Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

Oncotarget

Volumn 6, Issue 26, 2015, Pages 21853-21864

  Levring, Trine B ^a   Kongsbak, Martin ^a   Rode, Anna K O ^a   Woetmann, Anders ^a   Odum, Niels ^a   Bonefeld, Charlotte Menné ^a   Geisler, Carsten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cystine; DNA synthesis; Glutathione; Ribonucleotide reductase; T cell

Indexed keywords

CYSTINE; HISTONE H2AX; HISTONE H2AX GAMMA; RIBONUCLEOTIDE REDUCTASE; THIOREDOXIN; UNCLASSIFIED DRUG; DNA; GLUTATHIONE;

AMINO ACID TRANSPORT; ARTICLE; CD4+ T LYMPHOCYTE; CELL CYCLE S PHASE; CELL DIVISION; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; UPREGULATION; BIOSYNTHESIS; DRUG EFFECTS; IMMUNOLOGY; JURKAT CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM;

CD4-POSITIVE T-LYMPHOCYTES; CYSTINE; DNA; GLUTATHIONE; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; RIBONUCLEOTIDE REDUCTASES; THIOREDOXINS;

EID: 84941247999     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5213     Document Type: Article

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