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Volumn 4, Issue , 2015, Pages

Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis

Author keywords

Cytotoxic; Haemophagocytic lymphohistiocytosis; Natural killer lymphocytes

Indexed keywords


EID: 84988449686     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.6754.1     Document Type: Review
Times cited : (26)

References (76)
  • 1
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • 11728337
    • Stinchcombe JC Bossi G Booth S: The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity. 2001;15(5):751-61. 11728337 10.1016/S1074-7613(01)00234-5
    • (2001) Immunity , vol.15 , Issue.5 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3
  • 2
    • 0033520970 scopus 로고    scopus 로고
    • Perforin gene defects in familial hemophagocytic lymphohistiocytosis
    • 10583959
    • Stepp SE Dufourcq-Lagelouse R Le Deist F: Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999;286(5446):1957-9. 10583959 10.1126/science.286.5446.1957
    • (1999) Science , vol.286 , Issue.5446 , pp. 1957-1959
    • Stepp, S.E.1    Dufourcq-Lagelouse, R.2    Le Deist, F.3
  • 3
    • 0029582926 scopus 로고
    • The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses
    • 8566009
    • Kägi D Seiler P Pavlovic J: The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol. 1995;25(12):3256-62. 8566009 10.1002/eji.1830251209
    • (1995) Eur J Immunol , vol.25 , Issue.12 , pp. 3256-3262
    • Kägi, D.1    Seiler, P.2    Pavlovic, J.3
  • 4
    • 3242752040 scopus 로고    scopus 로고
    • + T cells and interferon gamma are essential for the disorder
    • 15069016
    • Jordan MB Hildeman D Kappler J: An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8 + T cells and interferon gamma are essential for the disorder. Blood. 2004;104(3):735-43. 15069016 10.1182/blood-2003-10-3413
    • (2004) Blood , vol.104 , Issue.3 , pp. 735-743
    • Jordan, M.B.1    Hildeman, D.2    Kappler, J.3
  • 5
    • 77951676108 scopus 로고    scopus 로고
    • Inherited defects in lymphocyte cytotoxic activity
    • 20536552
    • Pachlopnik Schmid J Côte M Ménager MM: Inherited defects in lymphocyte cytotoxic activity. Immunol Rev. 2010;235(1):10-23. 20536552
    • (2010) Immunol Rev , vol.235 , Issue.1 , pp. 10-23
    • Pachlopnik Schmid, J.1    Côte, M.2    Ménager, M.M.3
  • 6
    • 84855932987 scopus 로고    scopus 로고
    • Familial and acquired hemophagocytic lymphohistiocytosis
    • 22248322
    • Janka GE: Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med. 2012;63:233-46. 22248322 10.1146/annurev-med-041610-134208
    • (2012) Annu Rev Med , vol.63 , pp. 233-246
    • Janka, G.E.1
  • 7
    • 84903132528 scopus 로고    scopus 로고
    • Hemophagocytic syndromes--an update
    • 24792320
    • Janka GE Lehmberg K: Hemophagocytic syndromes--an update. Blood Rev. 2014;28(4):135-42. 24792320 10.1016/j.blre.2014.03.002
    • (2014) Blood Rev , vol.28 , Issue.4 , pp. 135-142
    • Janka, G.E.1    Lehmberg, K.2
  • 8
    • 77954956416 scopus 로고    scopus 로고
    • Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules
    • 20634814
    • de Saint Basile G Ménasché G Fischer A: Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules. Nat Rev Immunol. 2010;10(8):568-79. 20634814 10.1038/nri2803
    • (2010) Nat Rev Immunol , vol.10 , Issue.8 , pp. 568-579
    • de Saint Basile, G.1    Ménasché, G.2    Fischer, A.3
  • 9
    • 84929643315 scopus 로고    scopus 로고
    • Kill or be killed
    • 25980027
    • Behrens EM Cron RQ: Kill or be killed. J Immunol. 2015;194(11):5041-3. 25980027 10.4049/jimmunol.1500774
    • (2015) J Immunol , vol.194 , Issue.11 , pp. 5041-5043
    • Behrens, E.M.1    Cron, R.Q.2
  • 10
    • 84892143506 scopus 로고    scopus 로고
    • Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice
    • 24379813, 3864253
