompson MA, Hendley J, et al. Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer. Oncogene 1999;18:1983-91
    • (1999) Oncogene , vol.18 , pp. 1983-1991
    • Russell, A.1    Thompson, M.A.2    Hendley, J.3
  • 13
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: Putting checkpoints in perspective. Nature 2000;408:433-9
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 14
    • 42649131088 scopus 로고    scopus 로고
    • The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability
    • Chen Y, Poon RY. The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Front Biosci 2008;13:5016-29
    • (2008) Front Biosci , vol.13 , pp. 5016-5029
    • Chen, Y.1    Poon, R.Y.2
  • 15
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C. Blinded by the light: The growing complexity of p53. Cell 2009;137:413-31
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 16
    • 0038142215 scopus 로고    scopus 로고
    • Polar expeditions-provisioning the centrosome for mitosis
    • Blagden SP, Glover DM. Polar expeditions-provisioning the centrosome for mitosis. Nat Cell Biol 2003;5:505-11
    • (2003) Nat Cell Biol , vol.5 , pp. 505-511
    • Blagden, S.P.1    Glover, D.M.2
  • 17
    • 27144540976 scopus 로고    scopus 로고
    • Centrosome amplification, chromosome instability and cancer development
    • Fukasawa K. Centrosome amplification, chromosome instability and cancer development. Cancer Lett 2005;230:6-19
    • (2005) Cancer Lett , vol.230 , pp. 6-19
    • Fukasawa, K.1
  • 18
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009;460:278-82
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 19
    • 13244271313 scopus 로고    scopus 로고
    • Polo-like kinases (Plks) and cancer
    • Takai N, Hamanaka R, Yoshimatsu J, et al. Polo-like kinases (Plks) and cancer. Oncogene 2005;24:287-91
    • (2005) Oncogene , vol.24 , pp. 287-291
    • Takai, N.1    Hamanaka, R.2    Yoshimatsu, J.3
  • 20
    • 27644438338 scopus 로고    scopus 로고
    • Centrosome maturation: Aurora lights the way to the poles
    • Brittle AL, Ohkura H. Centrosome maturation: Aurora lights the way to the poles. Curr Biol 2005;15:R880-2
    • (2005) Curr Biol , vol.15
    • Brittle, A.L.1    Ohkura, H.2
  • 21
    • 0037048278 scopus 로고    scopus 로고
    • The role of nucleophosmin in centrosome duplication
    • Okuda M. The role of nucleophosmin in centrosome duplication. Oncogene 2002;21:6170-4
    • (2002) Oncogene , vol.21 , pp. 6170-6174
    • Okuda, M.1
  • 22
    • 65349102972 scopus 로고    scopus 로고
    • The decision to enter mitosis: Feedback and redundancy in the mitotic entry network
    • Lindqvist A, Rodriguez-Bravo V, Medema RH. The decision to enter mitosis: Feedback and redundancy in the mitotic entry network. J Cell Biol 2009;185:193-202
    • (2009) J Cell Biol , vol.185 , pp. 193-202
    • Lindqvist, A.1    Rodriguez-Bravo, V.2    Medema, R.H.3
  • 24
    • 29244468847 scopus 로고    scopus 로고
    • Secrets of a double agent: CDK7 in cell-cycle control and transcription
    • Fisher RP. Secrets of a double agent: CDK7 in cell-cycle control and transcription. J Cell Sci 2005;118:5171-80
    • (2005) J Cell Sci , vol.118 , pp. 5171-5180
    • Fisher, R.P.1
  • 25
    • 33751090746 scopus 로고    scopus 로고
    • Phosphorylation and functions of the RNA polymerase II CTD
    • Phatnani HP, Greenleaf AL. Phosphorylation and functions of the RNA polymerase II CTD. Genes Dev 2006;20:2922-36
    • (2006) Genes Dev , vol.20 , pp. 2922-2936
    • Phatnani, H.P.1    Greenleaf, A.L.2
  • 26
    • 44149124228 scopus 로고    scopus 로고
    • Cracking the RNA polymerase II CTD code
    • Egloff S, Murphy S. Cracking the RNA polymerase II CTD code. Trends Genet 2008;24:280-8
    • (2008) Trends Genet , vol.24 , pp. 280-288
    • Egloff, S.1    Murphy, S.2
  • 27
    • 0042971664 scopus 로고    scopus 로고
    • Cyclin D1 repression of peroxisome proliferator-Activated receptor gamma expression and transactivation
    • Wang C, Pattabiraman N, Zhou JN, et al. Cyclin D1 repression of peroxisome proliferator-Activated receptor gamma expression and transactivation. Mol Cell Biol 2003;23:6159-73
    • (2003) Mol Cell Biol , vol.23 , pp. 6159-6173
    • Wang, C.1    Pattabiraman, N.2    Zhou, J.N.3
  • 28
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    • Sicinski P, Donaher JL, Parker SB, et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 1995;82:621-30
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1    Donaher, J.L.2    Parker, S.B.3
  • 29
    • 0035866809 scopus 로고    scopus 로고
    • Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation
    • Evron E, Umbricht CB, Korz D, et al. Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation. Cancer Res 2001;61:2782-7
    • (2001) Cancer Res , vol.61 , pp. 2782-2787
    • Evron, E.1    Umbricht, C.B.2    Korz, D.3
  • 30
    • 10544256183 scopus 로고    scopus 로고
    • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    • Sicinski P, Donaher JL, Geng Y, et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 1996;384:470-4
    • (1996) Nature , vol.384 , pp. 470-474
    • Sicinski, P.1    Donaher, J.L.2    Geng, Y.3
  • 31
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska E, Aifantis I, Le Cam L, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 2003;4:451-61
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1    Aifantis, I.2    Le Cam, L.3
  • 32
    • 84866600774 scopus 로고    scopus 로고
    • Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number
    • Sankaran VG, Ludwig LS, Sicinska E, et al. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev 2012;26:2075-87
    • (2012) Genes Dev , vol.26 , pp. 2075-2087
    • Sankaran, V.G.1    Ludwig, L.S.2    Sicinska, E.3
  • 33
    • 84879377397 scopus 로고    scopus 로고
    • New roles of cyclin D1
    • Pestell RG. New roles of cyclin D1. Am J Pathol 2013;183:3-9
    • (2013) Am J Pathol , vol.183 , pp. 3-9
    • Pestell, R.G.1
  • 34
    • 0025806904 scopus 로고
    • A novel cyclin encoded by a bcl1-linked candidate oncogene
    • Motokura T, Bloom T, Kim HG, et al. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 1991;350:512-15
    • (1991) Nature , vol.350 , pp. 512-515
    • Motokura, T.1    Bloom, T.2    Kim, H.G.3
  • 35
    • 0021270716 scopus 로고
    • Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t (11;14) chromosome translocation
    • Tsujimoto Y, Yunis J, Onorato-Showe L, et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t (11;14) chromosome translocation. Science 1984;224:1403-6
    • (1984) Science , vol.224 , pp. 1403-1406
    • Tsujimoto, Y.1    Yunis, J.2    Onorato-Showe, L.3
  • 36
    • 27244445489 scopus 로고    scopus 로고
    • Molecular pathogenesis and a consequent classification of multiple myeloma
    • Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005;23:6333-8
    • (2005) J Clin Oncol , vol.23 , pp. 6333-6338
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 37
    • 0028331092 scopus 로고
    • Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
    • Gillett C, Fantl V, Smith R, et al. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994;54:1812-17
    • (1994) Cancer Res , vol.54 , pp. 1812-1817
    • Gillett, C.1    Fantl, V.2    Smith, R.3
  • 38
    • 0028960821 scopus 로고
    • Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer
    • Dickson C, Fantl V, Gillett C, et al. Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer. Cancer Lett 1995;90:43-50
    • (1995) Cancer Lett , vol.90 , pp. 43-50
    • Dickson, C.1    Fantl, V.2    Gillett, C.3
  • 39
    • 0036514435 scopus 로고    scopus 로고
    • Expression and amplification of cyclin D1 in primary breast carcinomas: Relationship with histopathological types and clinico-pathological parameters
    • Naidu R, Wahab NA, Yadav MM, et al. Expression and amplification of cyclin D1 in primary breast carcinomas: Relationship with histopathological types and clinico-pathological parameters. Oncol Rep 2002;9:409-16
    • (2002) Oncol Rep , vol.9 , pp. 409-416
    • Naidu, R.1    Wahab, N.A.2    Yadav, M.M.3
  • 40
    • 0037065939 scopus 로고    scopus 로고
    • Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays
    • Bieche I, Olivi M, Nogues C, et al. Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays. Br J Cancer 2002;86:580-6
    • (2002) Br J Cancer , vol.86 , pp. 580-586
    • Bieche, I.1    Olivi, M.2    Nogues, C.3
  • 41
    • 0031977436 scopus 로고    scopus 로고
    • Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: Analysis of allele-specific expression
    • Hosokawa Y, Arnold A. Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: Analysis of allele-specific expression. Genes Chromosomes Cancer 1998;22:66-71
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 66-71
    • Hosokawa, Y.1    Arnold, A.2
  • 42
    • 33749863640 scopus 로고    scopus 로고
    • Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1
    • Benzeno S, Lu F, Guo M, et al. Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene 2006;25:6291-303
    • (2006) Oncogene , vol.25 , pp. 6291-6303
    • Benzeno, S.1    Lu, F.2    Guo, M.3
