NOX2 (gp91 phox) is a predominant O 2 sensor in a human airway chemoreceptor cell line: Biochemical, molecular, and electrophysiological evidence

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 7, 2012, Pages

  Buttigieg, Josef ^a,b   Pan, Jie ^a,b   Yeger, Herman ^a,b   Cutz, Ernest ^a,b  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Chemotransduction; Electrophysiology; Molecular biology; Pulmonary neuroendocrine cells

Indexed keywords

MESSENGER RNA; QUANTUM DOT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SEROTONIN; SHAL POTASSIUM CHANNEL; SHAW POTASSIUM CHANNEL; CYBB PROTEIN, HUMAN; KCNC3 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; NOX4 PROTEIN, HUMAN; OXYGEN; POTASSIUM CHANNEL SUBFAMILY K MEMBER 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

AMPEROMETRY; ARTICLE; CELL HYPOXIA; CELL MEMBRANE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MEMBRANE ELECTROPHYSIOLOGY; NEUROEPITHELIAL BODY; OXYGEN SENSING; PATCH CLAMP; PRIORITY JOURNAL; WESTERN BLOTTING; CHEMISTRY; CHEMORECEPTOR; PHYSIOLOGY; SECRETION (PROCESS); TUMOR CELL LINE;

CELL LINE, TUMOR; CHEMORECEPTOR CELLS; DOWN-REGULATION; HUMANS; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; NERVE TISSUE PROTEINS; NEUROEPITHELIAL BODIES; OXYGEN; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; SEROTONIN; SHAL POTASSIUM CHANNELS; SHAW POTASSIUM CHANNELS;

EID: 84867165176     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00170.2012     Document Type: Article

References (41)