    • Jessen B Kögl T Sepulveda FE: Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice. Front Immunol. 2013;4:448. 24379813 10.3389/fimmu.2013.00448 3864253
    • (2013) Front Immunol , vol.4 , pp. 448
    • Jessen, B.1    Kögl, T.2    Sepulveda, F.E.3
  • 11
    • 84927610290 scopus 로고    scopus 로고
    • A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice
    • 25525117
    • Sepulveda FE Maschalidi S Vosshenrich CAJ: A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice. Blood. 2015;125(9):1427-34. 25525117 10.1182/blood-2014-09-602946
    • (2015) Blood , vol.125 , Issue.9 , pp. 1427-1434
    • Sepulveda, F.E.1    Maschalidi, S.2    Vosshenrich, C.A.J.3
  • 12
    • 50249184550 scopus 로고    scopus 로고
    • Formation and function of the lytic NK-cell immunological synapse
    • 19172692, 2772177
    • Orange JS: Formation and function of the lytic NK-cell immunological synapse. Nat Rev Immunol. 2008;8(9):713-25. 19172692 10.1038/nri2381 2772177
    • (2008) Nat Rev Immunol , vol.8 , Issue.9 , pp. 713-725
    • Orange, J.S.1
  • 13
    • 84929664587 scopus 로고    scopus 로고
    • Actin depletion initiates events leading to granule secretion at the immunological synapse
    • 25992860, 4448150
    • Ritter AT Asano Y Stinchcombe JC: Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity. 2015;42(5):864-76. 25992860 10.1016/j.immuni.2015.04.013 4448150
    • (2015) Immunity , vol.42 , Issue.5 , pp. 864-876
    • Ritter, A.T.1    Asano, Y.2    Stinchcombe, J.C.3
  • 14
    • 0034671856 scopus 로고    scopus 로고
    • Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis
    • 11050075
    • Browne KA Johnstone RW Jans DA: Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. J Biol Chem. 2000;275(50):39262-6. 11050075 10.1074/jbc.C000622200
    • (2000) J Biol Chem , vol.275 , Issue.50 , pp. 39262-39266
    • Browne, K.A.1    Johnstone, R.W.2    Jans, D.A.3
  • 15
    • 80053321288 scopus 로고    scopus 로고
    • Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse
    • 21931536, 3172191
    • Rak GD Mace EM Banerjee PP: Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. PLoS Biol. 2011;9(9):e1001151. 21931536 10.1371/journal.pbio.1001151 3172191
    • (2011) PLoS Biol , vol.9 , Issue.9
    • Rak, G.D.1    Mace, E.M.2    Banerjee, P.P.3
  • 16
    • 77951689563 scopus 로고    scopus 로고
    • Cytotoxic immunological synapses
    • 20536553, 2950621
    • Dustin ML Long EO: Cytotoxic immunological synapses. Immunol Rev. 2010;235(1):24-34. 20536553 10.1111/j.0105-2896.2010.00904.x 2950621
    • (2010) Immunol Rev , vol.235 , Issue.1 , pp. 24-34
    • Dustin, M.L.1    Long, E.O.2
  • 17
    • 33749185296 scopus 로고    scopus 로고
    • Centrosome polarization delivers secretory granules to the immunological synapse
    • 17006514
    • Stinchcombe JC Majorovits E Bossi G: Centrosome polarization delivers secretory granules to the immunological synapse. Nature. 2006;443(7110):462-5. 17006514 10.1038/nature05071
    • (2006) Nature , vol.443 , Issue.7110 , pp. 462-465
    • Stinchcombe, J.C.1    Majorovits, E.2    Bossi, G.3
  • 18
    • 84929961969 scopus 로고    scopus 로고
    • Perforin and granzymes: function, dysfunction and human pathology
    • 25998963
    • Voskoboinik I Whisstock JC Trapani JA: Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol. 2015;15(6):388-400. 25998963 10.1038/nri3839
    • (2015) Nat Rev Immunol , vol.15 , Issue.6 , pp. 388-400
    • Voskoboinik, I.1    Whisstock, J.C.2    Trapani, J.A.3
  • 19
    • 78549267766 scopus 로고    scopus 로고
    • The structural basis for membrane binding and pore formation by lymphocyte perforin
    • 21037563
    • Law RHP Lukoyanova N Voskoboinik I: The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature. 2010;468(7322):447-51. 21037563 10.1038/nature09518
    • (2010) Nature , vol.468 , Issue.7322 , pp. 447-451