  • 43
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, et al. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998;12:3499-511
    • (1998) Genes Dev , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3
  • 44
    • 78650963428 scopus 로고    scopus 로고
    • SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination
    • Mittal MK, Singh K, Misra S, et al. SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem 2011;286:469-79
    • (2011) J Biol Chem , vol.286 , pp. 469-479
    • Mittal, M.K.1    Singh, K.2    Misra, S.3
  • 45
    • 34547107098 scopus 로고    scopus 로고
    • RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells
    • Hattori H, Zhang X, Jia Y, et al. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood 2007;110:640-50
    • (2007) Blood , vol.110 , pp. 640-650
    • Hattori, H.1    Zhang, X.2    Jia, Y.3
  • 46
    • 84878577452 scopus 로고    scopus 로고
    • Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity
    • Wang W, Yang L, Hu L, et al. Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. PLoS One 2013;8:e64660
    • (2013) PLoS One , vol.8
    • Wang, W.1    Yang, L.2    Hu, L.3
  • 47
    • 0035853468 scopus 로고    scopus 로고
    • In vitro ubiquitination of cyclin d1 by roc1-cul1 and roc1-cul3
    • Maeda I, Ohta T, Koizumi H, et al. In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3. FEBS Lett 2001;494:181-5
    • (2001) FEBS Lett , vol.494 , pp. 181-185
    • Maeda, I.1    Ohta, T.2    Koizumi, H.3
  • 48
    • 0029910364 scopus 로고    scopus 로고
    • Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinasepRb-controlled G1 checkpoint
    • Lukas J, Bartkova J, Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinasepRb-controlled G1 checkpoint. Mol Cell Biol 1996;16:6917-25
    • (1996) Mol Cell Biol , vol.16 , pp. 6917-6925
    • Lukas, J.1    Bartkova, J.2    Bartek, J.3
  • 49
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl V, Stamp G, Andrews A, et al. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 1995;9:2364-72
    • (1995) Genes Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3
  • 50
    • 0027204555 scopus 로고
    • Physical interaction of the retinoblastoma protein with human D cyclins
    • Dowdy SF, Hinds PW, Louie K, et al. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 1993;73:499-511
    • (1993) Cell , vol.73 , pp. 499-511
    • Dowdy, S.F.1    Hinds, P.W.2    Louie, K.3
  • 52
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds PW, Mittnacht S, Dulic V, et al. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 1992;70:993-1006
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3
  • 53
    • 0029017456 scopus 로고
    • Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH3T3 cells
    • Liu J-J, Chao J-R, Jiang M-C, et al. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH3T3 cells. Mol Cell Biol 1995;15:3654-63
    • (1995) Mol Cell Biol , vol.15 , pp. 3654-3663
    • Liu, J.-J.1    Chao, J.-R.2    Jiang, M.-C.3
  • 54
    • 0033961809 scopus 로고    scopus 로고
    • Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
    • Lee RJ, Albanese C, Fu M, et al. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000;20:672-83
    • (2000) Mol Cell Biol , vol.20 , pp. 672-683
    • Lee, R.J.1    Albanese, C.2    Fu, M.3
  • 56
    • 0032529165 scopus 로고    scopus 로고
    • Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
    • Robles AI, Rodriguez-Puebla ML, Glick AB, et al. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev 1998;12:2469-74
    • (1998) Genes Dev , vol.12 , pp. 2469-2474
    • Robles, A.I.1    Rodriguez-Puebla, M.L.2    Glick, A.B.3
  • 57
    • 0028243879 scopus 로고
    • Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    • Wang TC, Cardiff RD, Zukerberg L, et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 1994;369:669-71
    • (1994) Nature , vol.369 , pp. 669-671
    • Wang, T.C.1    Cardiff, R.D.2    Zukerberg, L.3
  • 58
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001;411:1017-21
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 59
    • 0141816802 scopus 로고    scopus 로고
    • Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia
    • Rowlands TM, Pechenkina IV, Hatsell SJ, et al. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci USA 2003;100:11400-5
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11400-11405
    • Rowlands, T.M.1    Pechenkina, I.V.2    Hatsell, S.J.3
  • 60
    • 28544433465 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis
    • Reddy HK, Mettus RV, Rane SG, et al. Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res 2005;65:10174-8
    • (2005) Cancer Res , vol.65 , pp. 10174-10178
    • Reddy, H.K.1    Mettus, R.V.2    Rane, S.G.3
  • 61
    • 30344479175 scopus 로고    scopus 로고
    • Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    • Landis MW, Pawlyk BS, Li T, et al. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006;9:13-22
    • (2006) Cancer Cell , vol.9 , pp. 13-22
    • Landis, M.W.1    Pawlyk, B.S.2    Li, T.3
  • 62
    • 19644386407 scopus 로고    scopus 로고
    • Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation
    • Baker GL, Landis MW, Hinds PW. Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle 2005;4:330-8
    • (2005) Cell Cycle , vol.4 , pp. 330-338
    • Baker, G.L.1    Landis, M.W.2    Hinds, P.W.3
  • 63
    • 33750537272 scopus 로고    scopus 로고
    • Cyclin D1 induction of cellular migration requires p27(KIP1
    • Li Z, Jiao X, Wang C, et al. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 2006;66:9986-94
    • (2006) Cancer Res , vol.66 , pp. 9986-9994
    • Li, Z.1    Jiao, X.2    Wang, C.3
  • 64
    • 43749108882 scopus 로고    scopus 로고
    • Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration
    • Li Z, Wang C, Jiao X, et al. Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 2008;283:7007-15
    • (2008) J Biol Chem , vol.283 , pp. 7007-7015
    • Li, Z.1    Wang, C.2    Jiao, X.3
  • 65
    • 73649115686 scopus 로고    scopus 로고
    • Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis
    • Jeselsohn R, Brown NE, Arendt L, et al. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell 2010;17:65-76
    • (2010) Cancer Cell , vol.17 , pp. 65-76
    • Jeselsohn, R.1    Brown, N.E.2    Arendt, L.3
  • 66
    • 84867618851 scopus 로고    scopus 로고
    • The requirement for cyclin d function in tumor maintenance
    • Choi YJ, Li X, Hydbring P, et al. The requirement for cyclin d function in tumor maintenance. Cancer Cell 2012;22:438-51
    • (2012) Cancer Cell , vol.22 , pp. 438-451
    • Choi, Y.J.1    Li, X.2    Hydbring, P.3
  • 67
    • 0027500254 scopus 로고
    • Coding sequence of the overexpressed transcript of the putative oncogene PRAD1/cyclin D1 in two primary human tumors
    • Rosenberg CL, Motokura T, Kronenberg HM, et al. Coding sequence of the overexpressed transcript of the putative oncogene PRAD1/cyclin D1 in two primary human tumors. Oncogene 1993;8:519-21
    • (1993) Oncogene , vol.8 , pp. 519-521
    • Rosenberg, C.L.1    Motokura, T.2    Kronenberg, H.M.3
  • 68
    • 12444334543 scopus 로고    scopus 로고
    • Cyclin D1 governs adhesion and motility of macrophages
    • Neumeister P, Pixley FJ, Xiong Y, et al. Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell 2003;14:2005-15
    • (2003) Mol Biol Cell , vol.14 , pp. 2005-2015
    • Neumeister, P.1    Pixley, F.J.2    Xiong, Y.3
  • 69
    • 0037195920 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells
    • Holnthoner W, Pillinger M, Groger M, et al. Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem 2002;277:45847-53
    • (2002) J Biol Chem , vol.277 , pp. 45847-45853
    • Holnthoner, W.1    Pillinger, M.2    Groger, M.3
  • 70
    • 84883258960 scopus 로고    scopus 로고
    • Cyclin D1 determines estrogen signaling in the mammary gland in vivo
    • Casimiro MC, Wang C, Li Z, et al. Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol 2013;27:1415-28
    • (2013) Mol Endocrinol , vol.27 , pp. 1415-1428
    • Casimiro, M.C.1    Wang, C.2    Li, Z.3
  • 71
    • 84863256545 scopus 로고    scopus 로고
    • ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
    • Casimiro MC, Crosariol M, Loro E, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 2012;122:833-43
    • (2012) J Clin Invest , vol.122 , pp. 833-843
    • Casimiro, M.C.1    Crosariol, M.2    Loro, E.3
  • 72
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl P, Wolf K. Tumour-cell invasion and migration: Diversity and escape mechanisms. Nat Rev Cancer 2003;3:362-74
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 73
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S. Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell 2011;147:992-1009
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 74
    • 33646893508 scopus 로고    scopus 로고
    • Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    • Li Z, Wang C, Jiao X, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006;26:4240-56
    • (2006) Mol Cell Biol , vol.26 , pp. 4240-4256
    • Li, Z.1    Wang, C.2    Jiao, X.3
  • 75
