메뉴 건너뛰기




Volumn 310, Issue 8, 2016, Pages C629-C642

Oxygen sensing by the carotid body: Mechanisms and role in adaptation to hypoxia

Author keywords

Adaptation to hypoxia; Carotid body; Ion channels; Mitochondria; Mitochondrial complex I signaling; Oxygen sensing; Stem cells

Indexed keywords

GASOTRANSMITTER; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; ION CHANNEL; LACTIC ACID; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

EID: 84984615188     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00265.2015     Document Type: Article
Times cited : (106)

References (188)
  • 2
    • 0023937310 scopus 로고
    • Carotid sinus receptors participate in glucose homeostasis
    • Alvarez-Buylla R, de Alvarez-Buylla ER. Carotid sinus receptors participate in glucose homeostasis. Respir Physiol 72: 347–359, 1988.
    • (1988) Respir Physiol , vol.72 , pp. 347-359
    • Alvarez-Buylla, R.1    De Alvarez-Buylla, E.R.2
  • 5
    • 0017179154 scopus 로고
    • Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance
    • Arias-Stella J, Valcarcel J. Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance. Hum Pathol 7: 361–373, 1976.
    • (1976) Hum Pathol , vol.7 , pp. 361-373
    • Arias-Stella, J.1    Valcarcel, J.2
  • 7
    • 0024259862 scopus 로고
    • Measurement of carotid body blood flow in cats by use of radioactive microspheres
    • Barnett S, Mulligan E, Wagerle LC, Lahiri S. Measurement of carotid body blood flow in cats by use of radioactive microspheres. J Appl Physiol 65: 2484–2489, 1988.
    • (1988) J Appl Physiol , vol.65 , pp. 2484-2489
    • Barnett, S.1    Mulligan, E.2    Wagerle, L.C.3    Lahiri, S.4
  • 8
    • 0025087555 scopus 로고
    • + currents by dopamine in glomus cells of the carotid body
    • + currents by dopamine in glomus cells of the carotid body. Eur J Neurosci 2: 809–812, 1990.
    • (1990) Eur J Neurosci , vol.2 , pp. 809-812
    • Benot, A.R.1    Lopez-Barneo, J.2
  • 9
    • 1942453383 scopus 로고    scopus 로고
    • Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat
    • Bin-Jaliah I, Maskell PD, Kumar P. Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat. J Physiol 556: 255–266, 2004.
    • (2004) J Physiol , vol.556 , pp. 255-266
    • Bin-Jaliah, I.1    Maskell, P.D.2    Kumar, P.3
  • 11
    • 34447504549 scopus 로고    scopus 로고
    • Oxygen, a source of life and stress
    • Brahimi-Horn MC, Pouyssegur J. Oxygen, a source of life and stress. FEBS Lett 581: 3582–3591, 2007.
    • (2007) FEBS Lett , vol.581 , pp. 3582-3591
    • Brahimi-Horn, M.C.1    Pouyssegur, J.2
  • 12
    • 84862639554 scopus 로고    scopus 로고
    • Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells
    • Buckler KJ. Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells. Pflügers Arch 463: 743–754, 2012.
    • (2012) Pflügers Arch , vol.463 , pp. 743-754
    • Buckler, K.J.1
  • 13
    • 0031050606 scopus 로고    scopus 로고
    • A novel oxygen-sensitive potassium current in rat carotid body type I cells
    • Buckler KJ. A novel oxygen-sensitive potassium current in rat carotid body type I cells. J Physiol 498: 649–662, 1997.
    • (1997) J Physiol , vol.498 , pp. 649-662
    • Buckler, K.J.1
  • 14
    • 84939418128 scopus 로고    scopus 로고
    • TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing
    • Buckler KJ. TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing. Pflügers Arch 467: 1013–1025, 2015.
    • (2015) Pflügers Arch , vol.467 , pp. 1013-1025
    • Buckler, K.J.1
  • 15
    • 84880755425 scopus 로고    scopus 로고
    • Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells
    • Buckler KJ, Turner PJ. Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells. J Physiol 591: 3549–3563, 2013.
    • (2013) J Physiol , vol.591 , pp. 3549-3563
    • Buckler, K.J.1    Turner, P.J.2
  • 16
    • 0028291271 scopus 로고
    • Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells
    • Buckler KJ, Vaughan-Jones RD. Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J Physiol 476: 423–428, 1994.
    • (1994) J Physiol , vol.476 , pp. 423-428
    • Buckler, K.J.1    Vaughan-Jones, R.D.2
  • 17
    • 0042731766 scopus 로고    scopus 로고
    • Distribution of transient receptor potential channels in the rat carotid chemosensory pathway
    • Buniel MC, Schilling WP, Kunze DL. Distribution of transient receptor potential channels in the rat carotid chemosensory pathway. J Comp Neurol 464: 404–413, 2003.
    • (2003) J Comp Neurol , vol.464 , pp. 404-413
    • Buniel, M.C.1    Schilling, W.P.2    Kunze, D.L.3
  • 18
    • 84867165176 scopus 로고    scopus 로고
    • 2 sensor in a human airway chemoreceptor cell line: Biochemical, molecular, and electrophysiological evidence
    • 2 sensor in a human airway chemoreceptor cell line: biochemical, molecular, and electrophysiological evidence. Am J Physiol Lung Cell Mol Physiol 303: L598–L607, 2012.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. L598-L607
    • Buttigieg, J.1    Pan, J.2    Yeger, H.3    Cutz, E.4
  • 19
    • 34848903331 scopus 로고    scopus 로고
    • Chronic hypoxia up-regulates —1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells
    • Carabelli V, Marcantoni A, Comunanza V, de Luca A, Díaz J, Borges R, Carbone E. Chronic hypoxia up-regulates —1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells. J Physiol 584: 149–165, 2007.