    • Law, R.H.P.1    Lukoyanova, N.2    Voskoboinik, I.3
  • 20
    • 65549121526 scopus 로고    scopus 로고
    • The molecular basis for perforin oligomerization and transmembrane pore assembly
    • 19446473
    • Baran K Dunstone M Chia J: The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity. 2009;30(5):684-95. 19446473 10.1016/j.immuni.2009.03.016
    • (2009) Immunity , vol.30 , Issue.5 , pp. 684-695
    • Baran, K.1    Dunstone, M.2    Chia, J.3
  • 21
    • 84876174174 scopus 로고    scopus 로고
    • Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
    • 23377437
    • Lopez JA Susanto O Jenkins MR: Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood. 2013;121(14):2659-68. 23377437 10.1182/blood-2012-07-446146
    • (2013) Blood , vol.121 , Issue.14 , pp. 2659-2668
    • Lopez, J.A.1    Susanto, O.2    Jenkins, M.R.3
  • 22
    • 84883343650 scopus 로고    scopus 로고
    • Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse
    • 23885110
    • Lopez JA Jenkins MR Rudd-Schmidt JA: Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol. 2013;191(5):2328-34. 23885110 10.4049/jimmunol.1301205
    • (2013) J Immunol , vol.191 , Issue.5 , pp. 2328-2334
    • Lopez, J.A.1    Jenkins, M.R.2    Rudd-Schmidt, J.A.3
  • 23
    • 24944494048 scopus 로고    scopus 로고
    • Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis
    • 16169498
    • Keefe D Shi L Feske S: Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005;23(3):249-62. 16169498 10.1016/j.immuni.2005.08.001
    • (2005) Immunity , vol.23 , Issue.3 , pp. 249-262
    • Keefe, D.1    Shi, L.2    Feske, S.3
  • 24
    • 0036059819 scopus 로고    scopus 로고
    • Mosaic organization of the endocytic pathway
    • 11740860
    • Miaczynska M Zerial M: Mosaic organization of the endocytic pathway. Exp Cell Res. 2002;272(1):8-14. 11740860 10.1006/excr.2001.5401
    • (2002) Exp Cell Res , vol.272 , Issue.1 , pp. 8-14
    • Miaczynska, M.1    Zerial, M.2
  • 25
    • 80052035441 scopus 로고    scopus 로고
    • Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells
    • 21685908, 3140544
    • Thiery J Keefe D Boulant S: Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011;12(8):770-7. 21685908 10.1038/ni.2050 3140544
    • (2011) Nat Immunol , vol.12 , Issue.8 , pp. 770-777
    • Thiery, J.1    Keefe, D.2    Boulant, S.3
  • 26
    • 10744224641 scopus 로고    scopus 로고
    • Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
    • 14622600
    • Feldmann J Callebaut I Raposo G: Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell. 2003;115(4):461-73. 14622600 10.1016/S0092-8674(03)00855-9
    • (2003) Cell , vol.115 , Issue.4 , pp. 461-473
    • Feldmann, J.1    Callebaut, I.2    Raposo, G.3
  • 27
    • 20144363940 scopus 로고    scopus 로고
    • Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11
    • 15703195
    • Zur Stadt U Schmidt S Kasper B: Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. Hum Mol Genet. 2005;14(6):827-34. 15703195 10.1093/hmg/ddi076
    • (2005) Hum Mol Genet , vol.14 , Issue.6 , pp. 827-834
    • Zur Stadt, U.1    Schmidt, S.2    Kasper, B.3
  • 28
    • 70350500464 scopus 로고    scopus 로고
    • Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11
    • 19804848, 2756548
    • Zur Stadt U Rohr J Seifert W: Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet. 2009;85(4):482-92. 19804848 10.1016/j.ajhg.2009.09.005 2756548
    • (2009) Am J Hum Genet , vol.85 , Issue.4 , pp. 482-492
    • Zur Stadt, U.1    Rohr, J.2    Seifert, W.3
  • 29
    • 72849125357 scopus 로고    scopus 로고
    • Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells
    • 19884660, 2786810
    • Côte M Ménager MM Burgess A: Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest. 2009;119(12):3765-73. 19884660 10.1172/JCI40732 2786810
    • (2009) J Clin Invest , vol.119 , Issue.12 , pp. 3765-3773
