-
1
-
-
62649101158
-
Cancer: The nuances of therapy
-
10.1038/458290a, 19295595
-
Ellis LM, Reardon DA. Cancer: The nuances of therapy. Nature 2009, 458:290-292. 10.1038/458290a, 19295595.
-
(2009)
Nature
, vol.458
, pp. 290-292
-
-
Ellis, L.M.1
Reardon, D.A.2
-
2
-
-
75149155591
-
Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma
-
10.1017/S0022215109991435, 19840426
-
Li JJ, Guo YK, Tang QL, Li SS, Zhang XL, Wu PA, Yang XM. Prospective study of sensorineural hearing loss following radiotherapy for nasopharyngeal carcinoma. J Laryngol Otol 2010, 124:32-36. 10.1017/S0022215109991435, 19840426.
-
(2010)
J Laryngol Otol
, vol.124
, pp. 32-36
-
-
Li, J.J.1
Guo, Y.K.2
Tang, Q.L.3
Li, S.S.4
Zhang, X.L.5
Wu, P.A.6
Yang, X.M.7
-
3
-
-
0033570936
-
Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma
-
10.1002/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO;2-S, 10570413
-
Heng DM, Wee J, Fong KW, Lian LG, Sethi VK, Chua ET, Yang TL, Khoo Tan HS, Lee KS, Lee KM, et al. Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer 1999, 86:1912-1920. 10.1002/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO;2-S, 10570413.
-
(1999)
Cancer
, vol.86
, pp. 1912-1920
-
-
Heng, D.M.1
Wee, J.2
Fong, K.W.3
Lian, L.G.4
Sethi, V.K.5
Chua, E.T.6
Yang, T.L.7
Khoo Tan, H.S.8
Lee, K.S.9
Lee, K.M.10
-
4
-
-
0034240907
-
Chemotherapy in advanced nasopharyngeal cancer
-
discussion 1232-1227, 1239-1242.
-
Ali H, al-Sarraf M. Chemotherapy in advanced nasopharyngeal cancer. Oncology (Williston Park) 2000, 14:1223-1230. discussion 1232-1227, 1239-1242..
-
(2000)
Oncology (Williston Park)
, vol.14
, pp. 1223-1230
-
-
Ali, H.1
al-Sarraf, M.2
-
5
-
-
34147193472
-
Cell biology: autophagy and cancer
-
10.1038/446745a, 17429391
-
Levine B. Cell biology: autophagy and cancer. Nature 2007, 446:745-747. 10.1038/446745a, 17429391.
-
(2007)
Nature
, vol.446
, pp. 745-747
-
-
Levine, B.1
-
6
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
10.1016/j.ccr.2006.06.001, 2857533, 16843265
-
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64. 10.1016/j.ccr.2006.06.001, 2857533, 16843265.
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gelinas, C.9
Fan, Y.10
-
7
-
-
0026584008
-
Autophagy and other vacuolar protein degradation mechanisms
-
10.1007/BF01923509, 1740188
-
Seglen PO, Bohley P. Autophagy and other vacuolar protein degradation mechanisms. Experientia 1992, 48:158-172. 10.1007/BF01923509, 1740188.
-
(1992)
Experientia
, vol.48
, pp. 158-172
-
-
Seglen, P.O.1
Bohley, P.2
-
8
-
-
0034948738
-
The autophagosomal-lysosomal compartment in programmed cell death
-
10.1038/sj.cdd.4400852, 11536007
-
Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001, 8:569-581. 10.1038/sj.cdd.4400852, 11536007.
-
(2001)
Cell Death Differ
, vol.8
, pp. 569-581
-
-
Bursch, W.1
-
9
-
-
1842583789
-
Development by self-digestion: molecular mechanisms and biological functions of autophagy
-
10.1016/S1534-5807(04)00099-1, 15068787
-
Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004, 6:463-477. 10.1016/S1534-5807(04)00099-1, 15068787.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
10
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
10.1128/MCB.01453-06, 1698520, 17030611
-
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006, 26:9220-9231. 10.1128/MCB.01453-06, 1698520, 17030611.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
-
11
-
-
0037451783
-
Autophagy: a barrier or an adaptive response to cancer
-
Ogier-Denis E, Codogno P. Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta 2003, 1603:113-128.