    • (2007) J Physiol , vol.584 , pp. 149-165
    • Carabelli, V.1    Marcantoni, A.2    Comunanza, V.3    De Luca, A.4    Díaz, J.5    Borges, R.6    Carbone, E.7
  • 20
    • 0035947264 scopus 로고    scopus 로고
    • + conductance in rat carotid body type I cells
    • + conductance in rat carotid body type I cells. Neuroreport 12: 1421–1425, 2001.
    • (2001) Neuroreport , vol.12 , pp. 1421-1425
    • Carpenter, E.1    Peers, C.2
  • 21
    • 0032539050 scopus 로고    scopus 로고
    • Ionic currents in carotid body type I cells isolated from normoxic and chronically hypoxic adult rats
    • Carpenter E, Bee D, Peers C. Ionic currents in carotid body type I cells isolated from normoxic and chronically hypoxic adult rats. Brain Res 811: 79–87, 1998.
    • (1998) Brain Res , vol.811 , pp. 79-87
    • Carpenter, E.1    Bee, D.2    Peers, C.3
  • 22
    • 84946906811 scopus 로고    scopus 로고
    • Oxygen regulation of breathing through an olfactory receptor activated by lactate
    • Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA. Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature 527: 240–244, 2015.
    • (2015) Nature , vol.527 , pp. 240-244
    • Chang, A.J.1    Ortega, F.E.2    Riegler, J.3    Madison, D.V.4    Krasnow, M.A.5
  • 23
    • 34447570574 scopus 로고    scopus 로고
    • Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body
    • Chen J, He L, Liu X, Dinger B, Stensaas L, Fidone S. Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body. Am J Physiol Lung Cell Mol Physiol 292: L1257–L1262, 2007.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L1257-L1262
    • Chen, J.1    He, L.2    Liu, X.3    Dinger, B.4    Stensaas, L.5    Fidone, S.6
  • 24
    • 0030566634 scopus 로고    scopus 로고
    • + channels in carotid body cells of adult cats
    • + channels in carotid body cells of adult cats. Brain Res 742: 34–42, 1996.
    • (1996) Brain Res , vol.742 , pp. 34-42
    • Chou, C.L.1    Shirahata, M.2
  • 26
    • 0942287686 scopus 로고    scopus 로고
    • Hypoxia-mediated prolonged elevation of sympathetic nerve activity after periods of intermittent hypoxic apnea
    • Cutler MJ, Swift NM, Keller DM, Wasmund WL, Smith ML. Hypoxia-mediated prolonged elevation of sympathetic nerve activity after periods of intermittent hypoxic apnea. J Appl Physiol (1985) 96: 754–761, 2004.
    • (2004) J Appl Physiol (1985) , vol.96 , pp. 754-761
    • Cutler, M.J.1    Swift, N.M.2    Keller, D.M.3    Wasmund, W.L.4    Smith, M.L.5
  • 27
    • 84923304686 scopus 로고    scopus 로고
    • GDNFbased therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
    • d’Anglemont de Tassigny X, Pascual A, Lopez-Barneo J. GDNFbased therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease. Front Neuroanat 9: 10, 2015
    • (2015) Front Neuroanat , vol.9 , pp. 10
    • D’Anglemont De Tassigny, X.1    Pascual, A.2    Lopez-Barneo, J.3
  • 28
    • 84923304686 scopus 로고    scopus 로고
    • GDNF-based therapies, GDNFproducing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
    • D’ Anglemont de Tassigny, X., Pascual, A., & López-Barneo, J. (2015). GDNF-based therapies, GDNFproducing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease. Frontiers in Neuroanatomy, 9, 10. http://doi.org/10.3389/fnana.2015.00010.
    • (2015) Frontiers in Neuroanatomy , vol.9 , pp. 10
    • D’ Anglemont De Tassigny, X.1    Pascual, A.2    López-Barneo, J.3
  • 30
    • 84944496909 scopus 로고
    • Volume of blood flow of the carotid body of the cat
    • Daly MdB, Lambertsen CJ, Schweitzer A. Volume of blood flow of the carotid body of the cat. J Physiol 125: 67–89, 1954.
    • (1954) J Physiol , vol.125 , pp. 67-89
    • Daly, M.1    Lambertsen, C.J.2    Schweitzer, A.3
  • 31
    • 0024475351 scopus 로고
    • + channel in the type-I cell of the rabbit carotid body
    • + channel in the type-I cell of the rabbit carotid body. FEBS Lett 249: 195–198, 1989.
    • (1989) FEBS Lett , vol.249 , pp. 195-198
    • Delpiano, M.A.1    Hescheler, J.2
  • 32
    • 0038492596 scopus 로고    scopus 로고
    • Induction of T-type calcium channel gene expression by chronic hypoxia
    • Del Toro R, Levitsky KL, López-Barneo J, Chiara MD. Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem 278: 22316–22324, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 22316-22324
    • Del Toro, R.1    Levitsky, K.L.2    López-Barneo, J.3    Chiara, M.D.4
  • 33
    • 74949136860 scopus 로고    scopus 로고
    • O’Donnell CP. Pathophysiology of sleep apnea
    • Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP. Pathophysiology of sleep apnea. Physiol Rev 90: 47–112, 2010.