    • Côte, M.1    Ménager, M.M.2    Burgess, A.3
  • 30
    • 0344002689 scopus 로고    scopus 로고
    • Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
    • 10835631
    • Ménasché G Pastural E Feldmann J: Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat Genet. 2000;25(2):173-6. 10835631 10.1038/76024
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 173-176
    • Ménasché, G.1    Pastural, E.2    Feldmann, J.3
  • 31
    • 0030293556 scopus 로고    scopus 로고
    • Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome
    • 8896560
    • Nagle DL Karim MA Woolf EA: Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet. 1996;14(3):307-11. 8896560 10.1038/ng1196-307
    • (1996) Nat Genet , vol.14 , Issue.3 , pp. 307-311
    • Nagle, D.L.1    Karim, M.A.2    Woolf, E.A.3
  • 32
    • 84921373295 scopus 로고    scopus 로고
    • LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function
    • 25425525
    • Sepulveda FE Burgess A Heiligenstein X: LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function. Traffic. 2015;16(2):191-203. 25425525 10.1111/tra.12244
    • (2015) Traffic , vol.16 , Issue.2 , pp. 191-203
    • Sepulveda, F.E.1    Burgess, A.2    Heiligenstein, X.3
  • 33
    • 80051639052 scopus 로고    scopus 로고
    • The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane
    • 21693760
    • Elstak ED Neeft M Nehme NT: The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood. 2011;118(6):1570-8. 21693760 10.1182/blood-2011-02-339523
    • (2011) Blood , vol.118 , Issue.6 , pp. 1570-1578
    • Elstak, E.D.1    Neeft, M.2    Nehme, N.T.3
  • 34
    • 84861922902 scopus 로고    scopus 로고
    • Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion
    • 22508512, 3328385
    • Boswell KL James DJ Esquibel JM: Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion. J Cell Biol. 2012;197(2):301-12. 22508512 10.1083/jcb.201109132 3328385
    • (2012) J Cell Biol , vol.197 , Issue.2 , pp. 301-312
    • Boswell, K.L.1    James, D.J.2    Esquibel, J.M.3
  • 35
    • 84860330652 scopus 로고    scopus 로고
    • Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex
    • 22308290, 10.1182/blood-2011-09-382556, 3824283
    • Kurowska M Goudin N Nehme NT: Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex. Blood. 2012;119(17):3879-89. 22308290 10.1182/blood-2011-09-382556 3824283
    • (2012) Blood , vol.119 , Issue.17 , pp. 3879-3889
    • Kurowska, M.1    Goudin, N.2    Nehme, N.T.3
  • 36
    • 40449092959 scopus 로고    scopus 로고
    • Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse
    • 18266782, 2329822
    • Holt O Kanno E Bossi G: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic. 2008;9(4):446-57. 18266782 10.1111/j.1600-0854.2008.00714.x 2329822
    • (2008) Traffic , vol.9 , Issue.4 , pp. 446-457
    • Holt, O.1    Kanno, E.2    Bossi, G.3
  • 37
    • 58149388232 scopus 로고    scopus 로고
    • A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion
    • 18812475
    • Ménasché G Ménager MM Lefebvre JM: A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. Blood. 2008;112(13):5052-62. 18812475 10.1182/blood-2008-02-141069
    • (2008) Blood , vol.112 , Issue.13 , pp. 5052-5062
    • Ménasché, G.1    Ménager, M.M.2    Lefebvre, J.M.3
  • 38
    • 79959574557 scopus 로고    scopus 로고
    • Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
    • 21711522, 3149597
    • Stinchcombe JC Salio M Cerundolo V: Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems. BMC Biol. 2011;9:45. 21711522 10.1186/1741-7007-9-45 3149597
    • (2011) BMC Biol , vol.9 , pp. 45
    • Stinchcombe, J.C.1    Salio, M.2    Cerundolo, V.3
  • 39
    • 84876061817 scopus 로고    scopus 로고
    • An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse
    • 23536289, 3625254
