-
1
-
-
23844453399
-
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells
-
Bird C.H., Sun J., Ung K., Karambalis D., Whisstock J.C., Trapani J.A., and Bird P.I. Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol. Cell. Biol. 25 (2005) 7854-7867
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7854-7867
-
-
Bird, C.H.1
Sun, J.2
Ung, K.3
Karambalis, D.4
Whisstock, J.C.5
Trapani, J.A.6
Bird, P.I.7
-
2
-
-
0021228186
-
Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors
-
Blumenthal R., Millard P.J., Henkart M.P., Reynolds C.W., and Henkart P.A. Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors. Proc. Natl. Acad. Sci. USA 81 (1984) 5551-5555
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 5551-5555
-
-
Blumenthal, R.1
Millard, P.J.2
Henkart, M.P.3
Reynolds, C.W.4
Henkart, P.A.5
-
4
-
-
21144435788
-
A proportion of patients with lymphoma may harbor mutations of the perforin gene
-
Clementi R., Locatelli F., Dupre L., Garaventa A., Emmi L., Bregni M., Cefalo G., Moretta A., Danesino C., Comis M., et al. A proportion of patients with lymphoma may harbor mutations of the perforin gene. Blood 105 (2005) 4424-4428
-
(2005)
Blood
, vol.105
, pp. 4424-4428
-
-
Clementi, R.1
Locatelli, F.2
Dupre, L.3
Garaventa, A.4
Emmi, L.5
Bregni, M.6
Cefalo, G.7
Moretta, A.8
Danesino, C.9
Comis, M.10
-
5
-
-
15444378399
-
Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy
-
Dang T.X., Hotze E.M., Rouiller I., Tweten R.K., and Wilson-Kubalek E.M. Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy. J. Struct. Biol. 150 (2005) 100-108
-
(2005)
J. Struct. Biol.
, vol.150
, pp. 100-108
-
-
Dang, T.X.1
Hotze, E.M.2
Rouiller, I.3
Tweten, R.K.4
Wilson-Kubalek, E.M.5
-
6
-
-
0020532081
-
Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes
-
Dennert G., and Podack E.R. Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes. J. Exp. Med. 157 (1983) 1483-1495
-
(1983)
J. Exp. Med.
, vol.157
, pp. 1483-1495
-
-
Dennert, G.1
Podack, E.R.2
-
7
-
-
49649114605
-
Protein structure modeling with MODELLER
-
Eswar N., Eramian D., Webb B., Shen M.Y., and Sali A. Protein structure modeling with MODELLER. Methods Mol. Biol. 426 (2008) 145-159
-
(2008)
Methods Mol. Biol.
, vol.426
, pp. 145-159
-
-
Eswar, N.1
Eramian, D.2
Webb, B.3
Shen, M.Y.4
Sali, A.5
-
8
-
-
10544252275
-
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
-
Froelich C.J., Orth K., Turbov J., Seth P., Gottlieb R., Babior B., Shah G.M., Bleackley R.C., Dixit V.M., and Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol. Chem. 271 (1996) 29073-29079
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 29073-29079
-
-
Froelich, C.J.1
Orth, K.2
Turbov, J.3
Seth, P.4
Gottlieb, R.5
Babior, B.6
Shah, G.M.7
Bleackley, R.C.8
Dixit, V.M.9
Hanna, W.10
-
9
-
-
34548670476
-
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense
-
Hadders M.A., Beringer D.X., and Gros P. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science 317 (2007) 1552-1554
-
(2007)
Science
, vol.317
, pp. 1552-1554
-
-
Hadders, M.A.1
Beringer, D.X.2
Gros, P.3
-
10
-
-
20944449435
-
Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
-
Ishii E., Ueda I., Shirakawa R., Yamamoto K., Horiuchi H., Ohga S., Furuno K., Morimoto A., Imayoshi M., Ogata Y., et al. Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions. Blood 105 (2005) 3442-3448
-
(2005)
Blood
, vol.105
, pp. 3442-3448
-
-
Ishii, E.1
Ueda, I.2
Shirakawa, R.3
Yamamoto, K.4
Horiuchi, H.5
Ohga, S.6
Furuno, K.7
Morimoto, A.8
Imayoshi, M.9
Ogata, Y.10
-
11
-
-
0028219791
-
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
-
Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K.J., Podack E.R., Zinkernagel R.M., and Hengartner H. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369 (1994) 31-37
-
(1994)
Nature
, vol.369
, pp. 31-37
-
-
Kagi, D.1
Ledermann, B.2
Burki, K.3
Seiler, P.4
Odermatt, B.5
Olsen, K.J.6
Podack, E.R.7
Zinkernagel, R.M.8
Hengartner, H.9
-
12
-
-
1842289172
-
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
-
Kagi D., Odermatt B., Seiler P., Zinkernagel R.M., Mak T.W., and Hengartner H. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J. Exp. Med. 186 (1997) 989-997
-
(1997)
