-
1
-
-
19544371373
-
Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
-
Capecchi, M. R. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6, 507-512 (2005).
-
(2005)
Nat Rev Genet
, vol.6
, pp. 507-512
-
-
Capecchi, M.R.1
-
2
-
-
84879264708
-
ZFN TALEN CRISPR/Cas-based methods for genome engineering
-
Gaj, T., Gersbach, C. A. & Barbas, C. F. 3rd ZFN, TALEN, CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 31, 397-405 (2013).
-
(2013)
Trends Biotechnol
, vol.31
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas, C.F.3
-
3
-
-
84898778301
-
A guide to genome engineering with programmable nucleases
-
Kim, H. & Kim, J. S. A guide to genome engineering with programmable nucleases. Nat Rev Genet 15, 321-334 (2014).
-
(2014)
Nat Rev Genet
, vol.15
, pp. 321-334
-
-
Kim, H.1
Kim, J.S.2
-
4
-
-
84897594300
-
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
-
Hai, T., Teng, F., Guo, R., Li, W. & Zhou, Q. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res 24, 372-375 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 372-375
-
-
Hai, T.1
Teng, F.2
Guo, R.3
Li, W.4
Zhou, Q.5
-
5
-
-
84867911474
-
Efficient TALEN-mediated gene knockout in livestock
-
Carlson, D. F. et al. Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci USA 109, 17382-17387 (2012).
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 17382-17387
-
-
Carlson, D.F.1
-
6
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
-
7
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang, H. et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 154, 1370-1379 (2013).
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
-
8
-
-
77957005768
-
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
-
Meyer, M., de Angelis, M. H., Wurst, W. & Kuhn, R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA 107, 15022-15026 (2010).
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15022-15026
-
-
Meyer, M.1
De Angelis, M.H.2
Wurst, W.3
Kuhn, R.4
-
9
-
-
84878826580
-
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases
-
Qiu, Z. et al. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res 41, e120 (2013).
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e120
-
-
Qiu, Z.1
-
10
-
-
84894081986
-
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
-
Niu, Y. et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156, 836-843 (2014).
-
(2014)
Cell
, vol.156
, pp. 836-843
-
-
Niu, Y.1
-
11
-
-
84891745242
-
Generating rats with conditional alleles using CRISPR/Cas9
-
Ma, Y. et al. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res 24, 122-125 (2014).
-
(2014)
Cell Res
, vol.24
, pp. 122-125
-
-
Ma, Y.1
-
12
-
-
84907200149
-
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
-
Long, C. et al. Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA. Science (2014).
-
(2014)
Science
-
-
Long, C.1
-
13
-
-
84900314611
-
CRISPR-Cas systems for editing, regulating and targeting genomes
-
Sander, J. D. & Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32, 347-355 (2014).
-
(2014)
Nat Biotechnol
, vol.32
, pp. 347-355
-
-
Sander, J.D.1
Joung, J.K.2
-
14
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012).
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
15
-
-
77249170201
-
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
-
Marraffini, L. A. & Sontheimer, E. J. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet 11, 181-190 (2010).
-
(2010)
Nat Rev Genet
, vol.11
, pp. 181-190
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
16
-
-
74249095519
-
CRISPR/Cas, the immune system of bacteria and archaea
-
Horvath, P. & Barrangou, R. CRISPR/Cas, the immune system of bacteria and archaea. Science 327, 167-170 (2010).
-
(2010)
Science
, vol.327
, pp. 167-170
-
-
Horvath, P.1
Barrangou, R.2
-
17
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
18
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
-
(2013)
ELife
, vol.2
, pp. e00471
-
-
Jinek, M.1
-
19
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
20
-
-
84883819602
-
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
-
Li, D. et al. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat Biotechnol 31, 681-683 (2013).
-
(2013)
Nat Biotechnol
, vol.31
, pp. 681-683
-
-
Li, D.1
-
21
-
-
84879949311
-
Heritable and precise zebrafish genome editing using a CRISPR-Cas system
-
Hwang, W. Y. et al. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS One 8, e68708 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e68708
-
-
Hwang, W.Y.1
-
22
-
-
84883779087
-
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
-
Li, W., Teng, F., Li, T. & Zhou, Q. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol 31, 684-686 (2013).
-
(2013)
Nat Biotechnol
, vol.31
, pp. 684-686
-
-
Li, W.1
Teng, F.2
Li, T.3
Zhou, Q.4
-
23
-
-
84936765320
-
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
-
Chen, Y. et al. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet 24, 3764-3774 (2015).
-
(2015)
Hum Mol Genet
, vol.24
, pp. 3764-3774
-
-
Chen, Y.1
-
24
-
-
84959212853
-
CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH
-
Kang, Y. et al. CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Human molecular genetics 24, 7255-7264 (2015).
-
(2015)
Human Molecular Genetics
, vol.24
, pp. 7255-7264
-
-
Kang, Y.1
-
25
-
-
84975678715
-
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
-
Zetsche, B. et al. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System. Cell 163, 759-771 (2015).