    • Bertrand F Müller S Roh KH: An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse. Proc Natl Acad Sci U S A. 2013;110(15):6073-8. 23536289 10.1073/pnas.1218640110 3625254
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.15 , pp. 6073-6078
    • Bertrand, F.1    Müller, S.2    Roh, K.H.3
  • 40
    • 84876236461 scopus 로고    scopus 로고
    • Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells
    • 23576740, 3631668
    • Choi PJ Mitchison TJ: Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells. Proc Natl Acad Sci U S A. 2013;110(16):6488-93. 23576740 10.1073/pnas.1221312110 3631668
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.16 , pp. 6488-6493
    • Choi, P.J.1    Mitchison, T.J.2
  • 41
    • 84930758854 scopus 로고    scopus 로고
    • Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing
    • 26027932
    • Vasconcelos Z Müller S Guipouy D: Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing. Cell Rep. 2015;11(9):1474-85. 26027932 10.1016/j.celrep.2015.05.002
    • (2015) Cell Rep , vol.11 , Issue.9 , pp. 1474-1485
    • Vasconcelos, Z.1    Müller, S.2    Guipouy, D.3
  • 42
    • 79959950515 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis with Munc13-4 mutation: a cause of recurrent fatal hydrops fetalis
    • 21646258
    • Bechara E Dijoud F de Saint Basile G: Hemophagocytic lymphohistiocytosis with Munc13-4 mutation: a cause of recurrent fatal hydrops fetalis. Pediatrics. 2011;128(1):e251-4. 21646258 10.1542/peds.2010-0764
    • (2011) Pediatrics , vol.128 , Issue.1
    • Bechara, E.1    Dijoud, F.2    de Saint Basile, G.3
  • 43
    • 0036068408 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis presenting with thrombocytopenia in the newborn
    • 12142793
    • Levendoglu-Tugal O Ozkaynak MF LaGamma E: Hemophagocytic lymphohistiocytosis presenting with thrombocytopenia in the newborn. J Pediatr Hematol Oncol. 2002;24(5):405-9. 12142793 10.1097/00043426-200206000-00017
    • (2002) J Pediatr Hematol Oncol , vol.24 , Issue.5 , pp. 405-409
    • Levendoglu-Tugal, O.1    Ozkaynak, M.F.2    LaGamma, E.3
  • 44
    • 0025787430 scopus 로고
    • Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure
    • 1910175, 52485
    • Odermatt B Eppler M Leist TP: Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A. 1991;88(18):8252-6. 1910175 10.1073/pnas.88.18.8252 52485
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.18 , pp. 8252-8256
    • Odermatt, B.1    Eppler, M.2    Leist, T.P.3
  • 45
    • 84884187508 scopus 로고    scopus 로고
    • + T cells and dendritic cells
    • 23660960, 3695362
    • Terrell CE Jordan MB: Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8 + T cells and dendritic cells. Blood. 2013;121(26):5184-91. 23660960 10.1182/blood-2013-04-495309 3695362
    • (2013) Blood , vol.121 , Issue.26 , pp. 5184-5191
    • Terrell, C.E.1    Jordan, M.B.2
  • 46
    • 84872438906 scopus 로고    scopus 로고
    • Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11
    • 23160464
    • Sepulveda FE Debeurme F Ménasché G: Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013;121(4):595-603. 23160464 10.1182/blood-2012-07-440339
    • (2013) Blood , vol.121 , Issue.4 , pp. 595-603
    • Sepulveda, F.E.1    Debeurme, F.2    Ménasché, G.3
  • 47
    • 84855999478 scopus 로고    scopus 로고
    • Natural killer cells act as rheostats modulating antiviral T cells
    • 22101430, 3539796
    • Waggoner SN Cornberg M Selin LK: Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2012;481(7381):394-8. 22101430 10.1038/nature10624 3539796
    • (2012) Nature , vol.481 , Issue.7381 , pp. 394-398
    • Waggoner, S.N.1    Cornberg, M.2    Selin, L.K.3
  • 48
    • 84863011076 scopus 로고    scopus 로고
    • + T-cell immunity
    • 22167808, 3268324
    • Lang PA Lang KS Xu HC: Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity. Proc Natl Acad Sci U S A. 2012;109(4):1210-5. 22167808 10.1073/pnas.1118834109 3268324