J. Exp. Med.
, vol.186
, pp. 989-997
-
-
Kagi, D.1
Odermatt, B.2
Seiler, P.3
Zinkernagel, R.M.4
Mak, T.W.5
Hengartner, H.6
-
14
-
-
0024557362
-
The structure of the mouse lymphocyte pore-forming protein perforin
-
Kwon B.S., Wakulchik M., Liu C.C., Persechini P.M., Trapani J.A., Haq A.K., Kim Y., and Young J.D. The structure of the mouse lymphocyte pore-forming protein perforin. Biochem. Biophys. Res. Commun. 158 (1989) 1-10
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.158
, pp. 1-10
-
-
Kwon, B.S.1
Wakulchik, M.2
Liu, C.C.3
Persechini, P.M.4
Trapani, J.A.5
Haq, A.K.6
Kim, Y.7
Young, J.D.8
-
15
-
-
36448991500
-
Clustal W and Clustal X version 2.0
-
Larkin M.A., Blackshields G., Brown N.P., Chenna R., McGettigan P.A., McWilliam H., Valentin F., Wallace I.M., Wilm A., Lopez R., et al. Clustal W and Clustal X version 2.0. Bioinformatics 23 (2007) 2947-2948
-
(2007)
Bioinformatics
, vol.23
, pp. 2947-2948
-
-
Larkin, M.A.1
Blackshields, G.2
Brown, N.P.3
Chenna, R.4
McGettigan, P.A.5
McWilliam, H.6
Valentin, F.7
Wallace, I.M.8
Wilm, A.9
Lopez, R.10
-
16
-
-
0023813169
-
Structure and function of human perforin
-
Lichtenheld M.G., Olsen K.J., Lu P., Lowrey D.M., Hameed A., Hengartner H., and Podack E.R. Structure and function of human perforin. Nature 335 (1988) 448-451
-
(1988)
Nature
, vol.335
, pp. 448-451
-
-
Lichtenheld, M.G.1
Olsen, K.J.2
Lu, P.3
Lowrey, D.M.4
Hameed, A.5
Hengartner, H.6
Podack, E.R.7
-
17
-
-
0026078046
-
Small-volume extrusion apparatus for preparation of large, unilamellar vesicles
-
MacDonald R.C., MacDonald R.I., Menco B.P., Takeshita K., Subbarao N.K., and Hu L.R. Small-volume extrusion apparatus for preparation of large, unilamellar vesicles. Biochim. Biophys. Acta 1061 (1991) 297-303
-
(1991)
Biochim. Biophys. Acta
, vol.1061
, pp. 297-303
-
-
MacDonald, R.C.1
MacDonald, R.I.2
Menco, B.P.3
Takeshita, K.4
Subbarao, N.K.5
Hu, L.R.6
-
18
-
-
0022253052
-
Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes
-
Masson D., and Tschopp J. Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes. J. Biol. Chem. 260 (1985) 9069-9072
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 9069-9072
-
-
Masson, D.1
Tschopp, J.2
-
19
-
-
33747618010
-
Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
-
Mehta P.A., Davies S.M., Kumar A., Devidas M., Lee S., Zamzow T., Elliott J., Villanueva J., Pullen J., Zewge Y., and Filipovich A. Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group. Leukemia 20 (2006) 1539-1541
-
(2006)
Leukemia
, vol.20
, pp. 1539-1541
-
-
Mehta, P.A.1
Davies, S.M.2
Kumar, A.3
Devidas, M.4
Lee, S.5
Zamzow, T.6
Elliott, J.7
Villanueva, J.8
Pullen, J.9
Zewge, Y.10
Filipovich, A.11
-
20
-
-
1242292327
-
Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis
-
Molleran Lee S., Villanueva J., Sumegi J., Zhang K., Kogawa K., Davis J., and Filipovich A.H. Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis. J. Med. Genet. 41 (2004) 137-144
-
(2004)
