Characterization of Staphylococcus aureus Cas9: A smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Friedland, Ari E ^a   Baral, Reshica ^a   Singhal, Pankhuri ^a   Loveluck, Katherine ^a   Shen, Shen ^a   Sanchez, Minerva ^a   Marco, Eugenio ^a   Gotta, Gregory M ^a   Maeder, Morgan L ^a   Kennedy, Edward M ^b   Kornepati, Anand V R ^b   Sousa, Alexander ^a   Collins, McKensie A ^a   Jayaram, Hari ^a   Cullen, Bryan R ^b   Bumcrot, David ^a  

^a EDITAS MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adeno associated virus; Cas9; CRISPR; Genome engineering; GUIDE seq; Nickases; Staphylococcus aureus

Indexed keywords

AMINO ACID NUCLEASE; CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; ENZYME; GUIDE RNA; NICKASE; NUCLEASE; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE I; ENDONUCLEASE;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA SEQUENCE; ENZYME ACTIVITY; GENOMICS; HUMAN; HUMAN CELL; NONHUMAN; PROTOSPACER ADJACENT MOTIF; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; DEPENDOPARVOVIRUS; GENE TRANSFER; GENETIC ENGINEERING; GENETICS; METABOLISM; RNA EDITING;

BACTERIAL PROTEINS; CRISPR-CAS SYSTEMS; DEOXYRIBONUCLEASE I; DEPENDOVIRUS; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; RNA EDITING; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

EID: 84947714470     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0817-8     Document Type: Article

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