-
(2015)
Cell
, vol.163
, pp. 759-771
-
-
Zetsche, B.1
-
26
-
-
84884663630
-
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
-
Hou, Z. et al. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci USA 110, 15644-15649 (2013).
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 15644-15649
-
-
Hou, Z.1
-
27
-
-
84936765320
-
Functional disruption of the dystrophin gene in Rhesus Monkey Using CRISPR/Cas9
-
Chen, Y. et al. Functional disruption of the dystrophin gene in Rhesus Monkey Using CRISPR/Cas9. Hum Mol Genet (2015).
-
(2015)
Hum Mol Genet
-
-
Chen, Y.1
-
28
-
-
84940368054
-
Crystal Structure of Staphylococcus aureus Cas9
-
Nishimasu, H. et al. Crystal Structure of Staphylococcus aureus Cas9. Cell 162, 1113-1126 (2015).
-
(2015)
Cell
, vol.162
, pp. 1113-1126
-
-
Nishimasu, H.1
-
29
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran, F. A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-191 (2015).
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
-
30
-
-
84928895314
-
Staphylococcus aureus skin infection recurrences among household members: An examination of host, behavioral, pathogen-level predictors
-
Miller, L. G. et al. Staphylococcus aureus skin infection recurrences among household members: an examination of host, behavioral, pathogen-level predictors. Clin Infect Dis 60, 753-763 (2015).
-
(2015)
Clin Infect Dis
, vol.60
, pp. 753-763
-
-
Miller, L.G.1
-
31
-
-
84949791988
-
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
-
Kleinstiver, B. P. et al. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat Biotechnol (2015).
-
(2015)
Nat Biotechnol
-
-
Kleinstiver, B.P.1
-
32
-
-
84905732049
-
Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes
-
Yen, S. T. et al. Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes. Dev Biol 393, 3-9 (2014).
-
(2014)
Dev Biol
, vol.393
, pp. 3-9
-
-
Yen, S.T.1
-
33
-
-
84947714470
-
Characterization of Staphylococcus aureus Cas9: A smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
-
Friedland, A. E. et al. Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. Genome Biol 16, 257 (2015).
-
(2015)
Genome Biol
, vol.16
, pp. 257
-
-
Friedland, A.E.1
-
34
-
-
84920867879
-
A mouse geneticist's practical guide to CRISPR applications
-
Singh, P., Schimenti, J. C. & Bolcun-Filas, E. A mouse geneticist's practical guide to CRISPR applications. Genetics 199, 1-15 (2015).
-
(2015)
Genetics
, vol.199
, pp. 1-15
-
-
Singh, P.1
Schimenti, J.C.2
Bolcun-Filas, E.3
-
35
-
-
84922258547
-
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system
-
Wan, H. et al. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res 25, 258-261 (2015).
-
(2015)
Cell Res
, vol.25
, pp. 258-261
-
-
Wan, H.1
-
36
-
-
84962641038
-
Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
-
Kang, X. et al. Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing. J Assist Reprod Genet (2016).
-
(2016)
J Assist Reprod Genet
-
-
Kang, X.1
-
37
-
-
84930618439
-
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
-
Liang, P. et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & cell 6, 363-372 (2015).
-
(2015)
Protein & Cell
, vol.6
, pp. 363-372
-
-
Liang, P.1
-
38
-
-
84956929136
-
UK scientists gain licence to edit genes in human embryos
-
Callaway, E. UK scientists gain licence to edit genes in human embryos. Nature 530, 18 (2016).
-
(2016)
Nature
, vol.530
, pp. 18
-
-
Callaway, E.1
-
39
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol 33, 510-517 (2015).
-
(2015)
Nat Biotechnol
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
-
40
-
-
84885180675
-
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
-
Cheng, A. W. et al. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res 23, 1163-1171 (2013).
-
(2013)
Cell Res
, vol.23
, pp. 1163-1171
-
-
Cheng, A.W.1
-
41
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L. A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-451 (2013).
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
42
-
-
84979034770
-
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
-
Vojta, A. et al. Repurposing the CRISPR-Cas9 system for targeted DNA methylation. Nucleic Acids Res (2016).
-
(2016)
Nucleic Acids Res
-
-
Vojta, A.1
-
43
-
-
84954474813
-
Rationally engineered Cas9 nucleases with improved specificity
-
Slaymaker, I. M. et al. Rationally engineered Cas9 nucleases with improved specificity. Science (2015).
-
(2015)
Science
-
-
Slaymaker, I.M.1
-
44
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran, F. A. et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389 (2013).
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
45
-
-
84877103949
-
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
-
Shen, B. et al. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res 23, 720-723 (2013).
-
(2013)
Cell Res
, vol.23
, pp. 720-723
-
-
Shen, B.1
-
46
-
-
84963941043
-
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
-
Kleinstiver, B. P. et al. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature (2016).
-
(2016)
Nature
-
-
Kleinstiver, B.P.1
|