    • (2010) Physiol Rev , vol.90 , pp. 47-112
    • Dempsey, J.A.1    Veasey, S.C.2    Morgan, B.J.3
  • 35
    • 84946488819 scopus 로고    scopus 로고
    • Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction. Differential effects on neurogenesis
    • Diaz-Castro B, Pardal R, Garcia-Flores P, Sobrino V, Duran R, Piruat JI, Lopez-Barneo J. Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction. Differential effects on neurogenesis. EMBO Rep 16: 1511–1519, 2015.
    • (2015) EMBO Rep , vol.16 , pp. 1511-1519
    • Diaz-Castro, B.1    Pardal, R.2    Garcia-Flores, P.3    Sobrino, V.4    Duran, R.5    Piruat, J.I.6    Lopez-Barneo, J.7
  • 36
    • 0026703693 scopus 로고
    • Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors
    • Duchen MR, Biscoe TJ. Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. J Physiol 450: 13–31, 1992.
    • (1992) J Physiol , vol.450 , pp. 13-31
    • Duchen, M.R.1    Biscoe, T.J.2
  • 37
    • 0026767130 scopus 로고
    • + ]i in type I cells isolated from the rabbit carotid body
    • + ]i in type I cells isolated from the rabbit carotid body. J Physiol 450: 33–61, 1992.
    • (1992) J Physiol , vol.450 , pp. 33-61
    • Duchen, M.R.1    Biscoe, T.J.2
  • 41
    • 0021958742 scopus 로고
    • Oxygen chemoreception by carotid body cells in culture
    • Fishman MC, Greene WL, Platika D. Oxygen chemoreception by carotid body cells in culture. Proc Natl Acad Sci USA 82: 1448–1450, 1985.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 1448-1450
    • Fishman, M.C.1    Greene, W.L.2    Platika, D.3
  • 43
    • 67349100232 scopus 로고    scopus 로고
    • The impact of hypoxia and low glucose on the release of acetylcholine and ATP from the incubated cat carotid body
    • Fitzgerald RS, Shirahata M, Chang I, Kostuk E. The impact of hypoxia and low glucose on the release of acetylcholine and ATP from the incubated cat carotid body. Brain Res 1270: 39–44, 2009.
    • (2009) Brain Res , vol.1270 , pp. 39-44
    • Fitzgerald, R.S.1    Shirahata, M.2    Chang, I.3    Kostuk, E.4
  • 45
    • 0026656461 scopus 로고
    • Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea
    • Fletcher EC, Lesske J, Behm R, Miller CC, Stauss H, Unger T. Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol (1985) 72: 1978–1984, 1992.
    • (1992) J Appl Physiol (1985) , vol.72 , pp. 1978-1984
    • Fletcher, E.C.1    Lesske, J.2    Behm, R.3    Miller, C.C.4    Stauss, H.5    Unger, T.6
  • 47
    • 0034808011 scopus 로고    scopus 로고
    • Acute hypoxia elevates nitric oxide generation in rat carotid body in vitro
    • Fung ML, Ye JS, Fung PC. Acute hypoxia elevates nitric oxide generation in rat carotid body in vitro. Pflügers Arch 442: 903–909, 2001.
    • (2001) Pflügers Arch , vol.442 , pp. 903-909
    • Fung, M.L.1    Ye, J.S.2    Fung, P.C.3
  • 48
    • 0026744619 scopus 로고
    • Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen
    • Ganfornina MD, Lopez-Barneo J. Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen. J Gen Physiol 100: 401–426, 1992.
    • (1992) J Gen Physiol , vol.100 , pp. 401-426
    • Ganfornina, M.D.1    Lopez-Barneo, J.2
  • 51
    • 70549092785 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate hypoxic signaling
    • Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol 21: 894–899, 2009.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 894-899
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 54
    • 0014757042 scopus 로고
    • Post-mortem size and structure of the human carotid body
    • Heath D, Edwards C, Harris P. Post-mortem size and structure of the human carotid body. Thorax 25: 129–140, 1970.
    • (1970) Thorax , vol.25 , pp. 129-140
    • Heath, D.1    Edwards, C.2    Harris, P.3
  • 58
    • 84911885243 scopus 로고    scopus 로고
    • Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia
    • Iturriaga R, Andrade DC, del Río R. Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia. Front Physiol 5: 468, 2014. doi:10.3389/fphys.2014.0046.
    • (2014) Front Physiol , vol.5 , pp. 468
    • Iturriaga, R.1    Rade, D.C.2    Del Río, R.3
  • 59
    • 80052381647 scopus 로고    scopus 로고
    • Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
    • Joseph NM, He S, Quintana E, Kim YG, Nunez G, Morrison SJ. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest 121: 3398–3411, 2011.
    • (2011) J Clin Invest , vol.121 , pp. 3398-3411
    • Joseph, N.M.1    He, S.2    Quintana, E.3    Kim, Y.G.4    Nunez, G.5    Morrison, S.J.6
  • 61
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393–402, 2008.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 62
    • 85027946874 scopus 로고    scopus 로고
    • Signaling molecules and transcription factors involved in the development of the sympathetic nervous system, with special emphasis on the superior cervical ganglion
    • Kameda Y. Signaling molecules and transcription factors involved in the development of the sympathetic nervous system, with special emphasis on the superior cervical ganglion. Cell Tissue Res 357: 527–548, 2014.
    • (2014) Cell Tissue Res , vol.357 , pp. 527-548
    • Kameda, Y.1
  • 64
    • 0035968167 scopus 로고    scopus 로고
    • A central functional role for the 49-kDa subunit within the catalytic core of mitochondrial complex I
    • Kashani-Poor N, Zwicker K, Kerscher S, Brandt U. A central functional role for the 49-kDa subunit within the catalytic core of mitochondrial complex I. J Biol Chem 276: 24082–24087, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 24082-24087
    • Kashani-Poor, N.1    Zwicker, K.2    Kerscher, S.3    Brandt, U.4
  • 66
    • 84893469983 scopus 로고    scopus 로고
    • Oxygen sensing by the carotid body: Is it all just rotten eggs?
