The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases

Hypertension

Volumn 61, Issue 1, 2013, Pages 5-13

  Paton, Julian F R ^a   Sobotka, Paul A ^b   Fudim, Marat ^b   Engleman, Zoar J ^b   Hart, Emma C J ^a   McBryde, Fiona D ^a   Abdala, Ana P ^a   Marina, Nepthali ^c   Gourine, Alexander V ^c   Lobo, Mel ^d   Patel, Nik ^e   Burchell, Amy ^f   Ratcliffe, Laura ^f   Nightingale, Angus ^f  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Coridea NC1 ^*  (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e FRENCHAY HOSPITAL   (United Kingdom)

^f BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE REGULATION; CAROTID BODY; CAROTID BODY CHEMORECEPTOR; CAROTID BODY RESECTION; CHEMORECEPTOR REFLEX; CONGESTIVE HEART FAILURE; DENERVATION; DRUG TARGETING; HEART FAILURE; HUMAN; HYPERCAPNIA; HYPERTENSION; HYPOXIA; MORTALITY; NERVE SURGERY; NONHUMAN; PATIENT SAFETY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REVIEW; SURVIVAL RATE; SURVIVAL TIME; SYMPATHETIC FUNCTION; SYMPATHETIC REFLEX;

ANIMALS; CAROTID BODY; HEART FAILURE; HUMANS; HYPERTENSION; INSULIN RESISTANCE; SYMPATHETIC NERVOUS SYSTEM;

EID: 84871609238     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.00064     Document Type: Review