-
(2003)
Biochim Biophys Acta
, vol.1603
, pp. 113-128
-
-
Ogier-Denis, E.1
Codogno, P.2
-
12
-
-
39049194057
-
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
-
10.4161/auto.1.1.1542, 16874027
-
Furuya N, Yu J, Byfield M, Pattingre S, Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 2005, 1:46-52. 10.4161/auto.1.1.1542, 16874027.
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Pattingre, S.4
Levine, B.5
-
13
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
10.1038/nrc1692, 16148885
-
Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005, 5:726-734. 10.1038/nrc1692, 16148885.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
14
-
-
2442482810
-
Autophagy as a cell death and tumor suppressor mechanism
-
10.1038/sj.onc.1207521, 15077152
-
Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004, 23:2891-2906. 10.1038/sj.onc.1207521, 15077152.
-
(2004)
Oncogene
, vol.23
, pp. 2891-2906
-
-
Gozuacik, D.1
Kimchi, A.2
-
15
-
-
0035863399
-
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
-
Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001, 61:439-444.
-
(2001)
Cancer Res
, vol.61
, pp. 439-444
-
-
Paglin, S.1
Hollister, T.2
Delohery, T.3
Hackett, N.4
McMahill, M.5
Sphicas, E.6
Domingo, D.7
Yahalom, J.8
-
16
-
-
0037306785
-
Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
-
10.3171/jns.2003.98.2.0378, 12593626
-
Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003, 98:378-384. 10.3171/jns.2003.98.2.0378, 12593626.
-
(2003)
J Neurosurg
, vol.98
, pp. 378-384
-
-
Yao, K.C.1
Komata, T.2
Kondo, Y.3
Kanzawa, T.4
Kondo, S.5
Germano, I.M.6
-
17
-
-
20144373772
-
Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy
-
10.1158/0008-5472.CAN-04-4202, 15899829
-
Daido S, Yamamoto A, Fujiwara K, Sawaya R, Kondo S, Kondo Y. Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy. Cancer Res 2005, 65:4368-4375. 10.1158/0008-5472.CAN-04-4202, 15899829.
-
(2005)
Cancer Res
, vol.65
, pp. 4368-4375
-
-
Daido, S.1
Yamamoto, A.2
Fujiwara, K.3
Sawaya, R.4
Kondo, S.5
Kondo, Y.6
-
18
-
-
34247646062
-
The anticancer drug imatinib induces cellular autophagy
-
Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Duyster J, Elsasser HP, Schatzl HM. The anticancer drug imatinib induces cellular autophagy. Leukemia 2007, 21:936-942.
-
(2007)
Leukemia
, vol.21
, pp. 936-942
-
-
Ertmer, A.1
Huber, V.2
Gilch, S.3
Yoshimori, T.4
Erfle, V.5
Duyster, J.6
Elsasser, H.P.7
Schatzl, H.M.8
-
19
-
-
78449281238
-
Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death
-
10.1016/j.jss.2009.07.011, 20031162
-
Coates JM, Galante JM, Bold RJ. Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death. J Surg Res 2010, 164:301-308. 10.1016/j.jss.2009.07.011, 20031162.
-
(2010)
J Surg Res
, vol.164
, pp. 301-308
-
-
Coates, J.M.1
Galante, J.M.2
Bold, R.J.3
-
20
-
-
0442323561
-
Autophagy: in sickness and in health
-
10.1016/j.tcb.2003.12.002, 15102438
-
Cuervo AM. Autophagy: in sickness and in health. Trends Cell Biol 2004, 14:70-77. 10.1016/j.tcb.2003.12.002, 15102438.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 70-77
-
-
Cuervo, A.M.1
-
21
-
-
69449089962
-
Cancer cell death by design: apoptosis, autophagy and glioma virotherapy
-
Tyler MA, Ulasov IV, Lesniak MS. Cancer cell death by design: apoptosis, autophagy and glioma virotherapy. Autophagy 2009, 5:856-857.
