Transcriptional regulation of mammalian autophagy at a glance

Journal of Cell Science

Volumn 129, Issue 16, 2016, Pages 3059-3066

  Füllgrabe, Jens ^a   Ghislat, Ghita ^a,c   Cho, Dong Hyung ^b   Rubinsztein, David C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Kyung Hee University   (South Korea)

^c INSERM   (France)

Author keywords

Autophagy; Lysosome; Transcription

Indexed keywords

FXR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TFEB PROTEIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; ZKSCAN3 PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL DEATH; CELL SURVIVAL; HYPOXIA; MACROAUTOPHAGY; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; AUTOPHAGY; CELL HYPOXIA; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MAMMAL; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CELL HYPOXIA; GENE EXPRESSION REGULATION; HUMANS; MAMMALS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84983650227     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.188920     Document Type: Article

References (85)

1. Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J. and Mazure, N. M. (2009). Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29, 2570-2581.
2. Bowman, C. J., Ayer, D. E. and Dynlacht, B. D. (2014). Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat. Cell Biol. 16, 1202-1214.
3. Brigger, D., Proikas-Cezanne, T. and Tschan, M. P. (2014). WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell Death Dis. 5, e1315.
4. Chauhan, S., Goodwin, J. G., Chauhan, S., Manyam, G., Wang, J., Kamat, A. M. and Boyd, D. D. (2013). ZKSCAN3 is a master transcriptional repressor of autophagy. Mol. Cell 50, 16-28.
5. Cho, Y.-Y., Kim, D. J., Lee, H. S., Jeong, C.-H., Cho, E.-J., Kim, M.-O., Byun, S., Lee, K.-Y., Yao, K., Carper, A. et al. (2013). Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PLoS ONE 8, e57172.
6. Copetti, T., Bertoli, C., Dalla, E., Demarchi, F. and Schneider, C. (2009). p65/ RelA modulates BECN1 transcription and autophagy. Mol. Cell. Biol. 29, 2594-2608.
7. Cortes, C. J., Miranda, H. C., Frankowski, H., Batlevi, Y., Young, J. E., Le, A., Ivanov, N., Sopher, B. L., Carromeu, C., Muotri, A. R. et al. (2014). Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat. Neurosci. 17, 1180-1189.
8. Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J. and Björklund, A. (2013). TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity. Proc. Natl. Acad. Sci. USA 110, E1817-E1826.
9. Fiorentino, L., Cavalera, M., Menini, S., Marchetti, V., Mavilio, M., Fabrizi, M., Conserva, F., Casagrande, V., Menghini, R., Pontrelli, P. et al. (2013). Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay. EMBO Mol. Med. 5, 441-455.
10. Füllgrabe, J., Klionsky, D. J. and Joseph, B. (2014). The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat. Rev. Mol. Cell Biol. 15, 65-74.
11. Gao, W., Shen, Z., Shang, L. and Wang, X. (2011). Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNAdamage-induced cell death. Cell Death Differ. 18, 1598-1607.
12. Garcia-Garcia, A., Rodriguez-Rocha, H., Tseng, M. T., Montes de Oca-Luna, R., Zhou, H. S., McMasters, K. M. and Gomez-Gutierrez, J. G. (2012). E2F-1 lacking the transcriptional activity domain induces autophagy. Cancer Biol. Ther. 13, 1091-1101.
13. Ghosh, A., Jana, M., Modi, K., Gonzalez, F. J., Sims, K. B., Berry-Kravis, E. and Pahan, K. (2015). Activation of peroxisome proliferator-activated receptor a induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders. J. Biol. Chem. 290, 10309-10324.
14. Green, D. R. and Kroemer, G. (2009). Cytoplasmic functions of the tumour suppressor p53. Nature 458, 1127-1130.
15. Hervouet, E., Claude-Taupin, A., Gauthier, T., Perez, V., Fraichard, A., Adami, P., Despouy, G., Monnien, F., Algros, M.-P., Jouvenot, M. et al. (2015). The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models. BMC Cancer 15, 729.
16. Huang, Y., Guerrero-Preston, R. and Ratovitski, E. A. (2012). Phospho-DeltaNp63alpha-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle 11, 1247-1259.