J. Med. Genet.
, vol.41
, pp. 137-144
-
-
Molleran Lee, S.1
Villanueva, J.2
Sumegi, J.3
Zhang, K.4
Kogawa, K.5
Davis, J.6
Filipovich, A.H.7
-
21
-
-
0034292407
-
Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling
-
Myers M.A., Davies J.M., Tong J.C., Whisstock J., Scealy M., Mackay I.R., and Rowley M.J. Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling. J. Immunol. 165 (2000) 3830-3838
-
(2000)
J. Immunol.
, vol.165
, pp. 3830-3838
-
-
Myers, M.A.1
Davies, J.M.2
Tong, J.C.3
Whisstock, J.4
Scealy, M.5
Mackay, I.R.6
Rowley, M.J.7
-
22
-
-
0028967988
-
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin
-
Nakajima H., Park H.L., and Henkart P.A. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181 (1995) 1037-1046
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1037-1046
-
-
Nakajima, H.1
Park, H.L.2
Henkart, P.A.3
-
23
-
-
0024995537
-
Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin
-
Peitsch M.C., Amiguet P., Guy R., Brunner J., Maizel Jr. J.V., and Tschopp J. Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin. Mol. Immunol. 27 (1990) 589-602
-
(1990)
Mol. Immunol.
, vol.27
, pp. 589-602
-
-
Peitsch, M.C.1
Amiguet, P.2
Guy, R.3
Brunner, J.4
Maizel Jr., J.V.5
Tschopp, J.6
-
24
-
-
0026753009
-
Channel-forming activity of the perforin N-terminus and a putative α-helical region homologous with complement C9
-
Persechini P.M., Ojcius D.M., Adeodato S.C., Notaroberto P.C., Daniel C.B., and Young J.D. Channel-forming activity of the perforin N-terminus and a putative α-helical region homologous with complement C9. Biochemistry 31 (1992) 5017-5021
-
(1992)
Biochemistry
, vol.31
, pp. 5017-5021
-
-
Persechini, P.M.1
Ojcius, D.M.2
Adeodato, S.C.3
Notaroberto, P.C.4
Daniel, C.B.5
Young, J.D.6
-
25
-
-
0020679842
-
Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells
-
Podack E.R., and Dennert G. Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells. Nature 302 (1983) 442-445
-
(1983)
Nature
, vol.302
, pp. 442-445
-
-
Podack, E.R.1
Dennert, G.2
-
26
-
-
0020491521
-
Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation
-
Podack E.R., and Tschopp J. Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation. J. Biol. Chem. 257 (1982) 15204-15212
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 15204-15212
-
-
Podack, E.R.1
Tschopp, J.2
-
27
-
-
0001041396
-
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules
-
Podack E.R., Young J.D., and Cohn Z.A. Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc. Natl. Acad. Sci. USA 82 (1985) 8629-8633
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 8629-8633
-
-
Podack, E.R.1
Young, J.D.2
Cohn, Z.A.3
-
28
-
-
34548666167
-
A common fold mediates vertebrate defense and bacterial attack
-
Rosado C.J., Buckle A.M., Law R.H., Butcher R.E., Kan W.T., Bird C.H., Ung K., Browne K.A., Baran K., Bashtannyk-Puhalovich T.A., et al. A common fold mediates vertebrate defense and bacterial attack. Science 317 (2007) 1548-1551
-
(2007)
Science
, vol.317
, pp. 1548-1551
-
-
Rosado, C.J.1
Buckle, A.M.2
Law, R.H.3
Butcher, R.E.4
Kan, W.T.5
Bird, C.H.6
Ung, K.7
Browne, K.A.8
Baran, K.9
Bashtannyk-Puhalovich, T.A.10
-
29
-
-
48749111836
-
The MACPF/CDC family of pore forming toxins
-
Rosado C.J., Kondos S., Bull T.E., Kuiper M.J., Law R.H.P., Buckle A.M., Voskoboinik I., Bird P.I., Trapani J.A., Whisstock J.C., and Dunstone M.A. The MACPF/CDC family of pore forming toxins. Cell. Microbiol. 10 (2008) 1765-1774
-
(2008)
Cell. Microbiol.