References (66)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-223. (Pubitemid 40138015)
2. Lloyd-Jones DM, Evans JC, Levy D. Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA. 2005;294:466-472. (Pubitemid 41124179)
3. Ostchega Y, Yoon SS, Hughes J, Louis T. Hypertension awareness, treatment, and control\continued disparities in adults: United states, 2005-2006. NCHS Data Brief. 2008:1-8.
4. Egan BM, Zhao Y, Axon RN. Us trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303: 2043-2050.
5. Sarafdis PA, Bakris GL. Resistant hypertension: an overview of evaluation and treatment. J Am Coll Cardiol. 2008;52:1749-1757.
6. Symplicity HTN-1 Investigators. Catheter-based renal sympathetic dener-vation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension. 2011;57:911-917.
7. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373:1275-1281.
8. Patel NK, Javed S, Khan S, Papouchado M, Malizia AL, Pickering AE, Paton JF. Deep brain stimulation relieves refractory hypertension. Neurology. 2011;76:405-407.
9. Bisognano JD, Bakris G, Nadim MK, Sanchez L, Kroon AA, Schafer J, de Leeuw PW, Sica DA. Barorefex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial. J Am Coll Cardiol. 2011;58:765-773.
10. Schwartz PJ. Vagal stimulation for heart failure. Curr Opin Cardiol. 2011;26:51-54.
11. Floras JS. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll Cardiol. 2009;54:375-385.
12. Olshansky B, Sabbah HN, Hauptman PJ, Colucci WS. Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation. 2008;118:863-871.
13. Campese VM, Kogosov E. Renal afferent denervation prevents hypertension in rats with chronic renal failure. Hypertension. 1995;25(4 pt 2):878-882.
14. Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med. 2009;361:932-934.
15. Tan ZY, Lu Y, Whiteis CA, Simms AE, Paton JF, Chapleau MW, Abboud FM. Chemoreceptor hypersensitivity, sympathetic excitation, and overex-pression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res. 2010;106:536-545.
16. Habeck JO. Peripheral arterial chemoreceptors and hypertension. J Auton Nerv Syst. 1991;34:1-7.
17. Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. J Mol Med. 2012;90:265-272.
18. Li YL, Schultz HD. Enhanced sensitivity of Kv channels to hypoxia in the rabbit carotid body in heart failure: role of angiotensin II. J Physiol (Lond). 2006;575(pt 1):215-227. (Pubitemid 44178139)
19. Marshall JM. Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev. 1994;74:543-594. (Pubitemid 24224339)
20. Despas F, Lambert E, Vaccaro A, Labrunee M, Franchitto N, Lebrin M, Galinier M, Senard JM, Lambert G, Esler M, Pathak A. Peripheral che-morefex activation contributes to sympathetic barorefex impairment in chronic heart failure. J Hypertens. 2012;30:753-760.
21. Gabel RA, Kronenberg RS, Severinghaus JW. Vital capacity breaths of 5 percent or 15 percent CO 2 in N 2 or O 2 to test carotid chemosensitivity. Respir Physiol. 1973;17:195-208.
22. Duffn J. Measuring the ventilatory response to hypoxia. J Physiol (Lond). 2007;584(pt 1):285-293.
23. Ponikowski P, Chua TP, Piepoli M, Ondusova D, Webb-Peploe K, Harrington D, Anker SD, Volterrani M, Colombo R, Mazzuero G, Giordano A, Coats AJ. Augmented peripheral chemosensitivity as a potential input to barorefex impairment and autonomic imbalance in chronic heart failure. Circulation. 1997;96:2586-2594. (Pubitemid 27451350)
24. Giannoni A, Emdin M, Bramanti F, Iudice G, Francis DP, Barsotti A, Piepoli M, Passino C. Combined increased chemosensitivity to hypoxia and hypercapnia as a prognosticator in heart failure. J Am Coll Cardiol. 2009;53:1975-1980.
25. DiBona GF. The sympathetic nervous system and hypertension: recent developments. Hypertension. 2004;43:147-150.
26. Lesske J, Fletcher EC, Bao G, Unger T. Hypertension caused by chronic intermittent hypoxia-infuence of chemoreceptors and sympathetic nervous system. J Hypertens. 1997;15(12 pt 2):1593-1603. (Pubitemid 28029653)
27. Zoccal DB, Bonagamba LG, Oliveira FR, Antunes-Rodrigues J, Machado BH. Increased sympathetic activity in rats submitted to chronic intermittent hypoxia. Exp Physiol. 2007;92:79-85. (Pubitemid 46096255)
28. Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman Z, Fudim M, Sobotka PA, Gourine A, Paton J.F.R. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol. 2012. 590:4269-4277.
29. Abdala AP, Marina N, Gourine A, Paton JFR. Peripheral chemoreceptor inputs contribute to the development of high blood pressure in spontaneously hypertensive rats. Proc Physiol Soc. 2012;23:PC22.
30. Abdala APL, Paton JF, Gourine AV. Peripheral chemoreceptor (pc) inputs contribute to the development of high blood pressure in spontaneously hypertensive rats (SHR). FASEB J. 2011;25:640.10.
31. Whiteis CA, Post CE, Morgan DA, Rahmouni K, Chapleau MW, Abboud FM. Peripheral chemoreceptors contribute signifcantly to hypertension in spontaneously hypertensive rats (SHR) [abstract]. FASEB J. 2012;26:15.
32. Trzebski A, Tafl M, Zoltowski M, Przybylski J. Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res. 1982;16:163-172. (Pubitemid 12143113)
33. Izdebska E, Cybulska I, Sawicki M, Izdebski J, Trzebski A. Postexercise decrease in arterial blood pressure, total peripheral resistance and in circulatory responses to brief hyperoxia in subjects with mild essential hypertension. J Hum Hypertens. 1998;12:855-860. (Pubitemid 29010275)
34. Tafl-Klawe M, Trzebski A, Klawe J, Pałko T. Augmented chemorecep-tor refex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension. Acta Physiol Pol. 1985;36:51-58. (Pubitemid 16142227)
35. Izdebska E, Izdebski J, Cybulska I, Makowiecka-Ciesla M, Trzebski A. Moderate exercise training reduces arterial chemoreceptor refex drive in mild hypertension. J Physiol Pharmacol. 2006;57(suppl 11):93-102. (Pubitemid 46569835)