1. Acker H. Cellular oxygen sensors. Ann NY Acad Sci 718: 3-10, 1994.
2. Bolle T, Lauweryns JM, Lommel AV. Postnatal maturation of neuroepithelial bodies and carotid body innervation: a quantitative investigation in the rabbit. J Neurocytol 29: 241-248, 2000.
3. Brouns I, Oztay F, Pintelon I, De Proost I, Lembrechts R, Timmermans JP, Adriaensen D. Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs. Histochem Cell Biol 131: 55-74, 2009.
4. 2 sensing in immortalized adrenomedullary chromaffin cells. Am J Physiol Cell Physiol 294: C945-C956, 2008.
5. Buttigieg J, Zhang M, Thompson R, Nurse C. Potential role of mitochondria in hypoxia sensing by adrenomedullary chromaffin cells. Adv Exp Med Biol 580: 79-85, 2006.
6. 2-sensing mechanisms in efferent neurons to the rat carotid body. Adv Exp Med Biol 536: 179-185, 2003.
7. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269: 131-140, 2001.
8. Cutz E, Fu XW, Nurse CA. Ionotropic receptors in pulmonary neuroepithelial bodies (NEB) and their possible role in modulation of hypoxia signalling. Adv Exp Med Biol 536: 155-161, 2003.
9. Cutz E, Jackson A. Neuroepithelial bodies as airway oxygen sensors. Respir Physiol 115: 201-214, 1999.
10. 2 sensing. Adv Exp Med Biol 648: 427-438, 2009.
11. Cutz E, Yeger H, Pan J. Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances. Pediatr Dev Pathol 10: 419-435, 2007.
12. 2 signalling mechanisms in oxygen-sensing cells. Novartis Found Symp 272: 234-252, 2006.
13. Evans AM, Hardie DG, Peers C, Mahmoud A. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing. Curr Opin Anaesthesiol 24: 13-20, 2011.
14. 2-sensitive K channels in immortalised rat chromaffin-cell-derived MAH cells. J Physiol 545: 807-818, 2002.
15. Fu XW, Nurse CA, Wong V, Cutz E. Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit. J Physiol 539: 503-510, 2002.
16. 2 sensor in airway chemoreceptors: evidence from K current modulation in wild-type and oxidase-deficient mice. Proc Natl Acad Sci USA 97: 4374-4379, 2000.
17. Gazdar AF, Helman LJ, Israel MA, Russell EK, Linnoila RI, Mulshine JL, Schuller HM, Park JG. Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin. Cancer Res 48: 4078-4082, 1988.
18. Kazemian P, Stephenson R, Yeger H, Cutz E. Respiratory control in neonatal mice with NADPH oxidase deficiency. Respir Physiol 126: 89-101, 2001.
19. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4: 181-189, 2004.
20. Laurent E, McCoy JW 3rd, Macina RA, Liu W, Cheng G, Robine S, Papkoff J, Lambeth JD. Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer 123: 100-107, 2008.
21. Lauweryns JM, Cokelaere M, Lerut T, Theunynck P. Cross-circulation studies on the influence of hypoxia and hypoxaemia on neuro-epithelial bodies in young rabbits. Cell Tissue Res 193: 373-386, 1978.
22. Lee YM, Kim BJ, Chun YS, So I, Choi H, Kim MS, Park JW. NOX4 as an oxygen sensor to regulate TASK1 activity. Cell Signal 18: 499-507, 2006.
23. Moudgil R, Michelakis ED, Archer SL. The role of K channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 13: 615-632, 2006.
24. 2 sensing by airway chemoreceptor-derived cells. Protein kinase c activation reveals functional evidence for involvement of NADPH oxidase. J Biol Chem 275: 7684-7692, 2000.
25. 2-sensing in model airway chemoreceptor cells. Biochem Biophys Res Commun 283: 1131-1134, 2001.
26. Paravicini TM, Chrissobolis S, Drummond GR, Sobey CG. Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke 35: 584-589, 2004.
27. Park SJ, Chun YS, Park KS, Kim SJ, Choi SO, Kim HL, Park JW. Identification of subdomains in NADPH oxidase-4 critical for the oxygendependent regulation of TASK1 K channels. Am J Physiol Cell Physiol 297: C855-C864, 2009.
28. Patel AJ, Honore E. Molecular physiology of oxygen-sensitive potassium channels. Eur Respir J 18: 221-227, 2001.
29. Peers C, Kemp PJ. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Res 2: 145-149, 2001.
30. Quinn MT, Gauss KA. Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J Leukoc Biol 76: 760-781, 2004.
31. Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, Koenen M. Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature 352: 711-714, 1991.
32. Rybicka JM, Balce DR, Khan MF, Krohn RM, Yates RM. NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes. Proc Natl Acad Sci USA 107: 10496-10501, 2010.
33. 2 sensing in model airway chemoreceptors. Biochem Biophys Res Commun 291: 332-337, 2002.
34. Tang XD, Garcia ML, Heinemann SH, Hoshi T. Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat Struct Mol Biol 11: 171-178, 2004.
35. 2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells. Neuroscience 145: 130-141, 2007.
36. Van Lommel A. Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): chemoreceptors and regulators of lung development. Paediatr Respir Rev 2: 171-176, 2001.
37. Vega-Saenz de Miera E, Rudy B. Modulation of K channels by hydrogen peroxide. Biochem Biophys Res Commun 186: 1681-1687, 1992.
38. Wang D, Youngson C, Wong V, Yeger H, Dinauer MC, Vega-Saenz Miera E, Rudy B, Cutz E. NADPH-oxidase and a hydrogen peroxidesensitive K channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc Natl Acad Sci USA 93: 13182-13187, 1996.
39. Weir EK, Wyatt CN, Reeve HL, Huang J, Archer SL, Peers C. Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells. J Appl Physiol 76: 2611-2615, 1994.
40. 2 currents in type I cells isolated from the neonatal rat carotid body. Neuroscience letters 172: 63-66, 1994.
41. 2-sensing protein (NADPH oxidase) in chemoreceptor cells. Microsc Res Tech 37: 101-106, 1997.