-
(2009)
Autophagy
, vol.5
, pp. 856-857
-
-
Tyler, M.A.1
Ulasov, I.V.2
Lesniak, M.S.3
-
22
-
-
23344442168
-
Autophagy is the dominant type of programmed cell death in breast cancer MCF-7 cells exposed to AGS 115 and EFDAC, new sesquiterpene analogs of paclitaxel
-
10.1097/01.cad.0000171514.50310.85, 16027528
-
Gorka M, Daniewski WM, Gajkowska B, Lusakowska E, Godlewski MM, Motyl T. Autophagy is the dominant type of programmed cell death in breast cancer MCF-7 cells exposed to AGS 115 and EFDAC, new sesquiterpene analogs of paclitaxel. Anticancer Drugs 2005, 16:777-788. 10.1097/01.cad.0000171514.50310.85, 16027528.
-
(2005)
Anticancer Drugs
, vol.16
, pp. 777-788
-
-
Gorka, M.1
Daniewski, W.M.2
Gajkowska, B.3
Lusakowska, E.4
Godlewski, M.M.5
Motyl, T.6
-
23
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
10.1126/science.270.5240.1326, 7481820
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331. 10.1126/science.270.5240.1326, 7481820.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
24
-
-
0029753773
-
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
-
10.1074/jbc.271.50.31929, 8943238
-
Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 1996, 271:31929-31936. 10.1074/jbc.271.50.31929, 8943238.
-
(1996)
J Biol Chem
, vol.271
, pp. 31929-31936
-
-
Chen, Y.R.1
Wang, X.2
Templeton, D.3
Davis, R.J.4
Tan, T.H.5
-
25
-
-
68349110789
-
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy
-
10.1016/j.mod.2009.06.1082, 2750887, 19540338
-
Wu H, Wang MC, Bohmann D. JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev 2009, 126:624-637. 10.1016/j.mod.2009.06.1082, 2750887, 19540338.
-
(2009)
Mech Dev
, vol.126
, pp. 624-637
-
-
Wu, H.1
Wang, M.C.2
Bohmann, D.3
-
26
-
-
56349121130
-
Fas-mediated autophagy requires JNK activation in HeLa cells
-
10.1016/j.bbrc.2008.10.151, 18996088
-
Zhang Y, Wu Y, Cheng Y, Zhao Z, Tashiro S, Onodera S, Ikejima T. Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem Biophys Res Commun 2008, 377:1205-1210. 10.1016/j.bbrc.2008.10.151, 18996088.
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 1205-1210
-
-
Zhang, Y.1
Wu, Y.2
Cheng, Y.3
Zhao, Z.4
Tashiro, S.5
Onodera, S.6
Ikejima, T.7
-
27
-
-
77954381442
-
The PEA-15 protein regulates autophagy via activation of JNK
-
10.1074/jbc.M109.096628, 2898427, 20452983
-
Bock BC, Tagscherer KE, Fassl A, Kramer A, Oehme I, Zentgraf HW, Keith M, Roth W. The PEA-15 protein regulates autophagy via activation of JNK. J Biol Chem 2010, 285:21644-21654. 10.1074/jbc.M109.096628, 2898427, 20452983.
-
(2010)
J Biol Chem
, vol.285
, pp. 21644-21654
-
-
Bock, B.C.1
Tagscherer, K.E.2
Fassl, A.3
Kramer, A.4
Oehme, I.5
Zentgraf, H.W.6
Keith, M.7
Roth, W.8
-
28
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
10.1038/45257, 10604474
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676. 10.1038/45257, 10604474.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
29
-
-
60149098492
-
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells
-
10.1038/onc.2008.441, 19060920
-
Li DD, Wang LL, Deng R, Tang J, Shen Y, Guo JF, Wang Y, Xia LP, Feng GK, Liu QQ, et al. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 2009, 28:886-898. 10.1038/onc.2008.441, 19060920.