    • Kemp PJ, Telezhkin V. Oxygen sensing by the carotid body: is it all just rotten eggs? Antioxid Redox Signal 20: 794–804, 2014.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 794-804
    • Kemp, P.J.1    Telezhkin, V.2
  • 70
    • 0022497117 scopus 로고
    • Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo
    • Kirby GC, McQueen DS. Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo. Br J Pharmacol 88: 889–898, 1986.
    • (1986) Br J Pharmacol , vol.88 , pp. 889-898
    • Kirby, G.C.1    McQueen, D.S.2
  • 71
    • 0037085536 scopus 로고    scopus 로고
    • Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing
    • Kline DD, Overholt JL, Prabhakar NR. Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. J Physiol 539: 309–315, 2002.
    • (2002) J Physiol , vol.539 , pp. 309-315
    • Kline, D.D.1    Overholt, J.L.2    Prabhakar, N.R.3
  • 72
    • 35348812593 scopus 로고    scopus 로고
    • Taking neural crest stem cells to new heights
    • Kokovay E, Temple S. Taking neural crest stem cells to new heights. Cell 131: 234–236, 2007.
    • (2007) Cell , vol.131 , pp. 234-236
    • Kokovay, E.1    Temple, S.2
  • 74
    • 67651036549 scopus 로고    scopus 로고
    • The glial nature of embryonic and adult neural stem cells
    • Kriegstein A, Alvarez-Buylla A. The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32: 149–184, 2009.
    • (2009) Annu Rev Neurosci , vol.32 , pp. 149-184
    • Kriegstein, A.1    Alvarez-Buylla, A.2
  • 75
    • 0032565707 scopus 로고    scopus 로고
    • +-current modulated by PO2 in type I cells in rat carotid body is not a chemosensor
    • +-current modulated by PO2 in type I cells in rat carotid body is not a chemosensor. Brain Res 794: 162–165, 1998.
    • (1998) Brain Res , vol.794 , pp. 162-165
    • Lahiri, S.1    Roy, A.2    Rozanov, C.3    Mokashi, A.4
  • 79
    • 65449134776 scopus 로고    scopus 로고
    • + channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia
    • + channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia. J Physiol 587: 1917–1929, 2009.
    • (2009) J Physiol , vol.587 , pp. 1917-1929
    • Levitsky, K.L.1    López-Barneo, J.2
  • 80
    • 77950813147 scopus 로고    scopus 로고
    • A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels
    • Li Q, Sun B, Wang X, Jin Z, Zhou Y, Dong L, Jiang LH, Rong W. A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels. Antioxid Redox Signal 12: 1179–1189, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1179-1189
    • Li, Q.1    Sun, B.2    Wang, X.3    Jin, Z.4    Zhou, Y.5    Dong, L.6    Jiang, L.H.7    Rong, W.8
  • 81
    • 33746806783 scopus 로고    scopus 로고
    • Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: Role of angiotensin II
    • Li YL, Schultz HD. Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin II. J Physiol 575: 215–227, 2006.
    • (2006) J Physiol , vol.575 , pp. 215-227
    • Li, Y.L.1    Schultz, H.D.2
  • 83
    • 18244422577 scopus 로고    scopus 로고
    • Oxygen and glucose sensing by carotid body glomus cells
    • Lopez-Barneo J. Oxygen and glucose sensing by carotid body glomus cells. Curr Opin Neurobiol 13: 493–499, 2003.
    • (2003) Curr Opin Neurobiol , vol.13 , pp. 493-499
    • Lopez-Barneo, J.1
  • 84
    • 0028282112 scopus 로고
    • Oxygen-sensitive ion channels: How ubiquitous are they?
    • Lopez-Barneo J. Oxygen-sensitive ion channels: how ubiquitous are they? Trends Neurosci 17: 133–135, 1994.
    • (1994) Trends Neurosci , vol.17 , pp. 133-135
    • Lopez-Barneo, J.1
  • 85
    • 12944320988 scopus 로고
    • Oxygen sensing and the electrophysiology of arterial chemoreceptor cells
    • López-Barneo J, Benot A, Ureña J. Oxygen sensing and the electrophysiology of arterial chemoreceptor cells. NIPS 8: 191–195, 1993.
    • (1993) NIPS , vol.8 , pp. 191-195
    • López-Barneo, J.1    Benot, A.2    Ureña, J.3
  • 87
    • 33745777238 scopus 로고    scopus 로고
    • Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells
    • Lopez-Barneo J, Ortega-Saenz P, Piruat JI, Garcia-Fernandez M. Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells. Novart Found Symp 272: 54–64; discussion 64–72, 131–140, 2006.
    • Novart Found Symp , vol.272 , pp. 54-64
    • Lopez-Barneo, J.1    Ortega-Saenz, P.2    Piruat, J.I.3    Garcia-Fernandez, M.4
  • 90
    • 36049051632 scopus 로고    scopus 로고
    • An ASIC channel for acid chemotransduction
    • Lopez-Lopez JR, Perez-Garcia MT. An ASIC channel for acid chemotransduction. Circ Res 101: 965–967, 2007.
    • (2007) Circ Res , vol.101 , pp. 965-967
    • Lopez-Lopez, J.R.1    Perez-Garcia, M.T.2
  • 92
    • 84918566655 scopus 로고    scopus 로고
    • Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
    • Macias D, Fernandez-Agüera MC, Bonilla-Henao V, Lopez-Barneo J. Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia. EMBO Mol Med 6: 1577–1592, 2014.