    • 0030973878 scopus 로고    scopus 로고
    • New functional activities for the p21 family of CDK inhibitors
    • LaBaer J, Garrett MD, Stevenson LF, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997;11:847-62
    • (1997) Genes Dev , vol.11 , pp. 847-862
    • LaBaer, J.1    Garrett, M.D.2    Stevenson, L.F.3
  • 76
    • 0033559264 scopus 로고    scopus 로고
    • The P21(Cip1) And P27(Kip1) CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999;18:1571-83
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3
  • 77
    • 0037040984 scopus 로고    scopus 로고
    • P21 (Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    • Alt JR, Gladden AB, Diehl JA. p21 (Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J Biol Chem 2002;277:8517-23
    • (2002) J Biol Chem , vol.277 , pp. 8517-8523
    • Alt, J.R.1    Gladden, A.B.2    Diehl, J.A.3
  • 78
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 79
    • 1942466518 scopus 로고    scopus 로고
    • P27KIP1 modulates cell migration through the regulation of RhoA activation
    • Besson A, Gurian-West M, Schmidt A, et al. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004;18:862-76
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3
  • 80
    • 78449273892 scopus 로고    scopus 로고
    • Alternative cyclin d1 splice forms differentially regulate the DNA damage response
    • Li Z, Jiao X, Wang C, et al. Alternative cyclin d1 splice forms differentially regulate the DNA damage response. Cancer Res 2010;70:8802-11
    • (2010) Cancer Res , vol.70 , pp. 8802-8811
    • Li, Z.1    Jiao, X.2    Wang, C.3
  • 81
    • 79958254560 scopus 로고    scopus 로고
    • A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    • Jirawatnotai S, Hu Y, Michowski W, et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011;474:230-4
    • (2011) Nature , vol.474 , pp. 230-234
    • Jirawatnotai, S.1    Hu, Y.2    Michowski, W.3
  • 82
    • 84894192836 scopus 로고    scopus 로고
    • Inhibition of Cdk4 radiosensitizes breast cancer cells by increasing PP2A levels, and decreasing Bad136 phosphorylation [abstract 1467
    • Mar 31 - Apr 4 2012; American Association for Cancer Research, Chicago, IL
    • Hagen KR, Zeng X, Tucker-Kahn S, et al. Inhibition of Cdk4 radiosensitizes breast cancer cells by increasing PP2A levels, and decreasing Bad136 phosphorylation [abstract 1467]. In AACR 103rd Annual Meeting 2012; Mar 31 - Apr 4 2012; American Association for Cancer Research, Chicago, IL
    • (2012) AACR 103rd Annual Meeting
    • Hagen, K.R.1    Zeng, X.2    Tucker-Kahn, S.3
  • 83
    • 84859726409 scopus 로고    scopus 로고
    • Chromosomal instability and cancer: A complex relationship with therapeutic potential
    • Bakhoum SF, Compton DA. Chromosomal instability and cancer: A complex relationship with therapeutic potential. J Clin Invest 2012;122:1138-43
    • (2012) J Clin Invest , vol.122 , pp. 1138-1143
    • Bakhoum, S.F.1    Compton, D.A.2
  • 84
    • 84861853732 scopus 로고    scopus 로고
    • Losing balance: The origin and impact of aneuploidy in cancer
    • Holland AJ, Cleveland DW. Losing balance: The origin and impact of aneuploidy in cancer. EMBO Rep 2012;13:501-14
    • (2012) EMBO Rep , vol.13 , pp. 501-514
    • Holland, A.J.1    Cleveland, D.W.2
  • 85
    • 0032126542 scopus 로고    scopus 로고
    • Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast
    • Oyama T, Kashiwabara K, Yoshimoto K, et al. Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast. Cancer Res 1998;58:2876-80
    • (1998) Cancer Res , vol.58 , pp. 2876-2880
    • Oyama, T.1    Kashiwabara, K.2    Yoshimoto, K.3
  • 86
    • 0031031998 scopus 로고    scopus 로고
    • Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value
    • van Diest PJ, Michalides RJ, Jannink L, et al. Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value. Am J Pathol 1997;150:705-11
    • (1997) Am J Pathol , vol.150 , pp. 705-711
    • Van Diest, P.J.1    Michalides, R.J.2    Jannink, L.3
  • 87
    • 0035917617 scopus 로고    scopus 로고
    • Immunodetectable cyclin D (1)is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions
    • Shoker BS, Jarvis C, Davies MP, et al. Immunodetectable cyclin D(1)is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions. Br J Cancer 2001;84:1064-9
    • (2001) Br J Cancer , vol.84 , pp. 1064-1069
    • Shoker, B.S.1    Jarvis, C.2    Davies, M.P.3
  • 88
    • 0028845863 scopus 로고
    • Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from nonmalignant lesions