-
(2009)
Oncogene
, vol.28
, pp. 886-898
-
-
Li, D.D.1
Wang, L.L.2
Deng, R.3
Tang, J.4
Shen, Y.5
Guo, J.F.6
Wang, Y.7
Xia, L.P.8
Feng, G.K.9
Liu, Q.Q.10
-
30
-
-
4644362024
-
In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy
-
10.1074/jbc.M405860200, 15277523
-
Ichimura Y, Imamura Y, Emoto K, Umeda M, Noda T, Ohsumi Y. In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem 2004, 279:40584-40592. 10.1074/jbc.M405860200, 15277523.
-
(2004)
J Biol Chem
, vol.279
, pp. 40584-40592
-
-
Ichimura, Y.1
Imamura, Y.2
Emoto, K.3
Umeda, M.4
Noda, T.5
Ohsumi, Y.6
-
31
-
-
0034707036
-
A ubiquitin-like system mediates protein lipidation
-
10.1038/35044114, 11100732
-
Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M, et al. A ubiquitin-like system mediates protein lipidation. Nature 2000, 408:488-492. 10.1038/35044114, 11100732.
-
(2000)
Nature
, vol.408
, pp. 488-492
-
-
Ichimura, Y.1
Kirisako, T.2
Takao, T.3
Satomi, Y.4
Shimonishi, Y.5
Ishihara, N.6
Mizushima, N.7
Tanida, I.8
Kominami, E.9
Ohsumi, M.10
-
32
-
-
0034722378
-
Dissection of autophagosome biogenesis into distinct nucleation and expansion steps
-
10.1083/jcb.151.5.1025, 2174351, 11086004
-
Abeliovich H, Dunn WA, Kim J, Klionsky DJ. Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J Cell Biol 2000, 151:1025-1034. 10.1083/jcb.151.5.1025, 2174351, 11086004.
-
(2000)
J Cell Biol
, vol.151
, pp. 1025-1034
-
-
Abeliovich, H.1
Dunn, W.A.2
Kim, J.3
Klionsky, D.J.4
-
33
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
10.1093/emboj/19.21.5720, 305793, 11060023
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19:5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
34
-
-
4344624322
-
LC3 conjugation system in mammalian autophagy
-
10.1016/j.biocel.2004.05.009, 15325588
-
Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004, 36:2503-2518. 10.1016/j.biocel.2004.05.009, 15325588.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2503-2518
-
-
Tanida, I.1
Ueno, T.2
Kominami, E.3
-
35
-
-
4344712684
-
Methods for monitoring autophagy
-
10.1016/j.biocel.2004.02.005, 15325587
-
Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol 2004, 36:2491-2502. 10.1016/j.biocel.2004.02.005, 15325587.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2491-2502
-
-
Mizushima, N.1
-
36
-
-
0026007737
-
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation
-
Kim MY, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem 1991, 266:484-489.
-
(1991)
J Biol Chem
, vol.266
, pp. 484-489
-
-
Kim, M.Y.1
Linardic, C.2
Obeid, L.3
Hannun, Y.4
-
37
-
-
11144354259
-
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
-
10.1038/nm977, 14704790
-
Goggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schutze S, et al. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 2004, 10:155-160. 10.1038/nm977, 14704790.
-
(2004)
Nat Med
, vol.10
, pp. 155-160
-
-
Goggel, R.1
Winoto-Morbach, S.2
Vielhaber, G.3
Imai, Y.4
Lindner, K.5
Brade, L.6
Brade, H.7
Ehlers, S.8
Slutsky, A.S.9
Schutze, S.10
-
38
-
-
0027511687
-
Programmed cell death induced by ceramide
-
10.1126/science.8456305, 8456305
-
Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science 1993, 259:1769-1771. 10.1126/science.8456305, 8456305.
-
(1993)
Science
, vol.259
, pp. 1769-1771
-
-
Obeid, L.M.1
Linardic, C.M.2
Karolak, L.A.3
Hannun, Y.A.4
-
39
-
-
0028095477
-
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
-
10.1084/jem.180.4.1547, 2191710, 7523573
-
Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A, Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1994, 180:1547-1552. 10.1084/jem.180.4.1547, 2191710, 7523573.
