Hyperoxia blunts counterregulation during hypoglycaemia in humans: Possible role for the carotid bodies?

Journal of Physiology

Volumn 588, Issue 22, 2010, Pages 4593-4601

  Wehrwein, Erica A ^a   Basu, Rita ^b   Basu, Ananda ^b   Curry, Timothy B ^a   Rizza, Robert A ^b   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCAGON; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; INSULIN; NORADRENALIN;

ADULT; ARTICLE; BLOOD GAS; CAROTID BODY; CLINICAL ARTICLE; DEMOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HYPEROXIA; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; MALE; NORMOXIA; PRIORITY JOURNAL;

ADULT; CAROTID BODY; CHEMORECEPTOR CELLS; FEMALE; HUMANS; HYPEROXIA; HYPOGLYCEMIA; MALE; YOUNG ADULT;

EID: 78449254876     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.197491     Document Type: Article

References (30)

1. Al-Waili NS, Butler GJ, Beale J, Abdullah MS, Finkelstein M, Merrow M, Rivera R, Petrillo R, Carrey Z, Lee B & Allen M (2006). Influences of hyperbaric oxygen on blood pressure, heart rate and blood glucose levels in patients with diabetes mellitus and hypertension. Arch Med Res 37, 991-997.
2. Alvarez-Buylla R, Alvarez-Buylla E, Mendoza H, Montero SA & Alvarez-Buylla A (1997). Pituitary and adrenals are required for hyperglycemic reflex initiated by stimulation of CBR with cyanide. Am J Physiol Regul Integr Comp Physiol 272, R392-399.
3. Bin-Jaliah I, Maskell PD & Kumar P (2004). Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat. J Physiol 556, 255-266.
4. Conde SV, Obeso A & Gonzalez C (2007). Low glucose effects on rat carotid body chemoreceptor cells' secretory responses and action potential frequency in the carotid sinus nerve. J Physiol 585, 721-730.
5. Czupryniak L, Loba J, Pawlowski M, Nowak D & Bialasiewicz P (2005). Treatment with continuous positive airway pressure may affect blood glucose levels in nondiabetic patients with obstructive sleep apnea syndrome. Sleep 28, 601-603.
6. De Campos Cruz J, Bonagamba LG, Stern JE & Machado BH (2010). Fos expression in the NTS in response to peripheral chemoreflex activation in awake rats. Auton Neurosci 152, 27-34.
7. Diamond MP, Grainger DA, Rossi G, Connolly-Diamond M & Sherwin RS (1993). Counter-regulatory response to hypoglycemia in the follicular and luteal phases of the menstrual cycle. Fertil Steril 60, 988-993.
8. Dorkova Z, Petrasova D, Molcanyiova A, Popovnakova M & Tkacova R (2008). Effects of CPAP on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome. Chest 134, 686-692.
9. Downes JJ & Lambertsen CJ (1966). Dynamic characteristics of ventilatory depression in man on abrupt administration of O. J Appl Physiol 21, 447-453.
10. Fagius J, Niklasson F & Berne C (1986). Sympathetic outflow in human muscle nerves increases during hypoglycemia. Diabetes 35, 1124-1129.
11. Fanelli CG, Pampanelli S, Porcellati F, Bartocci L, Scionti L, Rossetti P & Bolli GB (2003). Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in Type I diabetes mellitus in the postprandial state. Diabetologia 46, 53-64.
12. Fitzgerald R & Lahiri S (1986). Reflex responses to chemoreceptor stimulation. In Handbook of Physiology, section 3, The Respiratory System, vol II, Control of Breathing, ed. Fishman AP, Cherniack NS, Widdicombe JG & Geiger SR, pp. 313-362, chapter 1010. American Physiological Society, Bethesda.
13. Garcia-Fernandez M, Ortega-Saenz P, Castellano A & Lopez-Barneo J (2007). Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes 56, 2893-2900.
14. Gerich J, Davis J, Lorenzi M, Rizza R, Bohannon N, Karam J, Lewis S, Kaplan R, Schultz T & Cryer P (1979). Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol Endocrinol Metab 236, E380-385.
15. Hjalmarsen A, Aasebo U, Birkeland K, Sager G & Jorde R (1996). Impaired glucose tolerance in patients with chronic hypoxic pulmonary disease. Diabetes Metab 22, 37-42.
16. Hoffman RP (2007). Sympathetic mechanisms of hypoglycemic counterregulation. Curr Diabetes Rev 3, 185-193.
17. Jakobsson P & Jorfeldt L (2006). Oxygen supplementation increases glucose tolerance during euglycaemic hyperinsulinaemic glucose clamp procedure in patients with severe COPD and chronic hypoxaemia. Clin Physiol Funct Imaging 26, 271-274.
18. Koyama Y, Coker RH, Denny JC, Lacy DB, Jabbour K, Williams PE & Wasserman DH (2001). Role of carotid bodies in control of the neuroendocrine response to exercise. Am J Physiol Endocrinol Metab 281, E742-748.
19. Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE & Wasserman DH (2000). Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes 49, 1434-1442.
20. Lahiri S & DeLaney RG (1975). Relationship between carotid chemoreceptor activity and ventilation in the cat. Respir Physiol 24, 267-286.
21. Lecavalier L, Bolli G, Cryer P & Gerich J (1989). Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol Endocrinol Metab 256, E844-851.
22. Nurse CA (2005). Neurotransmission and neuromodulation in the chemosensory carotid body. Auton Neurosci 120, 1-9.
23. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, Born J, Fehm HL & Peters A (2004). Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med 169, 1231-1237.
24. Pardal R & Lopez-Barneo J (2002). Low glucose-sensing cells in the carotid body. Nat Neurosci 5, 197-198.
25. Seals DR, Johnson DG & Fregosi RF (1991). Hyperoxia lowers sympathetic activity at rest but not during exercise in humans. Am J Physiol Regul Integr Comp Physiol 260, R873-878.
26. Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA & Ayata C (2007). Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain 130, 1631-1642.
27. Timmers HJ, Karemaker JM, Wieling W, Marres HA, Folgering HT & Lenders JW (2003). Baroreflex and chemoreflex function after bilateral carotid body tumor resection. J Hypertens 21, 591-599.
28. Ward DS, Voter WA & Karan S (2007). The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans. J Physiol 582, 859-869.
29. Ward DS, Voter WA & Karan S (2009). The role of the carotid bodies in the counter-regulatory response to hypoglycemia. Adv Exp Med Biol 648, 273-280.
30. Zhang M, Buttigieg J & Nurse CA (2007). Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J Physiol 578, 735-750.