    • Weinstat-Saslow D, Merino MJ, Manrow RE, et al. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from nonmalignant lesions. Nat Med 1995;1:1257-60
    • (1995) Nat Med , vol.1 , pp. 1257-1260
    • Weinstat-Saslow, D.1    Merino, M.J.2    Manrow, R.E.3
  • 89
    • 12844288920 scopus 로고    scopus 로고
    • Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy
    • Nelsen CJ, Kuriyama R, Hirsch B, et al. Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy. J Biol Chem 2005;280:768-76
    • (2005) J Biol Chem , vol.280 , pp. 768-776
    • Nelsen, C.J.1    Kuriyama, R.2    Hirsch, B.3
  • 90
    • 0035991848 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo [2,3-d] pyrimidines does not correlate with antiviral activity
    • Evers DL, Breitenbach JM, Borysko KZ, et al. Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d] pyrimidines does not correlate with antiviral activity. Antimicrob Agents Chemother 2002;46:2470-6
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2470-2476
    • Evers, D.L.1    Breitenbach, J.M.2    Borysko, K.Z.3
  • 91
    • 0028093182 scopus 로고
    • Inhibition of cyclin-dependent kinases by purine analogues
    • Vesely J, Havlicek L, Strnad M, et al. Inhibition of cyclin-dependent kinases by purine analogues. Eur J Biochem 1994;224:771-86
    • (1994) Eur J Biochem , vol.224 , pp. 771-786
    • Vesely, J.1    Havlicek, L.2    Strnad, M.3
  • 92
    • 33750714000 scopus 로고    scopus 로고
    • Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells
    • Boutis A, Papazisis K, Pistevou-Gompaki K, et al. Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells. Anticancer Res 2006;26:3493-8
    • (2006) Anticancer Res , vol.26 , pp. 3493-3498
    • Boutis, A.1    Papazisis, K.2    Pistevou-Gompaki, K.3
  • 93
    • 10744231077 scopus 로고    scopus 로고
    • 1 2 689-tetrasubstituted purines as new CDK1 inhibitors
    • Moravec J, Krystof V, Hanus J, et al. 2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors. Bioorg Med Chem Lett 2003;13:2993-6
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 2993-2996
    • Moravec, J.1    Krystof, V.2    Hanus, J.3
  • 94
    • 84866919926 scopus 로고    scopus 로고
    • Synthesis of a new series of pyridine and fused pyridine derivatives
    • Al-Issa SA. Synthesis of a new series of pyridine and fused pyridine derivatives. Molecules 2012;17:10902-15
    • (2012) Molecules , vol.17 , pp. 10902-10915
    • Al-Issa, S.A.1
  • 95
    • 0034086397 scopus 로고    scopus 로고
    • Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitors
    • Knockaert M, Gray N, Damiens E, et al. Intracellular targets of cyclin-dependent kinase inhibitors: Identification by affinity chromatography using immobilised inhibitors. Chem Biol 2000;7:411-22
    • (2000) Chem Biol , vol.7 , pp. 411-422
    • Knockaert, M.1    Gray, N.2    Damiens, E.3
  • 96
    • 3142580855 scopus 로고    scopus 로고
    • N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2
    • Hardcastle IR, Arris CE, Bentley J, et al. N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2. J Med Chem 2004;47:3710-22
    • (2004) J Med Chem , vol.47 , pp. 3710-3722
    • Hardcastle, I.R.1    Arris, C.E.2    Bentley, J.3
  • 97
    • 37549048987 scopus 로고    scopus 로고
    • Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening
    • Usui T, Ban HS, Kawada J, et al. Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening. Bioorg Med Chem Lett 2008;18:285-8
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 285-288
    • Usui, T.1    Ban, H.S.2    Kawada, J.3
  • 98
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
    • Fry DW, Harvey PJ, Keller PR, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004;3:1427-38
    • (2004) Mol Cancer Ther , vol.3 , pp. 1427-1438
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3
  • 99
    • 80955145693 scopus 로고    scopus 로고
    • Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as antiproliferative CDK2 inhibitors
    • Ibrahim DA, Ismail NS. Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as antiproliferative CDK2 inhibitors. Eur J Med Chem 2011;46:5825-32
    • (2011) Eur J Med Chem , vol.46 , pp. 5825-5832
    • Ibrahim, D.A.1    Ismail, N.S.2
  • 100
    • 79957873480 scopus 로고    scopus 로고
    • Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells
    • Sun Y, Li YX, Wu HJ, et al. Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells. J Cancer 2011;2:36-51
    • (2011) J Cancer , vol.2 , pp. 36-51
    • Sun, Y.1    Li, Y.X.2    Wu, H.J.3
  • 101
    • 0012365397 scopus 로고    scopus 로고