-
(1994)
J Exp Med
, vol.180
, pp. 1547-1552
-
-
Cifone, M.G.1
De Maria, R.2
Roncaioli, P.3
Rippo, M.R.4
Azuma, M.5
Lanier, L.L.6
Santoni, A.7
Testi, R.8
-
40
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
10.1038/380075a0, 8598911
-
Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996, 380:75-79. 10.1038/380075a0, 8598911.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
-
41
-
-
18544364918
-
Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide
-
10.1074/jbc.M106361200, 11706021
-
Mochizuki T, Asai A, Saito N, Tanaka S, Katagiri H, Asano T, Nakane M, Tamura A, Kuchino Y, Kitanaka C, Kirino T. Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide. J Biol Chem 2002, 277:2790-2797. 10.1074/jbc.M106361200, 11706021.
-
(2002)
J Biol Chem
, vol.277
, pp. 2790-2797
-
-
Mochizuki, T.1
Asai, A.2
Saito, N.3
Tanaka, S.4
Katagiri, H.5
Asano, T.6
Nakane, M.7
Tamura, A.8
Kuchino, Y.9
Kitanaka, C.10
Kirino, T.11
-
42
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
10.1074/jbc.M313561200, 14970205
-
Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R, Codogno P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 2004, 279:18384-18391. 10.1074/jbc.M313561200, 14970205.
-
(2004)
J Biol Chem
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
43
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
10.1016/j.cmet.2007.11.001, 18054315
-
Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, et al. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007, 6:458-471. 10.1016/j.cmet.2007.11.001, 18054315.
-
(2007)
Cell Metab
, vol.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
Masiero, E.4
Rudolf, R.5
Del Piccolo, P.6
Burden, S.J.7
Di Lisi, R.8
Sandri, C.9
Zhao, J.10
-
44
-
-
78649833334
-
P53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
-
10.1073/pnas.1006124107, 2972967, 20937856
-
Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci USA 2010, 107:18511-18516. 10.1073/pnas.1006124107, 2972967, 20937856.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18511-18516
-
-
Scherz-Shouval, R.1
Weidberg, H.2
Gonen, C.3
Wilder, S.4
Elazar, Z.5
Oren, M.6
-
45
-
-
34249746928
-
Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells
-
10.1038/sj.leu.2404652, 17392822
-
Liu JN, Deng R, Guo JF, Zhou JM, Feng GK, Huang ZS, Gu LQ, Zeng YX, Zhu XF. Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells. Leukemia 2007, 21:1300-1302. 10.1038/sj.leu.2404652, 17392822.
-
(2007)
Leukemia
, vol.21
, pp. 1300-1302
-
-
Liu, J.N.1
Deng, R.2
Guo, J.F.3
Zhou, J.M.4
Feng, G.K.5
Huang, Z.S.6
Gu, L.Q.7
Zeng, Y.X.8
Zhu, X.F.9
-
46
-
-
33750864014
-
Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis
-
10.1038/sj.onc.1209686, 16715131
-
Deng R, Li W, Guan Z, Zhou JM, Wang Y, Mei YP, Li MT, Feng GK, Huang W, Liu ZC, et al. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene 2006, 25:7070-7077. 10.1038/sj.onc.1209686, 16715131.
-
(2006)
Oncogene
, vol.25
, pp. 7070-7077
-
-
Deng, R.1
Li, W.2
Guan, Z.3
Zhou, J.M.4
Wang, Y.5
Mei, Y.P.6
Li, M.T.7
Feng, G.K.8
Huang, W.9
Liu, Z.C.10
-
47
-
-
31544441946
-
Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines
-
Zhou JM, Zhu XF, Lu YJ, Deng R, Huang ZS, Mei YP, Wang Y, Huang WL, Liu ZC, Gu LQ, Zeng YX. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene 2006, 25:503-511.