, vol.10
, pp. 1765-1774
-
-
Rosado, C.J.1
Kondos, S.2
Bull, T.E.3
Kuiper, M.J.4
Law, R.H.P.5
Buckle, A.M.6
Voskoboinik, I.7
Bird, P.I.8
Trapani, J.A.9
Whisstock, J.C.10
Dunstone, M.A.11
-
30
-
-
0030666371
-
Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
-
Rossjohn J., Feil S.C., McKinstry W.J., Tweten R.K., and Parker M.W. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell 89 (1997) 685-692
-
(1997)
Cell
, vol.89
, pp. 685-692
-
-
Rossjohn, J.1
Feil, S.C.2
McKinstry, W.J.3
Tweten, R.K.4
Parker, M.W.5
-
31
-
-
0030892138
-
Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization
-
Shi L., Mai S., Israels S., Browne K., Trapani J.A., and Greenberg A.H. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization. J. Exp. Med. 185 (1997) 855-866
-
(1997)
J. Exp. Med.
, vol.185
, pp. 855-866
-
-
Shi, L.1
Mai, S.2
Israels, S.3
Browne, K.4
Trapani, J.A.5
Greenberg, A.H.6
-
32
-
-
0023693490
-
Homology of perforin to the ninth component of complement (C9)
-
Shinkai Y., Takio K., and Okumura K. Homology of perforin to the ninth component of complement (C9). Nature 334 (1988) 525-527
-
(1988)
Nature
, vol.334
, pp. 525-527
-
-
Shinkai, Y.1
Takio, K.2
Okumura, K.3
-
33
-
-
0025973806
-
A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene
-
Shiver J.W., and Henkart P.A. A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene. Cell 64 (1991) 1175-1181
-
(1991)
Cell
, vol.64
, pp. 1175-1181
-
-
Shiver, J.W.1
Henkart, P.A.2
-
34
-
-
43049094015
-
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
-
Slade D.J., Lovelace L.L., Chruszcz M., Minor W., Lebioda L., and Sodetz J.M. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. J. Mol. Biol. 379 (2008) 331-342
-
(2008)
J. Mol. Biol.
, vol.379
, pp. 331-342
-
-
Slade, D.J.1
Lovelace, L.L.2
Chruszcz, M.3
Minor, W.4
Lebioda, L.5
Sodetz, J.M.6
-
35
-
-
0033520970
-
Perforin gene defects in familial hemophagocytic lymphohistiocytosis
-
Stepp S.E., Dufourcq-Lagelouse R., Le Deist F., Bhawan S., Certain S., Mathew P.A., Henter J.I., Bennett M., Fischer A., de Saint Basile G., and Kumar V. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286 (1999) 1957-1959
-
(1999)
Science
, vol.286
, pp. 1957-1959
-
-
Stepp, S.E.1
Dufourcq-Lagelouse, R.2
Le Deist, F.3
Bhawan, S.4
Certain, S.5
Mathew, P.A.6
Henter, J.I.7
Bennett, M.8
Fischer, A.9
de Saint Basile, G.10
Kumar, V.11
-
37
-
-
39749189017
-
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules
-
Sutton V.R., Waterhouse N.J., Baran K., Browne K., Voskoboinik I., and Trapani J.A. Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods 44 (2008) 241-249
-
(2008)
Methods
, vol.44
, pp. 241-249
-
-
Sutton, V.R.1
Waterhouse, N.J.2
Baran, K.3
Browne, K.4
Voskoboinik, I.5
Trapani, J.A.6
-
38
-
-
17444405610
-
Structural basis of pore formation by the bacterial toxin pneumolysin
-
Tilley S.J., Orlova E.V., Gilbert R.J., Andrew P.W., and Saibil H.R. Structural basis of pore formation by the bacterial toxin pneumolysin. Cell 121 (2005) 247-256
-
(2005)
Cell
, vol.121
, pp. 247-256
-
-
Tilley, S.J.1
Orlova, E.V.2
Gilbert, R.J.3
Andrew, P.W.4
Saibil, H.R.5
-
39
-
-
0031899584
-
Dual mechanisms of apoptosis induction by cytotoxic lymphocytes
-
Trapani J.A. Dual mechanisms of apoptosis induction by cytotoxic lymphocytes. Int. Rev. Cytol. 182 (1998) 111-192
-
(1998)
Int. Rev. Cytol.