17. Jahreiss, L., Menzies, F. M. and Rubinsztein, D. C. (2008). The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 9, 574-587.
18. Jia, G., Cheng, G., Gangahar, D. M. and Agrawal, D. K. (2006). Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol. Cell Biol. 84, 448-454.
19. Jiao, M., Ren, F., Zhou, L., Zhang, X., Zhang, L., Wen, T., Wie, L., Wang, X., Shi, H., Bai, L. et al. (2014). Peroxisome proliferator-activated receptor a activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway. Cell Death Dis. 5, e1397.
20. Jonker, J. W., Suh, J. M., Atkins, A. R., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T. et al. (2012). A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394.
21. Kang, Y.-A., Sanalkumar, R., O'Geen, H., Linnemann, A. K., Chang, C.-J., Bouhassira, E. E., Farnham, P. J., Keles, S. and Bresnick, E. H. (2012). Autophagy driven by a master regulator of hematopoiesis. Mol. Cell. Biol. 32, 226-239.
22. Kenzelmann Broz, D., Spano Mello, S., Bieging, K. T., Jiang, D., Dusek, R. L., Brady, C. A., Sidow, A. and Attardi, L. D. (2013). Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev. 27, 1016-1031.
23. Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T. and Ohsumi, Y. (1999). Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J. Cell Biol. 147, 435-446.
24. Lee, J. M., Wagner, M., Xiao, R., Kim, K. H., Feng, D., Lazar, M. A. and Moore, D. D. (2014). Nutrient-sensing nuclear receptors coordinate autophagy. Nature 516, 112-115.
25. Levine, B. and Kroemer, G. (2008). Autophagy in the pathogenesis of disease. Cell 132, 27-42.
26. Li, D.-D., Wang, L.-L., Deng, R., Tang, J., Shen, Y., Guo, J.-F., Wang, Y., Xia, L.-P., Feng, G.-K., Liu, Q. Q. et al. (2009). The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 28, 886-898.
27. Liao, X., Zhang, R., Lu, Y., Prosdocimo, D. A., Sangwung, P., Zhang, L., Zhou, G., Anand, P., Lai, L., Leone, T. C. et al. (2015). Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J. Clin. Invest. 125, 3461-3476.
28. Lin, F., Ghislat, G., Luo, S., Renna, M., Siddiqi, F. and Rubinsztein, D. C. (2015). XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFkappaB activation. Hum. Mol. Genet. 24, 2899-2913.
29. Ling, J., Kang, Y., Zhao, R., Xia, Q., Lee, D.-F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H. et al. (2012). KrasG12D-induced IKK2/β/NF-κB activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell 21, 105-120.
30. Liu, H.-Y., Han, J., Cao, S. Y., Hong, T., Zhuo, D., Shi, J., Liu, Z. and Cao, W. (2009). Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J. Biol. Chem. 284, 31484-31492.
31. Luo, T., Fu, J., Xu, A., Su, B., Ren, Y., Li, N., Zhu, J., Zhao, X., Dai, R., Cao, J. et al. (2015). PSMD10/Gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy [Epub ahead of print] doi:10.1080/15548627.2015.1034405.
32. Ma, D., Panda, S. and Lin, J. D. (2011). Temporal orchestration of circadian autophagy rhythm by C/EBPbeta. EMBO J. 30, 4642-4651.
33. Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J. et al. (2007). FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6, 458-471.
34. Mammucari, C., Schiaffino, S. and Sandri, M. (2008). Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 4, 524-526.
35. Margariti, A., Li, H., Chen, T., Martin, D., Vizcay-Barrena, G., Alam, S., Karamariti, E., Xiao, Q., Zampetaki, A., Zhang, Z. et al. (2013). XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. J. Biol. Chem. 288, 859-872.
36. Martina, J. A., Chen, Y., Gucek, M. and Puertollano, R. (2012). MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8, 903-914.
37. Martina, J. A., Diab, H. I., Lishu, L., Jeong-A, L., Patange, S., Raben, N. and Puertollano, R. (2014). The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci. Signal. 7, ra9.
38. Maruyama, Y., Sou, Y.-S., Kageyama, S., Takahashi, T., Ueno, T., Tanaka, K., Komatsu, M. and Ichimura, Y. (2014). LC3B is indispensable for selective autophagy of p62 but not basal autophagy. Biochem. Biophys. Res. Commun. 446, 309-315.
