K+-current modulated by P(O2) in type I cells in rat carotid body is not a chemosensor

Brain Research

Volumn 794, Issue 1, 1998, Pages 162-165

  Lahiri, Sukhamay ^a   Roy, Arijit ^a   Rozanov, Charmaine ^a   Mokashi, Anil ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

4 AP; Ca2+ (i); Glomus cell; K+ O2 current; Low Ca2+ (o) plus high Mg2+ (o); Membrane potential; Neurosecretion; TEA

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL; POTASSIUM ION; TETRYLAMMONIUM;

ARTICLE; CAROTID BODY CHEMORECEPTOR; CHANNEL GATING; NERVE CELL MEMBRANE POTENTIAL; NEUROMODULATION; POTASSIUM CURRENT; PRIORITY JOURNAL;

4-AMINOPYRIDINE; ANIMALS; CAROTID BODY; CHEMORECEPTORS; MEMBRANE POTENTIALS; OXYGEN; PARTIAL PRESSURE; POTASSIUM CHANNELS; RATS; TETRAETHYLAMMONIUM;

EID: 0032565707     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00276-5     Document Type: Article

References (20)

1. T.J. Biscoe, M.R. Duchen, Responses of type I cells dissociated from the rabbit carotid body to hypoxia, J. Physiol. 428 (1990) 39-59.
2. K.J. Buckler, R.D. Vaughan Jones, Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I calls, J. Physiol. 476 (1994) 423-428.
3. K.J. Buckler, A novel oxygen-sensitive potassium current in rat carotid body type I cells, J. Physiol. 498 (1997) 649-662.
4. C. Chou, M. Shirahata, Two types of voltage-gated K channels in carotid body cells of adult cats, Brain Res. 742 (1996) 34-42.
5. D.F. Donnelly, Modulation of glomus cell membrane currents of intact rat carotid body, J. Physiol. 489 (1995) 677-685.
6. M.D. Ganfornina, J. Lopez-Barneo, Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen, J. Gen. Physiol. 100 (1992) 401-426.
7. + currents and their modulation by hypoxia, J. Physiol. 501 (1997) 49-58.
8. 2 chemoreception: the carotid body model, News Physiol. Sci. 9 (1994) 161-165.
9. 2 sensor, Brain Res. 684 (1995) 194-200.
10. O2 in type I chemoreceptor cells, Science 241 (1988) 580-582.
11. J. Lopez-Barneo, Oxygen-sensing by ion channels and the regulation of cellular functions, TINS 19 (1996) 435-440.
12. + current in chemoreceptor cells of rabbit carotid body, J. Physiol. 460 (1993) 15-32.
13. M.H. Mojet, E. Mills, M.R. Duchen, Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration, J. Physiol. 504 (1997) 175-189.
14. R.J. Montoro, J. Urena, R. Fernandez-Chavon, G. Alvarez de Toledo, J. Lopez-Barneo, Oxygen-sensing by ion channels and chemotransduction in single glomus cell, J. Gen. Physiol. 107 (1996) 133-143.
15. S. Osanai, D.G. Buerk, A. Mokashi, D.K. Chugh, S. Lahiri, Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin, Brain Res. 747 (1997) 324-327.
16. + current, Neurosci. Lett. 119 (1990) 253-256.
17. C. Peers, J. O'Donnell, Potassium currents recorded in type I carotid body cells from neonatal rat and their modulation by chemoexcitatory agents, Brain Res. 552 (1990) 259-266.
18. C. Peers, K.J. Buckler, Transduction of chemostimuli by the type I carotid body cells, J. Membrane Biol. 144 (1995) 1-9.
19. i, dopamine release and chemosensory discharge from carotid body, Brain Res., in press.
20. H. Zhang, M. Zhang, C.A. Nurse, Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurons and carotid body type I cells, J. Physiol. 503 (1997) 599-612.