Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells

Biochemical and Biophysical Research Communications

Volumn 425, Issue 3, 2012, Pages 619-624

  Ohki, Tsuyoshi ^a,b   Sato, Yoshifumi ^a   Yoshizawa, Tatsuya ^a   Yamamura, Ken Ichi ^a   Yamada, Kentaro ^b   Yamagata, Kazuya ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetes mellitus; HGF; HNF1 ; Pancreatic cell; Transcription factor

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1ALPHA; SCATTER FACTOR; SERINE PROTEINASE; SERINE PROTEINASE HGFAC; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; HGFAC GENE; INSULIN RELEASE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELL LINE; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; INSULIN-SECRETING CELLS; MICE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES;

MUS;

EID: 84865563190     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.134     Document Type: Article

References (22)

1. Mendel D.B., Crabtree G.R. HNF-1, a member of a novel class of dimerizing homeodomain proteins. J. Biol. Chem. 1991, 266:677-680.
2. Nammo T., Yamagata K., Hamaoka R., Zhu Q., Akiyama T., Gonzalez F., Miyagawa J., Matsuzawa Y. Expression profile of MODY3/HNF-1α protein in the developing mouse pancreas. Diabetologia 2002, 45:1142-1153.
3. Frain M., Swart G., Monaci P., Nicosia A., Stilmpfli S., Frank R., Cortese R. The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 1989, 59:145-157.
4. Yamagata K., Oda N., Kaisaki P.J., Menzel S., Furuta H., Vaxillaire M., Southam L., Cox R.D., Lathrop G.M., Boriraj V.V., Chen X., Cox N.J., Oda Y., Yano H., Le Beau M.M., Yamada S., Nishigori H., Takeda J., Fajans S.S., Hattersleystar A.T., Iwasaki N., Hansen T., Pedersen O., Polonsky K.S., Turner R.C., Velho G., Chèvreparallel J-C., Froguel P., Bell G.I. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 1996, 384:455-458.
5. Byrne M.M., Sturis J., Menzel S., Yamagata K., Fajans S.S., Dronsfield M.J., Bain S.C., Hattersley A.T., Velho G., Froguel P., Bell G.I., Polonsky K.S. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 1996, 45:1503-1510.
6. Pontoglio M., Sreenan S., Roe M., Pugh W., Ostrega D., Doyen A., Pick A.J., Baldwin A., Velho G., Froguel P., Levisetti M., Bonner-Weir S., Bell G.I., Yaniv M., Polonsky K.S. Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice. J. Clin. Invest. 1998, 101:2215-2222.
7. Yamagata K., Nammo T., Moriwaki M., Ihara A., Iizuka K., Yang Q., Satoh T., Li M., Uenaka R., Okita K., Iwahashi H., Zhu Q., Cao Y., Imagawa A., Tochino Y., Hanafusa T., Miyagawa J., Matsuzawa Y. Mutant hepatocyte nuclear factor-1α in pancreatic β-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced β-cell proliferation, and diabetes. Diabetes 2002, 51:114-123.
8. Yamagata K., Yang Q., Yamamoto K., Iwahashi H., Miyagawa J., Okita K., Yoshiuchi I., Miyazaki J., Noguchi T., Nakajima H., Namba M., Hanafusa T., Matsuzawa Y. Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative. Diabetes 1998, 47:1231-1235.
9. Wang H., Maechler P., Hagenfeldt K.A., Wollheim C.B. Dominant-negative suppression of HNF-1α function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic β-cell line. EMBO J. 1998, 17:6701-6713.
10. Boj S.F., Parrizas M., Maestro M.A., Ferrer J. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc. Natl. Acad. Sci. USA 2001, 98:14481-14486.
11. Fukui K., Yang Q., Cao Y., Takahashi N., Atakeyama H.H., Wang H., Wada J., Zhang Y., Marselli L., Nammo T., Yoneda K., Onishi M., Higashiyama S., Matsuzawa Y., Gonzalez F.J., Weir G.C., Kasai H., Shimomura I., Miyagawa J., Wollheim C.B., Yamagata K. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005, 2:373-384.
12. Akpinar P., Kuwajima S., Krützfeldt J., Stoffel M. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab. 2005, 2:385-397.
13. Servitja J.M., Pignatelli M., Maestro M.A., Cardalda C., Boj S.F., Lozano J., Blanco E., Lafuente A., McCarthy M.I., Sumoy L., Guigó R., Ferrer J. Hnf1α (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol. Cell Biol. 2009, 29:2945-2959.
14. Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010, 277:2208-2214.
15. Miyazaki J., Araki K., Yamato E., Ikegami H., Asano T., Shibasaki Y., Oka Y., Yamamura K. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 1990, 127:126-132.
16. Kitamura T., Koshino Y., Shibata F., Oki T., Nakajima H., Nosaka T., Kumagai H. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 2003, 31:1007-1014.
17. Sato Y., Hatta M., Karim M.F., Sawa T., Wei F.Y., Sato S., Magnuson M.A., Gonzalez F.J., Tomizawa K., Akaike T., Yoshizawa T., Yamagata K. Anks4b, a novel target of HNF4α protein interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. J. Biol. Chem. 2012, 287:23236-23245.
18. Boj S.F., Petrov D., Ferrer J. Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1α and Hnf4α. PLoS Genetics 2010, 6:e1000970.
19. Nakamura T., Nishizawa T., Hagiya M., Seki T., Shimonishi M., Sugimura A., Tashiro K., Shimizu S. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989, 342:440-443.
20. Garcia-Ocaña A., Takane K.K., Syed M.A., Philbrick W.M., Vasavada R.C., Stewart A.F. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J. Biol. Chem. 2000, 275:1226-1232.
21. Mellado-Gil J., Rosa T.C., Demirci C., Gonzalez-Pertusa J.A., Velazquez-Garcia S., Ernst S., Valle S., Vasavada R.C., Stewart A.F., Alonso L.C., Garcia-Ocaña A. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes 2011, 60:525-536.
22. Demirci C., Ernst S., Alvarez-Perez J.C., Rosa T., Valle S., Shridhar V., Casinelli G.P., Alonso L.C., Vasavada R.C., García-Ocana A. Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes 2012, 61:1143-1152.