39. McCormick, J., Suleman, N., Scarabelli, T. M., Knight, R. A., Latchman, D. S. and Stephanou, A. (2012). STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy. J. Cell Mol. Med. 16, 386-393.
40. Menzies, F. M., Fleming, A. and Rubinsztein, D. C. (2015). Compromised autophagy and neurodegenerative diseases. Nat. Rev. Neurosci. 16, 345-357.
41. Milani, M., Rzymski, T., Mellor, H. R., Pike, L., Bottini, A., Generali, D. and Harris, A. L. (2009). The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res. 69, 4415-4423.
42. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. and Ohsumi, Y. (2004). In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111.
43. Moreau, K., Ghislat, G., Hochfeld, W., Renna, M., Zavodszky, E., Runwal, G., Puri, C., Lee, S., Siddiqi, F., Menzies, F. M. et al. (2015). Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. Nat. Commun. 6, 8045.
44. Pastore, N., Blomenkamp, K., Annunziata, F., Piccolo, P., Mithbaokar, P., Maria Sepe, R., Vetrini, F., Palmer, D., Ng, P., Polishchuk, E. et al. (2013). Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency. EMBO Mol. Med. 5, 397-412.
45. Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R. et al. (2015). Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature 524, 361-365.
46. Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. et al. (2013). Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO J. 32, 1903-1916.
47. Pietrocola, F., Izzo, V., Niso-Santano, M., Vacchelli, E., Galluzzi, L., Maiuri, M. C. and Kroemer, G. (2013). Regulation of autophagy by stress-responsive transcription factors. Semin. Cancer Biol. 23, 310-322.
48. Pike, L. R. G., Singleton, D. C., Buffa, F., Abramczyk, O., Phadwal, K., Li, J.-L., Simon, A. K., Murray, J. T. and Harris, A. L. (2013). Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. Biochem. J. 449, 389-400.
49. Polager, S. and Ginsberg, D. (2009). p53 and E2f: partners in life and death. Nat. Rev. Cancer 9, 738-748.
50. Polager, S., Ofir, M. and Ginsberg, D. (2008). E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene 27, 4860-4864.
51. Qin, H., Tan, W., Zhang, Z., Bao, L., Shen, H., Wang, F., Xu, F. and Wang, Z. (2015). 15d-prostaglandin J2 protects cortical neurons against oxygen-glucose deprivation/reoxygenation injury: involvement of inhibiting autophagy through upregulation of Bcl-2. Cell. Mol. Neurobiol. 35, 303-312.
52. Rabinowitz, J. D. and White, E. (2010). Autophagy and metabolism. Science 330, 1344-1348.
53. Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J. and Davis, R. J. (1995). Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426.
54. Ravikumar, B., Futter, M., Jahreiss, L., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C. O., Menzies, F. M., Narayanan, U., Renna, M. et al. (2009). Mammalian macroautophagy at a glance. J. Cell Sci. 122, 1707-1711.
55. Riz, I., Hawley, T. S. and Hawley, R. G. (2015). KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget 6, 14814-14831.
56. Rosenbluth, J. M., Mays, D. J., Pino, M. F., Tang, L. J. and Pietenpol, J. A. (2008). A gene signature-based approach identifies mTOR as a regulator of p73. Mol. Cell Biol. 19, 5951-5964.
57. Rosenbluth, J. M. and Pietenpol, J. A. (2009). mTOR regulates autophagyassociated genes downstream of p73. Autophagy 5, 114-116.
58. Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W. et al. (2010). The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Invest. 120, 127-141.
59. Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A. and Guan, K.-L. (2013). ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741-750.
60. Rzymski, T., Milani, M., Pike, L., Buffa, F., Mellor, H. R., Winchester, L., Pires, I., Hammond, E., Ragoussis, I. and Harris, A. L. (2010). Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 29, 4424-4435.
61. Sanchez, A. M., Csibi, A., Raibon, A., Cornille, K., Gay, S., Bernardi, H. and Candau, R. (2012). AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J. Cell Biochem. 113, 695-710.
62. Scherz-Shouval, R., Weidberg, H., Gonen, C., Wilder, S., Elazar, Z. and Oren, M. (2010). p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc. Natl. Acad. Sci. USA 107, 18511-18516.