36. Trzebski A. Arterial chemoreceptor refex and hypertension. Hypertension. 1992;19(6 pt 1):562-566.
37. Sinski M, Lewandowski J, Przybylski J, Bidiuk J, Abramczyk P, Ciarka A, Gaciong Z. Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension. Hypertens Res. 2012;35:487-491.
38. Nakayama K. Surgical removal of the carotid body for bronchial asthma. Dis Chest. 1961;40:595-604.
39. Winter B, Whipp BJ. Immediate effects of bilateral carotid body resection on total respiratory resistance and compliance in humans. Adv Exp Med Biol. 2004;551:15-21. (Pubitemid 40036647)
40. Heusser K, Tank J, Engeli S, Diedrich A, Menne J, Eckert S, Peters T, Sweep FC, Haller H, Pichlmaier AM, Luft FC, Jordan J. Carotid barore-ceptor stimulation, sympathetic activity, barorefex function, and blood pressure in hypertensive patients. Hypertension. 2010;55:619-626.
41. Tordoir JH, Scheffers I, Schmidli J, Savolainen H, Liebeskind U, Hansky B, Herold U, Irwin E, Kroon AA, de Leeuw P, Peters TK, Kieval R, Cody R. An implantable carotid sinus barorefex activating system: surgical technique and short-term outcome from a multi-center feasibility trial for the treatment of resistant hypertension. Eur J Vasc Endovasc Surg. 2007;33:414-421. (Pubitemid 46336600)
42. Brunner-La Rocca HP, Esler MD, Jennings GL, Kaye DM. Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure. Eur Heart J. 2001;22:1136-1143. (Pubitemid 32666655)
43. Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1986;73:615-621. (Pubitemid 16081418)
44. Grassi G, Seravalle G, Cattaneo BM, Lanfranchi A, Vailati S, Giannattasio C, Del Bo A, Sala C, Bolla GB, Pozzi M. Sympathetic activation and loss of refex sympathetic control in mild congestive heart failure. Circulation. 1995;92:3206-3211.
45. Despas F, Detis N, Dumonteil N, Labrunee M, Bellon B, Franchitto N, Galinier M, Senard JM, Pathak A. Excessive sympathetic activation in heart failure with chronic renal failure: role of chemorefex activation. J Hypertens. 2009;27:1849-1854.
46. Schultz HD, Li YL. Carotid body function in heart failure. Respir Physiol Neurobiol. 2007;157:171-185. (Pubitemid 46617445)
47. Ding YF LY, Cornish KG, Schultz HD. Reduced blood fow in carotid arteries is a trigger contributing to peripheral chemorefex hypersensitivity in chronic heart failure rabbits. FASEB J. 2007;21:A1268-A1269.
48. Li YL, Gao L, Zucker IH, Schultz HD. NADPH oxidase-derived superox-ide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits. Cardiovasc Res. 2007;75:546-554. (Pubitemid 47080964)
49. Li YL, Sun SY, Overholt JL, Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HD. Attenuated outward potassium currents in carotid body glo-mus cells of heart failure rabbit: involvement of nitric oxide. J Physiol (Lond). 2004;555(pt 1):219-229. (Pubitemid 38313072)
50. Li YL, Zheng H, Ding Y, Schultz HD. Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents. J Neurophysiol. 2010;103:3027-3033.
51. Ding Y, Li YL, Schultz HD. Role of blood fow in carotid body chemore-fex function in heart failure. J Physiol (Lond). 2011;589(pt 1):245-258.
52. Stickland MK, Miller JD, Smith CA, Dempsey JA. Carotid chemore-ceptor modulation of regional blood fow distribution during exercise in health and chronic heart failure. Circ Res. 2007;100:1371-1378. (Pubitemid 46742927)
53. Ponikowski P, Chua TP, Anker SD, Francis DP, Doehner W, Banasiak W, Poole-Wilson PA, Piepoli MF, Coats AJ. Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure. Circulation. 2001;104:544-549. (Pubitemid 32738123)
54. Moore DP, Weston AR, Hughes JM, Oakley CM, Cleland JG. Effects of increased inspired oxygen concentrations on exercise performance in chronic heart failure. Lancet. 1992;339:850-853.
55. Vermeire P, de Backer W, van Maele R, Bal J, van Kerckhoven W. Carotid body resection in patients with severe chronic airfow limitation. Bull Eur Physiopathol Respir. 1987;23(suppl 11):165s-166s. (Pubitemid 18011101)
56. Fallick C, Sobotka PA, Dunlap ME. Sympathetically mediated changes in capacitance: redistribution of the venous reservoir as a cause of decompensation. Circ Heart Fail. 2011;4:669-675.
57. Leor J, Poole WK, Kloner RA. Sudden cardiac death triggered by an earthquake. N Engl J Med. 1996;334:413-419. (Pubitemid 26055840)
58. Wilbert-Lampen U, Leistner D, Greven S, Pohl T, Sper S, Völker C, Güthlin D, Plasse A, Knez A, Küchenhoff H, Steinbeck G. Cardiovascular events during World Cup soccer. N Engl J Med. 2008;358:475-483. (Pubitemid 351185803)
59. Ukena C, Bauer A, Mahfoud F, Schreieck J, Neuberger HR, Eick C, Sobotka PA, Gawaz M, Böhm M. Renal sympathetic denervation for treatment of electrical storm: frst-in-man experience. Clin Res Cardiol. 2012;101:63-67.
60. Mahfoud F, Schlaich M, Kindermann I, Ukena C, Cremers B, Brandt MC, Hoppe UC, Vonend O, Rump LC, Sobotka PA, Krum H, Esler M, Böhm M. Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study. Circulation. 2011;123:1940-1946.
61. Schlaich MP. Sympathetic activation in chronic kidney disease: out of the shadow. Hypertension. 2011;57:683-685.
62. Winter B. Carotid body resection in chronic obstructive pulmonary disease. Chest. 1991;100:883.
63. Stulbarg MS, Winn WR, Kellett LE. Bilateral carotid body resection for the relief of dyspnea in severe chronic obstructive pulmonary disease. Physiologic and clinical observations in three patients. Chest. 1989;95:1123-1128. (Pubitemid 19137013)
64. Honda Y. Respiratory and circulatory activities in carotid body-resected humans. J Appl Physiol. 1992;73:1-8.
65. Whipp BJ, Ward SA. Physiologic changes following bilateral carotid-body resection in patients with chronic obstructive pulmonary disease. Chest. 1992;101:656-661.
66. Khan Q, Heath D, Smith P. Anatomical variations in human carotid bodies. J Clin Pathol. 1988;41:1196-1199. (Pubitemid 18266958)