    • (2014) EMBO Mol Med , vol.6 , pp. 1577-1592
    • Macias, D.1    Fernandez-Agüera, M.C.2    Bonilla-Henao, V.3    Lopez-Barneo, J.4
  • 96
    • 84892402912 scopus 로고    scopus 로고
    • Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure
    • Marcus NJ, Del Rio R, Schultz EP, Xia XH, Schultz HD. Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure. J Physiol 592: 391–408, 2014.
    • (2014) J Physiol , vol.592 , pp. 391-408
    • Marcus, N.J.1    Del Rio, R.2    Schultz, E.P.3    Xia, X.H.4    Schultz, H.D.5
  • 97
    • 77949571119 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: Role of the angiotensin II type 1 receptor
    • Marcus NJ, Li YL, Bird CE, Schultz HD, Morgan BJ. Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor. Respir Physiol Neurobiol 171: 36–45, 2010.
    • (2010) Respir Physiol Neurobiol , vol.171 , pp. 36-45
    • Marcus, N.J.1    Li, Y.L.2    Bird, C.E.3    Schultz, H.D.4    Morgan, B.J.5
  • 99
    • 0021751184 scopus 로고
    • A morphometric study of the carotid body in chronically hypoxic rats
    • McGregor KH, Gil J, Lahiri S. A morphometric study of the carotid body in chronically hypoxic rats. J Appl Physiol 57: 1430–1438, 1984.
    • (1984) J Appl Physiol , vol.57 , pp. 1430-1438
    • McGregor, K.H.1    Gil, J.2    Lahiri, S.3
  • 102
    • 0015369803 scopus 로고
    • Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension
    • Mills E, Jobsis FF. Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J Neurophysiol 35: 405–428, 1972.
    • (1972) J Neurophysiol , vol.35 , pp. 405-428
    • Mills, E.1    Jobsis, F.F.2
  • 105
    • 84952975013 scopus 로고    scopus 로고
    • Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation
    • Mori Y, Takahashi N, Polat OK, Kurokawa T, Takeda N, Inoue M. Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation. Pflügers Arch 468: 85–97, 2016.
    • (2016) Pflügers Arch , vol.468 , pp. 85-97
    • Mori, Y.1    Takahashi, N.2    Polat, O.K.3    Kurokawa, T.4    Takeda, N.5    Inoue, M.6
  • 108
    • 84881477445 scopus 로고    scopus 로고
    • TRP channels as sensors of oxygen availability
    • Numata T, Ogawa N, Takahashi N, Mori Y. TRP channels as sensors of oxygen availability. Pflügers Arch 465: 1075–1085, 2013.
    • (2013) Pflügers Arch , vol.465 , pp. 1075-1085
    • Numata, T.1    Ogawa, N.2    Takahashi, N.3    Mori, Y.4
  • 109
    • 84906074610 scopus 로고    scopus 로고
    • Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors
    • Nurse CA. Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors. J Physiol 592: 3419–3426, 2014.
    • (2014) J Physiol , vol.592 , pp. 3419-3426
    • Nurse, C.A.1
  • 111
    • 0022357826 scopus 로고
    • Correlation between adenosine triphosphate levels, dopamine release and electrical activity in the carotid body: Support for the metabolic hypothesis of chemoreception
    • Obeso A, Almaraz L, Gonzalez C. Correlation between adenosine triphosphate levels, dopamine release and electrical activity in the carotid body: support for the metabolic hypothesis of chemoreception. Brain Res 348: 64–68, 1985.
    • (1985) Brain Res , vol.348 , pp. 64-68
    • Obeso, A.1    Almaraz, L.2    Gonzalez, C.3
  • 114
    • 0037936785 scopus 로고    scopus 로고
    • Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
    • Ortega-Saenz P, Pardal R, Garcia-Fernandez M, Lopez-Barneo J. Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells. J Physiol 548: 789–800, 2003.
    • (2003) J Physiol , vol.548 , pp. 789-800
    • Ortega-Saenz, P.1    Pardal, R.2    Garcia-Fernandez, M.3    Lopez-Barneo, J.4
  • 117
    • 34247266691 scopus 로고    scopus 로고
    • Mechanisms of acute oxygen sensing by the carotid body: Lessons from genetically modified animals
    • Ortega-Saenz P, Pascual A, Piruat JI, Lopez-Barneo J. Mechanisms of acute oxygen sensing by the carotid body: lessons from genetically modified animals. Respir Physiol Neurobiol 157: 140–147, 2007.
    • (2007) Respir Physiol Neurobiol , vol.157 , pp. 140-147
    • Ortega-Saenz, P.1    Pascual, A.2    Piruat, J.I.3    Lopez-Barneo, J.4
  • 118
    • 84871756507 scopus 로고    scopus 로고
    • Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
    • Ortiz FC, Del Rio R, Ebensperger G, Reyes VR, Alcayaga J, Varas R, Iturriaga R. Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia. Respir Physiol Neurobiol 185: 600–607, 2013.
    • (2013) Respir Physiol Neurobiol , vol.185 , pp. 600-607
    • Ortiz, F.C.1    Del Rio, R.2    Ebensperger, G.3    Reyes, V.R.4    Alcayaga, J.5    Varas, R.6    Iturriaga, R.7
  • 120
    • 0036178788 scopus 로고    scopus 로고
    • Low glucose-sensing cells in the carotid body
    • Pardal R, Lopez-Barneo J. Low glucose-sensing cells in the carotid body. Nat Neurosci 5: 197–198, 2002.