63. Schips, T. G., Wietelmann, A., Hohn, K., Schimanski, S., Walther, P., Braun, T., Wirth, T. and Maier, H. J. (2011). FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model. Cardiovasc. Res. 91, 587-597.
64. Seo, Y.-K., Jeon, T.-I., Chong, H. K., Biesinger, J., Xie, X. and Osborne, T. F. (2011). Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy. Cell Metab. 13, 367-375.
65. Seok, S., Fu, T., Choi, S. E., Li, Y., Zhu, R., Kumar, S., Sun, X., Yoon, G., Kang, Y., Zhong, W. et al. (2014). Transcriptional regulation of autophagy by an FXRCREB axis. Nature 516, 108-111.
66. Settembre, C., Di Malta, C., Polito, V. A., Garcia Arencibia, M., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P. et al. (2011). TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433.
67. Shaw, J., Yurkova, N., Zhang, T., Gang, H., Aguilar, F., Weidman, D., Scramstad, C., Weisman, H. and Kirshenbaum, L. A. (2008). Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc. Natl. Acad. Sci. USA 105, 20734-20739.
68. Sheng, Z., Ma, L., Sun, J. E., Zhu, L. J. and Green, M. R. (2011). BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood 118, 2840-2848.
69. Spampanato, C., Feeney, E., Li, L., Cardone, M., Lim, J.-A., Annunziata, F., Zare, H., Polishchuk, R., Puertollano, R., Parenti, G. et al. (2013). Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease. EMBO Mol. Med. 5, 691-706.
70. Sun, T., Li, D., Wang, L., Xia, L., Ma, J., Guan, Z., Feng, G. and Zhu, X. (2011). c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells. J. Transl. Med. 9, 161.
71. Tamatani, M., Che, Y. H., Matsuzaki, H., Ogawa, S., Okado, H., Miyake, S.-I., Mizuno, T. and Tohyama, M. (1999). Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J. Biol. Chem. 274, 8531-8538.
72. Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F. et al. (2008). Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 10, 676-687.
73. Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P. and Macleod, K. F. (2007). BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol. Cell. Biol. 27, 6229-6242.
74. Tsunemi, T., Ashe, T. D., Morrison, B. E., Soriano, K. R., Au, J., Roque, R. A. V., Lazarowski, E. R., Damian, V. A., Masliah, E. and La Spada, A. R. (2012). PGC-1a rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci. Transl. Med. 4, 142ra97.
75. Wei, Y., Pattingre, S., Sinha, S., Bassik, M. and Levine, B. (2008). JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30, 678-688.
76. Xie, Z. and Klionsky, D. J. (2007). Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 9, 1102-1109.
77. Xiong, X., Tao, R., DePinho, R. A. and Dong, X. C. (2012). The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J. Biol. Chem. 287, 39107-39114.
78. Xu, P., Das, M., Reilly, J. and Davis, R. J. (2011). JNK regulates FoxO-dependent autophagy in neurons. Genes Dev. 25, 310-322.
79. Xu, F., Li, J., Ni, W., Shen, Y.-W. and Zhang, X.-P. (2013). Peroxisome proliferatoractivated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. PLoS ONE 8, e55080.
80. Yan, S., Yang, X., Chen, T., Xi, Z. and Jiang, X. (2014). The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Cancer Gene Ther. 21, 188-193.
81. Yurkova, N., Shaw, J., Blackie, K., Weidman, D., Jayas, R., Flynn, B. and Kirshenbaum, L. A. (2008). The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes. Circ. Res. 102, 472-479.
82. Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J. and Semenza, G. L. (2008). Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283, 10892-10903.
83. Zhang, Z., Guo, M., Zhao, S., Xu, W., Shao, J., Zhang, F., Wu, L., Lu, Y. and Zheng, S. (2015). The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target. Biomed. Pharmacother. 74, 17-29.
84. Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H. and Goldberg, A. L. (2007). FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6, 472-483.
85. Zhao, Y., Yang, J., Liao, W., Liu, X., Zhang, H., Wang, S., Wang, D., Feng, J., Yu, L. and Zhu, W. G. (2010). Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12, 665-675.