    • A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: Similarities and differences to the cell cycle checkpoint abrogator UCN-01
    • Eastman A, Kohn EA, Brown MK, et al. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: Similarities and differences to the cell cycle checkpoint abrogator UCN-01. Mol Cancer Ther 2002;1:1067-78
    • (2002) Mol Cancer Ther , vol.1 , pp. 1067-1078
    • Eastman, A.1    Kohn, E.A.2    Brown, M.K.3
  • 102
    • 2342576239 scopus 로고    scopus 로고
    • Synthesis and biological activity of Naryl-2-Aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases
    • Misra RN, Xiao HY, Williams DK, et al. Synthesis and biological activity of Naryl-2-Aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett 2004;14:2973-7
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 2973-2977
    • Misra, R.N.1    Xiao, H.Y.2    Williams, D.K.3
  • 103
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov 2009;8:547-66
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 104
    • 78649658736 scopus 로고    scopus 로고
    • Whether to target single or multiple CDKs for therapy? That is the question
    • Wesierska-Gadek J, Maurer M, Zulehner N, et al. Whether to target single or multiple CDKs for therapy? That is the question. J Cell Physiol 2011;226:341-9
    • (2011) J Cell Physiol , vol.226 , pp. 341-349
    • Wesierska-Gadek, J.1    Maurer, M.2    Zulehner, N.3
  • 106
    • 84881399114 scopus 로고    scopus 로고
    • Emerging drug profile: Cyclin-dependent kinase inhibitors
    • Blachly JS, Byrd JC. Emerging drug profile: Cyclin-dependent kinase inhibitors. Leuk Lymphoma 2013;54:2133-43
    • (2013) Leuk Lymphoma , vol.54 , pp. 2133-2143
    • Blachly, J.S.1    Byrd, J.C.2
  • 107
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
    • Sedlacek H, Czech J, Naik R, et al. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol 1996;9:1143-68
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.1    Czech, J.2    Naik, R.3
  • 108
    • 0031963058 scopus 로고    scopus 로고
    • Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
    • Parker BW, Kaur G, Nieves-Neira W, et al. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998;91:458-65
    • (1998) Blood , vol.91 , pp. 458-465
    • Parker, B.W.1    Kaur, G.2    Nieves-Neira, W.3
  • 109
    • 50249083873 scopus 로고    scopus 로고
    • Identification of N-(4-piperidinyl)-4- (2,6-dichlorobenzoylamino)- 1Hpyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design
    • Wyatt PG, Woodhead AJ, Berdini V, et al. Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1Hpyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. J Med Chem 2008;51:4986-99
    • (2008) J Med Chem , vol.51 , pp. 4986-4999
    • Wyatt, P.G.1    Woodhead, A.J.2    Berdini, V.3
  • 110
    • 60849123760 scopus 로고    scopus 로고
    • Biological characterization of AT7519, a small-molecule inhibitor of cyclindependent kinases, in human tumor cell lines
    • Squires MS, Feltell RE, Wallis NG, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclindependent kinases, in human tumor cell lines. Mol Cancer Ther 2009;8:324-32
    • (2009) Mol Cancer Ther , vol.8 , pp. 324-332
    • Squires, M.S.1    Feltell, R.E.2    Wallis, N.G.3
  • 111
    • 77955485400 scopus 로고    scopus 로고
    • Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor
    • Parry D, Guzi T, Shanahan F, et al. Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol Cancer Ther 2010;9:2344-53
    • (2010) Mol Cancer Ther , vol.9 , pp. 2344-2353
    • Parry, D.1    Guzi, T.2    Shanahan, F.3
  • 112
    • 80053398390 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
    • Feldmann G, Mishra A, Bisht S, et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther 2011;12:598-609
    • (2011) Cancer Biol Ther , vol.12 , pp. 598-609
    • Feldmann, G.1    Mishra, A.2    Bisht, S.3
  • 113
    • 84875888282 scopus 로고    scopus 로고
    • Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor
    • Fu W, Sharma SS, Ma L, et al. Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor. Cell Death Dis 2013;4:e566
    • (2013) Cell Death Dis , vol.4
    • Fu, W.1    Sharma, S.S.2    Ma, L.3
  • 114
    • 84875082183 scopus 로고    scopus 로고
    • The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling
    • Desai BM, Villanueva J, Nguyen TT, et al. The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PLoS One 2013;8:e59588
    • (2013) PLoS One , vol.8
    • Desai, B.M.1    Villanueva, J.2    Nguyen, T.T.3
  • 115
    • 84863299833 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program
