Hepatocyte growth factor activator (HGFA): A serine protease that links tissue injury to activation of hepatocyte growth factor

FEBS Journal

Volumn 277, Issue 10, 2010, Pages 2208-2214

  Miyazawa, Keiji ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Hepatocyte growth factor; Plasminogen; Proteolytic activation; Tissue injury

Indexed keywords

GROWTH FACTOR; HEPATOCYTE GROWTH FACTOR ACTIVATOR; PLASMINOGEN; SCATTER FACTOR; SERINE PROTEINASE; UNCLASSIFIED DRUG;

APOPTOSIS; BLOOD CLOTTING; CELL ADHESION; CELL MOTILITY; CELL PROLIFERATION; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; EPITHELIUM CELL; FIBRINOLYSIS; HOMEOSTASIS; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; TARGET CELL; TISSUE INJURY; TISSUE REGENERATION; TISSUE REPAIR;

ANIMALS; BLOOD COAGULATION; HEPATOCYTE GROWTH FACTOR; HUMANS; REGENERATION; SERINE ENDOPEPTIDASES;

EID: 77951720366     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07637.x     Document Type: Short Survey

References (37)

1. Plasminogen-related Growth Factors (Chiba Foundation Symposium 212 Bock GR Goode JA, eds 1997) Wiley
2. Okajima A, Miyazawa K Kitamura N (1990) Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury. Eur J Biochem 193, 375 381.
3. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S Daikuhara Y (1988) Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J Clin Invest 81, 414 419.
4. Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K et al. (1989) Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun 163, 967 973.
5. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K Shimizu S (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342, 440 443.
6. Miyazawa K, Kitamura A, Naka D Kitamura N (1991) An alternatively processed mRNA generated from human hepatocyte growth factor gene. Eur J Biochem 197, 15 22.
7. Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T Kitamura N (1992) Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J Biol Chem 267, 20114 20119.
8. Lokker NA, Mark MR, Luis EA, Bennett GL, Robbins KA, Baker JB Godowski PJ (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J 11, 2503 2510.
9. Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari MT, Billeci KL, Maun HR, Moran P, Santell L, Wiesmann C et al. (2004) Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in Met binding and signaling. J Biol Chem 279, 39915 39924.
10. Kirchhofer D, Lipari MT, Santell L, Billeci K, Maun HR, Sandoval WN, Moran P, Ridgway J, Eigenbrot C Lazarus RA (2007) Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist. Proc Natl Acad Sci USA 104, 5306 5311.
11. Miyazawa K, Shimomura T, Naka D Kitamura N (1994) Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 269, 8966 8970.
12. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y Kitamura N (1993) Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. J Biol Chem 268, 10024 10028.
13. Miyazawa K, Wang Y, Minoshima S, Shimizu N Kitamura N (1998) Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene. Phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. Eur J Biochem 258, 355 361.
14. Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeier W, Daikuhara Y, Tsubouchi H, Blasi F Comoglio PM (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11, 4825 4833.
15. Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y Kitamura N (1995) Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem 229, 257 261.
16. Peek M, Moran P, Mendoza N, Wickramasinghe D Kirchhofer D (2002) Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa. J Biol Chem 277, 47804 47809.
17. Lee SL, Dickson RB Lin CY (2000) Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem 275, 36720 36725.
18. Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B Moran P (2005) Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett 579, 1945 1950.
19. Itoh H, Naganuma S, Takeda N, Miyata S, Uchinokura S, Fukushima T, Uchiyama S, Tanaka H, Nagaike K, Shimormura T et al. (2004) Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Gastroenterology 127, 1423 1435.
20. Kataoka H Kawaguchi M (2010) Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo. FEBS J 277, 2230 2237.
21. Okajima A, Miyazawa K, Naito Y, Inoue K Kitamura N (1997) Induction of hepatocyte growth factor activator mRNA in the liver following tissue injury and acute inflammation. Hepatology 25, 97 102.
22. Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y Kitamura N (1993) Activation of the zymogen of hepatocyte growth factor activator by thrombin. J Biol Chem 268, 22927 22932.
23. Miyazawa K, Shimomura T Kitamura N (1996) Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem 271, 3615 3618.
24. Busolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, Naldini L, Gaudino G, Tamagnone L, Coffer A Comoglio PM (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial motility and growth. J Cell Biol 119, 629 641.
25. Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL, Polverini P Rosen EM (1993) Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 90, 1937 1941.
26. Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T Kitamura N (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373, 702 705.
27. Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, Gherardi E Birchmeier C (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373, 699 702.
28. Morisato D Anderson KV (1994) The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76, 677 688.
29. Hartmann G, Naldini L, Weidner KM, Sachs M, Vigna E, Comoglio PM Birchmeier W (1992) A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci USA 89, 11574 11578.
30. Cioce V, Csaky KG, Chan AML, Bottaro DP, Taylor WG, Jensen R, Aaronson SA Rubin JS (1996) Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity. J Biol Chem 271, 13110 13115.
31. Kaibori M, Inoue T, Sakakura Y, Oda M, Nagahama T, Kwon AH, Kamiyama Y, Miyazawa K Okumura T (2002) Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis. J Surg Res 106, 108 114.
32. Kaibori M, Inoue T, Oda M, Naka D, Kawaguchi T, Kitamura N, Miyazawa K, Kwon AH, Kamiyama Y Okumura T (2002) Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Biochem Biophys Res Commun 290, 475 481.
33. Takayama H, LaRochelle WJ, Sabnis SG, Otsuka T Merlino G (1997) Renal tubular hyperplasia, polycystic diseases, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Lab Invest 77, 131 138.
34. Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y Kataoka H (2008) Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases. FEBS J 275, 1003 1017.
35. Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K et al. (1997) Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 272, 6370 6376.
36. Eigenbrot C, Ganesan E Kirchhofer D (2010) Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HAI-1. FEBS J 277, 2215 2222.
37. Suzuki K (2010) Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor. FEBS J 277, 2223 2229.