    • (2002) Nat Neurosci , vol.5 , pp. 197-198
    • Pardal, R.1    Lopez-Barneo, J.2
  • 121
    • 0034050456 scopus 로고    scopus 로고
    • Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium
    • Pardal R, Ludewig U, Garcia-Hirschfeld J, Lopez-Barneo J. Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium. Proc Natl Acad Sci USA 97: 2361–2366, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2361-2366
    • Pardal, R.1    Ludewig, U.2    Garcia-Hirschfeld, J.3    Lopez-Barneo, J.4
  • 122
    • 35348906206 scopus 로고    scopus 로고
    • Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body
    • Pardal R, Ortega-Saenz P, Duran R, Lopez-Barneo J. Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131: 364–377, 2007.
    • (2007) Cell , vol.131 , pp. 364-377
    • Pardal, R.1    Ortega-Saenz, P.2    Duran, R.3    Lopez-Barneo, J.4
  • 125
    • 0025000175 scopus 로고
    • + current
    • + current. Neurosci Lett 119: 253–256, 1990.
    • (1990) Neurosci Lett , vol.119 , pp. 253-256
    • Peers, C.1
  • 129
    • 0042691713 scopus 로고    scopus 로고
    • Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas
    • Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci USA 100: 10073–10078, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10073-10078
    • Peng, Y.J.1    Overholt, J.L.2    Kline, D.3    Kumar, G.K.4    Prabhakar, N.R.5
  • 130
    • 1342283025 scopus 로고    scopus 로고
    • Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity
    • Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985) 96: 1236–1242, 2004.
    • (2004) J Appl Physiol (1985) , vol.96 , pp. 1236-1242
    • Peng, Y.J.1    Prabhakar, N.R.2
  • 132
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1— deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1— deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577: 705–716, 2006.
    • (2006) J Physiol , vol.577 , pp. 705-716
    • Peng, Y.J.1    Yuan, G.2    Ramakrishnan, D.3    Sharma, S.D.4    Bosch-Marce, M.5    Kumar, G.K.6    Semenza, G.L.7    Prabhakar, N.R.8
  • 133
    • 0034636477 scopus 로고    scopus 로고
    • Prospective study of the association between sleep disordered breathing and hypertension
    • Peppard P, Young T, Palta M, Skatrud J. Prospective study of the association between sleep disordered breathing and hypertension. N Engl J Med 342: 1378–1384, 2000.
    • (2000) N Engl J Med , vol.342 , pp. 1378-1384
    • Peppard, P.1    Young, T.2    Palta, M.3    Skatrud, J.4
  • 136
    • 0026560976 scopus 로고
    • Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
    • Post JM, Hume JR, Archer SL, Weir EK. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol Cell Physiol 262: C882–C890, 1992.
    • (1992) Am J Physiol Cell Physiol , vol.262 , pp. C882-C890
    • Post, J.M.1    Hume, J.R.2    Archer, S.L.3    Weir, E.K.4
  • 137
    • 84939811984 scopus 로고    scopus 로고
    • Last Word on Viewpoint: Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression
    • Potter JV, Moon RE. Last Word on Viewpoint: Why do some patients stop breathing after taking narcotics? Ventilatory chemosensitivity as a predictor of opioid-induced respiratory depression. J Appl Physiol 119: 426, 2015.
    • (2015) J Appl Physiol , vol.119 , pp. 426
    • Potter, J.V.1    Moon, R.E.2
  • 138
    • 84868004133 scopus 로고    scopus 로고
    • Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body
    • Prabhakar NR. Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body. Respir Physiol Neurobiol 184: 165–169, 2012.
    • (2012) Respir Physiol Neurobiol , vol.184 , pp. 165-169
    • Prabhakar, N.R.1
  • 139
    • 0032965968 scopus 로고    scopus 로고
    • NO and CO as second messengers in oxygen sensing in the carotid body
    • Prabhakar NR. NO and CO as second messengers in oxygen sensing in the carotid body. Respir Physiol 115: 161–168, 1999.
    • (1999) Respir Physiol , vol.115 , pp. 161-168
    • Prabhakar, N.R.1
  • 140
    • 84891553314 scopus 로고    scopus 로고
    • Gasotransmitter regulation of ion channels: A key step in O2 sensing by the carotid body
    • Prabhakar NR, Peers C. Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body. Physiology 29: 49–57, 2014.
    • (2014) Physiology , vol.29 , pp. 49-57
    • Prabhakar, N.R.1    Peers, C.2
  • 141
    • 84952977880 scopus 로고    scopus 로고
    • Regulation of carotid body oxygen sensing by hypoxia-inducible factors
    • Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. Pflügers Arch 468: 71–75, 2016.
    • (2016) Pflügers Arch , vol.468 , pp. 71-75
    • Prabhakar, N.R.1    Semenza, G.L.2
  • 142
    • 84876325985 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer
    • Ratcliffe PJ. Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol 591: 2027–2042, 2013.
    • (2013) J Physiol , vol.591 , pp. 2027-2042
    • Ratcliffe, P.J.1
  • 143
    • 7444220066 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
    • Rey S, Del Rio R, Alcayaga J, Iturriaga R. Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia. J Physiol 560: 577–586, 2004.
    • (2004) J Physiol , vol.560 , pp. 577-586
    • Rey, S.1    Del Rio, R.2    Alcayaga, J.3    Iturriaga, R.4
  • 144
    • 84880920071 scopus 로고    scopus 로고
    • Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets
    • Ribeiro MJ, Sacramento JF, González C, Guarino MP, Monteiro EC, Conde SV. Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets. Diabetes 62: 2905–2916, 2013.
