An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 15, 2013, Pages 6073-6078

  Bertrand, Florie ^a,b,c   Müller, Sabina ^a,b,c   Roh, Kyung Ho ^d   Laurent, Camille ^a,b,c   Dupré, Loïc ^a,b,c   Valitutti, Salvatore ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c Laboratoire d'Excellence Toulouse Cancer TOUCAN   (France)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunological synapse; Protein kinase C ; Signal transduction; T cell antigen receptor

Indexed keywords

ARTICLE; CELL CONTACT; CELL GRANULE; CELL STIMULATION; CELLULAR DISTRIBUTION; CELLULAR SECRETION; CENTROSOME; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROTUBULE ASSEMBLY; POLARIZATION; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; SYNAPSE; TARGET CELL;

CELL POLARITY; CENTROSOME; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HUMANS; IMMUNOLOGICAL SYNAPSES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ORGANIZING CENTER; MICROTUBULES; PROTEIN KINASE C; SECRETORY VESICLES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS;

EID: 84876061817     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218640110     Document Type: Article

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