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.4 , pp. 1210-1215
    • Lang, P.A.1    Lang, K.S.2    Xu, H.C.3
  • 49
    • 84872452706 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease
    • 23190531
    • Kögl T Müller J Jessen B: Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease. Blood. 2013;121(4):604-13. 23190531 10.1182/blood-2012-07-441139
    • (2013) Blood , vol.121 , Issue.4 , pp. 604-613
    • Kögl, T.1    Müller, J.2    Jessen, B.3
  • 50
    • 0345257150 scopus 로고    scopus 로고
    • Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold
    • 14610278, 283560
    • Faroudi M Utzny C Salio M: Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc Natl Acad Sci U S A. 2003;100(24):14145-50. 14610278 10.1073/pnas.2334336100 283560
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.24 , pp. 14145-14150
    • Faroudi, M.1    Utzny, C.2    Salio, M.3
  • 51
    • 84924707453 scopus 로고    scopus 로고
    • Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time
    • 25732304, 4354371
    • Jenkins MR Rudd-Schmidt JA Lopez JA: Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time. J Exp Med. 2015;212(3):307-17. 25732304 10.1084/jem.20140964 4354371
    • (2015) J Exp Med , vol.212 , Issue.3 , pp. 307-317
    • Jenkins, M.R.1    Rudd-Schmidt, J.A.2    Lopez, J.A.3
  • 52
    • 2942597667 scopus 로고    scopus 로고
    • Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis
    • 15187513
    • Strauss R Neureiter D Westenburger B: Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis. Crit Care Med. 2004;32(6):1316-21. 15187513 10.1097/01.CCM.0000127779.24232.15
    • (2004) Crit Care Med , vol.32 , Issue.6 , pp. 1316-1321
    • Strauss, R.1    Neureiter, D.2    Westenburger, B.3
  • 53
    • 79958292813 scopus 로고    scopus 로고
    • Hemophagocytosis causes a consumptive anemia of inflammation
    • 21624938, 3173248
    • Zoller EE Lykens JE Terrell CE: Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med. 2011;208(6):1203-14. 21624938 10.1084/jem.20102538 3173248
    • (2011) J Exp Med , vol.208 , Issue.6 , pp. 1203-1214
    • Zoller, E.E.1    Lykens, J.E.2    Terrell, C.E.3
  • 54
    • 84927628632 scopus 로고    scopus 로고
    • Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling
    • 25706096, 4563985
    • de Jesus AA Canna SW Liu Y: Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling. Annu Rev Immunol. 2015;33:823-74. 25706096 10.1146/annurev-immunol-032414-112227 4563985
    • (2015) Annu Rev Immunol , vol.33 , pp. 823-874
    • de Jesus, A.A.1    Canna, S.W.2    Liu, Y.3
  • 55
    • 79959242566 scopus 로고    scopus 로고
    • Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    • 21551232, 3123024
    • Krebs P Crozat K Popkin D: Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice. Blood. 2011;117(24):6582-8. 21551232 10.1182/blood-2011-01-329607 3123024
    • (2011) Blood , vol.117 , Issue.24 , pp. 6582-6588
    • Krebs, P.1    Crozat, K.2    Popkin, D.3
  • 56
    • 77957736074 scopus 로고    scopus 로고
    • Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    • 20570861, 2953884
    • Milner JD Orekov T Ward JM: Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood. 2010;116(14):2476-83. 20570861 10.1182/blood-2009-11-255174 2953884
    • (2010) Blood , vol.116 , Issue.14 , pp. 2476-2483
    • Milner, J.D.1    Orekov, T.2    Ward, J.M.3
  • 57
    • 79957889288 scopus 로고    scopus 로고
    • Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
    • 21576823, 3104738
    • Behrens EM Canna SW Slade K: Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest. 2011;121(6):2264-77. 21576823 10.1172/JCI43157 3104738
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2264-2277
    • Behrens, E.M.1    Canna, S.W.2    Slade, K.3
  • 58
    • 79551644967 scopus 로고    scopus 로고
    • Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