    • (2013) Diabetes , vol.62 , pp. 2905-2916
    • Ribeiro, M.J.1    Sacramento, J.F.2    González, C.3    Guarino, M.P.4    Monteiro, E.C.5    Conde, S.V.6
  • 148
    • 0032526018 scopus 로고    scopus 로고
    • Oxygensensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth
    • Rychkov GY, Adams MB, McMillen IC, Roberts ML. Oxygensensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth. J Physiol 509: 887–893, 1998.
    • (1998) J Physiol , vol.509 , pp. 887-893
    • Rychkov, G.Y.1    Adams, M.B.2    McMillen, I.C.3    Roberts, M.L.4
  • 150
    • 84862550684 scopus 로고    scopus 로고
    • Cognitive dysfunction in patients with chronic obstructive pulmonary disease-a systematic review
    • Schou L, Ostergaard B, Rasmussen LS, Rydahl-Hansen S, Phanareth K. Cognitive dysfunction in patients with chronic obstructive pulmonary disease-a systematic review. Respir Med 106: 1071–1081, 2012.
    • (2012) Respir Med , vol.106 , pp. 1071-1081
    • Schou, L.1    Ostergaard, B.2    Rasmussen, L.S.3    Rydahl-Hansen, S.4    Phanareth, K.5
  • 151
    • 84880923308 scopus 로고    scopus 로고
    • Role of the carotid body in the pathophysiology of heart failure
    • Schultz HD, Marcus NJ, Del Rio R. Role of the carotid body in the pathophysiology of heart failure. Curr Hypertens Rep 15: 356–362, 2013.
    • (2013) Curr Hypertens Rep , vol.15 , pp. 356-362
    • Schultz, H.D.1    Marcus, N.J.2    Del Rio, R.3
  • 152
    • 84897019542 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
    • Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 9: 47–71, 2014.
    • (2014) Annu Rev Pathol , vol.9 , pp. 47-71
    • Semenza, G.L.1
  • 153
    • 79955558300 scopus 로고    scopus 로고
    • Hypoxia. 4. Hypoxia and ion channel function
    • Shimoda LA, Polak J. Hypoxia. 4. Hypoxia and ion channel function. Am J Physiol Cell Physiol 300: C951–C967, 2011.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C951-C967
    • Shimoda, L.A.1    Polak, J.2
  • 154
    • 0017109237 scopus 로고
    • Oxygen consumption of the isolated carotid body tissue (Cat)
    • Starlinger H, Lubbers DW. Oxygen consumption of the isolated carotid body tissue (cat). Pflügers Arch 366: 61–66, 1976.
    • (1976) Pflügers Arch , vol.366 , pp. 61-66
    • Starlinger, H.1    Lubbers, D.W.2
  • 155
    • 0025959327 scopus 로고
    • 2-sensitive rat carotid body cells grown in short- and long-term culture
    • 2-sensitive rat carotid body cells grown in short- and long-term culture. Pflügers Arch 418: 93–101, 1991.
    • (1991) Pflügers Arch , vol.418 , pp. 93-101
    • Stea, A.1    Nurse, C.A.2
  • 157
    • 2942729608 scopus 로고    scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Sutherland ER, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med 350: 2689–2697, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 2689-2697
    • Sutherland, E.R.1    Cherniack, R.M.2
  • 159
    • 33846863977 scopus 로고    scopus 로고
    • 2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells
    • 2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience 145: 130–141, 2007.
    • (2007) Neuroscience , vol.145 , pp. 130-141
    • Thompson, R.J.1    Buttigieg, J.2    Zhang, M.3    Nurse, C.A.4
  • 160
    • 0031028005 scopus 로고    scopus 로고
    • Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells
    • Thompson RJ, Jackson A, Nurse CA. Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells. J Physiol 498: 503–510, 1997.
    • (1997) J Physiol , vol.498 , pp. 503-510
    • Thompson, R.J.1    Jackson, A.2    Nurse, C.A.3
  • 161
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320–3324, 1998.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 162
    • 84870663922 scopus 로고    scopus 로고
    • Autocrine and paracrine actions of ATP in rat carotid body
    • Tse A, Yan L, Lee AK, Tse FW. Autocrine and paracrine actions of ATP in rat carotid body. Can J Physiol Pharmacol 90: 705–711, 2012.
    • (2012) Can J Physiol Pharmacol , vol.90 , pp. 705-711
    • Tse, A.1    Yan, L.2    Lee, A.K.3    Tse, F.W.4
  • 163
    • 84888434747 scopus 로고    scopus 로고
    • Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells
    • Turner PJ, Buckler KJ. Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 channels in mouse carotid body type-1 cells. J Physiol 591: 5977–5998, 2013.
    • (2013) J Physiol , vol.591 , pp. 5977-5998
    • Turner, P.J.1    Buckler, K.J.2
  • 165
    • 0025350637 scopus 로고
    • Effects of metabolic inhibitors and hypoxia on the ATP, ADP and AMP content of the rabbit carotid body in vitro: The metabolic hypothesis in question
    • Verna A, Talib N, Roumy M, Pradet A. Effects of metabolic inhibitors and hypoxia on the ATP, ADP and AMP content of the rabbit carotid body in vitro: the metabolic hypothesis in question. Neurosci Lett 116: 156–161, 1990.
    • (1990) Neurosci Lett , vol.116 , pp. 156-161
    • Verna, A.1    Talib, N.2    Roumy, M.3    Pradet, A.4
  • 166
    • 17644392790 scopus 로고    scopus 로고
    • Selective glial cell linederived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation
    • Villadiego J, Mendez-Ferrer S, Valdes-Sanchez T, Silos-Santiago I, Farinas I, Lopez-Barneo J, Toledo-Aral JJ. Selective glial cell linederived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J Neurosci 25: 4091–4098, 2005.