-
(2006)
Oncogene
, vol.25
, pp. 503-511
-
-
Zhou, J.M.1
Zhu, X.F.2
Lu, Y.J.3
Deng, R.4
Huang, Z.S.5
Mei, Y.P.6
Wang, Y.7
Huang, W.L.8
Liu, Z.C.9
Gu, L.Q.10
Zeng, Y.X.11
-
48
-
-
17844405853
-
Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a component from Chinese herbal medicine
-
10.1124/mol.104.009894, 15703376
-
Zhu XF, Xie BF, Zhou JM, Feng GK, Liu ZC, Wei XY, Zhang FX, Liu MF, Zeng YX. Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a component from Chinese herbal medicine. Mol Pharmacol 2005, 67:1444-1450. 10.1124/mol.104.009894, 15703376.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1444-1450
-
-
Zhu, X.F.1
Xie, B.F.2
Zhou, J.M.3
Feng, G.K.4
Liu, Z.C.5
Wei, X.Y.6
Zhang, F.X.7
Liu, M.F.8
Zeng, Y.X.9
-
49
-
-
23744437996
-
C-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells
-
10.1182/blood-2004-10-3819, 1895189, 15890690
-
Gururajan M, Chui R, Karuppannan AK, Ke J, Jennings CD, Bondada S. c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells. Blood 2005, 106:1382-1391. 10.1182/blood-2004-10-3819, 1895189, 15890690.
-
(2005)
Blood
, vol.106
, pp. 1382-1391
-
-
Gururajan, M.1
Chui, R.2
Karuppannan, A.K.3
Ke, J.4
Jennings, C.D.5
Bondada, S.6
-
50
-
-
0029741890
-
Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy
-
10.1093/carcin/17.8.1595, 8761415
-
Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Hermann RS. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 1996, 17:1595-1607. 10.1093/carcin/17.8.1595, 8761415.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1595-1607
-
-
Bursch, W.1
Ellinger, A.2
Kienzl, H.3
Torok, L.4
Pandey, S.5
Sikorska, M.6
Walker, R.7
Hermann, R.S.8
-
51
-
-
0038743077
-
Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
-
Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003, 63:2103-2108.
-
(2003)
Cancer Res
, vol.63
, pp. 2103-2108
-
-
Kanzawa, T.1
Kondo, Y.2
Ito, H.3
Kondo, S.4
Germano, I.5
-
52
-
-
78149426794
-
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
-
10.2217/fon.10.116, 3071292, 21062159
-
Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol 2010, 6:1603-1624. 10.2217/fon.10.116, 3071292, 21062159.
-
(2010)
Future Oncol
, vol.6
, pp. 1603-1624
-
-
Ponnusamy, S.1
Meyers-Needham, M.2
Senkal, C.E.3
Saddoughi, S.A.4
Sentelle, D.5
Selvam, S.P.6
Salas, A.7
Ogretmen, B.8
-
53
-
-
0028846952
-
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells
-
10.1074/jbc.270.45.27326, 7592995
-
Sawai H, Okazaki T, Yamamoto H, Okano H, Takeda Y, Tashima M, Sawada H, Okuma M, Ishikura H, Umehara H, et al. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J Biol Chem 1995, 270:27326-27331. 10.1074/jbc.270.45.27326, 7592995.
-
(1995)
J Biol Chem
, vol.270
, pp. 27326-27331
-
-
Sawai, H.1
Okazaki, T.2
Yamamoto, H.3
Okano, H.4
Takeda, Y.5
Tashima, M.6
Sawada, H.7
Okuma, M.8
Ishikura, H.9
Umehara, H.10
-
54
-
-
0028981358
-
Ceramide activates the stress-activated protein kinases
-
10.1074/jbc.270.39.22689, 7559390
-
Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem 1995, 270:22689-22692. 10.1074/jbc.270.39.22689, 7559390.
-
(1995)
J Biol Chem
, vol.270
, pp. 22689-22692
-
-
Westwick, J.K.1
Bielawska, A.E.2
Dbaibo, G.3
Hannun, Y.A.4
Brenner, D.A.5
-
55
-
-
0030830687
-
Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells
-
Ohmori M, Shirasawa S, Furuse M, Okumura K, Sasazuki T. Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. Cancer Res 1997, 57:4714-4717.
