Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

Nature Immunology

Volumn 12, Issue 8, 2011, Pages 770-777

  Thiery, Jerome ^a,b   Keefe, Dennis ^a,b   Boulant, Steeve ^a,b   Boucrot, Emmanuel ^a,b   Walch, Michael ^a,b   Martinvalet, Denis ^a,b,c   Goping, Ing Swie ^d   Bleackley, R Chris ^d   Kirchhausen, Tomas ^a,b   Lieberman, Judy ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; PERFORIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CHANNEL GATING; CYTOSOL; ENDOCYTOSIS; ENDOSOME; ENZYME RELEASE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TARGET CELL;

AMMONIUM CHLORIDE; ANIMALS; APOPTOSIS; CELL MEMBRANE; CYTOSOL; ENDOCYTOSIS; ENDOSOMES; FLOW CYTOMETRY; GRANZYMES; HELA CELLS; HUMANS; KILLER CELLS, NATURAL; MACROLIDES; MICROSCOPY, CONFOCAL; MICROSCOPY, VIDEO; PORE FORMING CYTOTOXIC PROTEINS; RATS;

EID: 80052035441     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2050     Document Type: Article

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