Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Journal of Experimental Medicine

Volumn 212, Issue 3, 2015, Pages 307-317

  Jenkins, Misty R ^a,b   Rudd Schmidt, Jesse A ^a,b   Lopez, Jamie A ^a,b   Ramsbottom, Kelly M ^a,b   Mannering, Stuart I ^b,c   Andrews, Daniel M ^b   Voskoboinik, Ilia ^a,b   Trapani, Joseph A ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; PERFORIN; TUMOR NECROSIS FACTOR; CYTOKINE; GRANZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CALCIUM SIGNALING; CELL ACTIVATION; CELL KILLING; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE STORM; CYTOTOXIC T LYMPHOCYTE; DEATH; FEMALE; HEMOPHAGOCYTIC SYNDROME; HUMAN; HUMAN CELL; LYMPHOCYTE; MICROSCOPY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; SYNAPSE; TARGET CELL; WILD TYPE; ANIMAL; C57BL MOUSE; CELL SURVIVAL; GENETICS; MACROPHAGE; METABOLISM; SECRETION (PROCESS); TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; CALCIUM SIGNALING; CASPASES; CELL SURVIVAL; CYTOKINES; FEMALE; GRANZYMES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-6; KILLER CELLS, NATURAL; MACROPHAGES; MICE, INBRED C57BL; MICE, TRANSGENIC; PERFORIN; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS;

EID: 84924707453     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20140964     Document Type: Article

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