-
(1997)
Cancer Res
, vol.57
, pp. 4714-4717
-
-
Ohmori, M.1
Shirasawa, S.2
Furuse, M.3
Okumura, K.4
Sasazuki, T.5
-
56
-
-
40549093944
-
PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans
-
10.1172/JCI32053, 2230655, 18259613
-
Hu G, Hacham M, Waterman SR, Panepinto J, Shin S, Liu X, Gibbons J, Valyi-Nagy T, Obara K, Jaffe HA, et al. PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest 2008, 118:1186-1197. 10.1172/JCI32053, 2230655, 18259613.
-
(2008)
J Clin Invest
, vol.118
, pp. 1186-1197
-
-
Hu, G.1
Hacham, M.2
Waterman, S.R.3
Panepinto, J.4
Shin, S.5
Liu, X.6
Gibbons, J.7
Valyi-Nagy, T.8
Obara, K.9
Jaffe, H.A.10
-
57
-
-
77950501014
-
MTOR regulation of autophagy
-
10.1016/j.febslet.2010.01.017, 2846630, 20083114
-
Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010, 584:1287-1295. 10.1016/j.febslet.2010.01.017, 2846630, 20083114.
-
(2010)
FEBS Lett
, vol.584
, pp. 1287-1295
-
-
Jung, C.H.1
Ro, S.H.2
Cao, J.3
Otto, N.M.4
Kim, D.H.5
-
58
-
-
43949109275
-
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
-
Mammucari C, Schiaffino S, Sandri M. Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 2008, 4:524-526.
-
(2008)
Autophagy
, vol.4
, pp. 524-526
-
-
Mammucari, C.1
Schiaffino, S.2
Sandri, M.3
-
59
-
-
35848938724
-
Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy
-
Shinojima N, Yokoyama T, Kondo Y, Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007, 3:635-637.
-
(2007)
Autophagy
, vol.3
, pp. 635-637
-
-
Shinojima, N.1
Yokoyama, T.2
Kondo, Y.3
Kondo, S.4
-
60
-
-
77950912075
-
P38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stress-induced cell death and autophagy in human gingival fibroblasts
-
10.1248/bpb.33.545, 20410583
-
Kim DS, Kim JH, Lee GH, Kim HT, Lim JM, Chae SW, Chae HJ, Kim HR. p38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stress-induced cell death and autophagy in human gingival fibroblasts. Biol Pharm Bull 2010, 33:545-549. 10.1248/bpb.33.545, 20410583.
-
(2010)
Biol Pharm Bull
, vol.33
, pp. 545-549
-
-
Kim, D.S.1
Kim, J.H.2
Lee, G.H.3
Kim, H.T.4
Lim, J.M.5
Chae, S.W.6
Chae, H.J.7
Kim, H.R.8
-
61
-
-
77749254802
-
P38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting
-
10.1152/ajpcell.00192.2009, 2838571, 19955483
-
McClung JM, Judge AR, Powers SK, Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol 2010, 298:C542-549. 10.1152/ajpcell.00192.2009, 2838571, 19955483.
-
(2010)
Am J Physiol Cell Physiol
, vol.298
-
-
McClung, J.M.1
Judge, A.R.2
Powers, S.K.3
Yan, Z.4
-
62
-
-
0035984912
-
ROS, stress-activated kinases and stress signaling in cancer
-
10.1093/embo-reports/kvf094, 1084107, 11991946
-
Benhar M, Engelberg D, Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep 2002, 3:420-425. 10.1093/embo-reports/kvf094, 1084107, 11991946.
-
(2002)
EMBO Rep
, vol.3
, pp. 420-425
-
-
Benhar, M.1
Engelberg, D.2
Levitzki, A.3
-
63
-
-
34147210988
-
Hydrogen peroxide sensing and signaling
-
10.1016/j.molcel.2007.03.016, 17434122
-
Veal EA, Day AM, Morgan BA. Hydrogen peroxide sensing and signaling. Mol Cell 2007, 26:1-14. 10.1016/j.molcel.2007.03.016, 17434122.
