Dominant-negative suppression of HNF-1α function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic β-cell line

EMBO Journal

Volumn 17, Issue 22, 1998, Pages 6701-6713

  Wang, Haiyan ^a   Maechler, Pierre ^a   Hagenfeldt, Kerstin A ^a   Wollheim, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

HNF1 ; Insulin secretion; Insulin transcription; Mitochondria; MODY3

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; NUCLEAR FACTOR I; PYRUVATE KINASE;

ARTICLE; CELL LINE; CELL MEMBRANE POTENTIAL; GENE MUTATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; INSULIN METABOLISM; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MITOCHONDRIAL RESPIRATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; BINDING SITES; CALCIUM; CELL LINE; CELL MEMBRANE; DNA PRIMERS; DNA-BINDING PROTEINS; DOWN-REGULATION; GENES, DOMINANT; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; INSULIN; ISLETS OF LANGERHANS; LEUCINE; MEMBRANE POTENTIALS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032538883     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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