Exploring the role of the HNF-1α G319S polymorphism in β cell failure and youth-onset type 2 diabetes: Lessons from MODY and Hnf-1α -deficient animal models1

Biochemistry and Cell Biology

Volumn 93, Issue 5, 2015, Pages 487-494

  Jonasson, Michael E ^a   Wicklow, Brandy A ^a   Sellers, Elizabeth A C ^a   Dolinsky, Vernon W ^a   Doucette, Christine A ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b CHILDREN S HOSPITAL RESEARCH INSTITUTE OF MANITOBA   (Canada)

Author keywords

HNF 1 ; Insulin; Youth onset type 2 diabetes; cell

Indexed keywords

AMINO ACIDS; CYTOLOGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES; INSULIN;

BETA CELL FUNCTIONS; HEPATOCYTE NUCLEAR FACTORS; INSULIN RESISTANCE; INSULIN SECRETION; MATURITY-ONSET DIABETES OF THE YOUNG; MITOCHONDRIAL FUNCTION; PLASMA INSULIN LEVELS; TYPE-2 DIABETES;

CELLS;

GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INSULIN;

ADOLESCENT DISEASE; CELL GROWTH; CELL PROLIFERATION; CHILDHOOD DISEASE; DISEASE ASSOCIATION; ENVIRONMENTAL STRESS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLYCOLYSIS; GROWTH INHIBITION; HEREDITY; HUMAN; HYPERGLYCEMIA; INDIGENOUS PEOPLE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MANITOBA; MATURITY ONSET DIABETES MELLITUS OF THE YOUNG TYPE 3; METABOLIC INHIBITION; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONSET AGE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET DISEASE; PHENOTYPE; PREVALENCE; PROTEIN DEPLETION; REVIEW; SECRETORY PATHWAY; ANIMAL; CANADA; DEFICIENCY; DISEASE MODEL; GENETICS; METABOLISM; MUTATION;

ANIMALS; CANADA; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; INSULIN-SECRETING CELLS; MUTATION; POLYMORPHISM, GENETIC;

EID: 84984917516     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2015-0021     Document Type: Review

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