-
(2007)
Mol Cell
, vol.26
, pp. 1-14
-
-
Veal, E.A.1
Day, A.M.2
Morgan, B.A.3
-
64
-
-
77957681100
-
ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
-
10.4161/auto.6.7.12113, 20505317
-
Dewaele M, Maes H, Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010, 6:838-854. 10.4161/auto.6.7.12113, 20505317.
-
(2010)
Autophagy
, vol.6
, pp. 838-854
-
-
Dewaele, M.1
Maes, H.2
Agostinis, P.3
-
65
-
-
78650890352
-
Regulation of autophagy by ROS: physiology and pathology
-
10.1016/j.tibs.2010.07.007, 20728362
-
Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011, 36:30-38. 10.1016/j.tibs.2010.07.007, 20728362.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 30-38
-
-
Scherz-Shouval, R.1
Elazar, Z.2
-
66
-
-
77955423341
-
Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation
-
10.1371/journal.pone.0009996, 2848860, 20368806
-
Wong CH, Iskandar KB, Yadav SK, Hirpara JL, Loh T, Pervaiz S. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. PLoS One 2010, 5:e9996. 10.1371/journal.pone.0009996, 2848860, 20368806.
-
(2010)
PLoS One
, vol.5
-
-
Wong, C.H.1
Iskandar, K.B.2
Yadav, S.K.3
Hirpara, J.L.4
Loh, T.5
Pervaiz, S.6
-
67
-
-
58749105634
-
Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway
-
10.1016/j.canlet.2008.09.042, 19010591
-
Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK. Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett 2009, 275:54-60. 10.1016/j.canlet.2008.09.042, 19010591.
-
(2009)
Cancer Lett
, vol.275
, pp. 54-60
-
-
Liu, B.1
Cheng, Y.2
Zhang, B.3
Bian, H.J.4
Bao, J.K.5
-
68
-
-
80052391019
-
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells
-
10.1016/j.taap.2011.06.024, 21767558
-
Son YO, Wang X, Hitron JA, Zhang Z, Cheng S, Budhraja A, Ding S, Lee JC, Shi X. Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol 2011, 255:287-296. 10.1016/j.taap.2011.06.024, 21767558.
-
(2011)
Toxicol Appl Pharmacol
, vol.255
, pp. 287-296
-
-
Son, Y.O.1
Wang, X.2
Hitron, J.A.3
Zhang, Z.4
Cheng, S.5
Budhraja, A.6
Ding, S.7
Lee, J.C.8
Shi, X.9
-
69
-
-
43249104789
-
Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway
-
10.1182/blood-2007-08-106336, 18270325
-
Chen CL, Lin CF, Chang WT, Huang WC, Teng CF, Lin YS. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood 2008, 111:4365-4374. 10.1182/blood-2007-08-106336, 18270325.
-
(2008)
Blood
, vol.111
, pp. 4365-4374
-
-
Chen, C.L.1
Lin, C.F.2
Chang, W.T.3
Huang, W.C.4
Teng, C.F.5
Lin, Y.S.6
-
70
-
-
34848845834
-
Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells
-
10.1016/j.ygyno.2007.05.034, 17617446
-
Wang ZH, Xu L, Duan ZL, Zeng LQ, Yan NH, Peng ZL. Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells. Gynecol Oncol 2007, 107:107-113. 10.1016/j.ygyno.2007.05.034, 17617446.
-
(2007)
Gynecol Oncol
, vol.107
, pp. 107-113
-
-
Wang, Z.H.1
Xu, L.2
Duan, Z.L.3
Zeng, L.Q.4
Yan, N.H.5
Peng, Z.L.6
-
71
-
-
34447099450
-
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
-
10.1016/j.cell.2007.05.021, 17632063
-
Nakatogawa H, Ichimura Y, Ohsumi Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 2007, 130:165-178. 10.1016/j.cell.2007.05.021, 17632063.
-
(2007)
Cell
, vol.130
, pp. 165-178
-
-
Nakatogawa, H.1
Ichimura, Y.2
Ohsumi, Y.3
|