, vol.182
, pp. 111-192
-
-
Trapani, J.A.1
-
40
-
-
0037455545
-
A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death
-
Trapani J.A., Sutton V.R., Thia K.Y., Li Y.Q., Froelich C.J., Jans D.A., Sandrin M.S., and Browne K.A. A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell Biol. 160 (2003) 223-233
-
(2003)
J. Cell Biol.
, vol.160
, pp. 223-233
-
-
Trapani, J.A.1
Sutton, V.R.2
Thia, K.Y.3
Li, Y.Q.4
Froelich, C.J.5
Jans, D.A.6
Sandrin, M.S.7
Browne, K.A.8
-
41
-
-
0022466507
-
Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis
-
Tschopp J., Masson D., and Stanley K.K. Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis. Nature 322 (1986) 831-834
-
(1986)
Nature
, vol.322
, pp. 831-834
-
-
Tschopp, J.1
Masson, D.2
Stanley, K.K.3
-
42
-
-
0031464539
-
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain
-
Uellner R., Zvelebil M.J., Hopkins J., Jones J., MacDougall L.K., Morgan B.P., Podack E., Waterfield M.D., and Griffiths G.M. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. EMBO J. 16 (1997) 7287-7296
-
(1997)
EMBO J.
, vol.16
, pp. 7287-7296
-
-
Uellner, R.1
Zvelebil, M.J.2
Hopkins, J.3
Jones, J.4
MacDougall, L.K.5
Morgan, B.P.6
Podack, E.7
Waterfield, M.D.8
Griffiths, G.M.9
-
43
-
-
4644319653
-
The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene
-
Voskoboinik I., Thia M.C., De Bono A., Browne K., Cretney E., Jackson J.T., Darcy P.K., Jane S.M., Smyth M.J., and Trapani J.A. The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J. Exp. Med. 200 (2004) 811-816
-
(2004)
J. Exp. Med.
, vol.200
, pp. 811-816
-
-
Voskoboinik, I.1
Thia, M.C.2
De Bono, A.3
Browne, K.4
Cretney, E.5
Jackson, J.T.6
Darcy, P.K.7
Jane, S.M.8
Smyth, M.J.9
Trapani, J.A.10
-
44
-
-
14844321553
-
Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491
-
Voskoboinik I., Thia M.C., Fletcher J., Ciccone A., Browne K., Smyth M.J., and Trapani J.A. Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. J. Biol. Chem. 280 (2005) 8426-8434
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8426-8434
-
-
Voskoboinik, I.1
Thia, M.C.2
Fletcher, J.3
Ciccone, A.4
Browne, K.5
Smyth, M.J.6
Trapani, J.A.7
-
45
-
-
19344369831
-
A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis
-
Voskoboinik I., Thia M.C., and Trapani J.A. A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood 105 (2005) 4700-4706
-
(2005)
Blood
, vol.105
, pp. 4700-4706
-
-
Voskoboinik, I.1
Thia, M.C.2
Trapani, J.A.3
-
46
-
-
33845199637
-
Perforin-mediated target-cell death and immune homeostasis
-
Voskoboinik I., Smyth M.J., and Trapani J.A. Perforin-mediated target-cell death and immune homeostasis. Nat. Rev. Immunol. 6 (2006) 940-952
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 940-952
-
-
Voskoboinik, I.1
Smyth, M.J.2
Trapani, J.A.3
-
47
-
-
34548038182
-
Perforin activity and immune homeostasis: The common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function
-
Voskoboinik I., Sutton V.R., Ciccone A., House C.M., Chia J., Darcy P.K., Yagita H., and Trapani J.A. Perforin activity and immune homeostasis: The common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood 110 (2007) 1184-1190
-
(2007)
Blood
, vol.110
, pp. 1184-1190
-
-
Voskoboinik, I.1
Sutton, V.R.2
Ciccone, A.3
House, C.M.4
Chia, J.5
Darcy, P.K.6
Yagita, H.7
Trapani, J.A.8
-
48
-
-
0029808909
-
Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met→Arg)-thrombin, alpha 1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
-
Whisstock J., Lesk A.M., and Carrell R. Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met→Arg)-thrombin, alpha 1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase. Proteins 26 (1996) 288-303
-
(1996)
Proteins
, vol.26
, pp. 288-303
-
-
Whisstock, J.1
Lesk, A.M.2
Carrell, R.3
-
49
-
-
0022444350
-
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities
-
Young J.D., Cohn Z.A., and Podack E.R. The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities. Science 233 (1986) 184-190
-
(1986)
Science
, vol.233
, pp. 184-190
-
-
Young, J.D.1
Cohn, Z.A.2
Podack, E.R.3
-
50
-
-
0022494081
-
Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules
-
Young J.D., Podack E.R., and Cohn Z.A. Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules. J. Exp. Med. 164 (1986) 144-155
-
(1986)
J. Exp. Med.
, vol.164
, pp. 144-155
-
-
Young, J.D.1
Podack, E.R.2
Cohn, Z.A.3
|