    • 21119115
    • Pachlopnik Schmid J Canioni D Moshous D: Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency). Blood. 2011;117(5):1522-9. 21119115 10.1182/blood-2010-07-298372
    • (2011) Blood , vol.117 , Issue.5 , pp. 1522-1529
    • Pachlopnik Schmid, J.1    Canioni, D.2    Moshous, D.3
  • 59
    • 13144278345 scopus 로고    scopus 로고
    • Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
    • 9811875, 24894
    • Nichols KE Harkin DP Levitz S: Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998;95(23):13765-70. 9811875 10.1073/pnas.95.23.13765 24894
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.23 , pp. 13765-13770
    • Nichols, K.E.1    Harkin, D.P.2    Levitz, S.3
  • 60
    • 17344372694 scopus 로고    scopus 로고
    • Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
    • 9771704
    • Coffey AJ Brooksbank RA Brandau O: Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 1998;20(2):129-35. 9771704 10.1038/2424
    • (1998) Nat Genet , vol.20 , Issue.2 , pp. 129-135
    • Coffey, A.J.1    Brooksbank, R.A.2    Brandau, O.3
  • 61
    • 0032190081 scopus 로고    scopus 로고
    • The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
    • 9774102
    • Sayos J Wu C Morra M: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395(6701):462-9. 9774102 10.1038/26683
    • (1998) Nature , vol.395 , Issue.6701 , pp. 462-469
    • Sayos, J.1    Wu, C.2    Morra, M.3
  • 62
    • 82455175808 scopus 로고    scopus 로고
    • Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP
    • 22069374, 3206011
    • Palendira U Low C Chan A: Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol. 2011;9(11):e1001187. 22069374 10.1371/journal.pbio.1001187 3206011
    • (2011) PLoS Biol , vol.9 , Issue.11
    • Palendira, U.1    Low, C.2    Chan, A.3
  • 63
    • 84930898417 scopus 로고    scopus 로고
    • XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP
    • 25085526
    • Tangye SG: XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP. J Clin Immunol. 2014;34(7):772-9. 25085526 10.1007/s10875-014-0083-7
    • (2014) J Clin Immunol , vol.34 , Issue.7 , pp. 772-779
    • Tangye, S.G.1
  • 64
    • 33750597717 scopus 로고    scopus 로고
    • XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
    • 17080092
    • Rigaud S Fondanèche M Lambert N: XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. Nature. 2006;444(7115):110-4. 17080092 10.1038/nature05257
    • (2006) Nature , vol.444 , Issue.7115 , pp. 110-114
    • Rigaud, S.1    Fondanèche, M.2    Lambert, N.3
  • 65
    • 84891550264 scopus 로고    scopus 로고
    • Innate immune control of EBV-infected B cells by invariant natural killer T cells
    • 23974196
    • Chung BK Tsai K Allan LL: Innate immune control of EBV-infected B cells by invariant natural killer T cells. Blood. 2013;122(15):2600-8. 23974196 10.1182/blood-2013-01-480665
    • (2013) Blood , vol.122 , Issue.15 , pp. 2600-2608
    • Chung, B.K.1    Tsai, K.2    Allan, L.L.3
  • 66
    • 84903480849 scopus 로고    scopus 로고
    • XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation
    • 24882010
    • Yabal M Müller N Adler H: XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation. Cell Rep. 2014;7(6):1796-808. 24882010 10.1016/j.celrep.2014.05.008
    • (2014) Cell Rep , vol.7 , Issue.6 , pp. 1796-1808
    • Yabal, M.1    Müller, N.2    Adler, H.3
  • 67
    • 67649836342 scopus 로고    scopus 로고
    • Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer
    • 19487666, 2701033
    • Chia J Yeo KP Whisstock JC: Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A. 2009;106(24):9809-14. 19487666 10.1073/pnas.0903815106 2701033
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.24 , pp. 9809-9814
    • Chia, J.1    Yeo, K.P.2    Whisstock, J.C.3
  • 68
    • 34548723841 scopus 로고    scopus 로고
    • Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis
    • 17606450
    • Nagafuji K Nonami A Kumano T: Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis. Haematologica. 2007;92(7):978-81. 17606450 10.3324/haematol.11233
    • (2007) Haematologica , vol.92 , Issue.7 , pp. 978-981
    • Nagafuji, K.1    Nonami, A.2    Kumano, T.3
  • 69
    • 33748796888 scopus 로고    scopus 로고
    • Familial hemophagocytic lymphohistiocytosis in an adult patient homozygous for A91V in the perforin gene, with tuberculosis infection
    • 16956828
    • Mancebo E Allende LM Guzmán M: Familial hemophagocytic lymphohistiocytosis in an adult patient homozygous for A91V in the perforin gene, with tuberculosis infection. Haematologica. 2006;91(9):1257-60. 16956828
    • (2006) Haematologica , vol.91 , Issue.9 , pp. 1257-1260
    • Mancebo, E.1    Allende, L.M.2    Guzmán, M.3
  • 70
    • 79959258419 scopus 로고    scopus 로고
    • Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature
    • 20809477
    • Shabbir M Lucas J Lazarchick J: Secondary hemophagocytic syndrome in adults: a case series of 18 patients in a single institution and a review of literature. Hematol Oncol. 2011;29(2):100-6. 20809477 10.1002/hon.960
    • (2011) Hematol Oncol , vol.29 , Issue.2 , pp. 100-106
    • Shabbir, M.1    Lucas, J.2    Lazarchick, J.3
  • 71
    • 84905324940 scopus 로고    scopus 로고
    • Genetic defects in cytolysis in macrophage activation syndrome
    • 25086802
    • Zhang M Behrens EM Atkinson TP: Genetic defects in cytolysis in macrophage activation syndrome. Curr Rheumatol Rep. 2014;16(9):439. 25086802 10.1007/s11926-014-0439-2
    • (2014) Curr Rheumatol Rep , vol.16 , Issue.9 , pp. 439
    • Zhang, M.1    Behrens, E.M.2    Atkinson, T.P.3
  • 72
    • 82155184541 scopus 로고    scopus 로고
    • Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
    • 21881043, 3228496
    • Zhang K Jordan MB Marsh RA: Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH. Blood. 2011;118(22):5794-8. 21881043 10.1182/blood-2011-07-370148 3228496
    • (2011) Blood , vol.118 , Issue.22 , pp. 5794-5798
    • Zhang, K.1    Jordan, M.B.2    Marsh, R.A.3
  • 73
    • 84907348494 scopus 로고    scopus 로고
    • Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis
    • 24916509, 4141517
    • Zhang K Chandrakasan S Chapman H: Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis. Blood. 2014;124(8):1331-4. 24916509 10.1182/blood-2014-05-573105 4141517
    • (2014) Blood , vol.124 , Issue.8 , pp. 1331-1334
    • Zhang, K.1    Chandrakasan, S.2    Chapman, H.3
  • 74
    • 84922008927 scopus 로고    scopus 로고
    • Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
    • 25217960, 4177367
    • Romberg N Al Moussawi K Nelson-Williams C: Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat Genet. 2014;46(10):1135-9. 25217960 10.1038/ng.3066 4177367
    • (2014) Nat Genet , vol.46 , Issue.10 , pp. 1135-1139
    • Romberg, N.1    Al Moussawi, K.2    Nelson-Williams, C.3
  • 75
    • 84927126118 scopus 로고    scopus 로고
    • An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
    • 25217959, 4177369
    • Canna SW de Jesus AA Gouni S: An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet. 2014;46(10):1140-6. 25217959 10.1038/ng.3089 4177369
    • (2014) Nat Genet , vol.46 , Issue.10 , pp. 1140-1146
    • Canna, S.W.1    de Jesus, A.A.2    Gouni, S.3
  • 76
    • 84911922142 scopus 로고    scopus 로고
    • An inherited mutation in NLRC4 causes autoinflammation in human and mice
    • 25385754, 4235634
    • Kitamura A Sasaki Y Abe T: An inherited mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med. 2014;211(12):2385-96. 25385754 10.1084/jem.20141091 4235634
    • (2014) J Exp Med , vol.211 , Issue.12 , pp. 2385-2396
    • Kitamura, A.1    Sasaki, Y.2    Abe, T.3


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