    • Gorlick R, Kolb EA, Houghton PJ, et al. Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. Pediatr Blood Cancer 2012;59:1266-74
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 1266-1274
    • Gorlick, R.1    Kolb, E.A.2    Houghton, P.J.3
  • 116
    • 84885457420 scopus 로고    scopus 로고
    • A first-in-human, phase 1, doseescalation study of dinaciclib, a novel cyclindependent kinase inhibitor, administered weekly in subjects with advanced malignancies
    • Nemunaitis JJ, Small KA, Kirschmeier P, et al. A first-in-human, phase 1, doseescalation study of dinaciclib, a novel cyclindependent kinase inhibitor, administered weekly in subjects with advanced malignancies. J Transl Med 2013;11:259
    • (2013) J Transl Med , vol.11 , pp. 259
    • Nemunaitis, J.J.1    Small, K.A.2    Kirschmeier, P.3
  • 117
    • 76049104235 scopus 로고    scopus 로고
    • PD 0332991, a selective cyclin D kinase 4/ 6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptorpositive human breast cancer cell lines in vitro
    • Finn RS, Dering J, Conklin D, et al. PD 0332991, a selective cyclin D kinase 4/ 6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptorpositive human breast cancer cell lines in vitro. Breast Cancer Res 2009;11:R77
    • (2009) Breast Cancer Res , vol.11
    • Finn, R.S.1    Dering, J.2    Conklin, D.3
  • 118
    • 77951082119 scopus 로고    scopus 로고
    • Pharmacologic inhibition of cyclindependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    • Michaud K, Solomon DA, Oermann E, et al. Pharmacologic inhibition of cyclindependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 2010;70:3228-38
    • (2010) Cancer Res , vol.70 , pp. 3228-3238
    • Michaud, K.1    Solomon, D.A.2    Oermann, E.3
  • 119
    • 80052850363 scopus 로고    scopus 로고
    • Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression
    • Katsumi Y, Iehara T,MiyachiM, et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun 2011;413:62-8
    • (2011) Biochem Biophys Res Commun , vol.413 , pp. 62-68
    • Katsumi, Y.1    Iehara, T.2    Miyachi, M.3
  • 120
    • 84859079523 scopus 로고    scopus 로고
    • Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy
    • Roberts PJ, Bisi JE, Strum JC, et al. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J Natl Cancer Inst 2012;104:476-87
    • (2012) J Natl Cancer Inst , vol.104 , pp. 476-487
    • Roberts, P.J.1    Bisi, J.E.2    Strum, J.C.3
  • 121
    • 79958149971 scopus 로고    scopus 로고
    • Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1
    • Schwartz GK, LoRusso PM, Dickson MA, et al. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1). Br J Cancer 2011;104:1862-8
    • (2011) Br J Cancer , vol.104 , pp. 1862-1868
    • Schwartz, G.K.1    LoRusso, P.M.2    Dickson, M.A.3
  • 122
    • 84855983664 scopus 로고    scopus 로고
    • Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/ 6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer
    • Flaherty KT, Lorusso PM, Demichele A, et al. Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/ 6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer. Clin Cancer Res 2012;18:568-76
    • (2012) Clin Cancer Res , vol.18 , pp. 568-576
    • Flaherty, K.T.1    Lorusso, P.M.2    Demichele, A.3
  • 125
    • 84903844127 scopus 로고    scopus 로고
    • Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/ 6) with broad in vivo antitumor activity
    • Philadelphia (PA), San Francisco, CA
    • Gelbert LM, Cai S, Lin X, et al. Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/ 6) with broad in vivo antitumor activity. In AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; AACR, Philadelphia (PA), San Francisco, CA: 2011
    • (2011) AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; AACR
    • Gelbert, L.M.1    Cai, S.2    Lin, X.3
  • 126
    • 84903842102 scopus 로고    scopus 로고
    • LY2835219, a potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) that crosses the blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts
    • Philadelphia (PA), San Francisco, CA
    • Sanchez-Martinez C, Gelbert LM, Shannon H, et al. LY2835219, a potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) that crosses the blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts. In AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; AACR, Philadelphia (PA), San Francisco, CA: 2011
    • (2011) AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; AACR
    • Sanchez-Martinez, C.1    Gelbert, L.M.2    Shannon, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.