    • (2005) J Neurosci , vol.25 , pp. 4091-4098
    • Villadiego, J.1    Mendez-Ferrer, S.2    Valdes-Sanchez, T.3    Silos-Santiago, I.4    Farinas, I.5    Lopez-Barneo, J.6    Toledo-Aral, J.J.7
  • 167
    • 0030610004 scopus 로고    scopus 로고
    • The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells
    • Wang R, Wu L. The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells. J Biol Chem 272: 8222–8226, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 8222-8226
    • Wang, R.1    Wu, L.2
  • 168
    • 0028796381 scopus 로고
    • Nitric oxide mediates chemoreceptor inhibition in the cat carotid body
    • Wang ZZ, Stensaas LJ, Dinger BG, Fidone SJ. Nitric oxide mediates chemoreceptor inhibition in the cat carotid body. Neuroscience 65: 217–229, 1995.
    • (1995) Neuroscience , vol.65 , pp. 217-229
    • Wang, Z.Z.1    Stensaas, L.J.2    Dinger, B.G.3    Fidone, S.J.4
  • 169
    • 34447256120 scopus 로고    scopus 로고
    • The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans
    • Ward DS, Voter WA, Karan S. The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans. J Physiol 582: 859–869, 2007.
    • (2007) J Physiol , vol.582 , pp. 859-869
    • Ward, D.S.1    Voter, W.A.2    Karan, S.3
  • 170
    • 0035933388 scopus 로고    scopus 로고
    • Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing
    • Waypa GB, Chandel NS, Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 88: 1259–1266, 2001.
    • (2001) Circ Res , vol.88 , pp. 1259-1266
    • Waypa, G.B.1    Chandel, N.S.2    Schumacker, P.T.3
  • 172
    • 78449254876 scopus 로고    scopus 로고
    • Hyperoxia blunts counterregulation during hypoglycaemia in humans: Possible role for the carotid bodies?
    • Wehrwein EA, Basu R, Basu A, Curry TB, Rizza RA, Joyner MJ. Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies? J Physiol 588: 4593–4601, 2010.
    • (2010) J Physiol , vol.588 , pp. 4593-4601
    • Wehrwein, E.A.1    Basu, R.2    Basu, A.3    Curry, T.B.4    Rizza, R.A.5    Joyner, M.J.6
  • 174
    • 0036320934 scopus 로고    scopus 로고
    • 2-regulated gene expression
    • 2-regulated gene expression. FASEB J 16: 1151–1162, 2002.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 176
    • 58249139466 scopus 로고    scopus 로고
    • The cerebral effects of ascent to high altitudes
    • Wilson MH, Newman S, Imray CH. The cerebral effects of ascent to high altitudes. Lancet Neurol 8: 175–191, 2009.
    • (2009) Lancet Neurol , vol.8 , pp. 175-191
    • Wilson, M.H.1    Newman, S.2    Imray, C.H.3
  • 177
    • 1942453399 scopus 로고    scopus 로고
    • The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells
    • Wyatt CN, Buckler KJ. The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells. J Physiol 556: 175–191, 2004.
    • (2004) J Physiol , vol.556 , pp. 175-191
    • Wyatt, C.N.1    Buckler, K.J.2
  • 179
    • 0028988372 scopus 로고
    • + channels in isolated type I cells of the neonatal rat carotid body
    • + channels in isolated type I cells of the neonatal rat carotid body. J Physiol 483: 559–565, 1995.
    • (1995) J Physiol , vol.483 , pp. 559-565
    • Wyatt, C.N.1    Peers, C.2
  • 180
    • 0027462562 scopus 로고
    • The occurrence of sleep disordered breathing among middle-aged adults
    • Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle-aged adults. N Engl J Med 328: 1230–1235, 1993.
    • (1993) N Engl J Med , vol.328 , pp. 1230-1235
    • Young, T.1    Palta, M.2    Dempsey, J.3    Skatrud, J.4    Weber, S.5    Badr, S.6
  • 181
    • 0027327956 scopus 로고
    • Oxygen sensing in airway chemoreceptors
    • Youngson C, Nurse C, Yeger H, Cutz E. Oxygen sensing in airway chemoreceptors. Nature 365: 153–155, 1993.
    • (1993) Nature , vol.365 , pp. 153-155
    • Youngson, C.1    Nurse, C.2    Yeger, H.3    Cutz, E.4
  • 185
    • 33846553113 scopus 로고    scopus 로고
    • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body
    • Zhang M, Buttigieg J, Nurse CA. Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J Physiol 578: 735–750, 2007.
    • (2007) J Physiol , vol.578 , pp. 735-750
    • Zhang, M.1    Buttigieg, J.2    Nurse, C.A.3
  • 186
    • 0034658351 scopus 로고    scopus 로고
    • Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors
    • Zhang M, Zhong H, Vollmer C, Nurse CA. Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol 525: 143–158, 2000.
    • (2000) J Physiol , vol.525 , pp. 143-158
    • Zhang, M.1    Zhong, H.2    Vollmer, C.3    Nurse, C.A.4
  • 187
    • 0030660538 scopus 로고    scopus 로고
    • Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells
    • Zhong H, Zhang M, Nurse CA. Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells. J Physiol 503: 599–612, 1997.
    • (1997) J Physiol , vol.503 , pp. 599-612
    • Zhong, H.1    Zhang, M.2    Nurse, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.